Michael Sheppard
Publications
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A paradigm shift in the monitoring of patients with acromegaly: last available growth hormone may overestimate risk
Mark Sherlock, Raoul Reulen, Aurora Aragon Alonso, John Ayuk, Michael Sheppard, Michael Hawkins, Andrew Bates & Paul Stewart, Feb 2014, In: The Journal of clinical endocrinology and metabolism. 99, 2, p. 478-85 8 p.Research output: Contribution to journal › Article › peer-review
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A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the birmingham elderly thyroid study
Jim Parle, Lesley Roberts, Sue Wilson, Andrea Roalfe, Sayeed Haque, Michael Sheppard, Jayne Franklyn & Richard Hobbs, 1 Aug 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 8, p. 3623-32 10 p.Research output: Contribution to journal › Article
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ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy Are Independent Predictors of Mortality in Patients with Acromegaly
Mark Sherlock, Raoul Reulen, Aurora Aragon Alonso, John Ayuk, Michael Sheppard, Michael Hawkins, Andrew Bates & Paul Stewart, 1 Nov 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 11, p. 4216-4223 8 p.Research output: Contribution to journal › Article
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Abnormal expression of 11beta-HSD type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation
Elizabeth Rabbitt, John Ayuk, Kristien Boelaert, Michael Sheppard, Martin Hewison, Paul Stewart & Neil Gittoes, 20 Mar 2003, In: Oncogene. 22(11), 11, p. 1663-1667 5 p.Research output: Contribution to journal › Article
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Anaplastic carcinoma of the thyroid presenting with hyperthyroidism
Michael Sheppard & Jayne Franklyn, 1 Jan 2002, p. P59.Research output: Contribution to conference (unpublished) › Abstract
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Angiotensin-converting enzyme (ACE)-inhibitor suppresses glomerular transforming growth factor-beta (TGF-beta) receptor expression in experimental diabetes in rats
Ann Logan, Michael Sheppard, 6 Apr 2001, In: Diabetologia. 44, 4, p. 495-500 6 p.Research output: Contribution to journal › Article
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Association between serum TSH and free T4 concentrations and occurrence of atrial fibrillation in a large community-based population of elderly subjects. The Birmingham Elderly Thyroid Study
Michael Gammage, Jim Parle, Jayne Franklyn, Sue Wilson, Roger Holder, Michael Sheppard, Andrea Roalfe, 1 Jan 2005, p. OC34.Research output: Contribution to conference (unpublished) › Abstract
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Association between serum free T4 concentration and atrial fibrillation
Michael Gammage, Jim Parle, Roger Holder, Lesley Roberts, Richard Hobbs, Sue Wilson, Michael Sheppard & Jayne Franklyn, 14 May 2007, In: Archives of Internal Medicine. 167, 9, p. 928-934 7 p.Research output: Contribution to journal › Article
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Association between serum thyrotrophin concentrations and occurrence of atrial fibrillation in a large community-based population of elderly subjects (the Birmingham Elderly Thyroid Study)
Lesley Roberts, Jim Parle, Jayne Franklyn, Sue Wilson, Roger Holder, Michael Sheppard, Richard Hobbs & Michael Gammage, 1 Jan 2005, p. A40-A40.Research output: Contribution to conference (unpublished) › Abstract
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Atrial fibrillation predicts mortality in thyrotoxicosis
Faizel Osman, Michael Sheppard & Michael Gammage, 1 Jan 2002, p. P275.Research output: Contribution to conference (unpublished) › Paper
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Basic Fibroblast Growth Factor Is an Autocrine Factor for Rat Thyroid Follicular Cells
Michael Sheppard, 1 Jan 1991, In: Annals of the New York Academy of Sciences. 638, 1, p. 453-455 3 p.Research output: Contribution to journal › Article › peer-review
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Cardiac autonomic function in hyperthyroidism
Faizel Osman, Michael Sheppard, Michael Gammage & Jayne Franklyn, 1 Jan 2003, p. P263.Research output: Contribution to conference (unpublished) › Abstract
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Cardiovascular manifestations of hyperthyroidism before and after antithyroid therapy; a matched case-control study
Faizel Osman, Jayne Franklyn, Roger Holder, Michael Sheppard & Michael Gammage, 9 Jan 2007, In: Journal of the American College of Cardiology. 49, 1, p. 71-81 11 p.Research output: Contribution to journal › Article
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Clinical, quality of life, and economic value of acromegaly disease control
Michael Sheppard, 1 Sep 2011, In: Pituitary. 14, 3, p. 284-294 11 p.Research output: Contribution to journal › Article
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Collection and storage conditions of serum for the analysis of thyroglobulin
Michael Sheppard, 1 Jan 2002, p. pp36.Research output: Contribution to conference (unpublished) › Paper
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Consensus statement: medical management of acromegaly
Michael Sheppard, 1 Dec 2005, In: European Journal of Endocrinology. 153(6), p. 737-740 4 p.Research output: Contribution to journal › Article
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Disruption of the SH3 domain of PTTG reveals distinct mechanisms of FGF-induction and cell transformation
Kristien Boelaert, Lesley Tannahill, Jasbir Moore, Lawrence Young, Michael Sheppard, Jayne Franklyn, Neil Gittoes & Christopher McCabe, 1 Jan 2002.Research output: Contribution to conference (unpublished) › Abstract
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Does acromegaly enhance mortality?
