Mechanisms of Hepatitis C Virus Induced Hepatocyte Injury

Research output

Research output per year 2006 2007 2008 2009 2010 2011 2014 2017

• 75 Article
• 1 Review article

Research output per year

Research output per year

Search results

• 2017

  Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication

  Farquhar, M. J., Humphreys, I. S., Rudge, S. A., Wilson, G. K., Bhattacharya, B., Ciaccia, M., Hu, K., Zhang, Q., Mailly, L., Reynolds, G. M., Ashcroft, M., Balfe, P., Baumert, T. F., Roessler, S., Wakelam, M. J. O. & McKeating, J. A., 23 Jan 2017, (E-pub ahead of print) In: Journal of Hepatology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lysophosphatidic Acid Receptors 100%
  • Virus Replication 66%
  • Hepacivirus 61%
  • lysophosphatidic acid 49%
  • Hepatocellular Carcinoma 29%
  23 Citations (Scopus)

  392 Downloads (Pure)

• High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end stage liver disease

  Balfe, P., McKeating, J., Hedegaard, D., Reynolds, G., Hu, K., Wilhelm, A. & Kelly, D., 1 Jan 2017, In: Journal of Hepatology. 66, p. 28-38 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • End Stage Liver Disease 100%
  • Hepacivirus 78%
  • Liver 43%
  • Interferons 35%
  • RNA 26%
  15 Citations (Scopus)

  178 Downloads (Pure)

• TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway

  Fletcher, N., Clark, A. R., Balfe, P. & McKeating, J., 1 Mar 2017, In: Journal of General Virology. 98, 3, p. 405-412

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Myosin-Light-Chain Kinase 100%
  • Virus Internalization 89%
  • Hepacivirus 67%
  • Tight Junctions 23%
  • Liver Diseases 17%
  7 Citations (Scopus)

  159 Downloads (Pure)
• 2016

  Deep sequencing of hepatitis C virus reveals genetic compartmentalization in cerebrospinal fluid from cognitively impaired patients

  Tully, D. C., Hjerrild, S., Leutscher, P. D., Renvillard, S. G., Ogilvie, C. B., Bean, D. J., Videbech, P., Allen, T. M., McKeating, J. A. & Fletcher, N. F., 5 Apr 2016, In: Liver International.

  Research output: Contribution to journal › Article › peer-review

  • High-Throughput Nucleotide Sequencing 100%
  • Hepacivirus 96%
  • Cerebrospinal Fluid 90%
  • Central Nervous System 57%
  • Cognitive Dysfunction 53%
  14 Citations (Scopus)

• Lentiviral hepatitis B pseudotype entry requires NTCP and additional hepatocyte-specific factors

  Meredith, L. W., Hu, K., Cheng, X., Howard, C. R., Baumert, T. F., Balfe, P., van de Graaf, K. F., Protzer, U. & McKeating, J. A., Jan 2016, In: Journal of General Virology. 97, 1, p. 121-127

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepatitis B virus 100%
  • Hepatitis B 99%
  • Hepatocytes 86%
  • Virus Internalization 63%
  • Infections 49%
  11 Citations (Scopus)

  272 Downloads (Pure)
• 2015

  Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

  Mathiesen, C. K., Prentoe, J., Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, J. M. & Bukh, J., Aug 2015, In: Journal of virology. 89, 15, p. 7758-75 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatitis C virus 100%
  • Hepacivirus 63%
  • Genotype 49%
  • mutation 47%
  • genotype 40%
  15 Citations (Scopus)

• Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

  Mailly, L., Xiao, F., Lupberger, J., Wilson, G. K., Aubert, P., Duong, F. H. T., Calabrese, D., Leboeuf, C., Fofana, I., Thumann, C., Bandiera, S., Lütgehetmann, M., Volz, T., Davis, C., Harris, H. J., Mee, C. J., Girardi, E., Chane-Woon-Ming, B., Ericsson, M., Fletcher, N., & 14 othersBartenschlager, R., Pessaux, P., Vercauteren, K., Meuleman, P., Villa, P., Kaderali, L., Pfeffer, S., Heim, M. H., Neunlist, M., Zeisel, M. B., Dandri, M., McKeating, J. A., Robinet, E. & Baumert, T. F., May 2015, In: Nature Biotechnology. 33, 5, p. 549-554 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Monoclonal antibodies 100%
  • Claudin-1 91%
  • Viruses 75%
  • Clearance 69%
  • Tight Junction Proteins 62%
  94 Citations (Scopus)

