Michael Sheppard

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Publications

  1. 2014
  2. Published

    A paradigm shift in the monitoring of patients with acromegaly: last available growth hormone may overestimate risk

    Mark Sherlock, Raoul Reulen, Aurora Aragon Alonso, John Ayuk, Michael Sheppard, Michael Hawkins, Andrew Bates & Paul Stewart, Feb 2014, In : The Journal of clinical endocrinology and metabolism. 99, 2, p. 478-85 8 p.

    Research output: Contribution to journal › Article

  3. 2011
  4. Published

    Clinical, quality of life, and economic value of acromegaly disease control

    Michael Sheppard, 1 Sep 2011, In : Pituitary. 14, 3, p. 284-294 11 p.

    Research output: Contribution to journal › Article

  5. Published

    Medical therapy in acromegaly.

    Mark Sherlock & Michael Sheppard, 1 May 2011, In : Nature Reviews Endocrinology. 7, 5, p. 291-300 10 p.

    Research output: Contribution to journal › Article

  6. 2010
  7. Published

    A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the birmingham elderly thyroid study

    Jim Parle, Lesley Roberts, Sue Wilson, Andrea Roalfe, Sayeed Haque, Michael Sheppard, Jayne Franklyn & Richard Hobbs, 1 Aug 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 8, p. 3623-32 10 p.

    Research output: Contribution to journal › Article

  8. Published

    Management of acromegaly in Latin America: expert panel recommendations

    Michael Sheppard, 1 Jun 2010, In : Pituitary. 13, 2, p. 168-175 8 p.

    Research output: Contribution to journal › Article

  9. Published

    Mortality in Patients with Pituitary Disease

    Mark Sherlock, John Ayuk, Jeremy Tomlinson, Andrew Toogood, Aurora Aragon Alonso, Michael Sheppard, Andrew Bates & Paul Stewart, 1 Jun 2010, In : Endocrine Reviews. 31, 3, p. 301-342 42 p.

    Research output: Contribution to journal › Review article

  10. 2009
  11. Published

    The Network for the Enhancement of Endocrinology and Oncology Knowledge: A case-based consideration of current practice in Cushing's disease and acromegaly

    Michael Sheppard, 1 Dec 2009, In : Best practice & research. Clinical endocrinology & metabolism. 23, p. S1-S4

    Research output: Contribution to journal › Article

  12. Published

    ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy Are Independent Predictors of Mortality in Patients with Acromegaly

    Mark Sherlock, Raoul Reulen, Aurora Aragon Alonso, John Ayuk, Michael Sheppard, Michael Hawkins, Andrew Bates & Paul Stewart, 1 Nov 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 11, p. 4216-4223 8 p.

    Research output: Contribution to journal › Article

  13. Published

    Medical Therapy in Patients with Acromegaly: Predictors of Response and Comparison of Efficacy of Dopamine Agonists and Somatostatin Analogues

    Mark Sherlock, Aurora Aragon Alonso, Raoul Reulen, John Ayuk, Michael Sheppard, Andrew Bates & Paul Stewart, 1 Apr 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 4, p. 1255-1263 9 p.

    Research output: Contribution to journal › Article

  14. Published

    Prediction of cure and risk of hypothyroidism in patients receiving 131I for hyperthyroidism.

    Kristien Boelaert, Michael Sheppard, Roger Holder, Stephen Gough & Jayne Franklyn, 1 Jan 2009, In : Clinical Endocrinology. 70, 1, p. 129-38 10 p.

    Research output: Contribution to journal › Article

  15. 2008
  16. Published

    Monitoring disease activity using growth hormone and insulin like growth factor-I in the follow up of 501 patients with acromegaly.

    Mark Sherlock, Aurora Aragon Alonso, Raoul Reulen, John Ayuk, Michael Sheppard, Andrew Bates & Paul Stewart, 27 Oct 2008, In : Clinical Endocrinology.