John Ayuk & Michael Sheppard, 1 Mar 2008, In: Reviews in endocrine & metabolic disorders. 9, 1, p. 33-9 7 p.Research output: Contribution to journal › Article
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Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours
Lesley Tannahill, Christopher McCabe, Kachilele-Linjewile Kachilele, Kristien Boelaert, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jun 2002, In: Clinical Endocrinology. 56, 6, p. 735-743 9 p.Research output: Contribution to journal › Article
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Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery and/or radiotherapy
John Ayuk, Suzanne Stewart, Paul Stewart & Michael Sheppard, 1 Jan 2004, In: Clinical Endocrinology. 60(3), p. 375-381 7 p.Research output: Contribution to journal › Article
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Expression of 11beta-hydroxysteroid dehydrogenase in rat osteoblastic cells: a functional role for intracrine regulation of glucocorticoid metabolism in bone
Elizabeth Rabbitt, Rosemary Bland, Mark Cooper, Michael Sheppard, Paul Stewart & Martin Hewison, 1 Jun 2001, In: Journal of Cellular Biochemistry. 81, 3, p. 453-462 10 p.Research output: Contribution to journal › Article
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Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour.
Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Shakir Hussain, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Feb 2003, In: Clinical Endocrinology. 58, 2, p. 141-50 10 p.Research output: Contribution to journal › Article
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GH and mortality in acromegaly
Michael Sheppard, 1 Jan 2005, In: Journal of endocrinological investigation. 28(11), p. 75-77 3 p.Research output: Contribution to journal › Review article
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Graves' disease complicated by multiple analytical interferences
Michael Sheppard, 1 Jan 2002, p. pp18.Research output: Contribution to conference (unpublished) › Paper
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Growth hormone and its disorders
John Ayuk & Michael Sheppard, 1 Jan 2006, In: Postgraduate Medical Journal. 82, 963, p. 24-30 7 p.Research output: Contribution to journal › Review article
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Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly
John Ayuk, Michael Sheppard, Paul Stewart & Andrew Bates, 1 Jan 2004, In: Journal of Clinical Endocrinology and Metabolism. 89, 4, p. 1613-1617 5 p.Research output: Contribution to journal › Article
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Growth hormone assay standardization: an important clinical advance.
