Generation of Intrathymic Microenvironments to Establish T-Cell Tolerance

Research output

Research output per year 2010 2011 2012 2014 2015 2015

• 36 Article

Research output per year

Research output per year

Search results

• 2015

  Border control : anatomical origins of the thymus medulla

  Anderson, G. & Jenkinson, W. E., Aug 2015, In: European Journal of Immunology. 45, 8, p. 2203-2207 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thymus Gland 100%
  • Epithelial Cells 74%
  • T-Lymphocytes 42%
  • Thymocytes 37%
  • Self Tolerance 23%
  4 Citations (Scopus)

  155 Downloads (Pure)

• CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice

  Lucas, B., White, A. J., Ulvmar, M. H., Nibbs, R. J. B., Sitnik, K. M., Agace, W. W., Jenkinson, W., Anderson, G. & Rot, A., Feb 2015, In: European Journal of Immunology. 45, 2, p. 574-83 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphopoiesis 100%
  • Thymus Gland 66%
  • Thymocytes 50%
  • Epithelial Cells 16%
  • Ligands 16%
  19 Citations (Scopus)

• Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release

  Komarowska, I., Coe, D., Wang, G., Haas, R., Mauro, C., Kishore, M., Cooper, D., Nadkarni, S., Fu, H., Steinbruchel, D., Pitzalis, C., Anderson, G., Bucy, P., Lombardi, G., Breckenridge, R. & Marelli-berg, F., 16 Jun 2015, In: Immunity. 42, 6, p. 1087-1099 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Proto-Oncogene Proteins c-met 100%
  • Chemokines 68%
  • Cell Movement 59%
  • Heart 46%
  • T-Lymphocytes 44%
  44 Citations (Scopus)

  172 Downloads (Pure)

• Laying bare the nude mouse gene

  Anderson, G. & McCarthy, N. I., 1 Feb 2015, In: Journal of Immunology. 194, 3, p. 847-8 2 p.

  Research output: Contribution to journal › Article › peer-review

• Natural Th17 cells are critically regulated by functional medullary thymic microenvironments

  Jenkinson, W., McCarthy, N. I., Dutton, E. E., Cowan, J. E., Parnell, S. M., White, A. J. & Anderson, G., Sept 2015, In: Journal of Autoimmunity. 63, p. 13-22 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Th17 Cells 100%
  • T-Lymphocytes 52%
  • Epithelial Cells 40%
  • Nitric Oxide Synthase Type II 29%
  • Central Tolerance 21%
  13 Citations (Scopus)

  262 Downloads (Pure)

• The thymus medulla fosters generation of natural Treg cells, invariant γδ T Cells and invariant NKT cells : what we learn from intrathymic migration

  Cowan, J. E., Jenkinson, W. E. & Anderson, G., Mar 2015, In: European Journal of Immunology. 45, 3, p. 652-660 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Natural Killer T-Cells 100%
  • Regulatory T-Lymphocytes 83%
  • Thymus Gland 80%
  • T-Lymphocytes 51%
  • T-Lymphoid Precursor Cells 23%
  28 Citations (Scopus)

  206 Downloads (Pure)
• 2014

  An Essential Role for Medullary Thymic Epithelial Cells during the Intrathymic Development of Invariant NKT Cells

  White, A. J., Jenkinson, W., Cowan, J. E., Parnell, S. M., Bacon, A., Jones, N. D., Jenkinson, E. J. & Anderson, G., 15 Mar 2014, In: Journal of Immunology. 192, 6, p. 2659-66 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Natural Killer T-Cells 100%
  • Thymus Gland 60%
  • Epithelial Cells 59%
  • Interleukin-15 26%
  • CD1d Antigen 17%
  60 Citations (Scopus)

• Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus

  Cowan, J. E., McCarthy, N. I., Parnell, S. M., White, A. J., Bacon, A., Serge, A., Irla, M., Lane, P. J. L., Jenkinson, E. J., Jenkinson, W. & Anderson, G., 1 Aug 2014, In: Journal of Immunology. 193, 3, p. 1204-12 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Thymus Gland 100%
  • T-Lymphocytes 64%
  • Thymocytes 37%
  • Cell Lineage 36%
  • Natural Killer T-Cells 27%
  51 Citations (Scopus)

• Mechanisms of thymus medulla development and function

  Anderson, G., Baik, S., Cowan, J. E., Holland, A. M., McCarthy, N. I., Nakamura, K., Parnell, S. M., White, A. J., Lane, P. J. L., Jenkinson, E. J. & Jenkinson, W. E., 2014, In: Current Topics in Microbiology and Immunology. 373, p. 19-47 29 p.

