Michael Tomlinson

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Publications

  1. Article › Research › Not peer-reviewed
  2. Published

    A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein

    Yotis Senis, Michael Tomlinson, Stephanie Dumon, Victoria Heath, Jennifer Spalton, Roy Bicknell, Jon Frampton, Ashley Martin, Mike Wakelam & Steve Watson, 27 Dec 2006, In: Molecular and Cellular Proteomics. 6, p. 548-564 17 p.

    Research output: Contribution to journal › Article

  3. Published

    A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signalling pathways via PLCgamma2 in B cells

    Michael Tomlinson, 1 Jan 2001, In: BMC Immunology. 2, 1, p. 4 1 p.

    Research output: Contribution to journal › Article

  4. Published

    Collagen promotes sustained glycoprotein VI signaling in platelets and cell lines

    Michael Tomlinson, Simon Calaminus, Oscar Berlanga, Jocelyn Auger & Steve Watson, 1 Nov 2007, In: Journal of Thrombosis and Haemostasis. 5, 11, p. 2274-2283 10 p.

    Research output: Contribution to journal › Article

  5. Published

    Differentiation of murine committed megakaryocytic progenitors isolated by a novel strategy reveals the complexity of GATA and Ets factor involvement in megakaryocytopoiesis and an unexpected potential role for GATA-6

    Stephanie Dumon, Victoria Heath, Michael Tomlinson & Jon Frampton, 1 May 2006, In: Experimental Hematology. 34, 5, p. 654-63 10 p.

    Research output: Contribution to journal › Article

  6. Published

    Expression and function of Tec, Itk and Btk in lymphocytes: evidence for a unique role for Tec

    Michael Tomlinson, 15 Mar 2004, In: Molecular and Cellular Biology. 24, 6, p. 2455-2466 12 p.

    Research output: Contribution to journal › Article

  7. Published

    Glycoprotein VI oligomerization in cell lines and platelets

    Oscar Berlanga, Jon Frampton, Michael Tomlinson & Steve Watson, 1 May 2007, In: Journal of Thrombosis and Haemostasis. 5, 5, p. 1026-33 8 p.

    Research output: Contribution to journal › Article

  8. Published

    Platelet tetraspanins: small but interesting.

    Michael Tomlinson, 9 Sep 2009, In: Journal of Thrombosis and Haemostasis.

    Research output: Contribution to journal › Article

  9. Published

    SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase

    Michael Tomlinson, Victoria Heath, Steve Watson, 8 Oct 2004, In: Journal of Biological Chemistry. 279, p. 55089-55096 8 p.

    Research output: Contribution to journal › Article

  10. Published

    Tetraspanin microdomains: fine-tuning platelet function.

    Elizabeth Haining & Michael Tomlinson, 1 Apr 2011, In: Biochemical Society Transactions. 39, 2, p. 518-23 6 p.

    Research output: Contribution to journal › Article

  11. Published

    The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade.

    Michael Tomlinson, Steve Watson & Andrew Pearce, 27 Apr 2007, In: Journal of Biological Chemistry. 282, 17, p. 12397-409 13 p.

    Research output: Contribution to journal › Article

  12. Published

    The emerging role of tetraspanin microdomains on endothelial cells.

    John Herbert, Victoria Heath, Roy Bicknell & Michael Tomlinson, 1 Dec 2011, In: Biochemical Society Transactions. 39, 6, p. 1667-73 7 p.

    Research output: Contribution to journal › Article

  13. Article › Research › Peer-reviewed
  14. Published

    ADAM10-interacting tetraspanins Tspan5 and Tspan17 regulate VE-cadherin expression and promote T lymphocyte transmigration

    Jasmeet Reyat, Myriam Chimen, Peter Noy, Ed Rainger & Michael Tomlinson, 15 Jun 2017, In: Journal of Immunology. 199, 2, p. 666-676

    Research output: Contribution to journal › Article › peer-review

  15. Published

    C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37

    Helen McGettrick, Michael Tomlinson, 1 Oct 2018, In: Journal of Cell Science. 131, 19, 15 p., jcs214551.

