Research output per year
Research output per year
- 1 - 50 out of 111 results
Search results
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2023
Analyzing Angiotensin II Receptor Type 1 Clustering in PC12 Cells in Response to Hypoxia Using Direct Stochastic Optical Reconstruction Microscopy (dSTORM)
Aldossary, H. S., Nieves, D. J., Kavanagh, D. M., Owen, D., Ray, C. J., Kumar, P., Coney, A. M. & Holmes, A. P., 16 Jun 2023, Arterial Chemoreceptors: Mal(adaptive) Responses: O2 Dependent and Independent Mechanisms. Conde, S. V., Iturriaga, R., del Rio, R., Gauda, E. & Monteiro, E. C. (eds.). 1 ed. Springer, p. 175-184 10 p. (Advances in Experimental Medicine and Biology; vol. 1427).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Cultural adaptation and development of an educational intervention ‘Meri Sehat, Mere Rules’ relating to cardiovascular disease associated with rheumatoid arthritis for South Asian people.
Tiwana, R., Kamal, A., Singh, D., Misra, D., Usman, F., John, H., Kitas, G. D., Greenfield, S., Kumar, P., Ray, C., Bosworth, A., Ahmad, A., Reehal, J. & Kumar, K., 25 Oct 2023, (E-pub ahead of print) In: Mediterranean Journal of Rheumatology. 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Downloads (Pure) -
Low sugar and the drive to breathe: Is insulin another adequate stimulus for the carotid body?
Holmes, A. P. & Kumar, P., 1 Feb 2023, In: Experimental Physiology. 108, 2, p. 167-168 2 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Downloads (Pure) -
2022
Are multiple mitochondrial related signalling pathways involved in carotid body oxygen sensing?
Holmes, A. P., Swiderska, A., Nathanael, D., Aldossary, H. S., Ray, C. J., Coney, A. M. & Kumar, P., 31 May 2022, In: Frontiers in Physiology. 13, 12 p., 908617.Research output: Contribution to journal › Review article › peer-review
Open AccessFile27 Downloads (Pure) -
LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response
MacMillan, S., Holmes, A. P., Dallas, M. L., Mahmoud, A. D., Shipston, M. J., Peers, C., Hardie, D. G., Kumar, P. & Evans, A. M., Dec 2022, In: Communications Biology. 5, 1, 15 p., 642.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Publisher correction: LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response (Communications biology (2022) 5 1 (642))
MacMillan, S., Holmes, A. P., Dallas, M. L., Mahmoud, A. D., Shipston, M. J., Peers, C., Hardie, D. G., Kumar, P. & Evans, A. M., 29 Jul 2022, In: Communications Biology. 5, 1, 1 p., 765.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Risk of incident obstructive sleep apnoea in patients with type 1 diabetes: a population-based retrospective cohort study
Alshehri, Z., Subramanian, A., Adderley, N., Gokhale, K., Karamat, M. A., Ray, C., Kumar, P., Nirantharakumar, K. & Tahrani, A., Aug 2022, In: Diabetologia. 65, 8, p. 1353-1363 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Downloads (Pure) -
2021
Mitochondrial succinate metabolism and reactive oxygen species are important but not essential for eliciting carotid body and ventilatory responses to hypoxia in the rat
Swiderska, A., Coney, A. M., Alzahrani, A. A., Aldossary, H. S., Batis, N., Ray, C. J., Kumar, P. & Holmes, A. P., 25 May 2021, In: Antioxidants. 10, 6, 20 p., 840.Research output: Contribution to journal › Article › peer-review
Open AccessFile126 Downloads (Pure) -
β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia
Alzahrani, A. A., Cao, L. L., Aldossary, H. S., Nathanael, D., Fu, J., Ray, C. J., Brain, K. L., Kumar, P., Coney, A. M. & Holmes, A. P., Jan 2021, In: Pfluegers Archiv: European journal of physiology . 473, 1, p. 37-51 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)179 Downloads (Pure) -
2020
A student practical to conceptualize the importance of Poiseuille’s law and flow control in the cardiovascular system
Holmes, A. P., Ray, C. J., Kumar, P. & Coney, A. M., 1 Sept 2020, In: Advances in Physiology Education.Research output: Contribution to journal › Article › peer-review
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G-protein-coupled receptor (GPCR) signaling in the carotid body: roles in hypoxia and cardiovascular and respiratory disease
Aldossary, H. S., Alzahrani, A. A., Nathanael, D., Alhuthail, E. A., Ray, C. J., Batis, N., Kumar, P., Coney, A. M. & Holmes, A. P., 1 Sept 2020, In: International Journal of Molecular Sciences. 21, 17, 20 p., 6012.Research output: Contribution to journal › Review article › peer-review
Open AccessFile3 Citations (Scopus)202 Downloads (Pure) -
2018
Adrenaline activation of the carotid body: key to CO2 and pH homeostasis in hypoglycaemia and potential pathological implications in cardiovascular disease
Holmes, A., Ray, C., Thompson, E., Alshehri, Z., Coney, A. & Kumar, P., 25 May 2018, (E-pub ahead of print) In: Respiratory physiology & neurobiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)277 Downloads (Pure) -
Ecto-5′-nucleotidase (CD73) regulates peripheral chemoreceptor activity and cardiorespiratory responses to hypoxia: Ecto-5′-nucleotidase and carotid body chemosensitivity
Holmes, A. P., Ray, C. J., Pearson, S. A., Coney, A. M. & Kumar, P., 9 Aug 2018, In: The Journal of Physiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)204 Downloads (Pure) -
Is carotid body physiological O2 sensitivity determined by a unique mitochondrial phenotype?