  Research output: Contribution to journal › Article › peer-review

  • Thymus Gland 100%
  • T-Cell Antigen Receptor Specificity 49%
  • T-Lymphoid Precursor Cells 49%
  • Thymocytes 37%
  • Regulator Genes 35%
  16 Citations (Scopus)

• Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function

  Ross, E. A., Flores-langarica, A., Bobat, S., Coughlan, R. E., Marshall, J., Hitchcock, J. R., Cook, C. N., Carvalho Gaspar, M., Mitchell, A. M., Clarke, M., Garcia, P., Cobbold, M., Mitchell, T. J., Henderson, I. R., Jones, N. D., Anderson, G., Buckley, C. D. & Cunningham, A. F., Aug 2014, In: European Journal of Immunology. 44, 8, p. 2318-2330 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Salmonella Infections 100%
  • Bone Marrow Cells 75%
  • Stem Cells 58%
  • Phenotype 48%
  • Infections 38%
  9 Citations (Scopus)

  268 Downloads (Pure)

• Serial progression of cortical and medullary thymic epithelial microenvironments

  Alves, N. L., Takahama, Y., Ohigashi, I., Ribeiro, A. R., Baik, S., Anderson, G. & Jenkinson, W., 1 Jan 2014, In: European Journal of Immunology. 44, 1, p. 16-22

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epithelial Cells 100%
  • T-Lymphocytes 24%
  • Thymus Gland 19%
  • Cell- and Tissue-Based Therapy 18%
  • Cell Differentiation 16%
  61 Citations (Scopus)

  189 Downloads (Pure)

• The primordial thymus: everything you need under one roof

  Anderson, G. & Baik, S., 21 Aug 2014, In: Immunity. 41, 2, p. 178-180 3 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Lymphopoiesis 100%
  • Thymus Gland 66%
  • Lymphocytes 48%
  • T-Lymphocytes 42%
  149 Downloads (Pure)
• 2013

  Differential requirement for CCR4 in the maintenance but not establishment of the invariant Vγ5(+) dendritic epidermal T-cell pool

  Nakamura, K., White, A. J., Parnell, S. M., Lane, P. J., Jenkinson, E. J., Jenkinson, W. E. & Anderson, G., 2013, In: PLoS ONE. 8, 9, p. e74019

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epidermal Cells 100%
  • T-lymphocytes 78%
  • Dendritic Cells 76%
  • Maintenance 60%
  • T-Lymphocytes 53%
  14 Citations (Scopus)

• Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors

  Baik, S., Jenkinson, E. J., Lane, P. J. L., Anderson, G. & Jenkinson, W., Mar 2013, In: European Journal of Immunology. 43, 3, p. 589-94 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epithelial Cells 100%
  • Phenotype 18%
  • Thymocytes 16%
  • Thymus Gland 14%
  • Population 6%
  81 Citations (Scopus)

  557 Downloads (Pure)

• The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development

  Cowan, J. E., Parnell, S. M., Nakamura, K., Caamano, J. H., Lane, P. J. L., Jenkinson, E. J., Jenkinson, W. E. & Anderson, G., 8 Apr 2013, In: The Journal of Experimental Medicine. 210, 4, p. 675-81 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thymocytes 100%
  • Epithelial Cells 49%
  • T-Lymphocytes 42%
  • Foster Home Care 28%
  • Regulatory T-Lymphocytes 22%
  134 Citations (Scopus)

  239 Downloads (Pure)
• 2012

  A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo

  Gibson, VB., Benson, RA., Bryson, KJ., McInnes, IB., Rush, CM., Grassia, G., Maffia, P., Jenkinson, E., White, A., Anderson, G., Brewer, JM. & Garside, P., 1 Mar 2012, In: Blood. 119, 11, p. 2545-2551 7 p.