    Research output: Contribution to journal › Article › peer-review

  16. Published

    CLEC-2 activates Syk through dimerization

    Craig Hughes, Alice Pollitt, Jun Mori, Michael Tomlinson, Klaus Futterer & Steve Watson, 12 Feb 2010, In: Blood. 115, 14, p. 2947-2955

    Research output: Contribution to journal › Article › peer-review

  17. Published

    Circulating DBP level and prognosis in operated lung cancer: an exploration of pathophysiology.

    Alice Turner, Michael Tomlinson, Fedor Berditchevski & Babu Naidu, 3 May 2012, In: The European respiratory journal. 41, 2, p. 410-416 7 p.

    Research output: Contribution to journal › Article › peer-review

  18. Published

    Evidence that GPVI is expressed as a mixture of monomers and dimers, and that the D2 domain is not essential for GPVI activation: GPVI dimerisation is not critical for ligand binding

    Joanne Clark, Raluca Alexandra Iulia Neagoe, Malou Zuidscherwoude, Deirdre Kavanagh, Alexandre Slater, Eleyna Martin, Natalie Poulter, Dirk-Peter Herten, Michael Tomlinson & Steve Watson, 26 Feb 2021, In: Thrombosis and Haemostasis. 2021, 00, p. 1-26

    Research output: Contribution to journal › Article › peer-review

  19. Published

    G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.

    Jun Mori, Jennifer Spalton, Michael Tomlinson, Yotis Senis & Steve Watson, 19 Dec 2008, In: Journal of Biological Chemistry. 283, 51, p. 35419-27 9 p.

    Research output: Contribution to journal › Article › peer-review

  20. Published

    Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains

    Steven Thomas, Victoria Heath, John Herbert, Roy Bicknell, Yotis Senis, Fedor Berditchevski, Steve Watson & Michael Tomlinson, 1 Jan 2009, In: Biochemical Journal. 417, 1, p. 391-

    Research output: Contribution to journal › Article › peer-review

  21. Published

    Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI

    Pip Nicolson, Mark R. Thomas, Michael Tomlinson & Steve Watson, Dec 2018, In: Haematologica. 103, 12, p. 2097-2108 12 p.

    Research output: Contribution to journal › Article › peer-review

  22. Published

    LAR protein tyrosine phosphatase regulates focal adhesions via CDK1

    Trushar Patel, Michael Tomlinson, Carina Hellberg, John Heath, Debbie Cunningham & Neil Hotchin, 1 Aug 2016, In: Journal of Cell Science. 129, p. 2962-2971

    Research output: Contribution to journal › Article › peer-review

  23. Published

    Quantitative Phosphoproteomics Reveals a Role for Collapsin Response Mediator Protein 2 in PDGF-Induced Cell Migration

    Shabana Begum, Michael Tomlinson, Neil Hotchin, John Heath & Debbie Cunningham, 2017, In: Scientific Reports. 7, 3970.

    Research output: Contribution to journal › Article › peer-review

  24. E-pub ahead of print

    Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

    Peter Noy, Jasmeet Reyat & Michael Tomlinson, 2 Jun 2016, In: Platelets. 9 p.

    Research output: Contribution to journal › Article › peer-review

  25. Published

    Regulation of Leukocytes by TspanC8 Tetraspanins and the “Molecular Scissor” ADAM10

    Neale Harrison, Aditi Kanhere & Michael Tomlinson, 2 Jul 2018, In: Frontiers in immunology. 9, 1451.

    Research output: Contribution to journal › Article › peer-review

  26. Published

    Regulation of platelet derived growth factor signalling by LAR protein tyrosine phosphatase: a quantitative phosphoproteomics study

    Trushar Patel, Andrew Creese, Michael Tomlinson, Carina Hellberg, John Heath, Neil Hotchin & Debbie Cunningham, 1 Jun 2016, In: Molecular and Cellular Proteomics. 15, 6, p. 1823-1836 14 p.

    Research output: Contribution to journal › Article › peer-review

  27. Published

    SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice

    Craig Hughes, Steve Watson, Michael Tomlinson, 1 Jan 2015, In: Blood. 125, 1, p. 185-194 10 p.

    Research output: Contribution to journal › Article › peer-review

  28. Published

    T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression

    Michael Tomlinson, 17 Nov 2003, In: PLoS Biology. 1, 2, p. 271-287 17 p.