Holmes, A., Ray, C., Coney, A. & Kumar, P., 16 May 2018, In: Frontiers in Physiology. 9, 562.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)173 Downloads (Pure) -
2017
The effect of benign and malignant pleural disease on chest wall mechanics
Elshafie, G., Kumar, P., Djearaman, M., Aliverti, A. & Naidu, B., 15 Jul 2017, In: American Journal of Respiratory and Critical Care Medicine. 196, 2, p. 241-242 2 p.Research output: Contribution to journal › Letter › peer-review
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2016
Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2 sensitivity during hypoglycaemia: a role for the carotid body
Thompson, E. L., Ray, C. J., Holmes, A. P., Pye, R. L., Wyatt, C. N., Coney, A. M. & Kumar, P., 1 Aug 2016, In: The Journal of Physiology. 594, 15, p. 4439-52 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)236 Downloads (Pure) -
AMPK deficiency blocks the hypoxic ventilatory response and thus precipitates hypoventilation and apnea
Mahmoud, A. D., Lewis, S., Juričić, L., Udoh, U-A., Hartmann, S., Jansen, M. A., Ogunbayo, O. A., Puggioni, P., Holmes, A. P., Kumar, P., Navarro-Dorado, J., Foretz, M., Viollet, B., Dutia, M. B., Marshall, I. & Evans, A. M., 1 May 2016, In: American Journal of Respiratory and Critical Care Medicine. 193, 9Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)381 Downloads (Pure) -
Chest wall mechanics before and after diaphragm plication
Elshafie, G., Acosta, J., Aliverti, A., Bradley, A., Kumar, P., Rajesh, P. & Naidu, B., 2 Feb 2016, In: Journal of Cardiothoracic Surgery. 11, 25.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)207 Downloads (Pure) -
Measuring changes in chest wall motion after lung resection using structured light plethysmography: a feasibility study
Naidu, B. & Kumar, P., 16 Jun 2016, (E-pub ahead of print) In: Interactive CardioVascular and Thoracic Surgery. 23, 4, p. 544-547Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Moderate inhibition of mitochondrial function augments carotid body hypoxic sensitivity
Holmes, A. P., Turner, P. J., Buckler, K. J. & Kumar, P., Jan 2016, In: Pfluegers Archiv: European journal of physiology . 468, 1, p. 143-155Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)248 Downloads (Pure) -
2015
Ecto-5'-nucleotidase, adenosine and transmembrane adenylyl cyclase signalling regulate basal carotid body chemoafferent outflow and establish the sensitivity to hypercapnia
Holmes, A. P., Nunes, A. R., Cann, M. J. & Kumar, P., 2015, Arterial Chemoreceptors in Physiology and Pathophysiology. Peers, C., Kumar, P., Wyatt, C., Gauda, E., Nurse, C. A. & Prabhakar, N. (eds.). Springer, Vol. 860. p. 279-289 11 p. (Advances in Experimental Medicine and Biology; vol. 860).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
Open AccessFile11 Citations (Scopus)257 Downloads (Pure) -
Hypoxia is an effective stimulus for vesicular release of ATP from human umbilical vein endothelial cells