• Effect of scavenger receptor BI antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation

  Rowe, I. A., Tully, D. C., Armstrong, M. J., Parker, R., Guo, K., Barton, D., Morse, G. D., Venuto, C. S., Ogilvie, C. B., Hedegaard, D. L., McKelvy, J. F., Wong-Staal, F., Allen, T. M., Balfe, P., McKeating, J. A. & Mutimer, D. J., 2015, In: Liver Transplantation.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ITX-5061 100%
  • Scavenger Receptors 57%
  • Hepacivirus 40%
  • Liver Transplantation 40%
  • Virus Diseases 32%
  15 Citations (Scopus)

  261 Downloads (Pure)

• Hepatitis C virus infection of cholangiocarcinoma cell lines

  Fletcher, N. F., Humphreys, E. A., Jennings, E., Osburn, W., Lissauer, S., Wilson, G. K., Van Ijzendoorn, S. C., Baumert, T. F., Balfe, P., Afford, S. & Mckeating, J., Jun 2015, In: Journal of General Virology. 96, 6, p. 1380-1388 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cholangiocarcinoma 100%
  • Hepacivirus 80%
  • Virus Diseases 63%
  • Cell Line 51%
  • Virus Replication 49%
  6 Citations (Scopus)

  162 Downloads (Pure)

• Permissivity of primary hepatocytes and hepatoma cell lines to support hepatitis C virus infection

  Wilson, G. K., Farquhar, M. J., Meredith, L., Dhawan, A., Mitry, R., Balfe, P. & McKeating, J. A., 1 Jun 2015, In: Journal of General Virology. 96, 6, p. 1369-1373 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepacivirus 100%
  • Hepatocytes 90%
  • Hepatocellular Carcinoma 86%
  • Virus Diseases 79%
  • Cell Line 63%
  1 Citation (Scopus)

  140 Downloads (Pure)
• 2014

  Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner

  Fletcher, N. F., Sutaria, R., Jo, J., Barnes, A., Blahova, M., Meredith, L. W., Cosset, F., Curbishley, S. M., Adams, D. H., Bertoletti, A. & Mckeating, J. A., 1 Apr 2014, In: Hepatology. 59, 4, p. 1320-1330

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Virus Internalization 100%
  • Hepacivirus 74%
  • Tumor Necrosis Factor-alpha 57%
  • Macrophages 56%
  • Innate Immunity 24%
  33 Citations (Scopus)

  204 Downloads (Pure)

• A role for CD81 and hepatitis C virus in hepatoma mobility

  Brimacombe, C. L., Wilson, G. K., Hübscher, S. G., McKeating, J. A. & Farquhar, M. J., 24 Mar 2014, In: Viruses. 6, 3, p. 1454-72 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepacivirus 100%
  • Tetraspanins 90%
  • Hepatocellular Carcinoma 86%
  • radixin 23%
  • moesin 22%
  8 Citations (Scopus)

• Entry of hepatitis B and C viruses - recent progress and future impact

  Baumert, T. F., Meredith, L., Ni, Y., Felmlee, D. J., McKeating, J. A. & Urban, S., Feb 2014, In: Current Opinion in Virology. 4, p. 58-65 8 p.

  Research output: Contribution to journal › Article

  • Life Cycle Stages 100%
  • Hepatitis C 95%
  • Hepatitis B virus 90%
  • Viruses 62%
  • Virology 60%
  39 Citations (Scopus)

• Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions

  Wilson, G. K., Tennant, D. A. & Mckeating, J. A., Dec 2014, In: Journal of Hepatology. 61, 6, p. 1397-1406 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Liver Diseases 100%
  • Hepatocellular Carcinoma 95%
  • Hypoxia 93%
  • Transcription Factors 89%
  • Direction compound 86%
  80 Citations (Scopus)

  243 Downloads (Pure)

• Paracrine signals from liver sinusoidal endothelium regulate hepatitis C virus replication

