Targeting Periplasmic Adaptor Proteins to Improve Efficacy

Research output

Research output per year 2019 2019 2021 2022 2023

• 11 Article

Research output per year

Research output per year

Search results

• 2023

  Chelating silica nanoparticles for efficient antibiotic delivery and particle imaging in Gram-negative bacteria

  Muguruza, A. R., di Maio, A., Hodges, N. J., Blair, J. & Pikramenou, Z., 7 May 2023, In: Nanoscale Advances. 5, 9, p. 2453-2461 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Silicon Dioxide 100%
  • Gram-Negative Bacteria 88%
  • Nanoparticles 78%
  • Anti-Bacterial Agents 57%
  • Ruthenium 55%
  44 Downloads (Pure)
• 2022

  A role for the periplasmic adaptor protein AcrA in vetting substrate access to the RND efflux transporter AcrB

  Alav, I., Bavro, V. N. & Blair, J. M. A., 19 Mar 2022, In: Scientific Reports. 12, 1, 4752.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Periplasmic Proteins 100%
  • Microbial Drug Resistance 26%
  • Membrane Transport Proteins 16%
  • Active Biological Transport 16%
  • Membranes 15%
  45 Downloads (Pure)

• EnvR is a potent repressor of acrAB transcription in Salmonella

  Blair, J. M. A., Siasat, P., McNeil, H. E., Colclough, A., Ricci, V., Lawler, A. J., Abdalaal, H., Buckner, M. M. C., Baylay, A., Busby, S. J. & Piddock, L. J. V., 29 Oct 2022, (E-pub ahead of print) In: Journal of Antimicrobial Chemotherapy. dkac364.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Salmonella 100%
  • RNA-Seq 55%
  • Electrophoretic Mobility Shift Assay 26%
  • Eukaryotic Cells 25%
  • Microbial Drug Resistance 23%
  5 Downloads (Pure)

• Mathematical modelling highlights the potential for genetic manipulation as an adjuvant to counter efflux-mediated MDR in salmonella

  Youlden, G., McNeil, H. E., Blair, J. M. A., Jabbari, S. & King, J. R., 5 Apr 2022, In: Bulletin of Mathematical Biology. 84, 5, 38 p., 56.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pump 100%
  • Adjuvant 97%
  • multiple drug resistance 91%
  • salmonella 88%
  • Resistance 82%
  46 Downloads (Pure)

• The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria

  Blair, J. M. A., Zeth, K., Bavro, V. N. & Sancho-Vaello, E., 24 Jun 2022, (E-pub ahead of print) In: FEMS Microbiology Reviews. 2022, p. 1-28 28 p., fuac032.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gram-Negative Bacteria 100%
  • Peptides 63%
  • Bacteria 13%
  • Extracellular Space 11%
  • Microbial Drug Resistance 9%
  34 Downloads (Pure)
• 2021

  Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells

  Whittle, E., McNeil, H., Trampari, E., Webber, M., Overton, T. & Blair, J., 12 Oct 2021, In: mBio. 12, 5, e02608-21.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ethidium 100%
  • Permeability 66%
  • Anti-Bacterial Agents 63%
  • Growth 39%
  • Bacterial Infections 36%
  151 Downloads (Pure)

• Interchangeability of periplasmic adaptor proteins AcrA and AcrE in forming functional efflux pumps with AcrD in Salmonella enterica serovar Typhimurium

  Alav, I., Bavro, V. N. & Blair, J., 1 Oct 2021, In: Journal of Antimicrobial Chemotherapy. 76, 10, p. 2558-2564 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Periplasmic Proteins 100%
  • Salmonella enterica 80%
  • Serogroup 59%
  • Salmonella 19%
  • Membranes 11%
  81 Downloads (Pure)

• Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria

  Alav, I., Kobylka, J., Kuth, M. S., Pos, K. M., Picard, M., Blair, J. M. A. & Bavro, V. N., 12 May 2021, In: Chemical Reviews. 121, 9, p. 5479-5596 118 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • Pump 58%
  • Communication 54%
  140 Downloads (Pure)
• 2019

  Candida albicans enhances meropenem tolerance of Pseudomonas aeruginosa in a dual-species biofilm

  Alam, F., Catlow, D., Di Maio, A., Blair, J. & Hall, R., 22 Dec 2019, (E-pub ahead of print) In: Journal of Antimicrobial Chemotherapy. p. 1-11 11 p., dkz514.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Meropenem 100%
  • Candida albicans 82%
  • Biofilms 79%
  • Pseudomonas aeruginosa 75%
  • Mannans 46%
  7 Citations (Scopus)

  184 Downloads (Pure)

• Flow cytometric analysis of efflux by dye accumulation

  Whittle, E. E., Legood, S. W., Alav, I., Dulyayangkul, P., Overton, T. W. & Blair, J. M. A., 4 Oct 2019, In: Frontiers in Microbiology. 10, 10 p., 2319.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ethidium 100%
  • Coloring Agents 89%
  • Fluorescence 25%
  • Population 18%
  • Gram-Positive Bacteria 17%
  6 Citations (Scopus)

  158 Downloads (Pure)

• Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance

  McNeil, H., Alav, I., Corona Torres, R., Rossiter, A., Laycock, E., Legood, S., Kaur, I., Davies, M., Wand, M., Webber, M., Bavro, V. & Blair, J., 26 Dec 2019, In: PLoS pathogens. 15, 12, e1008101.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Periplasmic Proteins 100%
  • antibiotic resistance 63%
  • pumps 61%
  • transporters 56%
  • protein binding 55%
  8 Citations (Scopus)

  211 Downloads (Pure)