    Research output: Contribution to journal › Article

  17. Published

    Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults

    Michael Sheppard, 1 Sep 2008, In : Journal of endocrinological investigation. 31, 9, p. 820-838 19 p.

    Research output: Contribution to journal › Review article

  18. Published

    Does acromegaly enhance mortality?

    John Ayuk & Michael Sheppard, 1 Mar 2008, In : Reviews in endocrine & metabolic disorders. 9, 1, p. 33-9 7 p.

    Research output: Contribution to journal › Article

  19. 2007
  20. Published

    Association between serum free T4 concentration and atrial fibrillation

    Michael Gammage, Jim Parle, Roger Holder, Lesley Roberts, Richard Hobbs, Sue Wilson, Michael Sheppard & Jayne Franklyn, 14 May 2007, In : Archives of Internal Medicine. 167, 9, p. 928-934 7 p.

    Research output: Contribution to journal › Article

  21. Published

    Growth hormone assay standardization: an important clinical advance.

    Michael Sheppard, 1 Feb 2007, In : Clinical Endocrinology. 66, 2, p. 157-61 5 p.

    Research output: Contribution to journal › Article

  22. Published

    Cardiovascular manifestations of hyperthyroidism before and after antithyroid therapy; a matched case-control study

    Faizel Osman, Jayne Franklyn, Roger Holder, Michael Sheppard & Michael Gammage, 9 Jan 2007, In : Journal of the American College of Cardiology. 49, 1, p. 71-81 11 p.

    Research output: Contribution to journal › Article

  23. Published

    The assessment of thyroid neoplasia

    Kristien Boelaert, Jayne Franklyn, Michael Sheppard, 1 Jan 2007, Clinical Endocrine Oncology.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  24. Published

    Using an increased fixed dose of 1311 (600MBq) leads to improved outcome in patients with hyperthyroidism

    Kristien Boelaert, Michael Sheppard, Stephen Gough & Jayne Franklyn, 1 Jan 2007, p. P312.

    Research output: Contribution to conference (unpublished) › Abstract

  25. 2006
  26. Published

    Growth hormone therapy does not induce cancer

    Michael Sheppard, 1 Oct 2006, In : Nature clinical practice. Endocrinology & metabolism. 2, 10, p. 532-533 2 p.

    Research output: Contribution to journal › Article

  27. Published

    Prevalence of subclinical thyroid dysfunction and its relation to socioeconomic deprivation in the elderly: a community based cross-sectional survey

    Jim Parle, Lesley Roberts, Andrea Roalfe, Richard Hobbs, Michael Sheppard, Michael Gammage, 26 Sep 2006, In : Clinical Endocrinology. 91, p. 4809-4816 8 p.

    Research output: Contribution to journal › Article

  28. Published

    Serum TSH concentration as a novel predictor of malignancy in thyroid nodules investigated by fine needle aspiration

    Kristien Boelaert, Roger Holder, Michael Sheppard & Jayne Franklyn, 5 Sep 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4295-4301 7 p.

    Research output: Contribution to journal › Article

  29. Published

    Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects

    Kristien Boelaert, Michael Sheppard, Roger Holder, Stephen Gough & Jayne Franklyn, 1 Feb 2006, In : Clinical Endocrinology. 64, 2, p. 125-128 4 p.

    Research output: Contribution to journal › Article

  30. Published

    Cardiac dysrhythmias in hyperthyroidism before and after antithyroid therapy

    Faizel Osman, Jayne Franklyn, Michael Sheppard & Michael Gammage, 1 Jan 2006, p. 215. 1 p.

    Research output: Contribution to conference (unpublished) › Abstract

  31. Published

    Growth hormone and its disorders

    John Ayuk & Michael Sheppard, 1 Jan 2006, In : Postgraduate Medical Journal. 82, 963, p. 24-30 7 p.