  Rowe, I. A., Galsinh, S. K., Wilson, G. K., Parker, R., Durant, S., Lazar, C., Branza-Nichita, N., Bicknell, R., Adams, D. H., Balfe, P. & McKeating, J. A., Feb 2014, In: Hepatology. 59, 2, p. 375–384

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Bone Morphogenetic Protein 4 100%
  • Virus Replication 70%
  • Hepacivirus 64%
  • Endothelium 61%
  • Liver 35%
  25 Citations (Scopus)

  307 Downloads (Pure)

• Type I interferon rapidly restricts infectious hepatitis C virus particle genesis

  Meredith, L. W., Farquhar, M. J., Tarr, A. W. & Mckeating, J. A., 24 Nov 2014, In: Hepatology. 60, 6, p. 1891-1901

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepatovirus 100%
  • Interferon Type I 73%
  • Interferon-alpha 61%
  • Virion 58%
  • Hepacivirus 56%
  4 Citations (Scopus)

  135 Downloads (Pure)
• 2013

  An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission

  Tarr, A. W., Lafaye, P., Meredith, L., Damier-Piolle, L., Urbanowicz, R. A., Meola, A., Jestin, J-L., Brown, R. J. P., McKeating, J. A., Rey, F. A., Ball, J. K. & Krey, T., Sept 2013, In: Hepatology. 58, 3, p. 932-9 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Single-Domain Antibodies 100%
  • New World Camelids 99%
  • Virus Internalization 83%
  • Hepacivirus 62%
  • Epitopes 24%
  53 Citations (Scopus)

• Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission

  Meredith, L. W., Zitzmann, N. & McKeating, J., 1 Dec 2013, In: Antiviral Research. 100, 3, p. 636-639

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepacivirus 100%
  • Genotype 20%
  • Viruses 19%
  • Virus Release 9%
  • Virus Assembly 9%
  10 Citations (Scopus)

  251 Downloads (Pure)

• Early infection events highlight the limited transmissibility of hepatitis C virus in vitro

  Meredith, L. W., Harris, H. J., Wilson, G. K., Fletcher, N. F., Balfe, P. & McKeating, J. A., Jun 2013, In: Journal of Hepatology. 58, 6, p. 1074-80 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepacivirus 100%
  • Infections 51%
  • In Vitro Techniques 47%
  • Viruses 19%
  • Satellite Viruses 9%
  17 Citations (Scopus)

• Production, purification and characterization of recombinant, full-length human claudin-1

  Bonander, N., Jamshad, M., Oberthür, D., Clare, M., Barwell, J., Hu, K., Farquhar, M. J., Stamataki, Z., Harris, H. J., Dierks, K., Dafforn, T. R., Betzel, C., McKeating, J. A. & Bill, R. M., 2013, In: PLoS ONE. 8, 5, p. e64517

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Claudin-1 100%
  • Proteoliposome 94%
  • Hepatitis C virus 67%
  • Oligomer 55%
  • Purification 47%
  8 Citations (Scopus)
• 2012

  Hepatitis C virus and the brain

  Fletcher, N. & McKeating, J., 1 May 2012, In: Journal of viral hepatitis. 19, 5, p. 301-306 6 p.

  Research output: Contribution to journal › Article

  • Hepacivirus 100%
  • Central Nervous System 63%
  • Brain 52%
  • Liver Diseases 36%
  • Flaviviridae 31%
  65 Citations (Scopus)

• Hepatitis C virus entry: beyond receptors.

  Meredith, L., Wilson, G., Fletcher, N. & McKeating, J., 6 Mar 2012, In: Reviews in Medical Virology.

  Research output: Contribution to journal › Article

  • Blood-Borne Pathogens 100%
  • Tetraspanins 98%
  • Zonula Occludens-1 Protein 98%
  • Claudin-1 96%
  • Occludin 87%
  70 Citations (Scopus)

• Hepatitis C Virus Envelope Glycoprotein Fitness Defines Virus Population Composition following Transmission to a New Host

  Brown, R. J. P., Hudson, N., Wilson, G., Rehman, S. U., Jabbari, S., Hu, K., Tarr, A. W., Borrow, P., Joyce, M., Lewis, J., Zhu, L. F., Law, M., Kneteman, N., Tyrrell, D. L., McKeating, J. A. & Ball, J. K., Nov 2012, In: Journal of virology. 86, 22, p. 11956-66 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepatitis C virus 100%
  • Hepacivirus 63%
  • Glycoproteins 58%
  • inoculum 58%
  • glycoproteins 58%
  28 Citations (Scopus)

  152 Downloads (Pure)

• Hepatitis C virus induces CD81 and claudin-1 endocytosis.