    Research output: Contribution to journal › Article › peer-review

  29. E-pub ahead of print

    TRPM7 (Transient Receptor Potential Melastatin-Like 7 Channel) Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice

    Michael Tomlinson, 16 Nov 2017, In: Arteriosclerosis Thrombosis and Vascular Biology.

    Research output: Contribution to journal › Article › peer-review

  30. Published

    Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation

    Elizabeth Haining, Peter Noy, Hanna Romanska, Helen Harris, Jeremy Pike, Fedor Berditchevski, Natalie Poulter, Steve Watson & Michael Tomlinson, 2017, In: Platelets. 28, 7, p. 629-642

    Research output: Contribution to journal › Article › peer-review

  31. Published

    The TspanC8 subgroup of tetraspanins interacts with a disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

    Elizabeth Haining, Steve Watson, Jon Frampton, Paloma Garcia & Michael Tomlinson, 16 Nov 2012, In: Journal of Biological Chemistry. 287, 47, p. 39753-39765 13 p.

    Research output: Contribution to journal › Article › peer-review

  32. E-pub ahead of print

    The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation

    Peter Noy, Michael Tomlinson, 7 Feb 2018, In: FASEB Journal. p. fj201700823RR

    Research output: Contribution to journal › Article › peer-review

  33. Published

    The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

    Neale Harrison, Peter Noy, Clara Apicella & 11 others, , Eleanor Cull, Natalie Poulter & Michael Tomlinson, 4 Sep 2020, In: The Journal of biological chemistry. 295, 36, p. 12822-12839 18 p.

    Research output: Contribution to journal › Article › peer-review

  34. Published

    The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

    Yotis Senis, Michael Tomlinson, Alexandra Mazharian, Kristin Kornerup, Jocelyn Auger, Steven Thomas, Tarvinder Dhanjal, Neena Kalia & Steve Watson, 14 May 2009, In: Blood. 113, 20, p. 4942-4954 13 p.

    Research output: Contribution to journal › Article › peer-review

  35. Published

    Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells

    Peter Noy, Elizabeth Haining, Jasmeet Reyat, Neale Harrison, Victoria Heath, Joseph Robinson, Paul Harrison, Steve Lee & 7 others, , Neena Kalia, Ed Rainger, Alexander Brill, Steve Watson & Michael Tomlinson, Sep 2019, In: Haematologica. 104, 9, p. 1892-1905 34 p.

    Research output: Contribution to journal › Article › peer-review

  36. Published

    TspanC8 tetraspanins and a disintegrin and metalloprotease 10 (ADAM10) interact via their extracellular regions: evidence for distinct binding mechanisms for different TspanC8 proteins

    Peter Noy, Jasmeet Reyat, Ed Rainger & Michael Tomlinson, 12 Feb 2016, In: Journal of Biological Chemistry. 291, 7, p. 3145-3157 13 p.

    Research output: Contribution to journal › Article › peer-review

  37. Published

    Utilizing Lentiviral Gene Transfer in Primary Endothelial Cells to Assess Lymphocyte-Endothelial Interactions

    Jasmeet Reyat, Michael Tomlinson & Peter Noy, 28 Mar 2017, In: Methods in molecular biology. 1591, p. 155-168 14 p.

    Research output: Contribution to journal › Article › peer-review

  38. Editorial › Research › Peer-reviewed
  39. Published

    Eye-opening potential for tetraspanin Tspan12 as a therapeutic target for diseases of the retinal vasculature

    Michael Tomlinson, 11 Jul 2017, In: Circulation. p. 196-199

    Research output: Contribution to journal › Editorial › peer-review

  40. Review article › Research › Peer-reviewed
  41. Published

    Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins

    Peter Noy & Michael Tomlinson, Jun 2017, In: Biochemical Society Transactions. 45, 3, p. 719-730 12 p.

    Research output: Contribution to journal › Review article › peer-review

  42. Published

    Tspan18 is a novel regulator of thrombo-inflammation

    Michael Tomlinson, 23 May 2020, In: Medical Microbiology and Immunology. 209, 4, p. 553-564 12 p.

    Research output: Contribution to journal › Review article › peer-review