The Role of Hepatitis C Virus Glycoprotein-Receptor Polymorphism in Viral Pathogenesis

Research output

Research output per year 2010 2011 2012 2013 2014 2015 2017

• 36 Article
• 1 Editorial

Research output per year

Research output per year

Search results

• 2017

  Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication

  Farquhar, M. J., Humphreys, I. S., Rudge, S. A., Wilson, G. K., Bhattacharya, B., Ciaccia, M., Hu, K., Zhang, Q., Mailly, L., Reynolds, G. M., Ashcroft, M., Balfe, P., Baumert, T. F., Roessler, S., Wakelam, M. J. O. & McKeating, J. A., 23 Jan 2017, (E-pub ahead of print) In: Journal of Hepatology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lysophosphatidic Acid Receptors 100%
  • Virus Replication 66%
  • Hepacivirus 61%
  • lysophosphatidic acid 49%
  • Hepatocellular Carcinoma 29%
  23 Citations (Scopus)

  392 Downloads (Pure)

• High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end stage liver disease

  Balfe, P., McKeating, J., Hedegaard, D., Reynolds, G., Hu, K., Wilhelm, A. & Kelly, D., 1 Jan 2017, In: Journal of Hepatology. 66, p. 28-38 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • End Stage Liver Disease 100%
  • Hepacivirus 78%
  • Liver 43%
  • Interferons 35%
  • RNA 26%
  15 Citations (Scopus)

  178 Downloads (Pure)

• TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway

  Fletcher, N., Clark, A. R., Balfe, P. & McKeating, J., 1 Mar 2017, In: Journal of General Virology. 98, 3, p. 405-412

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Myosin-Light-Chain Kinase 100%
  • Virus Internalization 89%
  • Hepacivirus 67%
  • Tight Junctions 23%
  • Liver Diseases 17%
  7 Citations (Scopus)

  159 Downloads (Pure)
• 2016

  Deep sequencing of hepatitis C virus reveals genetic compartmentalization in cerebrospinal fluid from cognitively impaired patients

  Tully, D. C., Hjerrild, S., Leutscher, P. D., Renvillard, S. G., Ogilvie, C. B., Bean, D. J., Videbech, P., Allen, T. M., McKeating, J. A. & Fletcher, N. F., 5 Apr 2016, In: Liver International.

  Research output: Contribution to journal › Article › peer-review

  • High-Throughput Nucleotide Sequencing 100%
  • Hepacivirus 96%
  • Cerebrospinal Fluid 90%
  • Central Nervous System 57%
  • Cognitive Dysfunction 53%
  14 Citations (Scopus)

• Lentiviral hepatitis B pseudotype entry requires NTCP and additional hepatocyte-specific factors

  Meredith, L. W., Hu, K., Cheng, X., Howard, C. R., Baumert, T. F., Balfe, P., van de Graaf, K. F., Protzer, U. & McKeating, J. A., Jan 2016, In: Journal of General Virology. 97, 1, p. 121-127

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepatitis B virus 100%
  • Hepatitis B 99%
  • Hepatocytes 86%
  • Virus Internalization 63%
  • Infections 49%
  11 Citations (Scopus)

  272 Downloads (Pure)

• Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

  Desombere, I., Fafi-Kremer, S., Van Houtte, F., Pessaux, P., Farhoudi, A., Heydmann, L., Verhoye, L., Cole, S., McKeating, J. A., Leroux-Roels, G., Baumert, T. F., Patel, A. H. & Meuleman, P., Apr 2016, In: Hepatology. 63, 4, p. 1120-1134 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepacivirus 100%
  • Anti-Idiotypic Antibodies 90%
  • Monoclonal Antibodies 78%
  • Liver Transplantation 36%
  • End Stage Liver Disease 31%
  26 Citations (Scopus)
• 2015

  Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

  Mathiesen, C. K., Prentoe, J., Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, J. M. & Bukh, J., Aug 2015, In: Journal of virology. 89, 15, p. 7758-75 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis C virus 100%
  • Hepacivirus 63%
  • Genotype 49%
  • mutation 47%
  • genotype 40%
  15 Citations (Scopus)

• Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

  Mailly, L., Xiao, F., Lupberger, J., Wilson, G. K., Aubert, P., Duong, F. H. T., Calabrese, D., Leboeuf, C., Fofana, I., Thumann, C., Bandiera, S., Lütgehetmann, M., Volz, T., Davis, C., Harris, H. J., Mee, C. J., Girardi, E., Chane-Woon-Ming, B., Ericsson, M., Fletcher, N., & 14 othersBartenschlager, R., Pessaux, P., Vercauteren, K., Meuleman, P., Villa, P., Kaderali, L., Pfeffer, S., Heim, M. H., Neunlist, M., Zeisel, M. B., Dandri, M., McKeating, J. A., Robinet, E. & Baumert, T. F., May 2015, In: Nature Biotechnology. 33, 5, p. 549-554 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Monoclonal antibodies 100%
  • Claudin-1 91%
  • Viruses 75%
  • Clearance 69%
  • Tight Junction Proteins 62%
  94 Citations (Scopus)

• Effect of scavenger receptor BI antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation

  Rowe, I. A., Tully, D. C., Armstrong, M. J., Parker, R., Guo, K., Barton, D., Morse, G. D., Venuto, C. S., Ogilvie, C. B., Hedegaard, D. L., McKelvy, J. F., Wong-Staal, F., Allen, T. M., Balfe, P., McKeating, J. A. & Mutimer, D. J., 2015, In: Liver Transplantation.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ITX-5061 100%
  • Scavenger Receptors 57%
  • Hepacivirus 40%
  • Liver Transplantation 40%
  • Virus Diseases 32%
  15 Citations (Scopus)

  261 Downloads (Pure)

• Hepatitis C virus infection of cholangiocarcinoma cell lines

  Fletcher, N. F., Humphreys, E. A., Jennings, E., Osburn, W., Lissauer, S., Wilson, G. K., Van Ijzendoorn, S. C., Baumert, T. F., Balfe, P., Afford, S. & Mckeating, J., Jun 2015, In: Journal of General Virology. 96, 6, p. 1380-1388 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cholangiocarcinoma 100%
  • Hepacivirus 80%
  • Virus Diseases 63%
  • Cell Line 51%
  • Virus Replication 49%
  6 Citations (Scopus)

  162 Downloads (Pure)

• Permissivity of primary hepatocytes and hepatoma cell lines to support hepatitis C virus infection

  Wilson, G. K., Farquhar, M. J., Meredith, L., Dhawan, A., Mitry, R., Balfe, P. & McKeating, J. A., 1 Jun 2015, In: Journal of General Virology. 96, 6, p. 1369-1373 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepacivirus 100%
  • Hepatocytes 90%
  • Hepatocellular Carcinoma 86%
  • Virus Diseases 79%
  • Cell Line 63%
  1 Citation (Scopus)

  140 Downloads (Pure)
• 2014

  Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner

  Fletcher, N. F., Sutaria, R., Jo, J., Barnes, A., Blahova, M., Meredith, L. W., Cosset, F., Curbishley, S. M., Adams, D. H., Bertoletti, A. & Mckeating, J. A., 1 Apr 2014, In: Hepatology. 59, 4, p. 1320-1330

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Virus Internalization 100%
  • Hepacivirus 74%
  • Tumor Necrosis Factor-alpha 57%
  • Macrophages 56%
  • Innate Immunity 24%
  33 Citations (Scopus)

  204 Downloads (Pure)

• A role for CD81 and hepatitis C virus in hepatoma mobility

  Brimacombe, C. L., Wilson, G. K., Hübscher, S. G., McKeating, J. A. & Farquhar, M. J., 24 Mar 2014, In: Viruses. 6, 3, p. 1454-72 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepacivirus 100%
  • Tetraspanins 90%
  • Hepatocellular Carcinoma 86%
  • radixin 23%
  • moesin 22%
  8 Citations (Scopus)

• Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses

  Chmielewska, A. M., Naddeo, M., Capone, S., Ammendola, V., Hu, K., Meredith, L., Verhoye, L., Rychlowska, M., Rappuoli, R., Ulmer, J. B., Colloca, S., Nicosia, A., Cortese, R., Leroux-Roels, G., Balfe, P., Bienkowska-Szewczyk, K., Meuleman, P., McKeating, J. A. & Folgori, A., May 2014, In: Journal of virology. 88, 10, p. 5502-10 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis C virus 100%
  • Viral Envelope Proteins 95%
  • neutralizing antibodies 79%
  • Adenoviridae 79%
  • Neutralizing Antibodies 68%
  40 Citations (Scopus)

• Editorial overview - virus entry: towards reality - refining models of virus entry

  Marsh, M. & McKeating, J. A., Feb 2014, In: Current Opinion in Virology. 4, p. v-vi 2 p.