  Farquhar, M., Hu, K., Harris, H., Davis, C., Brimacombe, C., Fletcher, S., Baumert, TF., Rappoport, J., Balfe, P. & McKeating, J., 8 Feb 2012, In: Journal of virology.

  Research output: Contribution to journal › Article

  • Hepatitis C virus 100%
  • Claudin-1 98%
  • endocytosis 77%
  • Endocytosis 69%
  • Hepacivirus 63%
  90 Citations (Scopus)

• In silico directed mutagenesis identifies the CD81/claudin-1 hepatitis C virus receptor interface

  Davis, C., Harris, H. J., Hu, K., Drummer, H. E., McKeating, J. A., Mullins, J. G. L. & Balfe, P., Dec 2012, In: Cellular Microbiology. 14, 12, p. 1892-903 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Claudin-1 100%
  • Virus Receptors 95%
  • Mutagenesis 69%
  • Computer Simulation 66%
  • Hepacivirus 64%
  28 Citations (Scopus)

  223 Downloads (Pure)
• 2011

  A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration.

  Wilson, G., Brimacombe, C., Rowe, I., Reynolds, G., Fletcher, N., Stamataki, Z., Bhogal, R., Simões, M., Ashcroft, M., Afford, S., Mitry, RR., Dhawan, A., Mee, CJ., Hubscher, S., Balfe, P. & McKeating, J., 15 Dec 2011, In: Journal of Hepatology.

  Research output: Contribution to journal › Article

  • Hypoxia-Inducible Factor 1 100%
  • Hepacivirus 73%
  • Hepatocellular Carcinoma 63%
  • Glycoproteins 33%
  • Transforming Growth Factor beta 18%
  53 Citations (Scopus)

• EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

  Lupberger, J., Zeisel, MB., Xiao, F., Thumann, C., Fofana, I., Zona, L., Davis, C., Mee, C., Turek, M., Gorke, S., Royer, C., Fischer, B., Zahid, MN., Lavillette, D., Fresquet, J., Cosset, FL., Rothenberg, SM., Pietschmann, T., Patel, AH., Pessaux, P., & 6 othersDoffoel, M., Raffelsberger, W., Poch, O., McKeating, J., Brino, L. & Baumert, TF., 1 May 2011, In: Nature Medicine. 17, 5, p. 589-U109

  Research output: Contribution to journal › Article

  • Virus Internalization 100%
  • Hepacivirus 74%
  • Tyrosine 73%
  • Antiviral Agents 69%
  • Cofactor 49%
  499 Citations (Scopus)

• Hepatitis C virus entry and the tetraspanin CD81.

  Farquhar, M., Harris, H. & McKeating, J., 1 Apr 2011, In: Biochemical Society Transactions. 39, 2, p. 532-6 5 p.

  Research output: Contribution to journal › Article

  • Tetraspanins 100%
  • Virus Internalization 84%
  • Hepacivirus 63%
  • Diffusion 41%
  • Protein 28%
  33 Citations (Scopus)

• Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier.

  Fletcher, N., Wilson, G., Murray, J., Hu, K., Lewis, A., Reynolds, G., Stamataki, Z., Meredith, L., Rowe, I., Luo, G., Lopez-Ramirez, MA., Baumert, TF., Weksler, B., Couraud, PO., Kim, KS., Romero, IA., Jopling, C., Morgello, S., Balfe, P. & McKeating, J., 30 Nov 2011, In: Gastroenterology. 142, 3, p. 634-643,e1-e6 16 p.

