Novel hybrid anti-MRSA antibiotics from manipulation of the mupirocin and thiomarinol biosynthetic pathways

Thomas, Chris (Principal Investigator)
Winn, Peter (Co-Investigator)

Biosciences

Short title	Novel hybrid anti-MRSA antibiotics from manipulation of the mupirocin and thiomarinol biosynthetic pathways
Status	Finished
Effective start/end date	1/10/11 → 31/12/14

Funding

Biotechnology & Biological Sciences Research Council

7 Article

Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586
Connolly, J., Wilson, A., Macioszek, M., Song, Z., Wang, L., Mohammad, H., Yadav, M., di Martino, M., Litchfield, C., Hothersall, J., Haines, A., Stephens, E., Crump, M. P., Willis, C. L., Simpson, T. J., Winn, P. & Thomas, C., May 2019, In: Scientific Reports. 9, 1, 1542.
Research output: Contribution to journal › Article › peer-review

Open Access
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3 Citations (Scopus)

176 Downloads (Pure)
Fine tuning of antibiotic activity by a tailoring hydroxylase in a trans-AT polyketide synthase pathway
Mohammad, H., Connolly, J., Song, Z., Hothersall, J., Race, P. R., Willis, C. L., Simpson, T. J., Winn, P. & Thomas, C., 24 Jan 2018, (E-pub ahead of print) In: ChemBioChem. 5 p., cbic.201800036.
Research output: Contribution to journal › Article › peer-review

Open Access
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223 Downloads (Pure)
Selected mutations reveal new intermediates in the biosynthesis of mupirocin and the thiomarinol antibiotics
Gao, S-S., Wang, L., Song, Z., Hothersall, J., Stevens, E. R., Connolly, J., Winn, P. J., Cox, R. J., Crump, M. P., Race, P. R., Thomas, C., Simpson, T. J. & Willis, C. L., 9 Feb 2017, (E-pub ahead of print) In: Angewandte Chemie (International Edition) . 56, 14, p. 3930-3934
Research output: Contribution to journal › Article › peer-review

Open Access
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5 Citations (Scopus)

332 Downloads (Pure)