  Research output: Contribution to journal › Editorial

• Entry of hepatitis B and C viruses - recent progress and future impact

  Baumert, T. F., Meredith, L., Ni, Y., Felmlee, D. J., McKeating, J. A. & Urban, S., Feb 2014, In: Current Opinion in Virology. 4, p. 58-65 8 p.

  Research output: Contribution to journal › Article

  • Life Cycle Stages 100%
  • Hepatitis C 95%
  • Hepatitis B virus 90%
  • Viruses 62%
  • Virology 60%
  39 Citations (Scopus)

• Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions

  Wilson, G. K., Tennant, D. A. & Mckeating, J. A., Dec 2014, In: Journal of Hepatology. 61, 6, p. 1397-1406 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Liver Diseases 100%
  • Hepatocellular Carcinoma 95%
  • Hypoxia 93%
  • Transcription Factors 89%
  • Direction compound 86%
  80 Citations (Scopus)

  243 Downloads (Pure)

• Paracrine signals from liver sinusoidal endothelium regulate hepatitis C virus replication

  Rowe, I. A., Galsinh, S. K., Wilson, G. K., Parker, R., Durant, S., Lazar, C., Branza-Nichita, N., Bicknell, R., Adams, D. H., Balfe, P. & McKeating, J. A., Feb 2014, In: Hepatology. 59, 2, p. 375–384

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Bone Morphogenetic Protein 4 100%
  • Virus Replication 70%
  • Hepacivirus 64%
  • Endothelium 61%
  • Liver 35%
  25 Citations (Scopus)

  307 Downloads (Pure)

• The past, present and future of neutralizing antibodies for hepatitis C virus

  Ball, J. K., Tarr, A. W. & Mckeating, J. A., 1 May 2014, In: Antiviral Research. 105, p. 100-111

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neutralizing Antibodies 100%
  • Hepacivirus 92%
  • Antibodies 41%
  • Virus Diseases 36%
  • Drug Combinations 25%
  89 Citations (Scopus)

  259 Downloads (Pure)
• 2013

  An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission

  Tarr, A. W., Lafaye, P., Meredith, L., Damier-Piolle, L., Urbanowicz, R. A., Meola, A., Jestin, J-L., Brown, R. J. P., McKeating, J. A., Rey, F. A., Ball, J. K. & Krey, T., Sept 2013, In: Hepatology. 58, 3, p. 932-9 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Single-Domain Antibodies 100%
  • New World Camelids 99%
  • Virus Internalization 83%
  • Hepacivirus 62%
  • Epitopes 24%
  53 Citations (Scopus)

• Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission

  Meredith, L. W., Zitzmann, N. & McKeating, J., 1 Dec 2013, In: Antiviral Research. 100, 3, p. 636-639

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepacivirus 100%
  • Genotype 20%
  • Viruses 19%
  • Virus Release 9%
  • Virus Assembly 9%
  10 Citations (Scopus)

  251 Downloads (Pure)

• Early infection events highlight the limited transmissibility of hepatitis C virus in vitro

  Meredith, L. W., Harris, H. J., Wilson, G. K., Fletcher, N. F., Balfe, P. & McKeating, J. A., Jun 2013, In: Journal of Hepatology. 58, 6, p. 1074-80 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepacivirus 100%
  • Infections 51%
  • In Vitro Techniques 47%
  • Viruses 19%
  • Satellite Viruses 9%
  17 Citations (Scopus)

• Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies

  Fofana, I., Zona, L., Thumann, C., Heydmann, L., Durand, S. C., Lupberger, J., Blum, H. E., Pessaux, P., Gondeau, C., Reynolds, G. M., McKeating, J. A., Grunert, F., Thompson, J., Zeisel, M. B. & Baumert, T. F., Sept 2013, In: Journal of virology. 87, 18, p. 10405-10 6 p.

