Michael Sheppard

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Publications

  1. Published

    A paradigm shift in the monitoring of patients with acromegaly: last available growth hormone may overestimate risk

    Mark Sherlock, Raoul Reulen, Aurora Aragon Alonso, John Ayuk, Michael Sheppard, Michael Hawkins, Andrew Bates & Paul Stewart, Feb 2014, In: The Journal of clinical endocrinology and metabolism. 99, 2, p. 478-85 8 p.

    Research output: Contribution to journal › Article › peer-review

  2. Published

    A potential role for human securin/PTTG in the developing fetal brain

    Kristien Boelaert, Christopher McCabe, Lesley Tannahill, Neil Gittoes, Michael Sheppard, Mark Kilby & Jayne Franklyn, 1 Jan 2003, p. P164.

    Research output: Contribution to conference (unpublished) › Abstract

  3. Published

    A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the birmingham elderly thyroid study

    Jim Parle, Lesley Roberts, Sue Wilson, Andrea Roalfe, Sayeed Haque, Michael Sheppard, Jayne Franklyn & Richard Hobbs, 1 Aug 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 8, p. 3623-32 10 p.

    Research output: Contribution to journal › Article

  4. Published

    ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy Are Independent Predictors of Mortality in Patients with Acromegaly

    Mark Sherlock, Raoul Reulen, Aurora Aragon Alonso, John Ayuk, Michael Sheppard, Michael Hawkins, Andrew Bates & Paul Stewart, 1 Nov 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 11, p. 4216-4223 8 p.

    Research output: Contribution to journal › Article

  5. Published

    Abnormal expression of 11beta-HSD type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation

    Elizabeth Rabbitt, John Ayuk, Kristien Boelaert, Michael Sheppard, Martin Hewison, Paul Stewart & Neil Gittoes, 20 Mar 2003, In: Oncogene. 22(11), 11, p. 1663-1667 5 p.

    Research output: Contribution to journal › Article

  6. Published

    An audit of management of differentiated thyroid cancer in specialist and non-specialist clinic settings

    Harish Kumar, Roger Holder, Michael Sheppard & Jayne Franklyn, 1 Jun 2001, In: Clinical Endocrinology. 54, 6, p. 719-723 5 p.

    Research output: Contribution to journal › Article

  7. Published

    Anaplastic carcinoma of the thyroid presenting with hyperthyroidism

    Michael Sheppard & Jayne Franklyn, 1 Jan 2002, p. P59.

    Research output: Contribution to conference (unpublished) › Abstract

  8. Published

    Angiotensin-converting enzyme (ACE)-inhibitor suppresses glomerular transforming growth factor-beta (TGF-beta) receptor expression in experimental diabetes in rats

    Ann Logan, Michael Sheppard, 6 Apr 2001, In: Diabetologia. 44, 4, p. 495-500 6 p.

    Research output: Contribution to journal › Article

  9. Published

    Association between premature mortality and hypopituitarism

    Jeremy Tomlinson, Robert Hills, Keith Wheatley, Andrew Bates, Michael Sheppard & Paul Stewart, 10 Feb 2001, In: Lancet. 357, 9254, p. 425-431 7 p.

    Research output: Contribution to journal › Article

  10. Published

    Association between serum TSH and free T4 concentrations and occurrence of atrial fibrillation in a large community-based population of elderly subjects. The Birmingham Elderly Thyroid Study

    Michael Gammage, Jim Parle, Jayne Franklyn, Sue Wilson, Roger Holder, Michael Sheppard, Andrea Roalfe, 1 Jan 2005, p. OC34.

    Research output: Contribution to conference (unpublished) › Abstract

  11. Published

    Association between serum free T4 concentration and atrial fibrillation

    Michael Gammage, Jim Parle, Roger Holder, Lesley Roberts, Richard Hobbs, Sue Wilson, Michael Sheppard & Jayne Franklyn, 14 May 2007, In: Archives of Internal Medicine. 167, 9, p. 928-934 7 p.

    Research output: Contribution to journal › Article

  12. Published

    Association between serum thyrotrophin concentrations and occurrence of atrial fibrillation in a large community-based population of elderly subjects (the Birmingham Elderly Thyroid Study)

    Lesley Roberts, Jim Parle, Jayne Franklyn, Sue Wilson, Roger Holder, Michael Sheppard, Richard Hobbs & Michael Gammage, 1 Jan 2005, p. A40-A40.

    Research output: Contribution to conference (unpublished) › Abstract

  13. Published

    Atrial fibrillation predicts mortality in hyperthyroidism

    Jayne Franklyn, Faizel Osman, Michael Sheppard & Michael Gammage, 1 Jan 2003.

    Research output: Contribution to conference (unpublished) › Abstract

  14. Published

    Atrial fibrillation predicts mortality in thyrotoxicosis

    Faizel Osman, Michael Sheppard & Michael Gammage, 1 Jan 2002, p. P275.

    Research output: Contribution to conference (unpublished) › Paper

  15. Published

    Atrial fibrillation predicts mortality in thyrotoxicosis

    Jayne Franklyn, Faizel Osman, Michael Sheppard & Michael Gammage, 1 Jan 2002, p. 102. 1 p.

