Colleges, School and Institutes
Willingness to take PhD students
The primary focus of Yotis Senis’s research and doctoral supervision is the regulation of platelet activation and thrombosis by protein tyrosine phosphatases (PTPs). PTPs are a family of enzymes that work in conjunction with protein tyrosine kinases (PTKs) to regulate protein phosphorylation. Dr Senis employs a combination of classical and modern biochemical proteomics techniques, andex vivoandin vivoplatelet functional assays to explore the functional roles of PTPs in platelets. He is also specifically interested in understanding how these enzymes regulate signalling from platelet surface receptors, including the collagen activation receptor GPVI, the fibrinogen integrin αIIbβ3 and the G protein-coupled thrombin receptors PAR-1 and PAR-4.