Michael Sheppard, 1 Feb 2007, In: Clinical Endocrinology. 66, 2, p. 157-61 5 p.Research output: Contribution to journal › Article
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Growth hormone therapy does not induce cancer
Michael Sheppard, 1 Oct 2006, In: Nature clinical practice. Endocrinology & metabolism. 2, 10, p. 532-533 2 p.Research output: Contribution to journal › Article
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Growth hormone--from molecule to mortality
Michael Sheppard, 1 Jan 2004, In: Clinical Medicine. 4, 5, p. 437-40 4 p.Research output: Contribution to journal › Review article
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Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults
Michael Sheppard, 1 Sep 2008, In: Journal of endocrinological investigation. 31, 9, p. 820-838 19 p.Research output: Contribution to journal › Review article
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Heart rate variability and turbulence in hyperthyroidism before, during, and after treatment
Faizel Osman, Jayne Franklyn, Saqib Chowdhary, Roger Holder, Michael Sheppard & Michael Gammage, 15 Aug 2004, In: The American Journal of Cardiology. 94, 4, p. 465-9 5 p.Research output: Contribution to journal › Article
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Iodothyronine deiodinase enzyme mRNA expression in normal pituitary and pituitary adenomas
Lesley Tannahill, Christopher McCabe, Kachilele-Linjewile Kachilele, Kristien Boelaert, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001.Research output: Contribution to conference (unpublished) › Paper
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Levothyroxine treatment and occurrence of fracture of the hip
Michael Sheppard, Roger Holder & Jayne Franklyn, 11 Feb 2002, In: Archives of Internal Medicine. 162, 3, p. 338-343 6 p.Research output: Contribution to journal › Article
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Long-acting octreotide and prolonged-release lanreotide formulations have different pharmacokinetic profiles
Michael Sheppard, 1 Jul 2005, In: Journal of Clinical Pharmacology. 45(7), p. 836-844 9 p.Research output: Contribution to journal › Article
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Long-term safety and efficacy of depot long-acting somatostatin analogs for the treatment of acromegaly
John Ayuk, Paul Stewart & Michael Sheppard, 1 Sep 2002, In: Journal of Clinical Endocrinology and Metabolism. 87, 9, p. 4142-4146 5 p.Research output: Contribution to journal › Article
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Management of acromegaly in Latin America: expert panel recommendations
Michael Sheppard, 1 Jun 2010, In: Pituitary. 13, 2, p. 168-175 8 p.Research output: Contribution to journal › Article
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Medical Therapy in Patients with Acromegaly: Predictors of Response and Comparison of Efficacy of Dopamine Agonists and Somatostatin Analogues
Mark Sherlock, Aurora Aragon Alonso, Raoul Reulen, John Ayuk, Michael Sheppard, Andrew Bates & Paul Stewart, 1 Apr 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 4, p. 1255-1263 9 p.Research output: Contribution to journal › Article
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Medical therapy in acromegaly.
Mark Sherlock & Michael Sheppard, 1 May 2011, In: Nature Reviews Endocrinology. 7, 5, p. 291-300 10 p.Research output: Contribution to journal › Article
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Modulation of 11beta-hydroxysteroid dehydrogenase by pro-inflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation
Mark Cooper, Iwona Bujalska, Elizabeth Rabbitt, Elizabeth Walker, Rosemary Bland, Michael Sheppard, Martin Hewison & Paul Stewart, 1 Jun 2001, In: Journal of Bone and Mineral Research. 16, 6, p. 1037-1044 8 p.Research output: Contribution to journal › Article
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Monitoring disease activity using growth hormone and insulin like growth factor-I in the follow up of 501 patients with acromegaly.
Mark Sherlock, Aurora Aragon Alonso, Raoul Reulen, John Ayuk, Michael Sheppard, Andrew Bates & Paul Stewart, 27 Oct 2008, In: Clinical Endocrinology.Research output: Contribution to journal › Article
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Mortality in elderly patients with subclinical hyperthyroidism
Jim Parle, Michael Sheppard & Jayne Franklyn, 2 Mar 2002, In: Lancet. 359, 9308, p. 799-799 1 p.Research output: Contribution to journal › Article
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NIS gene expression is a potential prognostic indicator for thyroid cancer and is inhibited by PTTG
Kristien Boelaert, Lesley Tannahill, Margaret Eggo, Neil Gittoes, Michael Sheppard, Jayne Franklyn & Christopher McCabe, 1 Jan 2003, p. 28. 1 p.Research output: Contribution to conference (unpublished) › Abstract
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Pituitary Disease