    Research output: Contribution to journal › Review article

  32. Published

    Poor outcome of atrial fibrillation associated with hyperthyroidism

    Faizel Osman, Jayne Franklyn, Michael Sheppard & Michael Gammage, 1 Jan 2006, p. 214. 1 p.

    Research output: Contribution to conference (unpublished) › Abstract

  33. 2005
  34. Published

    Consensus statement: medical management of acromegaly

    Michael Sheppard, 1 Dec 2005, In : European Journal of Endocrinology. 153(6), p. 737-740 4 p.

    Research output: Contribution to journal › Article

  35. Published

    Thyroid function and mortality in patients treated for hyperthyroidism

    Jayne Franklyn, Michael Sheppard, 6 Jul 2005, In : JAMA The Journal of the American Medical Association. 294, 1, p. 71-80 10 p.

    Research output: Contribution to journal › Article

  36. Published

    Long-acting octreotide and prolonged-release lanreotide formulations have different pharmacokinetic profiles

    Michael Sheppard, 1 Jul 2005, In : Journal of Clinical Pharmacology. 45(7), p. 836-844 9 p.

    Research output: Contribution to journal › Article

  37. Published

    Letter re: Monitoring the Response to Treatment in Acromegaly

    John Ayuk, Michael Sheppard, Andrew Bates & Paul Stewart, 10 May 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4980-4980 1 p.

    Research output: Contribution to journal › Letter

  38. Published

    Association between serum TSH and free T4 concentrations and occurrence of atrial fibrillation in a large community-based population of elderly subjects. The Birmingham Elderly Thyroid Study

    Michael Gammage, Jim Parle, Jayne Franklyn, Sue Wilson, Roger Holder, Michael Sheppard, Andrea Roalfe, 1 Jan 2005, p. OC34.

    Research output: Contribution to conference (unpublished) › Abstract

  39. Published

    Association between serum thyrotrophin concentrations and occurrence of atrial fibrillation in a large community-based population of elderly subjects (the Birmingham Elderly Thyroid Study)

    Lesley Roberts, Jim Parle, Jayne Franklyn, Sue Wilson, Roger Holder, Michael Sheppard, Richard Hobbs & Michael Gammage, 1 Jan 2005, p. A40-A40.

    Research output: Contribution to conference (unpublished) › Abstract

  40. Published

    GH and mortality in acromegaly

    Michael Sheppard, 1 Jan 2005, In : Journal of endocrinological investigation. 28(11), p. 75-77 3 p.

    Research output: Contribution to journal › Review article

  41. Published

    The Birmingham Elderly Thyroid Study: TSH and fT4 values in 5784 community-living subjects aged 60 and over

    Jim Parle, Jayne Franklyn, Sue Wilson, Roger Holder, Michael Sheppard, Richard Hobbs, Andrea Roalfe, Michael Gammage, 1 Jan 2005, p. P157.

    Research output: Contribution to conference (unpublished) › Abstract

  42. Published

    The Skeletal System in Hyperthyroidism

    Michael Sheppard & Neil Gittoes, 1 Jan 2005, The Thyroid, 9th edition. Vol. Ch 40.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  43. Published

    The Skeletal System in Hypothyroidism

    Neil Gittoes & Michael Sheppard, 1 Jan 2005, The Thyroid, 9th edition. Vol. Ch 62.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  44. Published

    The critical parameters in GH excess

    Michael Sheppard, 1 Jan 2005, In : Journal of endocrinological investigation. 28, 5 Suppl, p. 92-5 4 p.

    Research output: Contribution to journal › Review article

  45. 2004
  46. Published

    Evidence for the Use of IGF-I as a Predictor of Mortality in Acromegaly Is Lacking

    John Ayuk, Michael Sheppard, Andrew Bates & Paul Stewart, 1 Nov 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 11, p. 5867-5868 2 p.

