A Bug in the System: How Does Salmonella Induce Novel B Cell Responses?

Research output

Research output per year 2009 2011 2012 2014 2016

• 29 Article
• 1 Editorial

Research output per year

Research output per year

Search results

• 2016

  Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen

  Hart, P. J., O'Shaughnessy, C. M., Siggins, M. K., Bobat, S., Kingsley, R. A., Goulding, D. A., Crump, J. A., Reyburn, H., Micoli, F., Dougan, G., Cunningham, A. F. & MacLennan, C. A., 7 Jan 2016, In: PLoS ONE. 11, 1, e0145945.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Salmonella typhi 100%
  • Salmonella Typhi 97%
  • Lipopolysaccharide 84%
  • lipopolysaccharides 73%
  • Lipopolysaccharides 65%
  24 Citations (Scopus)

  168 Downloads (Pure)
• 2015

  Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

  Hitchcock, J. R., Cook, C. N., Bobat, S., Ross, E. A., Flores-Langarica, A., Lowe, K. L., Khan, M., Dominguez Medina, C., Lax, S., Carvalho-Gaspar, M., Hubscher, S., Rainger, G., Cobbold, M., Buckley, C. D., Mitchell, T. J., Mitchell, A., Jones, N., Van Rooijen, N., Kirchhofer, D., Henderson, I. R., & 3 othersAdams, D. H., Watson, S. P. & Cunningham, A. F., 16 Nov 2015, In: Journal of Clinical Investigation. 125, 12, p. 4429–4446

  Research output: Contribution to journal › Article › peer-review

  • C-Type Lectins 100%
  • Salmonella Infections 92%
  • Blood Platelets 57%
  • Thrombosis 57%
  • Inflammation 43%
  95 Citations (Scopus)

  102 Downloads (Pure)
• 2014

  B1b cells recognize protective antigens after natural infection and vaccination

  Cunningham, A. F., Flores-langarica, A., Bobat, S., Dominguez Medina, C. C., Cook, C. N. L., Ross, E. A., Lopez-macias, C. & Henderson, I. R., 31 Oct 2014, In: Frontiers in immunology. 5, 535.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Vaccination 100%
  • Antigens 79%
  • Infections 59%
  • Salmonella capsular polysaccharide 33%
  • Immunity 29%
  39 Citations (Scopus)

  208 Downloads (Pure)

• Bacterial infections and vaccines

  Bobat, S. & Cunningham, A. F., 2014, In: Advances in Experimental Medicine and Biology. 828, p. 75-98 24 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Differential timing of antibody-mediated phagocytosis and cell-free killing of invasive African Salmonella allows immune evasion

  Siggins, M. K., O'shaughnessy, C. M., Pravin, J., Cunningham, A. F., Henderson, I. R., Drayson, M. T. & Maclennan, C. A., Apr 2014, In: European Journal of Immunology. 44, 4, p. n/a-n/a

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytophagocytosis 100%
  • Immune Evasion 96%
  • Salmonella 80%
  • Salmonella enterica 56%
  • Phagocytosis 45%
  13 Citations (Scopus)

  351 Downloads (Pure)

• Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing

  Wells, T. J., Whitters, D., Sevastsyanovich, Y. R., Heath, J. N., Pravin, J., Goodall, M., Browning, D. F., O'Shea, M. K., Cranston, A., De Soyza, A., Cunningham, A. F., MacLennan, C. A., Henderson, I. R. & Stockley, R. A., 25 Aug 2014, In: The Journal of Experimental Medicine. 211, 9, p. 1893-1904 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O Antigens 100%
  • Respiratory Tract Infections 89%
  • Immunoglobulin G 73%
  • Antibodies 53%
  • Serum 44%
  37 Citations (Scopus)

  173 Downloads (Pure)

• Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis

  Bobat, S., Darby, M., Mrdjen, D., Cook, C., Logan, E., Auret, J., Jones, E., Schnoeller, C., Flores-langarica, A., Ross, E. A., Vira, A., López-macías, C., Henderson, I. R., Alexander, J., Brombacher, F., Horsnell, W. G. & Cunningham, A. F., 4 Dec 2014, In: PLoS Neglected Tropical Diseases. 8, 12, e3341.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nippostrongylus 100%
  • Helminths 77%
  • Salmonella typhimurium 74%
  • immunity 73%
  • Immunity 52%
  15 Citations (Scopus)

