Nguyet -Thin Luu

2023

Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease

Vaikunthanathan, T., Landmann, E., Correa, D. M., Romano, M., Trevelin, S. C., Peng, Q., Crespo, E., Corrado, M., Lozano, J-J., Pearce, E. L., Perpinan, E., Zoccarato, A., Siew, L., Edwards-Hicks, J., Khan, R., Luu, N-T., Thursz, M. R., Newsome, P. N., Martinez-Llordella, M., Shah, N., & 5 othersLechler, R. I., Shah, A. M., Sanchez-Fueyo, A., Lombardi, G. & Safinia, N., Sept 2023, In: EBioMedicine. 95, 17 p., 104778.

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Downloads (Pure)

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

Ast, J., Nasteska, D., Fine, N. H. F., Nieves, D. J., Koszegi, Z., Lanoiselée, Y., Cuozzo, F., Viloria, K., Bacon, A., Luu, N. T., Newsome, P. N., Calebiro, D., Owen, D. M., Broichhagen, J. & Hodson, D. J., 18 Jan 2023, In: Nature Communications. 14, 1, 15 p., 301.

Research output: Contribution to journal › Article › peer-review

Open Access

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34 Downloads (Pure)

TGFβ₁ priming enhances CXCR3-mediated mesenchymal stromal cell engraftment to the liver and enhances anti-inflammatory efficacy

Garg, A., Khan, S., Luu, N., Nicholas, D. J., Day, V., King, A. L., Fear, J., Lalor, P. F. & Newsome, P. N., Mar 2023, In: Journal of Cellular and Molecular Medicine. 27, 6, p. 864-878 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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31 Downloads (Pure)

2020

Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2-/- animals

Sheriff, L., Khan, R. S., Saborano, R., Wilkin, R., Luu, N., Gunther, U. L., Hubscher, S. G., Newsome, P. N. & Lalor, P. F., 29 Dec 2020, In: Disease Models & Mechanisms. 13, 12, dmm046383.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

178 Downloads (Pure)

2019

Resolving the fibrotic niche of human liver cirrhosis at single-cell level.

Ramachandran, P., Dobie, R., Wilson-Kanamori, JR., Dora, EF., Henderson, BEP., Luu, NT., Portman, JR., Matchett, KP., Brice, M., Marwick, JA., Taylor, RS., Efremova, M. & Henderson, NC., Oct 2019, In: Nature. 575, p. 512-518

Research output: Contribution to journal › Article › peer-review

2018

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.

Rashidi, H., Luu, NT., Alwahsh, SM., Ginai, M., Alhaque, S., Dong, H., Tomaz, RA., Vernay, B., Vigneswara, V., Hallett, JM., Chandrashekran, A., Dhawan, A., Vallier, L. & Hay, DC., 28 Aug 2018, In: Archives of toxicology. 92, p. 3117-3129

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

The ROS-Mitophagy Signalling Pathway regulates liver endothelial cell survival during ischaemia-reperfusion injury

Bhogal, R., Weston, C., Velduis, S., Henri GD, L., Reynolds, G., Davies, S., Luu, N. -T., Alfaifi, M., Shepherd, E., Boteon, Y., Wallace, L., Oo, Y. H., Adams, D., Mirza, D. F., Mergentel, H., Muirhead, G., Stephenson, B. & Afford, S., 24 Jul 2018, (E-pub ahead of print) In: Liver Transplantation.

Research output: Contribution to journal › Article › peer-review

Open Access

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10 Citations (Scopus)

282 Downloads (Pure)

2017

Sphingosine-1-phosphate prevents egress of hematopoietic stem cells from liver to reduce fibrosis

King, A., Houlihan, D. D., Kavanagh, D., Haldar, D., Luu, N., Owen, A., Suresh, S., Than, N. N., Reynolds, G., Penny, J., Sumption, H., Ramachandran, P., Henderson, N. C., Kalia, N., Frampton, J., Adams, D. H. & Newsome, P. N., Jul 2017, In: Gastroenterology. 153, 1, p. 233–248.e16

Research output: Contribution to journal › Article › peer-review

Open Access

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26 Citations (Scopus)

296 Downloads (Pure)

2016

Comparative ability of mesenchymal stromal cells from different tissues to limit neutrophil recruitment to inflamed endothelium

Munir, H., Luu, N. -T., Clarke, L., Nash, G. & McGettrick, H., 12 May 2016, In: PLoS ONE. 11, 5, e0155161.