  Research output: Contribution to journal › Article › peer-review

  • claudin 6 100%
  • Hepatitis C virus 76%
  • Claudins 73%
  • Hepacivirus 48%
  • hepatocytes 46%
  25 Citations (Scopus)

• HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex

  Zona, L., Lupberger, J., Sidahmed-Adrar, N., Thumann, C., Harris, H. J., Barnes, A., Florentin, J., Tawar, R. G., Xiao, F., Turek, M., Durand, S. C., Duong, F. H. T., Heim, M. H., Cosset, F-L., Hirsch, I., Samuel, D., Brino, L., Zeisel, M. B., Le Naour, F., McKeating, J. A., & 1 othersBaumert, T. F., 13 Mar 2013, In: Cell Host & Microbe. 13, 3, p. 302-13 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Tetraspanins 100%
  • Hepatitis C virus 99%
  • Virus Internalization 84%
  • Hepacivirus 63%
  • signal transduction 60%
  114 Citations (Scopus)

• IFITM1 is a tight junction protein that inhibits hepatitis C virus entry

  Wilkins, C., Woodward, J., Lau, D. T-Y., Barnes, A., Joyce, M., McFarlane, N., McKeating, J. A., Tyrrell, D. L. & Gale, M., Feb 2013, In: Hepatology. 57, 2, p. 461-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  • leu-13 antigen 100%
  • Tight Junction Proteins 65%
  • Virus Internalization 62%
  • Hepacivirus 46%
  • Interferons 36%
  107 Citations (Scopus)

• Production, purification and characterization of recombinant, full-length human claudin-1

  Bonander, N., Jamshad, M., Oberthür, D., Clare, M., Barwell, J., Hu, K., Farquhar, M. J., Stamataki, Z., Harris, H. J., Dierks, K., Dafforn, T. R., Betzel, C., McKeating, J. A. & Bill, R. M., 2013, In: PLoS ONE. 8, 5, p. e64517

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Claudin-1 100%
  • Proteoliposome 94%
  • Hepatitis C virus 67%
  • Oligomer 55%
  • Purification 47%
  8 Citations (Scopus)
• 2012

  Hepatitis C virus and the brain

  Fletcher, N. & McKeating, J., 1 May 2012, In: Journal of viral hepatitis. 19, 5, p. 301-306 6 p.

  Research output: Contribution to journal › Article

  • Hepacivirus 100%
  • Central Nervous System 63%
  • Brain 52%
  • Liver Diseases 36%
  • Flaviviridae 31%
  65 Citations (Scopus)

• Hepatitis C virus entry: beyond receptors.

  Meredith, L., Wilson, G., Fletcher, N. & McKeating, J., 6 Mar 2012, In: Reviews in Medical Virology.

  Research output: Contribution to journal › Article

  • Blood-Borne Pathogens 100%
  • Tetraspanins 98%
  • Zonula Occludens-1 Protein 98%
  • Claudin-1 96%
  • Occludin 87%
  70 Citations (Scopus)

• Hepatitis C Virus Envelope Glycoprotein Fitness Defines Virus Population Composition following Transmission to a New Host

  Brown, R. J. P., Hudson, N., Wilson, G., Rehman, S. U., Jabbari, S., Hu, K., Tarr, A. W., Borrow, P., Joyce, M., Lewis, J., Zhu, L. F., Law, M., Kneteman, N., Tyrrell, D. L., McKeating, J. A. & Ball, J. K., Nov 2012, In: Journal of virology. 86, 22, p. 11956-66 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepatitis C virus 100%
  • Hepacivirus 63%
  • Glycoproteins 58%
  • inoculum 58%
  • glycoproteins 58%
  28 Citations (Scopus)

  152 Downloads (Pure)

• Hepatitis C virus induces CD81 and claudin-1 endocytosis.

  Farquhar, M., Hu, K., Harris, H., Davis, C., Brimacombe, C., Fletcher, S., Baumert, TF., Rappoport, J., Balfe, P. & McKeating, J., 8 Feb 2012, In: Journal of virology.

