Novel hybrid anti-MRSA antibiotics from manipulation of the mupirocin and thiomarinol biosynthetic pathways

  • Thomas, Chris (Principal Investigator)
  • Winn, Peter (Co-Investigator)

Search results

  • 2019

    Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586

    Connolly, J., Wilson, A., Macioszek, M., Song, Z., Wang, L., Mohammad, H., Yadav, M., di Martino, M., Litchfield, C., Hothersall, J., Haines, A., Stephens, E., Crump, M. P., Willis, C. L., Simpson, T. J., Winn, P. & Thomas, C., May 2019, In: Scientific Reports. 9, 1, 1542.

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    3 Citations (Scopus)
    172 Downloads (Pure)
  • 2018

    Fine tuning of antibiotic activity by a tailoring hydroxylase in a trans-AT polyketide synthase pathway

    Mohammad, H., Connolly, J., Song, Z., Hothersall, J., Race, P. R., Willis, C. L., Simpson, T. J., Winn, P. & Thomas, C., 24 Jan 2018, (E-pub ahead of print) In: ChemBioChem. 5 p., cbic.201800036.

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  • 2017

    Selected mutations reveal new intermediates in the biosynthesis of mupirocin and the thiomarinol antibiotics

    Gao, S-S., Wang, L., Song, Z., Hothersall, J., Stevens, E. R., Connolly, J., Winn, P. J., Cox, R. J., Crump, M. P., Race, P. R., Thomas, C., Simpson, T. J. & Willis, C. L., 9 Feb 2017, (E-pub ahead of print) In: Angewandte Chemie (International Edition) . 56, 14, p. 3930-3934

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    5 Citations (Scopus)
    332 Downloads (Pure)
  • 2015

    Minimum Information about a Biosynthetic Gene cluster

    Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A., Hadjithomas, M., & 135 othersHaines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., Van Der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H. J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Müller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J. L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Süssmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., Van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E., Glöckner, F. O. & Thomas, C., 18 Aug 2015, In: Nature Chemical Biology. 11, 9, p. 625-631 7 p.

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    387 Citations (Scopus)
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  • 2014

    Antimicrobial properties of Pseudomonas strains producing the antibiotic mupirocin

    Matthijs, S., Vander Wauven, C., Cornu, B., Ye, L., Cornelis, P., Thomas, C. & Ongena, M., Oct 2014, In: Research in Microbiology. 165, 8, p. 695-704

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    12 Citations (Scopus)
    1053 Downloads (Pure)

  • Biosynthesis of mupirocin by pseudomonas fluorescens NCIMB 10586 involves parallel pathways

    Gao, S. S., Hothersall, J., Wu, JE., Murphy, A. C., Song, Z., Stephens, E. R., Thomas, C. M., Crump, M. P., Cox, R. J., Simpson, T. J. & Willis, C. L., 9 Apr 2014, In: Journal of the American Chemical Society. 136, 14, p. 5501-5507 7 p.

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    20 Citations (Scopus)
  • 2013

    A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

    Haines, A. S., Dong, X., Song, Z., Farmer, R., Williams, C., Hothersall, J., Płoskoń, E., Wattana-amorn, P., Stephens, E. R., Yamada, E., Gurney, R., Takebayashi, Y., Masschelein, J., Cox, R. J., Lavigne, R., Willis, C. L., Simpson, T. J., Crosby, J., Winn, P. J., Thomas, C. M., & 1 othersCrump, M. P., Nov 2013, In: Nature Chemical Biology. 9, 11, p. 685-692 8 p.

    Research output: Contribution to journal › Article › peer-review

    39 Citations (Scopus)