  Research output: Contribution to journal › Article

  • Effector 100%
  • Marker 80%
  • Immune System 72%
  • Lymph Nodes 65%
  • Lymphocytes 38%
  23 Citations (Scopus)

• Cutting edge: lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue

  Withers, D. R., Gaspal, F. M., Mackley, E. C., Marriott, C. L., Ross, E. A., Desanti, G. E., Roberts, N. A., White, A. J., Flores-Langarica, A., McConnell, F. M., Anderson, G. & Lane, P. J. L., 2012, In: Journal of Immunology. 189, 5, p. 2094-8 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphoid Tissue 100%
  • Helper-Inducer T-Lymphocytes 96%
  • T-Lymphocytes 57%
  • Cell Survival 23%
  • Eutheria 22%
  67 Citations (Scopus)

• Developmentally Regulated Availability of RANKL and CD40 Ligand Reveals Distinct Mechanisms of Fetal and Adult Cross-Talk in the Thymus Medulla

  Desanti, G. E., Cowan, J. E., Baik, S., Parnell, S. M., White, A. J., Penninger, J. M., Lane, P. J. L., Jenkinson, E. J., Jenkinson, W. & Anderson, G., 2012, In: Journal of Immunology. 189, 12, p. 5519-26 8 p.

  Research output: Contribution to journal › Article › peer-review

  • CD40 Ligand 100%
  • Thymus Gland 77%
  • Epithelial Cells 57%
  • Regulatory T-Lymphocytes 22%
  • T-Lymphocytes 21%
  46 Citations (Scopus)

• Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses?

  Lane, P., Gaspal, F., McConnell, F., Kim, MY., Anderson, G. & Withers, D., 1 Jan 2012, In: Annals of the New York Academy of Sciences. 1247, p. 1-15 15 p.

  Research output: Contribution to journal › Article

  • Inducer 100%
  • Lymphoid Tissue 92%
  • Helper-Inducer T-Lymphocytes 89%
  • Cells 60%
  • T-Lymphocytes 53%
  12 Citations (Scopus)

• Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?

  Lane, P., Gaspal, F., McConnell, F., Withers, D. & Anderson, G., 1 Jan 2012, In: Frontiers in immunology. 3, p. 24 1 p.

  Research output: Contribution to journal › Article

  Open Access

  • Lymphoid Tissue 100%
  • Helper-Inducer T-Lymphocytes 96%
  • Immunity 75%
  • CD30 Ligand 57%
  • Mammals 54%
  17 Citations (Scopus)

• Lymphotoxin-β receptor signaling through NF-κB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells

  Bénézech, C., Mader, E., Desanti, G., Khan, M., Nakamura, K., White, A., Ware, C. F., Anderson, G. & Caamaño, J. H., 2012, In: Immunity. 37, 4, p. 721-34 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphotoxin-alpha 100%
  • Stromal Cells 76%
  • Adipocytes 72%
  • Lymph Nodes 54%
  • Lymphoid Tissue 27%
  83 Citations (Scopus)

• Mesenchymal cells regulate retinoic acid receptor-dependent cortical thymic epithelial cell homeostasis

  Sitnik, K. M., Kotarsky, K., White, A. J., Jenkinson, W. E., Anderson, G. & Agace, W. W., 15 May 2012, In: Journal of Immunology. 188, 10, p. 4801-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinoic Acid Receptors 100%
  • Tretinoin 79%
  • Homeostasis 56%
  • Epithelial Cells 55%
  • Mesoderm 37%
  34 Citations (Scopus)

• Normal T cell selection occurs in CD205-deficient thymic microenvironments

  Jenkinson, W. E., Nakamura, K., White, A. J., Jenkinson, E. J. & Anderson, G., 2012, In: PLoS ONE. 7, 12, p. e53416

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apoptotic 100%
  • T-lymphocytes 79%
  • Thymocytes 62%
  • Peptides 55%
  • T-Lymphocytes 53%
  8 Citations (Scopus)

• Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire(+) Medullary Epithelium.