  Research output: Contribution to journal › Article

  • Blood-Brain Barrier 100%
  • Hepacivirus 95%
  • Endothelial Cells 76%
  • Virus Internalization 38%
  • Brain 35%
  153 Citations (Scopus)

• Hepatitis C Virus Targets the T Cell Secretory Machinery as a Mechanism of Immune Evasion

  Petrovic, D., Stamataki, Z., Dempsey, E., Golden-Mason, L., Freeley, M., Doherty, D., Prichard, D., Keogh, C., Conroy, J., Mitchell, S., Volkov, Y., McKeating, J., O'Farrelly, C., Kelleher, D. & Long, A., 1 Jun 2011, In: Hepatology. 53, 6, p. 1846-1853 8 p.

  Research output: Contribution to journal › Article

  • Immune Evasion 100%
  • Hepacivirus 73%
  • T-Lymphocytes 49%
  • Interleukin-2 38%
  • Protein Kinase C beta 31%
  17 Citations (Scopus)

• Immunization of Human Volunteers With Hepatitis C Virus Envelope Glycoproteins Elicits Antibodies That Cross-Neutralize Heterologous Virus Strains

  Stamataki, Z., Coates, S., Abrignani, S., Houghton, M. & McKeating, J., 1 Sept 2011, In: The Journal of Infectious Diseases. 204, 5, p. 811-813 3 p.

  Research output: Contribution to journal › Article
  43 Citations (Scopus)

• Naturally occurring antibodies recognizing linear epitopes in the amino-terminus of the hepatitis C virus E2 protein confer non-interfering, additive neutralization.

  Tarr, AW., Urbanowicz, RA., Jayaraj, D., Brown, RJ., McKeating, J., Irving, WL. & Ball, JK., 14 Dec 2011, In: Journal of virology.

  Research output: Contribution to journal › Article

  • Hepatitis C virus 100%
  • neutralization 71%
  • epitopes 66%
  • Hepacivirus 63%
  • Epitopes 59%
  49 Citations (Scopus)

• Rituximab treatment in hepatitis C infection: an in vitro model to study the impact of B cell depletion on virus infectivity.

  Stamataki, Z., Tilakaratne, S., Adams, D. & McKeating, J., 1 Jan 2011, In: PLoS ONE. 6, 9, p. e25789

  Research output: Contribution to journal › Article

  Open Access

  • hepatitis C 100%
  • Hepatitis C virus 84%
  • Rituximab 63%
  • Hepatitis C 59%
  • B-lymphocytes 57%
  6 Citations (Scopus)

• Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors

  Syder, AJ., Lee, H., Zeisel, MB., Grove, J., Soulier, E., Macdonald, J., Chow, S., Baumert, TF., McKeating, J., McKelvy, J., Wong-Staal, F. & Chang, J., 1 Jan 2011, In: Journal of Hepatology. 54, 1, p. 48-55 8 p.

  Research output: Contribution to journal › Article › peer-review

  • ITX-5061 100%
  • Scavenger Receptors 57%
  • HDL Lipoproteins 23%
  • Infections 21%
  • Tritium 14%
  109 Citations (Scopus)

• Structural characterization of CD81-Claudin-1 hepatitis C virus receptor complexes.

  Bonander, N., Jamshad, M., Hu, K., Farquhar, M., Stamataki, Z., Balfe, P., McKeating, J. & Bill, RM., 1 Apr 2011, In: Biochemical Society Transactions. 39, 2, p. 537-40 4 p.

  Research output: Contribution to journal › Article

  • Claudin-1 100%
  • Virus Receptors 95%
  • Tetraspanins 76%
  • Hepacivirus 64%
  • Claudins 48%
  5 Citations (Scopus)
• 2010

  Claudin association with CD81 defines hepatitis C virus entry.

  Harris, H., Davis, C., Mullins, JG., Hu, K., Goodall, D., Farquhar, M., Mee, C., McCaffrey, K., Young, S., Drummer, H., Balfe, P. & McKeating, J., 7 Apr 2010, In: Journal of Biological Chemistry. 285, 27, p. 21092-21102

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Claudins 100%
  • Virus Internalization 88%
  • Claudin-1 85%
  • Hepacivirus 66%
  • Mutation 60%
  164 Citations (Scopus)

  339 Downloads (Pure)

• Hepatitis C Virus Infection of Neuroepithelioma Cell Lines.