  Research output: Contribution to journal › Article

  • Hepatitis C virus 100%
  • Claudin-1 98%
  • endocytosis 77%
  • Endocytosis 69%
  • Hepacivirus 63%
  90 Citations (Scopus)

• In silico directed mutagenesis identifies the CD81/claudin-1 hepatitis C virus receptor interface

  Davis, C., Harris, H. J., Hu, K., Drummer, H. E., McKeating, J. A., Mullins, J. G. L. & Balfe, P., Dec 2012, In: Cellular Microbiology. 14, 12, p. 1892-903 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Claudin-1 100%
  • Virus Receptors 95%
  • Mutagenesis 69%
  • Computer Simulation 66%
  • Hepacivirus 64%
  28 Citations (Scopus)

  223 Downloads (Pure)
• 2011

  A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration.

  Wilson, G., Brimacombe, C., Rowe, I., Reynolds, G., Fletcher, N., Stamataki, Z., Bhogal, R., Simões, M., Ashcroft, M., Afford, S., Mitry, RR., Dhawan, A., Mee, CJ., Hubscher, S., Balfe, P. & McKeating, J., 15 Dec 2011, In: Journal of Hepatology.

  Research output: Contribution to journal › Article

  • Hypoxia-Inducible Factor 1 100%
  • Hepacivirus 73%
  • Hepatocellular Carcinoma 63%
  • Glycoproteins 33%
  • Transforming Growth Factor beta 18%
  53 Citations (Scopus)

• Hepatitis C virus entry and the tetraspanin CD81.

  Farquhar, M., Harris, H. & McKeating, J., 1 Apr 2011, In: Biochemical Society Transactions. 39, 2, p. 532-6 5 p.

  Research output: Contribution to journal › Article

  • Tetraspanins 100%
  • Virus Internalization 84%
  • Hepacivirus 63%
  • Diffusion 41%
  • Protein 28%
  33 Citations (Scopus)

• Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier.

  Fletcher, N., Wilson, G., Murray, J., Hu, K., Lewis, A., Reynolds, G., Stamataki, Z., Meredith, L., Rowe, I., Luo, G., Lopez-Ramirez, MA., Baumert, TF., Weksler, B., Couraud, PO., Kim, KS., Romero, IA., Jopling, C., Morgello, S., Balfe, P. & McKeating, J., 30 Nov 2011, In: Gastroenterology. 142, 3, p. 634-643,e1-e6 16 p.

  Research output: Contribution to journal › Article

  • Blood-Brain Barrier 100%
  • Hepacivirus 95%
  • Endothelial Cells 76%
  • Virus Internalization 38%
  • Brain 35%
  153 Citations (Scopus)

• Naturally occurring antibodies recognizing linear epitopes in the amino-terminus of the hepatitis C virus E2 protein confer non-interfering, additive neutralization.

  Tarr, AW., Urbanowicz, RA., Jayaraj, D., Brown, RJ., McKeating, J., Irving, WL. & Ball, JK., 14 Dec 2011, In: Journal of virology.

  Research output: Contribution to journal › Article

  • Hepatitis C virus 100%
  • neutralization 71%
  • epitopes 66%
  • Hepacivirus 63%
  • Epitopes 59%
  49 Citations (Scopus)

• Structural characterization of CD81-Claudin-1 hepatitis C virus receptor complexes.

  Bonander, N., Jamshad, M., Hu, K., Farquhar, M., Stamataki, Z., Balfe, P., McKeating, J. & Bill, RM., 1 Apr 2011, In: Biochemical Society Transactions. 39, 2, p. 537-40 4 p.

  Research output: Contribution to journal › Article

  • Claudin-1 100%
  • Virus Receptors 95%
  • Tetraspanins 76%
  • Hepacivirus 64%
  • Claudins 48%
  5 Citations (Scopus)
• 2010

  Neutralizing antibody resistant hepatitis C virus cell-to-cell transmission.

  Brimacombe, C., Grove, J., Meredith, L., Hu, K., Syder, AJ., Flores, MV., Timpe, JM., Krieger, SE., Baumert, TF., Tellinghuisen, TL., Wong-Staal, F., Balfe, P. & McKeating, J., 20 Oct 2010, In: Journal of virology.

  Research output: Contribution to journal › Article › peer-review

  File

  • Hepatitis C virus 100%
  • neutralizing antibodies 79%
  • Neutralizing Antibodies 68%
  • Hepacivirus 63%
  • cells 21%
  181 Citations (Scopus)

  178 Downloads (Pure)