  Roberts, NA., White, A., Jenkinson, W., Turchinovich, G., Nakamura, K., Withers, D., McConnell, F., Desanti, G., Benezech, C., Parnell, SM., Cunningham, A., Paolino, M., Penninger, JM., Simon, AK., Nitta, T., Ohigashi, I., Takahama, Y., Caamano, J., Hayday, AC., Lane, P., & 2 othersJenkinson, E. & Anderson, G., 14 Mar 2012, In: Immunity. 36, 3, p. 427-437 11 p.

  Research output: Contribution to journal › Article

  • Epithelium 100%
  • Epithelial Cells 93%
  • T-Lymphocytes 80%
  • Gene Rearrangement 38%
  • Thymocytes 35%
  115 Citations (Scopus)

• Thymic epithelial cells: working class heroes for T cell development and repertoire selection.

  Anderson, G. & Takahama, Y., 14 May 2012, In: Trends in Immunology.

  Research output: Contribution to journal › Article

  • Antigen Presentation 100%
  • Thymocytes 99%
  • Thymus Gland 88%
  • Epithelial Cells 65%
  • T-Lymphocytes 56%
  228 Citations (Scopus)

• Thymic function is maintained during Salmonella-induced atrophy and recovery

  Ross, E. A., Coughlan, R. E., Flores-Langarica, A., Lax, S., Nicholson, J., Desanti, G. E., Marshall, J. L., Bobat, S., Hitchcock, J., White, A., Jenkinson, W. E., Khan, M., Henderson, I. R., Lavery, G. G., Buckley, C. D., Anderson, G. & Cunningham, A. F., 1 Nov 2012, In: Journal of Immunology. 189, 9, p. 4266-4274 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Salmonella 100%
  • Atrophy 82%
  • T-Lymphocytes 58%
  • Thymocytes 51%
  • Cell Count 35%
  28 Citations (Scopus)

  21 Downloads (Pure)
• 2011

  Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice

  Gaspal, F., Withers, D., Saini, M., Bekiaris, V., McConnell, F., White, A., Khan, M., Yagita, H., Walker, L., Anderson, G. & Lane, P., 1 Aug 2011, In: The Journal of Experimental Medicine. 208, 8, p. 1579-1584 6 p.

  Research output: Contribution to journal › Article

  • Autoimmune Diseases 100%
  • Autoimmunity 56%
  • OX40 Receptor 54%
  • CD30 Ligand 54%
  • OX40 Ligand 49%
  43 Citations (Scopus)

• CD117(+)CD3(-)CD56(-)OX40L(high) cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues

  Kim, S., Han, S., Withers, D., Gaspal, F., Bae, J., Baik, S., Shin, HC., Kim, KS., Bekiaris, V., Anderson, G., Lane, P. & Kim, MY., 1 Jun 2011, In: European Journal of Immunology. 41, 6, p. 1563-1572 10 p.

  Research output: Contribution to journal › Article

  • interleukin-22 100%
  • Lymphoid Tissue 79%
  • Helper-Inducer T-Lymphocytes 47%
  • Phenotype 44%
  • Perforin 11%
  34 Citations (Scopus)

• Clonal Analysis Reveals Uniformity in the Molecular Profile and Lineage Potential of CCR9+ and CCR9- Thymus-Settling Progenitors

  Desanti, G., Jenkinson, W., Parnell, S., Boudil, A., Gautreau-Rolland, L., Eksteen, J., Ezine, S., Lane, P., Jenkinson, E. & Anderson, G., 18 Mar 2011, In: Journal of Immunology. 186, 9, p. 5227-5235 9 p.

  Research output: Contribution to journal › Article

  • Thymus Gland 100%
  • T-Lymphocytes 40%
  • Gene Expression 11%
  • Chemokine Receptors 10%
  • Multiplex Polymerase Chain Reaction 10%
  13 Citations (Scopus)

• Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence

  Varecza, Z., Kvell, K., Talaber, G., Miskei, G., Csongei, V., Bartis, D., Anderson, G., Jenkinson, E. & Pongracz, JE., 1 May 2011, In: Mechanisms of Ageing and Development. 132, 5, p. 249-256 8 p.

