Sovan Sarkar

Publications

  1. 2020
  2. Published

    Autophagy in rare (nonlysosomal) neurodegenerative diseases

    Malgosia Zatyka, Sovan Sarkar & Timothy Barrett, 3 Apr 2020, In: Journal of Molecular Biology. 432, 8, p. 2735-2753 19 p.

    Research output: Contribution to journalReview articlepeer-review

  3. Published

    Human induced pluripotent stem cell models of neurodegenerative disorders for studying the biomedical implications of autophagy

    Timothy Barrett & Sovan Sarkar, 3 Apr 2020, In: Journal of Molecular Biology. 432, 8, p. 2754-2798 45 p.

    Research output: Contribution to journalReview articlepeer-review

  4. Published
  5. 2019
  6. Published

    Biomedical Implications of Autophagy in Macromolecule Storage Disorders

    Sovan Sarkar, 6 Sep 2019, In: Frontiers in cell and developmental biology. 7, 179.

    Research output: Contribution to journalReview articlepeer-review

  7. 2017
  8. Published

    Dysregulation of autophagy as a common mechanism in lysosomal storage diseases

    Malgosia Zatyka, Timothy Barrett, Richard Tuxworth & Sovan Sarkar, 12 Dec 2017, In: Essays in Biochemistry. 61, 6, p. 733-749 17 p.

    Research output: Contribution to journalReview articlepeer-review

  9. E-pub ahead of print

    Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms

    Carl Ward, Sovan Sarkar, 9 Aug 2017, (E-pub ahead of print) In: Autophagy. 13, 9, p. 1556-1572 17 p.

    Research output: Contribution to journalArticlepeer-review

  10. Published
  11. 2016
  12. E-pub ahead of print

    PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder

    Carl Ward, Sovan Sarkar, 30 Aug 2016, (E-pub ahead of print) In: Scientific Reports. 6, p. 31750

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Autophagy, lipophagy and lysosomal lipid storage disorders

    Carl Ward, Sovan Sarkar, Apr 2016, In: Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1861, 4, p. 269-284

    Research output: Contribution to journalArticlepeer-review

  14. Published

    Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

    Sovan Sarkar, 7 Jan 2016, In: eLife. 5, 23 p., e11058.

    Research output: Contribution to journalArticlepeer-review

  15. 2015
  16. Published

    Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis

    Sovan Sarkar, Oct 2015, In: Amino Acids. 47, 10, p. 2065-2088 24 p.

    Research output: Contribution to journalArticlepeer-review

  17. Published

    Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

    Sovan Sarkar, 4 Aug 2015, In: National Academy of Sciences. Proceedings. 112, 31, p. E4281-E4287

    Research output: Contribution to journalArticlepeer-review

  18. 2014
  19. Published

    Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells

    Sovan Sarkar, 9 Dec 2014, In: Stem Cell Reports. 3, 6, p. 948-56 9 p.

    Research output: Contribution to journalArticlepeer-review

  20. Published

    The developmental potential of iPSCs is greatly influenced by reprogramming factor selection

    Sovan Sarkar & 4 others, , 4 Sep 2014, In: Cell stem cell. 15, 3, p. 295-309 15 p.

    Research output: Contribution to journalArticlepeer-review

  21. Published
  22. Published

    Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease

    Sovan Sarkar, 10 Apr 2014, In: Autophagy. 10, 6, p. 1137-1140 4 p.

    Research output: Contribution to journalArticle

  23. Published

    Autophagy researchers

    Sovan Sarkar, Apr 2014, In: Autophagy. 10, 4, p. 552-555 4 p.

    Research output: Contribution to journalArticlepeer-review

  24. Published
  25. 2013
  26. Published

    Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease

    Sovan Sarkar, 12 Dec 2013, In: Cell Reports. 5, 5, p. 1302-15 14 p.

    Research output: Contribution to journalArticlepeer-review

  27. Published
  28. Published

    Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

    Sovan Sarkar, Jul 2013, In: Nature Biotechnology. 31, 7, p. 653-8 6 p.

    Research output: Contribution to journalArticlepeer-review

  29. Published
  30. 2012
  31. Published

    Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors

    Sovan Sarkar, 7 Sep 2012, In: Cell stem cell. 11, 3, p. 373-86 14 p.

    Research output: Contribution to journalArticlepeer-review

  32. 2011
  33. Published

    Complex inhibitory effects of nitric oxide on autophagy

    Sovan Sarkar, 8 Jul 2011, In: Molecular Cell. 43, 1, p. 19-32 14 p.

    Research output: Contribution to journalArticlepeer-review

  34. Published

    Lysosomal positioning coordinates cellular nutrient responses

    Sovan Sarkar, Apr 2011, In: Nature Cell Biology. 13, 4, p. 453-60 8 p.

    Research output: Contribution to journalArticlepeer-review

  35. Published

    Role of autophagy in neurodegenerative diseases

    Sovan Sarkar, 2011, In: Current Science. 101, 4, p. 514-9 6 p.

    Research output: Contribution to journalArticlepeer-review

  36. 2010
  37. Published

    Impaired autophagy in Lafora disease

    Sovan Sarkar, Oct 2010, In: Autophagy. 6, 7, p. 991-3 3 p.

    Research output: Contribution to journalArticle

  38. Published

    Regulation of mammalian autophagy in physiology and pathophysiology

    Sovan Sarkar, Oct 2010, In: Physiological Reviews. 90, 4, p. 1383-435 53 p.