  203 Downloads (Pure)

• Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function

  Ross, E. A., Flores-langarica, A., Bobat, S., Coughlan, R. E., Marshall, J., Hitchcock, J. R., Cook, C. N., Carvalho Gaspar, M., Mitchell, A. M., Clarke, M., Garcia, P., Cobbold, M., Mitchell, T. J., Henderson, I. R., Jones, N. D., Anderson, G., Buckley, C. D. & Cunningham, A. F., Aug 2014, In: European Journal of Immunology. 44, 8, p. 2318-2330 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Salmonella Infections 100%
  • Bone Marrow Cells 75%
  • Stem Cells 58%
  • Phenotype 48%
  • Infections 38%
  9 Citations (Scopus)

  268 Downloads (Pure)
• 2013

  IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection

  Horsnell, W. G. C., Darby, M. G., Hoving, J. C., Nieuwenhuizen, N., McSorley, H. J., Ndlovu, H., Bobat, S., Kimberg, M., Kirstein, F., Cutler, A. J., Dewals, B., Cunningham, A. F. & Brombacher, F., Oct 2013, In: PLoS pathogens. 9, 10, e1003662.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nippostrongylus 100%
  • Nippostrongylus brasiliensis 97%
  • Antigen Presentation 70%
  • B-lymphocytes 63%
  • immunity 56%
  25 Citations (Scopus)
• 2012

  CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines

  Serre, K., Cunningham, A. F., Coughlan, R. E., Lino, A. C., Rot, A., Hub, E., Moser, K., Manz, R., Ferraro, A., Bird, R., Toellner, K-M., Demengeot, J., MacLennan, I. C. M. & Mohr, E., 29 Nov 2012, In: Blood. 120, 23, p. 4552-9 8 p.

  Research output: Contribution to journal › Article › peer-review

  • aluminum sulfate 100%
  • B-Lymphocytes 56%
  • Vaccines 55%
  • Ligands 51%
  • Germinal Center 49%
  22 Citations (Scopus)

  141 Downloads (Pure)

• Death receptor 3 is essential for generating optimal protective CD41 T-cell immunity against Salmonella

  Buchan, SL., Taraban, VY., Slebioda, TJ., James, S., Cunningham, A. & Al-Shamkhani, A., 1 Mar 2012, In: European Journal of Immunology. 42, 3, p. 580-588 9 p.

  Research output: Contribution to journal › Editorial

  • Receptors, Tumor Necrosis Factor, Member 25 100%
  • Salmonella 58%
  • Immunity 45%
  • T-Lymphocytes 34%
  • Salmonella enterica 20%
  28 Citations (Scopus)

• Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node

  Flores-Langarica, A., Marshall, J. L., Hitchcock, J., Cook, C., Jobanputra, J., Bobat, S., Ross, E. A., Coughlan, R. E., Henderson, I. R., Uematsu, S., Akira, S. & Cunningham, A. F., 15 Dec 2012, In: Journal of Immunology. 189, 12, p. 5745-54 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Flagellin 100%
  • Regulatory T-Lymphocytes 73%
  • Immunoglobulin A 68%
  • Dendritic Cells 65%
  • Immunization 61%
  43 Citations (Scopus)

• The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen

  Marshall, J. L., Flores-Langarica, A., Kingsley, R. A., Hitchcock, J. R., Ross, E. A., López-Macías, C., Lakey, J., Martin, L. B., Toellner, K-M., MacLennan, C. A., MacLennan, I. C., Henderson, I. R., Dougan, G. & Cunningham, A. F., 15 Dec 2012, In: Journal of Immunology. 189, 12, p. 5527-5532 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Salmonella capsular polysaccharide 100%
  • Antigens 33%
  • Salmonella 33%
  • Immunization 26%
  • B-Lymphocytes 24%
  33 Citations (Scopus)

• The stability of complement-mediated bactericidal activity in human serum against Salmonella

  O’shaughnessy, C. M., Cunningham, A. F., Maclennan, C. A. & Manganelli, R. (ed.), 8 Nov 2012, In: PLoS ONE. 7, 11, e49147.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Haemolytic 100%
  • Salmonella 91%
  • Human Activities 88%
  • Safety 74%
  • complement 73%
  12 Citations (Scopus)

  200 Downloads (Pure)
• 2011

  Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody

  Siggins, M. K., Cunningham, A. F., Marshall, J. L., Chamberlain, J. L., Henderson, I. R. & MacLennan, C. A., 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2365-71 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Salmonella 100%
  • Antibodies 52%
  • Serum 43%
  • Immunity 32%
  • Immune Sera 14%
  36 Citations (Scopus)

• B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

  Lee, SK., Rigby, RJ., Zotos, D., Tsai, LM., Kawamoto, S., Marshall, J., Ramiscal, RR., Chan, TD., Gatto, D., Brink, R., Yu, D., Fagarasan, S., Tarlinton, DM., Cunningham, A. & Vinuesa, CG., 1 Jul 2011, In: The Journal of Experimental Medicine. 208, 7, p. 1377-1388 12 p.