    Research output: Contribution to conference (unpublished) › Paper

  16. Published

    Basic Fibroblast Growth Factor Is an Autocrine Factor for Rat Thyroid Follicular Cells

    Michael Sheppard, 1 Jan 1991, In: Annals of the New York Academy of Sciences. 638, 1, p. 453-455 3 p.

    Research output: Contribution to journal › Article › peer-review

  17. Published

    Cardiac autonomic function in hyperthyroidism

    Faizel Osman, Michael Sheppard, Michael Gammage & Jayne Franklyn, 1 Jan 2003, p. P263.

    Research output: Contribution to conference (unpublished) › Abstract

  18. Published

    Cardiac dysrhythmias and thyroid dysfunction: The hidden menace?

    Faizel Osman, Michael Gammage, Michael Sheppard & Jayne Franklyn, 1 Mar 2002, In: Journal of Clinical Endocrinology and Metabolism. 87, 3, p. 963-967 5 p.

    Research output: Contribution to journal › Review article

  19. Published

    Cardiac dysrhythmias in hyperthyroidism before and after antithyroid therapy

    Faizel Osman, Jayne Franklyn, Michael Sheppard & Michael Gammage, 1 Jan 2006, p. 215. 1 p.

    Research output: Contribution to conference (unpublished) › Abstract

  20. Published

    Cardiovascular manifestations of hyperthyroidism before and after antithyroid therapy; a matched case-control study

    Faizel Osman, Jayne Franklyn, Roger Holder, Michael Sheppard & Michael Gammage, 9 Jan 2007, In: Journal of the American College of Cardiology. 49, 1, p. 71-81 11 p.

    Research output: Contribution to journal › Article

  21. Published

    Clinical, quality of life, and economic value of acromegaly disease control

    Michael Sheppard, 1 Sep 2011, In: Pituitary. 14, 3, p. 284-294 11 p.

    Research output: Contribution to journal › Article

  22. Published

    Collection and storage conditions of serum for the analysis of thyroglobulin

    Michael Sheppard, 1 Jan 2002, p. pp36.

    Research output: Contribution to conference (unpublished) › Paper

  23. Published

    Consensus statement: medical management of acromegaly

    Michael Sheppard, 1 Dec 2005, In: European Journal of Endocrinology. 153(6), p. 737-740 4 p.

    Research output: Contribution to journal › Article

  24. Published

    Disruption of the SH3 domain of PTTG reveals distinct mechanisms of FGF-induction and cell transformation

    Kristien Boelaert, Lesley Tannahill, Jasbir Moore, Lawrence Young, Michael Sheppard, Jayne Franklyn, Neil Gittoes & Christopher McCabe, 1 Jan 2002.

    Research output: Contribution to conference (unpublished) › Abstract

  25. Published

    Does acromegaly enhance mortality?

    John Ayuk & Michael Sheppard, 1 Mar 2008, In: Reviews in endocrine & metabolic disorders. 9, 1, p. 33-9 7 p.

    Research output: Contribution to journal › Article

  26. Published

    Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours

    Lesley Tannahill, Christopher McCabe, Kachilele-Linjewile Kachilele, Kristien Boelaert, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jun 2002, In: Clinical Endocrinology. 56, 6, p. 735-743 9 p.

    Research output: Contribution to journal › Article

  27. Published

    Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery and/or radiotherapy

    John Ayuk, Suzanne Stewart, Paul Stewart & Michael Sheppard, 1 Jan 2004, In: Clinical Endocrinology. 60(3), p. 375-381 7 p.

    Research output: Contribution to journal › Article

  28. Published

    Evidence for the Use of IGF-I as a Predictor of Mortality in Acromegaly Is Lacking

    John Ayuk, Michael Sheppard, Andrew Bates & Paul Stewart, 1 Nov 2004, In: Journal of Clinical Endocrinology and Metabolism. 89, 11, p. 5867-5868 2 p.

    Research output: Contribution to journal › Article

  29. Published

    Expression and function of VEGF and its receptor KDR in pituitary tumors

    Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Michael Sheppard, Neil Gittoes & Jayne Franklyn, 1 Jan 2002, p. P2-231.

    Research output: Contribution to conference (unpublished) › Paper

  30. Published

    Expression and function of VEGF and its receptor in pituitary tumours

    Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Jattinder Khaira, Michael Sheppard, Neil Gittoes & Jayne Franklyn, 1 Jan 2002, p. OC14.

    Research output: Contribution to conference (unpublished) › Paper

  31. Published

    Expression of 11beta hydroxysteroid dehydrogenase isozyme mRNAs in normal pituitary and pituitary adenomas

    John Ayuk, Kristien Boelaert, Michael Sheppard, Martin Hewison, Paul Stewart & Neil Gittoes, 1 Jan 2001, p. OC17.

    Research output: Contribution to conference (unpublished) › Paper

  32. Published

    Expression of 11beta-hydroxysteroid dehydrogenase in rat osteoblastic cells: a functional role for intracrine regulation of glucocorticoid metabolism in bone

    Elizabeth Rabbitt, Rosemary Bland, Mark Cooper, Michael Sheppard, Paul Stewart & Martin Hewison, 1 Jun 2001, In: Journal of Cellular Biochemistry. 81, 3, p. 453-462 10 p.

