Design, synthesis, and assessment of specific iNKT cell agonists for clinical applications

Research output

Research output per year 2011 2012 2013 2014 2015 2016

• 30 Article

Research output per year

Research output per year

Search results

• 2016

  CD1d‐mediated activation of group 3 innate lymphoid cells drives IL‐22 production

  Saez de Guiona, J., Jimeno, R., Farhadi, N., Jervis, P., Cox, L., Besra, G. & Barral, P., 31 Oct 2016, (E-pub ahead of print) In: EMBO Reports. e201642412.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lymphocytes 100%
  • Lipid 99%
  • Natural Cytotoxicity Triggering Receptors 81%
  • Lipids 70%
  • Immunity 59%
  23 Citations (Scopus)

  438 Downloads (Pure)

• Human autoreactive T cells recognize CD1b and phospholipids

  Van Rhijn, I., van Berlo, T., Hilmenyuk, T., Cheng, T-Y., Wolf, B. J., Tatituri, R. V. V., Uldrich, A. P., Napolitani, G., Cerundolo, V., Altman, J. D., Willemsen, P., Huang, S., Rossjohn, J., Besra, G. S., Brenner, M. B., Godfrey, D. I. & Moody, D. B., 12 Jan 2016, In: National Academy of Sciences. Proceedings. 113, 2, p. 380-385

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phosphatidylglycerols 100%
  • Phospholipids 96%
  • T-Lymphocytes 66%
  • T-Cell Antigen Receptor 31%
  • Lipids 30%
  50 Citations (Scopus)

  176 Downloads (Pure)
• 2015

  A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production

  Birkholz, A. M., Girardi, E., Wingender, G., Khurana, A., Wang, J., Zhao, M., Zahner, S., Illarionov, P. A., Wen, X., Li, M., Yuan, W., Porcelli, S. A., Besra, G. S., Zajonc, D. M. & Kronenberg, M., 15 Jun 2015, In: Journal of Immunology.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer T-Cells 100%
  • Glycolipids 99%
  • Galactosylceramides 97%
  • Antigens 53%
  • Natural Killer Cells 38%
  18 Citations (Scopus)

• Antigen specificity of type I NKT cells is governed by TCR β-chain diversity

  Cameron, G., Pellicci, D. G., Uldrich, A. P., Besra, G. S., Illarionov, P., Williams, S. J., La Gruta, N. L., Rossjohn, J. & Godfrey, D. I., 15 Nov 2015, In: Journal of Immunology. 195, 10, p. 4604-4614 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer T-Cells 100%
  • Antigens 53%
  • isoglobotrihexosylceramide 29%
  • Galactosylceramides 21%
  • invariant chain 20%
  18 Citations (Scopus)

• A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model

  Wen, X., Kim, S., Xiong, R., Li, M., Lawrenczyk, A., Huang, X., Chen, S-Y., Rao, P., Besra, G. S., Delabona, P., Casorati, G., Porcelli, S. A., Akbari, O., Exley, M. A. & Yuan, W., 8 Jul 2015, In: Journal of Immunology.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer T-Cells 100%
  • Thymus Gland 13%
  • Immunotherapy 6%
  • Up-Regulation 5%
  • Ligands 4%
  6 Citations (Scopus)

• Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells

  Vomhof-DeKrey, E. E., Yates, J., Hägglöf, T., Lanthier, P., Amiel, E., Veerapen, N., Besra, G. S., Karlsson, M. C. I. & Leadbetter, E. A., 6 Oct 2015, In: National Academy of Sciences. Proceedings. 112, 40, p. 12474-12479 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Regulatory B-Lymphocytes 100%
  • Natural Killer T-Cells 79%
  • Interleukin-10 59%
  • B-Lymphocytes 51%
  • Glycolipids 26%
  20 Citations (Scopus)

• In contrast to other species, α-Galactosylceramide (α-GalCer) is not an immunostimulatory NKT cell agonist in horses

  Dossa, R. G., Alperin, D. C., Garzon, D., Mealey, R. H., Brown, W. C., Jervis, P. J., Besra, G. S., Cox, L. R. & Hines, S. A., 1 Mar 2015, In: Developmental & comparative immunology. 49, 1, p. 49-58 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Galactosylceramides 100%
  • Natural Killer T-Cells 76%
  • Horses 60%
  • CD1 Antigens 14%
  • CD1d Antigen 13%
  2 Citations (Scopus)

