Willingness to take PhD students
Nigel Simpkins’s research group is interested in the development of new synthetic methods and strategies for organic synthesis, particularly those involving a symmetry-breaking approach, for example, using chiral bases to effect asymmetric deprotonation. They aim to devise concise, efficient and elegant syntheses of complex biologically active molecules and their analogues in order to probe their medicinal potential. Targets of current interest include gelsemine, welwistatin, stephacidins, paraherquamides and various polyprenylated acylphloroglucinols. These compounds display varied activities, including anti-cancer and anti-parasitic activity, and inhibition of multi-drug resistance.
Professor Simpkins is interested in supervising doctoral research students in the following areas:
Asymmetric organic synthesis
Synthesis of natural products and analogues
Synthesis aimed at novel molecular scaffolds, including boxes formed using templating methods