    Research output: Contribution to journal › Article

  47. Published

    The role of growth hormone-receptor antagonism in relation to acromegaly

    John Ayuk & Michael Sheppard, 1 Nov 2004, In : Expert Opinion on Pharmacotherapy. 5(11), p. 2279-2285 7 p.

    Research output: Contribution to journal › Review article

  48. Published

    Heart rate variability and turbulence in hyperthyroidism before, during, and after treatment

    Faizel Osman, Jayne Franklyn, Saqib Chowdhary, Roger Holder, Michael Sheppard & Michael Gammage, 15 Aug 2004, In : The American Journal of Cardiology. 94, 4, p. 465-9 5 p.

    Research output: Contribution to journal › Article

  49. Published

    Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery and/or radiotherapy

    John Ayuk, Suzanne Stewart, Paul Stewart & Michael Sheppard, 1 Jan 2004, In : Clinical Endocrinology. 60(3), p. 375-381 7 p.

    Research output: Contribution to journal › Article

  50. Published

    Gender, age, goitre type and sereum TSH predict thyroid neoplasia in 1500 patients with thyroid enlargement investigated by FNAC

    Kristien Boelaert, Michael Sheppard & Jayne Franklyn, 1 Jan 2004, p. OC21.

    Research output: Contribution to conference (unpublished) › Abstract

  51. Published

    Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly

    John Ayuk, Michael Sheppard, Paul Stewart & Andrew Bates, 1 Jan 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 4, p. 1613-1617 5 p.

    Research output: Contribution to journal › Article

  52. Published

    Growth hormone--from molecule to mortality

    Michael Sheppard, 1 Jan 2004, In : Clinical Medicine. 4, 5, p. 437-40 4 p.

    Research output: Contribution to journal › Review article

  53. Published

    Outcome of atrial fibrillation complicating hyperthyroidism

    Faizel Osman, Michael Sheppard, Michael Gammage & Jayne Franklyn, 1 Jan 2004, p. P226.

    Research output: Contribution to conference (unpublished) › Abstract

  54. Published

    Simple clinical and biochemical parameters predict thyroid neoplasia and malignancy in 1500 patients investigated by FNAB

    Kristien Boelaert, Roger Holder, Michael Sheppard & Jayne Franklyn, 1 Jan 2004.

    Research output: Contribution to conference (unpublished) › Paper

  55. 2003
  56. Published

    Pituitary tumour transforming gene and fibroblast growth factor 2 expression: potential prognostic indicators in differentiated thyroid cancer

    Kristien Boelaert, Christopher McCabe, Lesley Tannahill, Neil Gittoes, Roger Holder, Jo Bradwell, Michael Sheppard & Jayne Franklyn, 1 May 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 5, p. 2341-2347 7 p.

    Research output: Contribution to journal › Article

  57. Published

    Primary medical therapy for acromegaly.

    Michael Sheppard, 1 Apr 2003, In : Clinical Endocrinology. 58, 4, p. 387-99 13 p.

    Research output: Contribution to journal › Article

  58. Published

    Abnormal expression of 11beta-HSD type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation

    Elizabeth Rabbitt, John Ayuk, Kristien Boelaert, Michael Sheppard, Martin Hewison, Paul Stewart & Neil Gittoes, 20 Mar 2003, In : Oncogene. 22(11), 11, p. 1663-1667 5 p.

    Research output: Contribution to journal › Article

  59. Published

    Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour.

    Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Shakir Hussain, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Feb 2003, In : Clinical Endocrinology. 58, 2, p. 141-50 10 p.

    Research output: Contribution to journal › Article

  60. Published

    A potential role for human securin/PTTG in the developing fetal brain

    Kristien Boelaert, Christopher McCabe, Lesley Tannahill, Neil Gittoes, Michael Sheppard, Mark Kilby & Jayne Franklyn, 1 Jan 2003, p. P164.

    Research output: Contribution to conference (unpublished) › Abstract

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