    Research output: Contribution to journalArticlepeer-review

  39. Published

    Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

    Sovan Sarkar, Stephen Murphy, 1 Sep 2010, In: Human Molecular Genetics. 19, 17, p. 3413-29 17 p.

    Research output: Contribution to journalArticlepeer-review

  40. Published

    Laforin, the most common protein mutated in Lafora disease, regulates autophagy

    Sovan Sarkar, 15 Jul 2010, In: Human Molecular Genetics. 19, 14, p. 2867-76 10 p.

    Research output: Contribution to journalArticlepeer-review

  41. Published

    Cystamine suppresses polyalanine toxicity in a mouse model of oculopharyngeal muscular dystrophy

    Sovan Sarkar, 2 Jun 2010, In: Science Translational Medicine. 2, 34, p. 34ra40

    Research output: Contribution to journalArticlepeer-review

  42. Published

    Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases

    Sovan Sarkar, 9 Apr 2010, In: Journal of Biological Chemistry. 285, 15, p. 11061-7 7 p.

    Research output: Contribution to journalArticlepeer-review

  43. Published

    Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice

    Sovan Sarkar, Feb 2010, In: PLoS Genetics. 6, 2, p. e1000838

    Research output: Contribution to journalArticlepeer-review

  44. 2009
  45. Published

    In search of an "autophagomometer"

    Sovan Sarkar, Jul 2009, In: Autophagy. 5, 5, p. 585-9 5 p.

    Research output: Contribution to journalArticle

  46. Published

    Mammalian macroautophagy at a glance

    Sovan Sarkar, 1 Jun 2009, In: Journal of Cell Science. 122, Pt 11, p. 1707-11 5 p.

    Research output: Contribution to journalArticlepeer-review

  47. Published

    Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates

    Sovan Sarkar, Apr 2009, In: Autophagy. 5, 3, p. 307-13 7 p.

    Research output: Contribution to journalArticlepeer-review

  48. Published
  49. Published

    Autophagic clearance of aggregate-prone proteins associated with neurodegeneration

    Sovan Sarkar, 2009, In: Methods in Enzymology. 453, p. 83-110 28 p.

    Research output: Contribution to journalArticlepeer-review

  50. 2008
  51. Published

    Huntington's disease: degradation of mutant huntingtin by autophagy

    Sovan Sarkar, Sep 2008, In: The FEBS journal. 275, 17, p. 4263-70 8 p.

    Research output: Contribution to journalArticlepeer-review

  52. Published

    Small molecule enhancers of autophagy for neurodegenerative diseases

    Sovan Sarkar, Sep 2008, In: Molecular BioSystems. 4, 9, p. 895-901 7 p.

    Research output: Contribution to journalArticlepeer-review

  53. Published

    Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

    Sovan Sarkar, 15 May 2008, In: Journal of Cell Science. 121, Pt 10, p. 1649-60 12 p.

    Research output: Contribution to journalArticlepeer-review

  54. Published

    Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

    Sovan Sarkar, May 2008, In: Nature Chemical Biology. 4, 5, p. 295-305 11 p.

    Research output: Contribution to journalArticlepeer-review

  55. Published

    Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation

    Sovan Sarkar, 15 Apr 2008, In: Human Molecular Genetics. 17, 8, p. 1097-108 12 p.

    Research output: Contribution to journalArticlepeer-review

  56. Published

    A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin

    Sovan Sarkar, 15 Jan 2008, In: Human Molecular Genetics. 17, 2, p. 170-8 9 p.

    Research output: Contribution to journalArticlepeer-review

  57. Published

    Clearance of mutant aggregate-prone proteins by autophagy

    Sovan Sarkar, 2008, In: Methods in molecular biology. 445, p. 195-211 17 p.

    Research output: Contribution to journalArticlepeer-review

  58. 2007
  59. Published

    Hydrophilic protein associated with desiccation tolerance exhibits broad protein stabilization function

    Sovan Sarkar, 13 Nov 2007, In: National Academy of Sciences. Proceedings. 104, 46, p. 18073-8 6 p.

    Research output: Contribution to journalArticlepeer-review

  60. Published
  61. Published

    Small molecules enhance autophagy and reduce toxicity in Huntington's disease models

    Sovan Sarkar, Jun 2007, In: Nature Chemical Biology. 3, 6, p. 331-8 8 p.

    Research output: Contribution to journalArticlepeer-review

  62. Published
  63. Published

    The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias

    Sovan Sarkar, 2007, In: Biochemistry. 8 Suppl 1, p. S2

    Research output: Contribution to journalArticlepeer-review

  64. 2006
  65. Published

    Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations

    Sovan Sarkar, 29 Jul 2006, In: Autophagy. 2, 2, p. 132-4 3 p.

    Research output: Contribution to journalArticle

  66. Published
  67. Published

    Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

    Sovan Sarkar, 2006, In: Current Topics in Developmental Biology. 76, p. 89-101 13 p.

    Research output: Contribution to journalArticlepeer-review

  68. 2005
  69. Published

    Lithium induces autophagy by inhibiting inositol monophosphatase

    Sovan Sarkar, 26 Sep 2005, In: Journal of Cell Biology. 170, 7, p. 1101-11 11 p.

    Research output: Contribution to journalArticlepeer-review

  70. 2004
  71. Published
  72. 2003
  73. Published
  74. 2002
  75. Published

    Untangling the mystery of Alzheimer’s disease: Understanding molecular mechanisms for novel therapeutic approaches

    Sovan Sarkar, Feb 2002, In: Resonance. 7, 2, p. 33-45 13 p.

    Research output: Contribution to journalArticlepeer-review