  Research output: Contribution to journal › Article

  • Germinal Center 100%
  • Antibody Formation 75%
  • B-Lymphocytes 65%
  • T-Lymphocytes 52%
  • Helper-Inducer T-Lymphocytes 50%
  177 Citations (Scopus)

• CD31 Is Required on CD4(+) T Cells To Promote T Cell Survival during Salmonella Infection

  Ross, E., Coughlan, R., Flores-Langarica, A., Bobat, S., Marshall, J., Hussain, K., Charlesworth, J., Abhyankar, N., Hitchcock, J., Gil, C., Lopez-Macias, C., Henderson, I., Khan, M., Watson, S., MacLennan, I., Buckley, C. & Cunningham, A., 1 Aug 2011, In: Journal of Immunology. 187, 4, p. 1553-1565 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Salmonella Infections 100%
  • Cell Survival 60%
  • T-Lymphocytes 49%
  • Homeostasis 8%
  • adhesion receptor 7%
  20 Citations (Scopus)

• Early B blasts acquire a capacity for Ig class switch recombination that is lost as they become plasmablasts.

  Marshall, J., Zhang, Y., Pallan, L., Hsu, MC., Khan, M., Cunningham, AC., MacLennan, I. & Toellner, K-M., 1 Dec 2011, In: European Journal of Immunology. 41, 12, p. 3506-12 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetic Recombination 100%
  • AICDA (activation-induced cytidine deaminase) 68%
  • Ficoll 61%
  • 4-hydroxy-5-nitrophenyl acetic acid 20%
  • Antigens 14%
  33 Citations (Scopus)

  366 Downloads (Pure)

• Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression

  Serre, K., Benezech, C., Desanti, G., Bobat, S., Toellner, K-M., Bird, R., Chan, S., Kastner, P., Cunningham, A., MacLennan, I. & Mohr, E., 1 Jun 2011, In: PLoS ONE. 6, 6, p. e20731

  Research output: Contribution to journal › Article

  Open Access

  • Th2 Cells 100%
  • ovalbumin-alum 86%
  • Interleukin-4 78%
  • alum 78%
  • T-lymphocytes 77%
  44 Citations (Scopus)

• SadA, a Trimeric Autotransporter from Salmonella enterica Serovar Typhimurium, Can Promote Biofilm Formation and Provides Limited Protection against Infection.

  Raghunathan, D., Wells, T., Morris, F., Shaw, R., Bobat, S., Peters, SE., Paterson, GK., Jensen, KT., Leyton, D., Blair, J., Browning, D., Pravin, J., Flores-Langarica, A., Hitchcock, J., Moraes, CT., Piazza, RM., Maskell, DJ., Webber, M., May, R., MacLennan, C., & 3 othersPiddock, L., Cunningham, A. & Henderson, I., 1 Nov 2011, In: Infection and Immunity. 79, 11, p. 4342-52 11 p.

  Research output: Contribution to journal › Article

  • Type V Secretion Systems 100%
  • Salmonella enterica 78%
  • Salmonella 67%
  • biofilm 65%
  • Biofilms 62%
  57 Citations (Scopus)

• Selective effects of NF-κB1 deficiency in CD4 T cells on Th2 and TFh induction by alum-precipitated protein vaccines.

  Serre, K., Mohr, E., Benezech, C., Bird, R., Khan, MA., Caamaño, JH., Cunningham, A. & MacLennan, I., 6 Apr 2011, In: European Journal of Immunology.

  Research output: Contribution to journal › Article

  • aluminum sulfate 100%
  • ovalbumin-alum 99%
  • Vaccines 55%
  • T-Lymphocytes 45%
  • Germinal Center 34%
  17 Citations (Scopus)

• Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella Typhimurium infection.

  Bobat, S., Flores-Langarica, A., Hitchcock, J., Marshall, J., Kingsley, RA., Goodall, M., Gil-Cruz, C., Serre, K., Leyton, D., Letran, SE., Gaspal, F., Chester, R., Chamberlain, J., Dougan, G., López-Macías, C., Henderson, I., Alexander, J., MacLennan, I. & Cunningham, A., Jun 2011, In: European Journal of Immunology. 41, 6, p. 1606-1618 13 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Flagellin 100%
  • Salmonella Infections 91%
  • Salmonella typhimurium 84%
  • Immunization 61%
  • T-Lymphocytes 45%
  61 Citations (Scopus)

  450 Downloads (Pure)

• Trypanosoma cruzi infection induces a massive extrafollicular and follicular splenic B-cell response which is a high source of non-parasite-specific antibodies