  Fletcher, N., Yang, J., Farquhar, M., Hu, K., Davis, C., He, Q., Dowd, K., Ray, SC., Krieger, SE., Neyts, J., Baumert, TF., Balfe, P., McKeating, J. & Wong-Staal, F., 9 Jun 2010, In: Gastroenterology.

  Research output: Contribution to journal › Article › peer-review

  • Hepacivirus 100%
  • Virus Diseases 79%
  • Cell Line 63%
  • Claudin-1 57%
  • Scavenger Receptors 52%
  50 Citations (Scopus)

• Inhibition of Hepatitis C Virus Infection by Anti-Claudin-1 Antibodies Is Mediated by Neutralization of E2-CD81-Claudin-1 Associations

  Krieger, SE., Zeisel, MB., Davis, C., Thumann, C., Harris, H., Schnober, EK., Mee, C., Soulier, E., Royer, C., Lambotin, M., Grunert, F., Thi, VLD., Dreux, M., Cosset, FL., McKeating, J., Schuster, C. & Baumert, TF., 1 Apr 2010, In: Hepatology. 51, 4, p. 1144-1157 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Claudin-1 100%
  • Hepacivirus 64%
  • Virus Diseases 51%
  • Antibodies 38%
  • Virus Internalization 14%
  138 Citations (Scopus)

• Mechanisms of viral entry: sneaking in the front door

  Thorley, J., McKeating, J. & Rappoport, J., 1 Aug 2010, In: Protoplasma. 244, 1-4, p. 15-24 10 p.

  Research output: Contribution to journal › Review article › peer-review

  File

  • Hepatitis C virus 100%
  • Viruses 91%
  • viruses 89%
  • Virion 87%
  • Hepacivirus 85%
  33 Citations (Scopus)

  145 Downloads (Pure)

• Monoclonal Anti-Claudin 1 Antibodies Prevent Hepatitis C Virus Infection of Primary Human Hepatocytes

  Fofana, I., Krieger, SE., Grunert, F., Glauben, S., Xiao, F., Fafi-Kremer, S., Soulier, E., Royer, C., Thumann, C., Mee, C., McKeating, J., Dragic, T., Pessaux, P., Stoll-Keller, F., Schuster, C., Thompson, J. & Baumert, TF., 1 Sept 2010, In: Gastroenterology. 139, 3, p. 953-U339

  Research output: Contribution to journal › Article › peer-review

  • Claudin-1 100%
  • Hepatitis C Antibodies 84%
  • Hepacivirus 64%
  • Hepatocytes 58%
  • Virus Diseases 51%
  129 Citations (Scopus)

• Multiple Effects of Silymarin on the Hepatitis C Virus Lifecycle

  Wagoner, J., Negash, A., Kane, OJ., Martinez, LE., Nahmias, Y., Bourne, N., Owen, DM., Grove, J., Brimacombe, C., McKeating, J., Pecheur, EI., Graf, TN., Oberlies, NH., Lohmann, V., Cao, F., Tavis, JE. & Polyak, SJ., 1 Jun 2010, In: Hepatology. 51, 6, p. 1912-1921 10 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • Silymarin 100%
  • Hepacivirus 67%
  • Milk Thistle 22%
  • Antiviral Agents 18%
  • Virus Internalization 18%
  162 Citations (Scopus)

  265 Downloads (Pure)

• Neutralizing antibody resistant hepatitis C virus cell-to-cell transmission.

  Brimacombe, C., Grove, J., Meredith, L., Hu, K., Syder, AJ., Flores, MV., Timpe, JM., Krieger, SE., Baumert, TF., Tellinghuisen, TL., Wong-Staal, F., Balfe, P. & McKeating, J., 20 Oct 2010, In: Journal of virology.