To, W., Kumar, P. & Marshall, J., 1 Jul 2015, In: Placenta. 36, 7, p. 759-766 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)196 Downloads (Pure) -
Mild chronic intermittent hypoxia in wistar rats evokes significant cardiovascular pathophysiology but no overt changes in carotid body-mediated respiratory responses
Ray, C. J., Dow, B., Kumar, P. & Coney, A. M., 2015, Arterial Chemoreceptors in Physiology and Pathophysiology. Peers, C., Kumar, P., Wyatt, C., Gauda, E., Nurse, C. A. & Prabhakar, N. (eds.). Springer, Vol. 860. p. 245-254 10 p. (Advances in Experimental Medicine and Biology; vol. 860).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
4 Citations (Scopus) -
Surgery corrects asynchrony of ribcage secondary to extra-thoracic tumor but leads to expiratory dysfunction during exercise
Elshafie, G., Aliverti, A., Pippa, L., Kumar, P., Kalkat, M. & Naidu, B., 18 Dec 2015, In: Journal of Cardiothoracic Surgery. 10, 1, 187.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)139 Downloads (Pure) -
2014
Glycogen metabolism protects against metabolic insult to preserve carotid body function during glucose deprivation
Holmes, A. P., Turner, P. J., Carter, P., Leadbeater, W., Ray, C. J., Hauton, D., Buckler, K. J. & Kumar, P., 15 Oct 2014, In: The Journal of Physiology. 592, 20, p. 4493-4506Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)167 Downloads (Pure) -
2013
Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors
Nunes, A. R., Holmes, A. P. S., Sample, V., Kumar, P., Cann, M. J., Monteiro, E. C., Zhang, J. & Gauda, E. B., 15 Aug 2013, In: Respiratory physiology & neurobiology. 188, 2, p. 83-93 11 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
The impact of acute and chronic catecholamines on respiratory responses to hypoxic stress in the rat
Hauton, D., Holmes, A., Ziff, O. & Kumar, P., 2013, In: Pfluegers Archiv: European journal of physiology . 465, 2, p. 209-219 11 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
2012
Foreword. The emergence of carbon monoxide (CO) and hydrogen sulphide (H(2)S) as biologically active gases
Kumar, P. & Peers, C., 15 Nov 2012, In: Respiratory physiology & neurobiology. 184, 2, p. 115-6 2 p.Research output: Contribution to journal › Article
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Long-term facilitation of ventilation following acute continuous hypoxia in awake humans during sustained hypercapnia
Griffin, H. S., Pugh, K., Kumar, P. & Balanos, G. M., 13 Sept 2012, In: The Journal of Physiology. 590, Pt 20, p. 5151-65 15 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
Peripheral chemoreceptors: function and plasticity of the carotid body
Kumar, P. & Prabhakar, N. R., Jan 2012, In: Comprehensive Physiology. 2, 1, p. 141-219 79 p.Research output: Contribution to journal › Article › peer-review
283 Citations (Scopus) -
The carotid body in cardiovascular disease: more chicken and egg than horse and cart?