Research output: Contribution to journal › Article › peer-review

Open Access

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24 Citations (Scopus)

201 Downloads (Pure)

2015

Inflammation-induced formation of fat-associated lymphoid clusters

Bénézech, C., Luu, N-T., Walker, J. A., Kruglov, A. A., Loo, Y., Nakamura, K., Zhang, Y., Nayar, S., Jones, L. H., Flores-Langarica, A., McIntosh, A., Marshall, J., Barone, F., Besra, G., Miles, K., Allen, J. E., Gray, M., Kollias, G., Cunningham, A. F., Withers, D. R., & 6 othersToellner, K. M., Jones, N. D., Veldhoen, M., Nedospasov, S. A., McKenzie, A. N. J. & Caamaño, J. H., Aug 2015, In: Nature Immunology. 16, 8, p. 819-828 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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90 Citations (Scopus)

695 Downloads (Pure)

2013

Crosstalk between mesenchymal stem cells and endothelial cells leads to down-regulation of cytokine-induced leukocyte recruitment

Luu, N-T., McGettrick, H. M., Buckley, C. D., Newsome, P., Rainger, E., Frampton, J. & Nash, G. B., Dec 2013, In: Stem Cells. 31, 12, p. 2690-2702

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

21 Downloads (Pure)

2012

Modulation of functional responses of endothelial cells linked to angiogenesis and inflammation by shear stress: differential effects of the mechanotransducer CD31

Glen, K., Luu, N. -T., Ross, E., Buckley, C., Rainger, G., Egginton, S. & Nash, G., Jun 2012, In: Journal of Cellular Physiology. 227, 6, p. 2710-2721 12 p.

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

11 Downloads (Pure)

2011

Mesenchymal stem cells inhibit recruitment of flowing neutrophils and lymphocytes by endothelial cells: roles of interleukin-6 and transforming growth factor-{beta}

Buckley, C., Luu, N. -T., Newsome, P., Frampton, J. & Nash, G., Oct 2011.

Research output: Contribution to conference (unpublished) › Poster

4 Downloads (Pure)

2010

Responses of Endothelial Cells from Different Vessels to Inflammatory Cytokines and Shear Stress: Evidence for the Pliability of Endothelial Phenotype

Luu, N-T., Rahman, M., Stone, P., Rainger, G. & Nash, G., 1 Jan 2010, In: Journal of Vascular Research. 47, 5, p. 451-461 11 p.

Research output: Contribution to journal › Article

25 Citations (Scopus)

Suppression of inflammatory responses of endothelial cells by shear stress: Role of integrin signalling

Luu, N-T., Glen, K., Egginton, S., Rainger, G. & Nash, G., 1 Jan 2010, p. E14.

Research output: Contribution to conference (unpublished) › Abstract

2008

Responses to shear stress and to cytokines by endothelial cells from different vessels

Luu, N-T., Stone, P., Bibi, S., Rainger, G. & Nash, G., 1 Jan 2008, In: Biorheology. 45, p. 120-121 2 p.

Research output: Contribution to journal › Article

2007

Comparison of the pro-inflammatory potential of monocytes from healthy adults and those with peripheral arterial disease using an in vitro culture model.

Luu, N-T., Madden, J., Calder, PC., Grimble, RF., Shearman, CP., Chan, T., Tull, S., Dastur, N., Rainger, G. & Nash, G., 1 Aug 2007, In: Atherosclerosis. 193, 2, p. 259-68 10 p.

Research output: Contribution to journal › Article

25 Citations (Scopus)

Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response.

Luu, N-T., Madden, J., Calder, PC., Grimble, RF., Shearman, CP., Chan, T., Dastur, N., Howell, WM., Rainger, G. & Nash, G., 1 Dec 2007, In: Journal of Nutrition. 137, 12, p. 2769-74 6 p.

Research output: Contribution to journal › Article

30 Citations (Scopus)

2005

Differing mechanisms of leukocyte recruitment and sensitivity to conditioning by shear stress for endothelial cells treated with tumour necrosis factor-a or interleukin-1

Sheikh, S., Rainger, G., Gale, Z., Luu, N-T., Rahman, M. & Nash, G., 23 May 2005, In: British Journal of Pharmacology. 145, p. 1052-1061 10 p.

Research output: Contribution to journal › Article

36 Citations (Scopus)

2004

Effect of fish oil supplementation on ability of monocytes to invoke a pro-inflammatory response in endothelial cells

Grimble, RF., Luu, N-T., Madden, J., Hadley, J., Dastur, N., Shearman, CP., Howell, WM., Calder, PC., Rainger, G. & Nash, G., 1 Jan 2004, p. 833. 1 p.

Research output: Contribution to conference (unpublished) › Abstract

Effects of fish oil supplementation on cytokine production by PBMCs of patients with peripheral vascular disease

Grimble, RF., Madden, J., Hadley, J., Dastur, N., Luu, N-T., Rainger, G., Nash, G., Shearman, CP., Howell, WM. & Calder, PC., 1 Jan 2004, p. 787. 1 p.

Research output: Contribution to conference (unpublished) › Abstract

Fish oil alters the balance between LPS-stimulated leukotriene B4 and prostaglandin E2 production by PBMCs in patients with peripheral vascular disease but not in controls

Carrero, JJ., Madden, J., Hadley, J., Dastur, N., Luu, N-T., Rainger, G., Nash, G., Shearman, CP., Howell, WM., Calder, PC. & Grimble, RF., Aug 2004, In: Clinical Nutrition. 23, 4, p. 789-789 1 p., 04-A-194-ESPEN.

Research output: Contribution to journal › Abstract

2003