Can combined cellular and 11beta-hydroxysteroid dehydrogenase-1 gene therapy attenuate inflammation in acute respiratory distress syndrome

Mahida, Rahul (Principal Investigator)
Thickett, David (Co-Investigator)

Inflammation and Ageing

Short title	Can combined cellular and 11beta-hydroxysteroid dehydrogenase-1 gene therapy attenuate inflammation in acute respiratory distress syndrome
Status	Finished
Effective start/end date	3/08/16 → 2/11/19

Funding

Medical Research Council

5 Article

Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS
Mahida, R. Y., Lax, S., Bassford, C. R., Scott, A., Parekh, D., Hardy, R. S., Naidu, B., Matthay, M. A., Stewart, P. M., Cooper, M. C., Perkins, G. D. & Thickett, D. R., 27 Apr 2023, In: Frontiers in immunology. 14, 14 p., 1159831.
Research output: Contribution to journal › Article › peer-review

Open Access
File
31 Downloads (Pure)
CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome
Mahida, R. Y., Price, J., Lugg, S. T., Li, H., Parekh, D., Scott, A., Harrison, P., Matthay, M. A. & Thickett, D. R., 6 Apr 2022, In: American journal of physiology. Lung cellular and molecular physiology. 322, 4, p. L617-L624
Research output: Contribution to journal › Article › peer-review

Open Access
File
69 Downloads (Pure)
Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis
Mahida, R. Y., Scott, A., Parekh, D., Lugg, S. T., Hardy, R. S., Lavery, G. G., Matthay, M. A., Naidu, B., Perkins, G. D. & Thickett, D. R., 9 Sept 2021, In: The European respiratory journal. 58, 3, 2100829.
Research output: Contribution to journal › Article › peer-review

Open Access
File

32 Downloads (Pure)