Kumar, P., 1 Sept 2012, In: The Journal of Physiology. 590, Pt 17, p. 4123Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
The interaction between low glucose and hypoxia in the in vitro, rat carotid body
Holmes, A. P. S., Hauton, D. & Kumar, P., 2012, In: Advances in Experimental Medicine and Biology. 758, p. 123-7 5 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
2011
High Altitude Tolerance is Not Determined By Class
Egginton, S. & Kumar, P., 1 Nov 2011, In: Journal of Applied Physiology. 111, 5, p. 1524-1524 1 p.Research output: Contribution to journal › Article
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The effect of chronic catecholamine treatment upon vascular reactivity
Duglan, D., Ziff, O., To, W., Holmes, A., Kumar, P. & Hauton, D., 1 Jan 2011, p. PC35.Research output: Contribution to conference (unpublished) › Abstract
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The role of catecholamines in the augmented chemosensitivity of heart
Ziff, O., Duglan, D., Holmes, A., Hauton, D. & Kumar, P., 1 Jan 2011, p. PC32.Research output: Contribution to conference (unpublished) › Abstract
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2010
Interaction between hypoxia and glucose in the rat carotid body, in vitro
Holmes, A., Hauton, D. & Kumar, P., 1 Jan 2010, p. C09 and PC09.Research output: Contribution to conference (unpublished) › Abstract
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The effects of hypoxia on ATP release from Human Umbilical Artery and Vein endothelial cells (HUAEC, HUVEC
To, WK., Gu, Y., Kumar, P. & Marshall, J., 1 Jan 2010, p. PC30.Research output: Contribution to conference (unpublished) › Abstract
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Ventilatory long-term facilitation following a bout of intermittent hypoxia: the role of carotid chemoreceptors and ventilatory drift due to carbon dioxide
Griffin, HS., Kumar, P. & Balanos, G., 1 Jan 2010, p. PC38.Research output: Contribution to conference (unpublished) › Abstract
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2009
An airway occlusion model for studying obstructive sleep apnoea-induced intermitten hypoxia in humans
Griffin, H., Kumar, P. & Balanos, G., 1 Jan 2009.Research output: Contribution to conference (unpublished) › Abstract
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A respiratory response to the activation of the muscle metaboreflex during concurrent hypercapnia in man
Lykidis, C., Kumar, P., Vianna, L., White, M. & Balanos, G., 1 Jan 2009, In: Experimental Physiology. 95, 1, p. 194-201 8 p.Research output: Contribution to journal › Article
16 Citations (Scopus) -
Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery
Evans, AM., Hardie, DG., Peers, C., Wyatt, CN., Viollet, B., Kumar, P., Dallas, ML. & Ross, F., 1 Jan 2009, In: Hypoxia and Consequences: Ann. N.Y. Acad. Sci. 1177, p. 89-100 12 p.Research output: Contribution to journal › Article
34 Citations (Scopus) -
Systemic effects resulting from carotid body stimulation-invited article.
Kumar, P., 1 Jan 2009, In: Advances in Experimental Medicine and Biology. 648, p. 223-33 11 p.Research output: Contribution to journal › Article
39 Citations (Scopus) -
The respiratory responses to the combined activation of the muscle metaboreflex and the ventilatory chemoreflex.
Lykidis, CK., Kumar, P. & Balanos, G., 1 Jan 2009, In: Advances in Experimental Medicine and Biology. 648, p. 281-7 7 p.Research output: Contribution to journal › Article
4 Citations (Scopus) -
2008
Carotid body and ventilatory responses to acute hypoxia in the anaesthetised adult rat following prenatal hypoxia
Coney, A., Pearson, S., Kumar, P. & Marshall, J., 1 Jan 2008, p. PC42.Research output: Contribution to conference (unpublished) › Abstract
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Human vascular endothelial cells show a time-dependent response to the stress of hypoglycaemia following their isolation and culture
Hale, O., To, W. & Kumar, P., 1 Jan 2008, p. PC17.Research output: Contribution to conference (unpublished) › Abstract
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Key Roles for AMP-activated Protein Kinase in the Function of the Carotid Body?
Wyatt, CN., Pearson, S., Kumar, P., Peers, C., Hardie, DG. & Evans, AM., 1 Jan 2008, Advances in experimental medicine and biology. Vol. 605. (Advances in Experimental Medicine and Biology; vol. 605).Research output: Chapter in Book/Report/Conference proceeding › Chapter
6 Citations (Scopus) -
Matching ventilation to systemic metabolism: a role for peripheral chemoreceptors?
Kumar, P., 1 Jan 2008, p. SA12.Research output: Contribution to conference (unpublished) › Abstract
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The role of peripheral and central chemoreceptors in the hypermetabolism-induced increases in the ventilatory chemosensitivity to CO2 in humans
Lykidis, C., Kumar, P. & Balanos, G., 1 Jan 2008, p. PC3.Research output: Contribution to conference (unpublished) › Abstract
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2007
Adequate stimuli of the carotid body: more than an oxygen sensor?
Kumar, P. & Bin Jaliah, I., 1 Jul 2007, In: Respiratory physiology & neurobiology. In Press, p. 12-21 10 p.Research output: Contribution to journal › Article
52 Citations (Scopus) -
AMP-activated protein kinase mediates carotid body excitation by hypoxia
Wyatt, CN., Mustard, K., Pearson, SA., Dallas, ML., Atkinson, L., Kumar, P., Peers, C., Hardie, DG. & Evans, AM., 16 Jan 2007, In: Journal of Biological Chemistry. 282, 11, p. 8092-8098 7 p.Research output: Contribution to journal › Article
116 Citations (Scopus)