Biosynthesis of the Polyketide Antibiotic Mupirocin by Pseudomonas Fluorescens

Project Details

Short titleBiosynthesis of the Polyketide Antibiotic Mupirocin by Pseudomonas Fluorescens
StatusFinished
Effective start/end date14/05/0413/05/07

Funding

  • Biotechnology & Biological Sciences Research Council

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  • Minimum Information about a Biosynthetic Gene cluster

    Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A., Hadjithomas, M., & 135 othersHaines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., Van Der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H. J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Müller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J. L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Süssmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., Van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E., Glöckner, F. O. & Thomas, C., 18 Aug 2015, In: Nature Chemical Biology. 11, 9, p. 625-631 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
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    387 Citations (Scopus)
    159 Downloads (Pure)
  • Biosynthesis of mupirocin by pseudomonas fluorescens NCIMB 10586 involves parallel pathways

    Gao, S. S., Hothersall, J., Wu, JE., Murphy, A. C., Song, Z., Stephens, E. R., Thomas, C. M., Crump, M. P., Cox, R. J., Simpson, T. J. & Willis, C. L., 9 Apr 2014, In: Journal of the American Chemical Society. 136, 14, p. 5501-5507 7 p.

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)
  • Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production.

    Hothersall, J., Murphy, AC., Iqbal, Z., Campbell, G., Stephens, E., Wu, J., Cooper, H., Atkinson, S., Williams, P., Crosby, J., Willis, CL., Cox, RJ., Simpson, TJ. & Thomas, C., 12 Feb 2011, In: Applied Microbiology and Biotechnology.

    Research output: Contribution to journalArticle

    7 Citations (Scopus)