  Bermejo, DA., Amezcua-Vesely, MC., Khan, M., Acosta-Rodríguez, EV., Montes, CL., Merino, MC., Toellner, K-M., Mohr, E., Taylor, D., Cunningham, A. & Gruppi, A., Jan 2011, In: Immunology. 132, 1, p. 123–133

  Research output: Contribution to journal › Article

  • Chagas Disease 100%
  • B-Lymphocytes 64%
  • Antibodies 46%
  • Infections 40%
  • Parasites 20%
  43 Citations (Scopus)

  67 Downloads (Pure)

• T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella

  Flores-Langarica, A., Marshall, J., Bobat, S., Mohr, E., Hitchcock, J., Ross, E., Coughlan, R., Khan, M., Van Rooijen, N., Henderson, I., MacLennan, I. & Cunningham, A., 1 Sept 2011, In: European Journal of Immunology. 41, 9, p. 2654-2665 12 p.

  Research output: Contribution to journal › Article

  • Salmonella 100%
  • Dendritic Cells 85%
  • Monocytes 79%
  • Salmonella Infections 29%
  • T-Lymphocytes 22%
  33 Citations (Scopus)
• 2010

  Dysregulated Humoral Immunity to Nontyphoidal Salmonella in HIV-Infected African Adults

  MacLennan, C., Gilchrist, JJ., Gordon, MA., Cunningham, A., Cobbold, M., Goodall, D., Kingsley, RA., van Oosterhout, JJG., Msefula, CL., Mandala, WL., Leyton, D., Marshall, J., Gondwe, E., Bobat, S., Lopez-Macias, C., Doffinger, R., Henderson, I., Zijlstra, EE., Dougan, G., Drayson, M., & 2 othersMacLennan, I. & Molyneux, ME., 1 Apr 2010, In: Science. 328, 5977, p. 508-512 5 p.

  Research output: Contribution to journal › Article

  • Salmonella 100%
  • Humoral Immunity 98%
  • HIV 65%
  • Lipopolysaccharides 40%
  • Antibodies 36%
  119 Citations (Scopus)

• IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine.

  Mohr, E., Cunningham, A., Toellner, K-M., Bobat, S., Coughlan, R., Bird, R., MacLennan, I. & Serre, K., 20 Sept 2010, In: National Academy of Sciences. Proceedings.

  Research output: Contribution to journal › Article

  • Immunoglobulin Class Switching 100%
  • aluminum sulfate 96%
  • B-Lymphocytes 54%
  • Vaccines 53%
  • T-Lymphocytes 44%
  51 Citations (Scopus)

• IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo.

  Serre, K., Mohr, E., Gaspal, F., Lane, P., Bird, R., Cunningham, A. & MacLennan, I., 1 Jun 2010, In: Molecular immunology. 47, 10, p. 1914-22 9 p.

  Research output: Contribution to journal › Article

  • aluminum sulfate 100%
  • Interleukin-4 68%
  • Cytokines 45%
  • T-Lymphocytes 45%
  • In Vitro Techniques 32%
  31 Citations (Scopus)

• Ligation of CD11c during vaccination promotes germinal centre induction and robust humoral responses without adjuvant

  White, AL., Tutt, AL., James, S., Wilkinson, KA., Castro, FVV., Dixon, SV., Hitchcock, J., Khan, M., Al-Shamkhani, A., Cunningham, A. & Glennie, MJ., 1 Sept 2010, In: Immunology. 131, 1, p. 141-151 11 p.

  Research output: Contribution to journal › Article

  • Germinal Center 100%
  • Ovalbumin 94%
  • Ligation 74%
  • Vaccination 67%
  • Dendritic Cells 33%
  21 Citations (Scopus)
• 2009

  Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature.

  Mohr, E., Serre, K., Manz, R., Cunningham, A., Khan, M., Hardie, D., Bird, R. & MacLennan, I., 15 Feb 2009, In: Journal of Immunology. 182, 4, p. 2113-23 11 p.

  Research output: Contribution to journal › Article

  • Dendritic Cells 100%
  • Monocytes 92%
  • Interleukin-6 86%
  • Lymph Nodes 79%
  • Macrophages 78%
  140 Citations (Scopus)

• The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response

  Gil-Cruz, C., Bobat, S., Marshall, J., Kingsley, RA., Ross, E., Henderson, I., Leyton, D., Coughlan, R., Khan, M., Jensen, KT., Buckley, C., Dougan, G., MacLennan, I., López-Macías, C. & Cunningham, A., 16 Jun 2009, In: National Academy of Sciences. Proceedings. 106, 24, p. 9803-8 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Porins 100%
  • Salmonella typhimurium 88%
  • Salmonella 80%
  • Antibody Formation 69%
  • Bacteremia 39%
  126 Citations (Scopus)

  185 Downloads (Pure)