    Research output: Contribution to journal › Article

  33. Published

    Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour.

    Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Shakir Hussain, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Feb 2003, In: Clinical Endocrinology. 58, 2, p. 141-50 10 p.

    Research output: Contribution to journal › Article

  34. Published

    GH and mortality in acromegaly

    Michael Sheppard, 1 Jan 2005, In: Journal of endocrinological investigation. 28(11), p. 75-77 3 p.

    Research output: Contribution to journal › Review article

  35. Published

    Gender, age, goitre type and sereum TSH predict thyroid neoplasia in 1500 patients with thyroid enlargement investigated by FNAC

    Kristien Boelaert, Michael Sheppard & Jayne Franklyn, 1 Jan 2004, p. OC21.

    Research output: Contribution to conference (unpublished) › Abstract

  36. Published

    Graves' disease complicated by multiple analytical interferences

    Michael Sheppard, 1 Jan 2002, p. pp18.

    Research output: Contribution to conference (unpublished) › Paper

  37. Published

    Growth hormone and its disorders

    John Ayuk & Michael Sheppard, 1 Jan 2006, In: Postgraduate Medical Journal. 82, 963, p. 24-30 7 p.

    Research output: Contribution to journal › Review article

  38. Published

    Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly

    John Ayuk, Michael Sheppard, Paul Stewart & Andrew Bates, 1 Jan 2004, In: Journal of Clinical Endocrinology and Metabolism. 89, 4, p. 1613-1617 5 p.

    Research output: Contribution to journal › Article

  39. Published

    Growth hormone assay standardization: an important clinical advance.

    Michael Sheppard, 1 Feb 2007, In: Clinical Endocrinology. 66, 2, p. 157-61 5 p.

    Research output: Contribution to journal › Article

  40. Published

    Growth hormone therapy does not induce cancer

    Michael Sheppard, 1 Oct 2006, In: Nature clinical practice. Endocrinology & metabolism. 2, 10, p. 532-533 2 p.

    Research output: Contribution to journal › Article

  41. Published

    Growth hormone--from molecule to mortality

    Michael Sheppard, 1 Jan 2004, In: Clinical Medicine. 4, 5, p. 437-40 4 p.

    Research output: Contribution to journal › Review article

  42. Published

    Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults

    Michael Sheppard, 1 Sep 2008, In: Journal of endocrinological investigation. 31, 9, p. 820-838 19 p.

    Research output: Contribution to journal › Review article

  43. Published

    Heart rate variability and turbulence in hyperthyroidism

    Faizel Osman, Saqib Chowdhary, Michael Sheppard, Jayne Franklyn & Michael Gammage, 1 Jan 2003, p. 157. 1 p.

    Research output: Contribution to conference (unpublished) › Abstract

  44. Published

    Heart rate variability and turbulence in hyperthyroidism before, during, and after treatment

    Faizel Osman, Jayne Franklyn, Saqib Chowdhary, Roger Holder, Michael Sheppard & Michael Gammage, 15 Aug 2004, In: The American Journal of Cardiology. 94, 4, p. 465-9 5 p.

    Research output: Contribution to journal › Article

  45. Published

    Inhibition of 11beta-HSD2 has an anti-proliferative effect in human pituitary cells

    Elizabeth Rabbitt, Martin Hewison, Paul Stewart, Michael Sheppard & Neil Gittoes, 1 Jan 2002, p. P146.

    Research output: Contribution to conference (unpublished) › Paper

  46. Published

    Iodothyronine deiodinase enzyme mRNA expression in normal pituitary and pituitary adenomas

    Lesley Tannahill, Christopher McCabe, Kachilele-Linjewile Kachilele, Kristien Boelaert, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001.

    Research output: Contribution to conference (unpublished) › Paper

  47. Published

    Isolation and characterisation of human thyroid endothelial cells

    Ann Logan, Michael Sheppard, James Ramsden & Margaret Eggo, 1 Jan 2003, In: American Journal of Physiology: Endocrinology and Metabolism. 284(1), p. E168-E176

    Research output: Contribution to journal › Article

  48. Published

    Isolation and characterization of human thyroid endothelial cells

    Ann Logan, Michael Sheppard, James Ramsden & Margaret Eggo, Jan 2003, In: American Journal of Physiology Endocrinology and Metabolism. 284, 1, p. E168-76

    Research output: Contribution to journal › Article › peer-review

  49. Published

    Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects

    Kristien Boelaert, Michael Sheppard, Roger Holder, Stephen Gough & Jayne Franklyn, 1 Feb 2006, In: Clinical Endocrinology. 64, 2, p. 125-128 4 p.

    Research output: Contribution to journal › Article

  50. Published

    Letter re: Monitoring the Response to Treatment in Acromegaly

    John Ayuk, Michael Sheppard, Andrew Bates & Paul Stewart, 10 May 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4980-4980 1 p.

    Research output: Contribution to journal › Letter

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