  338 Downloads (Pure)

• Inflammation-induced formation of fat-associated lymphoid clusters

  Bénézech, C., Luu, N-T., Walker, J. A., Kruglov, A. A., Loo, Y., Nakamura, K., Zhang, Y., Nayar, S., Jones, L. H., Flores-Langarica, A., McIntosh, A., Marshall, J., Barone, F., Besra, G., Miles, K., Allen, J. E., Gray, M., Kollias, G., Cunningham, A. F., Withers, D. R., & 6 othersToellner, K. M., Jones, N. D., Veldhoen, M., Nedospasov, S. A., McKenzie, A. N. J. & Caamaño, J. H., Aug 2015, In: Nature Immunology. 16, 8, p. 819-828 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fats 100%
  • Inflammation 78%
  • Chemokine CXCL13 38%
  • CD1d Antigen 36%
  • B-Lymphocytes 34%
  90 Citations (Scopus)

  695 Downloads (Pure)

• Reprint of: "Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes"

  Arora, P., Kharkwal, S. S., Ng, T. W., Kunnath-Velayudhan, S., Saini, N. K., Johndrow, C. T., Chang, Y-T., Besra, G. S. & Porcelli, S. A., 6 Nov 2015, (E-pub ahead of print) In: Chemistry and Physics of Lipids.

  Research output: Contribution to journal › Article › peer-review

  • CD1d Antigen 100%
  • Glycolipids 72%
  • Glycolipid 70%
  • Antigen 51%
  • Natural Killer T-Cells 36%
  3 Citations (Scopus)

• The mycobacterial receptor, Clec4d (CLECSF8, MCL) is co-regulated with Mincle and upregulated on mouse myeloid cells following microbial challenge

  Kerscher, B., Wilson, G. J., Reid, D. M., Mori, D., Taylor, J. A., Besra, G. S., Yamasaki, S., Willment, J. A. & Brown, G. D., 8 Dec 2015, (E-pub ahead of print) In: European Journal of Immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • mouse dectin-2 100%
  • Mycobacterium bovis 59%
  • Myeloid Cells 55%
  • Cord Factors 44%
  • C-Type Lectins 36%
  26 Citations (Scopus)
• 2014

  Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction

  Brennan, P. J., Tatituri, R. V. V., Heiss, C., Watts, G. F. M., Hsu, F-F., Veerapen, N., Cox, L. R., Azadi, P., Besra, G. S. & Brenner, M. B., 16 Sept 2014, In: National Academy of Sciences. Proceedings. 111, 37, p. 13433-8 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Glucosylceramides 100%
  • Natural Killer T-Cells 82%
  • Lipids 45%
  • Antigens 26%
  • Fatty Acids 23%
  72 Citations (Scopus)

• A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens

  Arora, P., Baena, A., Yu, K. O. A., Saini, N. K., Kharkwal, S. S., Goldberg, M. F., Kunnath-Velayudhan, S., Carreño, L. J., Venkataswamy, M. M., Kim, J., Lazar-Molnar, E., Lauvau, G., Chang, Y-T., Liu, Z., Bittman, R., Al-Shamkhani, A., Cox, L. R., Jervis, P. J., Veerapen, N., Besra, G. S., & 1 othersPorcelli, S. A., 16 Jan 2014, In: Immunity. 40, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Natural Killer T-Cells 100%
  • Glycolipids 99%
  • Dendritic Cells 74%
  • Antigens 53%
  • Cytokines 51%
  71 Citations (Scopus)

• Gal-3 regulates the capacity of dendritic cells to promote NKT cell-induced liver injury

  Volarevic, V., Markovic, B. S., Bojic, S., Stojanovic, M., Nilsson, U., Leffler, H., Besra, G. S., Arsenijevic, N., Paunovic, V., Trajkovic, V. & Lukic, M. L., 31 Oct 2014, In: European Journal of Immunology.

  Research output: Contribution to journal › Article › peer-review

  • Galectin 3 100%
  • Natural Killer T-Cells 90%
  • Dendritic Cells 67%
  • Liver 39%
  • Wounds and Injuries 36%
  31 Citations (Scopus)

• Improving Mycobacterium bovis Bacillus Calmette-Guèrin as a Vaccine Delivery Vector for Viral Antigens by Incorporation of Glycolipid Activators of NKT Cells

  Venkataswamy, M. M., Ng, T. W., Kharkwal, S. S., Carreño, L. J., Johnson, A. J., Kunnath-Velayudhan, S., Liu, Z., Bittman, R., Jervis, P. J., Cox, L. R., Besra, G. S., Wen, X., Yuan, W., Tsuji, M., Li, X., Ho, D. D., Chan, J., Lee, S., Frothingham, R., Haynes, B. F., & 8 othersPanas, M. W., Gillard, G. O., Sixsmith, J. D., Korioth-Schmitz, B., Schmitz, J. E., Larsen, M. H., Jacobs, W. R. & Porcelli, S. A., 25 Sept 2014, In: PLoS ONE. 9, 9, e108383.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • viral antigens 100%
  • Mycobacterium bovis 95%
  • natural killer cells 93%
  • Natural Killer T-Cells 89%
  • Glycolipids 88%
  18 Citations (Scopus)

• Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

  Lynch, L., Michelet, X., Zhang, S., Brennan, P. J., Moseman, A., Lester, C., Besra, G., Vomhof-Dekrey, E. E., Tighe, M., Koay, H-F., Godfrey, D. I., Leadbetter, E. A., Sant'Angelo, D. B., von Andrian, U. & Brenner, M. B., 1 Dec 2014, In: Nature Immunology.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer T-Cells 100%
  • Regulatory T-Lymphocytes 83%
  • Adipose Tissue 69%
  • Transcription Factors 62%
  • Homeostasis 61%
  217 Citations (Scopus)

• The molecular bases of δ/αβ T cell-mediated antigen recognition

  Pellicci, D. G., Uldrich, A. P., Le Nours, J., Ross, F., Chabrol, E., Eckle, S. B. G., de Boer, R., Lim, R. T., McPherson, K., Besra, G., Howell, A. R., Moretta, L., McCluskey, J., Heemskerk, M. H. M., Gras, S., Rossjohn, J. & Godfrey, D. I., 1 Dec 2014, In: The Journal of Experimental Medicine.

  Research output: Contribution to journal › Article › peer-review

  • T-Cell Antigen Receptor 100%
  • Antigens 62%
  • T-Lymphocytes 60%
  • Natural Killer T-Cells 29%
  • Lipids 24%
  34 Citations (Scopus)
• 2013

  Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome

  Shenderov, K., Barber, D. L., Mayer-Barber, K. D., Gurcha, S. S., Jankovic, D., Feng, C. G., Oland, S., Hieny, S., Caspar, P., Yamasaki, S., Lin, X., Ting, J. P-Y., Trinchieri, G., Besra, G. S., Cerundolo, V. & Sher, A., 1 Jun 2013, In: Journal of Immunology. 190, 11, p. 5722-30 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cord Factors 100%
  • Caspase Activation and Recruitment Domain 91%
  • Peptidoglycan 74%
  • Inflammasomes 74%
  • Mycobacterium 66%
  81 Citations (Scopus)

• Endoplasmic Reticulum Glycoprotein Quality Control Regulates CD1d Assembly and CD1d-mediated Antigen Presentation

  Kunte, A., Zhang, W., Paduraru, C., Veerapen, N., Cox, L. R., Besra, G. S. & Cresswell, P., 7 Jun 2013, In: Journal of Biological Chemistry. 288, 23, p. 16391-402 12 p.

  Research output: Contribution to journal › Article › peer-review

  • CD1d Antigen 100%
  • Antigen Presentation 66%
  • Quality Control 59%
  • Endoplasmic Reticulum 58%
  • Glycoprotein 56%
  6 Citations (Scopus)

• Expression of CD1c enhances human invariant NKT cell activation by α-GalCer

  Fox, L. M., Miksanek, J., May, N. A., Scharf, L., Lockridge, J. L., Veerapen, N., Besra, G. S., Adams, E. J., Hudson, A. W. & Gumperz, J. E., 2013, In: Cancer Immunity. 13, p. 9

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer T-Cells 100%
  • B-Lymphocytes 24%
  • CD1d Antigen 17%
  • Galactosylceramides 16%
  • Glycosphingolipids 13%
  9 Citations (Scopus)

• Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

  Tatituri, R. V. V., Watts, G. F. M., Bhowruth, V., Barton, N., Rothchild, A., Hsu, F-F., Almeida, C. F., Cox, L. R., Eggeling, L., Cardell, S., Rossjohn, J., Godfrey, D. I., Behar, S. M., Besra, G. S., Brenner, M. B. & Brigl, M., 2013, In: National Academy of Sciences. Proceedings. 110, 5, p. 1827-32 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer T-Cells 100%
  • Phosphatidylglycerols 91%
  • Hybridomas 79%
  • Phospholipids 74%
  • Antigens 53%
  80 Citations (Scopus)

• Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition

  Paduraru, C., Bezbradica, J. S., Kunte, A., Kelly, R., Shayman, J. A., Veerapen, N., Cox, L. R., Besra, G. S. & Cresswell, P., 26 Mar 2013, In: National Academy of Sciences. Proceedings. 110, 13, p. 5097-102 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer T-Cells 100%
  • Phospholipases A2 99%
  • Autoantigens 69%
  • CD1d Antigen 68%
  • group XV phospholipase A2 50%
  26 Citations (Scopus)

• Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

  Salio, M., Ghadbane, H., Dushek, O., Shepherd, D., Cypen, J., Gileadi, U., Aichinger, M. C., Napolitani, G., Qi, X., van der Merwe, P. A., Wojno, J., Veerapen, N., Cox, L. R., Besra, G. S., Yuan, W., Cresswell, P. & Cerundolo, V., 18 Nov 2013, In: National Academy of Sciences. Proceedings.

