Towards a Single-Molecule Pharmacology of G-Protein-Coupled Receptors: Understanding Receptor Dynamics to Develop Innovative Drugs

Calebiro, Davide (Principal Investigator)

Metabolism and Systems Research

Short title	Towards a Single-Molecule Pharmacology of G-Protein-Coupled Receptors: Understanding Receptor Dynamics to Develop Innovative Drugs
Status	Active
Effective start/end date	12/03/19 → 12/09/25

Funding

THE WELLCOME TRUST

8 Article

Thyroid-stimulating hormone pulses finely tune thyroid hormone release and TSH receptor transduction
Guillou, A., Kemkem, Y., Lafont, C., Fontanaud, P., Calebiro, D., Campos, P., Bonnefont, X., Fiordelisio-Coll, T., Wang, Y., Brûlé, E., Bernard, D. J., Le Tissier, P., Steyn, F. & Mollard, P., Jan 2024, In: Endocrinology. 165, 1, 9 p., bqad164.
Research output: Contribution to journal › Article › peer-review

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Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane
Jobin, M-L., Siddig, S., Koszegi, Z., Lanoiselée, Y., Khayenko, V., Sungkaworn, T., Werner, C., Seier, K., Misigaiski, C., Mantovani, G., Sauer, M., Maric, H. M. & Calebiro, D., 3 Jan 2023, In: Nature Communications. 14, 1, 14 p., 34.
Research output: Contribution to journal › Article › peer-review

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Plasma membrane preassociation drives β-arrestin coupling to receptors and activation
Grimes, J., Koszegi, Z., Lanoiselee, Y., Miljus, T., O'Brien, S. L., Stepniewski, T. M., Medel-Lacruz, B., Baidya, M., Makarova, M., Mistry, R., Goulding, J., Drube, J., Hoffmann, C., Owen, D. M., Shukla, A. K., Selent, J., Hill, S. J. & Calebiro, D., 11 May 2023, In: Cell. 186, 10, p. 2238-2255.e20 39 p.
Research output: Contribution to journal › Article › peer-review

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