  Research output: Contribution to journal › Article › peer-review

  File

  • Hepatitis C virus 100%
  • neutralizing antibodies 79%
  • Neutralizing Antibodies 68%
  • Hepacivirus 63%
  • cells 21%
  181 Citations (Scopus)

  178 Downloads (Pure)
• 2009

  Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells

  Stamataki, Z., Shannon-Lowe, C., Shaw, J., Mutimer, D., Rickinson, A., Gordon, J., Adams, D., Balfe, P. & McKeating, J., 15 Jan 2009, In: Blood. 113, 3, p. 585-593 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Hydrolysis 100%
  • Lectin 94%
  • Trypsin 87%
  • Hepacivirus 85%
  • Hepatocellular Carcinoma 74%
  62 Citations (Scopus)

• Hepatitis C virus infection reduces hepatocellular polarity in a vascular endothelial growth factor dependent manner

  Mee, C., Farquhar, M., Harris, H., Ramma, W., Ahmed, A., Maurel, P., Bicknell, R., Balfe, P. & McKeating, J., 25 Nov 2009, In: Gastroenterology. 138, 3, p. 1134-1142 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepacivirus 100%
  • Vascular Endothelial Growth Factor A 92%
  • Virus Diseases 79%
  • Hepatocellular Carcinoma 67%
  • Hepatocytes 30%
  59 Citations (Scopus)

• Hepatoma cell density promotes Claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization

  Schwarz, AK., Grove, J., Hu, K., Mee, C., Balfe, P. & McKeating, J., 1 Dec 2009, In: Journal of virology. 83, 23, p. 12407-12414

  Research output: Contribution to journal › Article › peer-review

  File

  • Hepatitis C virus 100%
  • Claudin-1 98%
  • Class B Scavenger Receptors 93%
  • Scavenger Receptors 89%
  • Virus Internalization 85%
  35 Citations (Scopus)

  154 Downloads (Pure)

• Mutations in Hepatitis C Virus E2 Located outside the CD81 Binding Sites Lead to Escape from Broadly Neutralizing Antibodies but Compromise Virus Infectivity

  Keck, ZY., Li, SH., Xia, J., von Hahn, T., Balfe, P., McKeating, J., Witteveldt, J., Patel, AH., Alter, H., Rice, CM. & Foung, SKH., 1 Jun 2009, In: Journal of virology. 83, 12, p. 6149-6160 12 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • Hepatitis C virus 100%
  • Broadly Neutralizing Antibodies 97%
  • neutralizing antibodies 79%
  • Hepacivirus 63%
  • monoclonal antibodies 61%
  69 Citations (Scopus)

  209 Downloads (Pure)

• Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells.

  Mee, C., Harris, H., Farquhar, M., Wilson, G., Reynolds, G., Davis, C., van IJzendoorn, SC., Balfe, P. & McKeating, J., 1 Jun 2009, In: Journal of virology. 83, 12, p. 6211-6221 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hepatitis C virus 100%
  • Virus Internalization 85%
  • hepatoma 75%
  • Hep G2 Cells 73%
  • Hepacivirus 63%
  104 Citations (Scopus)

  186 Downloads (Pure)

• The complexities of hepatitis C virus entry

  Balfe, P. & McKeating, J., 1 Sept 2009, In: Journal of Hepatology. 51, 3, p. 609-11 3 p.

  Research output: Contribution to journal › Article
  7 Citations (Scopus)
• 2008

  Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

  Law, M., Maruyama, T., Lewis, J., Giang, E., Tarr, AW., Stamataki, Z., Gastaminza, P., Chisari, FV., Jones, IM., Fox, RI., Ball, JK., McKeating, J., Kneteman, NM. & Burton, DR., 1 Jan 2008, In: Nature Medicine. 14, 1, p. 25-27 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Broadly Neutralizing Antibodies 100%
  • Quasispecies 99%
  • Hepacivirus 65%
  • Vaccines 21%
  • Immunotherapy 12%
  441 Citations (Scopus)

• CD81 and claudin 1 coreceptor association: Role in hepatitis C virus entry

  Harris, H., Farquhar, M., Mee, C., Davis, C., Reynolds, G., Jennings, A., Hu, K., Yuan, F., Deng, H., Hubscher, S., Han, JH., Balfe, P. & McKeating, J., 1 Jan 2008, In: Journal of virology. 82, 10, p. 5007-5020 14 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • Hepatitis C virus 100%
  • Claudin-1 98%
  • Virus Internalization 85%
  • Hepacivirus 63%
  • Fluorescence Resonance Energy Transfer 45%
  151 Citations (Scopus)

  216 Downloads (Pure)