  Research output: Contribution to journal › Article › peer-review

  • Saposins 100%
  • CD1d Antigen 97%
  • Natural Killer T-Cells 71%
  • Antigen Presentation 65%
  • Lipids 39%
  26 Citations (Scopus)

• The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid

  Nguyen, T. K. A., Koets, A. P., Vordermeier, M., Jervis, P. J., Cox, L. R., Graham, S. P., Santema, W. J., Moody, D. B., van Calenbergh, S., Zajonc, D. M., Besra, G. S. & Van Rhijn, I., 2013, In: International Immunology. 25, 2, p. 91-8 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Galactosylceramides 100%
  • Natural Killer T-Cells 76%
  • Fatty Acids 54%
  • Cattle 51%
  • Rodentia 26%
  11 Citations (Scopus)

• β-mannosylceramide activates type I natural killer T cells to induce tumor immunity without inducing long-term functional anergy

  O'Konek, J. J., Kato, S., Takao, S., Izhak, L., Xia, Z., Illarionov, P., Besra, G. S., Terabe, M. & Berzosfky, J. A., 26 Jun 2013, In: Clinical Cancer Research.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer T-Cells 100%
  • Immunity 68%
  • Galactosylceramides 32%
  • Neoplasms 26%
  • Therapeutics 3%
  12 Citations (Scopus)
• 2012

  Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

  Wu, L., Parekh, V. V., Gabriel, C. L., Bracy, D. P., Marks-Shulman, P. A., Tamboli, R. A., Kim, S., Mendez-Fernandez, Y. V., Besra, G. S., Lomenick, J. P., Williams, B., Wasserman, D. H. & Van Kaer, L., 2012, In: National Academy of Sciences. Proceedings. 109, 19, p. E1143-52

  Research output: Contribution to journal › Article › peer-review

  • Obese Mice 100%
  • Natural Killer T-Cells 97%
  • Insulin Resistance 66%
  • Lipids 53%
  • Obesity 48%
  123 Citations (Scopus)

• Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production

  Wojno, J., Jukes, J-P., Ghadbane, H., Shepherd, D., Besra, G. S., Cerundolo, V. & Cox, L. R., 18 May 2012, In: ACS chemical biology. 7, 5, p. 847-855 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Threitol 100%
  • Natural Killer T-Cells 90%
  • Amides 89%
  • threitol 89%
  • Agonist 72%
  20 Citations (Scopus)

• Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner

  King, I. L., Fortier, A., Tighe, M., Dibble, J., Watts, G. F. M., Veerapen, N., Haberman, A. M., Besra, G. S., Mohrs, M., Brenner, M. B. & Leadbetter, E. A., 2012, In: Nature Immunology. 13, 1, p. 44-50 7 p.

  Research output: Contribution to journal › Article › peer-review

  • interleukin-21 100%
  • Natural Killer T-Cells 87%
  • B-Lymphocytes 56%
  • Lipids 47%
  • Antigens 46%
  146 Citations (Scopus)

• Saposins utilize two strategies for lipid transfer and CD1 antigen presentation

  Leon, L., Tatituri, RVV., Grenha, R., Sun, Y., Barral, DC., Minnaard, AJ., Bhowruth, V., Veerapen, N., Besra, G., Kasmar, A., Peng, W., Moody, DB., Grabowski, GA. & Brenner, MB., 1 Mar 2012, In: National Academy of Sciences. Proceedings. 109, 12, p. 4357-4364 8 p.

  Research output: Contribution to journal › Article

  • CD1 Antigens 100%
  • Saposins 94%
  • Antigen Presentation 61%
  • Lipids 37%
  • Antigens 20%
  35 Citations (Scopus)

• Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.

  Jervis, P., Moulis, M., Jukes, JP., Ghadbane, H., Cox, L., Cerundolo, V. & Besra, G., 7 Mar 2012, In: Carbohydrate Research.

  Research output: Contribution to journal › Article

  • Galactosylceramides 100%
  • Ceramide 77%
  • Diynes 64%
  • Bioactivity 46%
  • Ligands 45%
  22 Citations (Scopus)
• 2011

  Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors

  Pellicci, D. G., Clarke, A. J., Patel, O., Mallevaey, T., Beddoe, T., Le Nours, J., Uldrich, A. P., McCluskey, J., Besra, G. S., Porcelli, S. A., Gapin, L., Godfrey, D. I. & Rossjohn, J., 1 Sept 2011, In: Nature Immunology. 12, 9, p. 827-33 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer T-Cells 100%
  • Glycolipids 99%
  • T-Cell Antigen Receptor 85%
  • Antigens 35%
  • Ligands 29%
  98 Citations (Scopus)