Characterising novel regulators of the PI-3-kinase-like kinase-dependent DNA damage response and their role in preventing human disease and cancer

Stewart, Grant (Principal Investigator)

Cancer and Genomic Sciences

Short title	Characterising novel regulators of the PI-3-kinase-like kinase-dependent DNA damage response and their role in preventing human disease and cancer
Status	Active
Effective start/end date	1/09/17 → 30/11/24

Funding

Cancer Research Uk

8 Article

Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability
Hagkarim, N. C., Hajkarim, M. C., Suzuki, T., Fujiwara, T., Winkler, G. S., Stewart, G. S. & Grand, R. J., 17 Jul 2023, In: Cells. 12, 14, 34 p., 1868.
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Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans
Fletcher, S. C., Hall, C., Kennedy, T. J., Pajusalu, S., Wojcik, M. H., Boora, U., Li, C., Oja, K. T., Hendrix, E., Westrip, C. A., Andrijes, R., Piasecka, S. K., Singh, M., El-Asrag, M. E., Ptasinska, A., Tillmann, V., Higgs, M. R., Carere, D. A., Beggs, A. D., Pappas, J., & 5 othersRabin, R., Smerdon, S. J., Stewart, G. S., Õunap, K. & Coleman, M. L., 3 Apr 2023, In: Journal of Clinical Investigation. 133, 7, e152784.
Research output: Contribution to journal › Article › peer-review

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The structural mechanism of dimeric DONSON in replicative helicase activation
Cvetković, M., Passaretti, P., Butryn, A., Reynolds-Winczura, A., Kingsley, G., Skagia, A., Fernandez Cuesta, C., Poovathumkadavil, D., George, R., Chauhan, A., Jhujh, S., Stewart, G., Gambus, A. & Costa, A., 16 Nov 2023, In: Molecular Cell. 83, 22, p. 4017-4031.e9 24 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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