  Research output: Contribution to journal › Article

  • Wnt Signaling Pathway 100%
  • T-Lymphocytes 54%
  • Wnt Receptors 45%
  • Protein Kinase C-delta 42%
  • Epithelial Cells 42%
  15 Citations (Scopus)

• OX40 and CD30 signals in CD4(+) T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector function.

  Withers, D., Gaspal, F., Bekiaris, V., McConnell, F., Kim, M., Anderson, G. & Lane, P., 1 Nov 2011, In: Immunological Reviews. 244, 1, p. 134-48 15 p.

  Research output: Contribution to journal › Article

  • Lymphoid Tissue 100%
  • Helper-Inducer T-Lymphocytes 96%
  • Memory 67%
  • T-Lymphocytes 57%
  • Tumor Necrosis Factor-alpha 21%
  39 Citations (Scopus)

• Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.

  Qureshi, O., Zheng, Y., Nakamura, K., Attridge, K., Manzotti, C., Schmidt, EM., Baker, J., Jeffery, L., Kaur, S., Briggs, Z., Hou, T., Futter, CE., Anderson, G., Walker, L. & Sansom, D., 29 Apr 2011, In: Science. 332, 6029, p. 600-3 4 p.

  Research output: Contribution to journal › Article

  • CTLA-4 Antigen 100%
  • Endocytosis 72%
  • Ligands 33%
  • B7-2 Antigen 20%
  • Antigen-Presenting Cells 12%
  848 Citations (Scopus)

• Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence

  Talaber, G., Kvell, K., Varecza, Z., Boldizsar, F., Parnell, S., Jenkinson, E., Anderson, G., Berki, T. & Pongracz, JE., 1 Jun 2011, In: Rejuvenation Research. 14, 3, p. 241-248 8 p.

  Research output: Contribution to journal › Article

  • Dexamethasone 100%
  • Glucocorticoids 99%
  • Epithelial Cells 77%
  • Thymocytes 58%
  • lamina-associated polypeptide 2 53%
  32 Citations (Scopus)
• 2010

  A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis.

  Hou, T., Bystrom, J., Sherlock, J., Qureshi, O., Parnell, S., Anderson, G., Gilroy, DW. & Buckley, C., 24 Sept 2010, In: FEBS Letters. 584, 18, p. 3955-61 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Zymosan 100%
  • Peritonitis 83%
  • Phagocytosis 79%
  • Macrophages 56%
  • Peritoneal Cavity 29%
  29 Citations (Scopus)

  253 Downloads (Pure)

• Lymphoid tissue inducer cells and the evolution of CD4 dependent high-affinity antibody responses

  Lane, P., McConnell, F., Withers, D., Gaspal, F., Saini, M. & Anderson, G., 1 Jan 2010, In: Progress in molecular biology and translational science. 92, p. 159-74 16 p.

  Research output: Contribution to journal › Article

  • Lymphoid Tissue 100%
  • Helper-Inducer T-Lymphocytes 96%
  • Antibody Formation 83%
  • T-Lymphocytes 57%
  • Mammals 54%
  7 Citations (Scopus)

• Lymphotoxin Signals from Positively Selected Thymocytes Regulate the Terminal Differentiation of Medullary Thymic Epithelial Cells

  White, A., Nakamura, K., Jenkinson, W., Saini, M., Sinclair, C., Seddon, B., Narendran, P., Pfeffer, K., Nitta, T., Takahama, Y., Caamano, J., Lane, P., Jenkinson, E. & Anderson, G., 1 Oct 2010, In: Journal of Immunology. 185, 8, p. 4769-4776 8 p.

  Research output: Contribution to journal › Article

  • Lymphotoxin-alpha 100%
  • Thymocytes 82%
  • Epithelial Cells 54%
  • involucrin 33%
  • Thymus Gland 14%
  106 Citations (Scopus)