Michael Sheppard & Paul Stewart, 1 Jan 2002, Kluwer Academic Publishers.Research output: Book/Report › Book
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Pituitary tumor transforming gene (PTTG), PTTG binding factor (PBF) and related growth factor expression in sporadic pituitary tumours
Christopher McCabe, Jattinder Khaira, Kristien Boelaert, Lesley Tannahill, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001, p. OC18.Research output: Contribution to conference (unpublished) › Abstract
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Pituitary tumour transforming gene and fibroblast growth factor 2 expression: potential prognostic indicators in differentiated thyroid cancer
Kristien Boelaert, Christopher McCabe, Lesley Tannahill, Neil Gittoes, Roger Holder, Jo Bradwell, Michael Sheppard & Jayne Franklyn, 1 May 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 5, p. 2341-2347 7 p.Research output: Contribution to journal › Article
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Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study
Jim Parle, Michael Sheppard & Jayne Franklyn, 15 Sep 2001, In: Lancet. 358, 9285, p. 861-865 5 p.Research output: Contribution to journal › Article
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Premature mortality and hypopituitarism - Authors' reply
Paul Stewart, Jeremy Tomlinson, Andrew Bates & Michael Sheppard, 1 Jun 2001, In: Lancet. 357, 9272, p. 1973-1974 2 p.Research output: Contribution to journal › Article
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Prevalence of subclinical thyroid dysfunction and its relation to socioeconomic deprivation in the elderly: a community based cross-sectional survey
Jim Parle, Lesley Roberts, Andrea Roalfe, Richard Hobbs, Michael Sheppard, Michael Gammage, 26 Sep 2006, In: Clinical Endocrinology. 91, p. 4809-4816 8 p.Research output: Contribution to journal › Article
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Primary medical therapy for acromegaly.
Michael Sheppard, 1 Apr 2003, In: Clinical Endocrinology. 58, 4, p. 387-99 13 p.Research output: Contribution to journal › Article
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Quantitation of thyroglobulin (Tg) mRNA in peripheral blood of thyroid cancer patients
Margaret Eggo, Michael Sheppard, Jayne Franklyn, 1 Jan 2001, p. 226. 1 p.Research output: Contribution to conference (unpublished) › Abstract
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Serum TSH concentration as a novel predictor of malignancy in thyroid nodules investigated by fine needle aspiration
Kristien Boelaert, Roger Holder, Michael Sheppard & Jayne Franklyn, 5 Sep 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4295-4301 7 p.Research output: Contribution to journal › Article
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Sodium iodide gene expression is a potential prognostic indicator for thyroid cancer and is inhibited by PTTG
Kristien Boelaert, Margaret Eggo, Neil Gittoes, Michael Sheppard, Jayne Franklyn & Christopher McCabe, 1 Jan 2003, p. OC37.Research output: Contribution to conference (unpublished) › Abstract
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Sodium iodide symporter (NIS) gene expression is a potential prognostic indicator for thyroid cancer and is inhibited by pituitary tumor transforming gene
Kristien Boelaert, Lesley Tannahill, Margaret Eggo, Neil Gittoes, Michael Sheppard, Jayne Franklyn & Christopher McCabe, 1 Jan 2003.Research output: Contribution to conference (unpublished) › Paper
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The Birmingham Elderly Thyroid Study: TSH and fT4 values in 5784 community-living subjects aged 60 and over
Jim Parle, Jayne Franklyn, Sue Wilson, Roger Holder, Michael Sheppard, Richard Hobbs, Andrea Roalfe, Michael Gammage, 1 Jan 2005, p. P157.Research output: Contribution to conference (unpublished) › Abstract
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The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression
Michael Sheppard, Jie Xiong, Farida Latif, 1 May 1998, In: Molecular and Cellular Neuroscience. 11, 1-2, p. 29-35 7 p.Research output: Contribution to journal › Article
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The Network for the Enhancement of Endocrinology and Oncology Knowledge: A case-based consideration of current practice in Cushing's disease and acromegaly
Michael Sheppard, 1 Dec 2009, In: Best practice & research. Clinical endocrinology & metabolism. 23, p. S1-S4Research output: Contribution to journal › Article
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The SH3 domain of PTTG differentially mediates FGF-2 transactivation and cell transformation
Kristien Boelaert, Lesley Tannahill, Jasbir Moore, Lawrence Young, Michael Sheppard, Neil Gittoes, Jayne Franklyn & Christopher McCabe, 1 Jan 2002, p. OR 40-42.Research output: Contribution to conference (unpublished) › Paper
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The Skeletal System in Hyperthyroidism
Michael Sheppard & Neil Gittoes, 1 Jan 2005, The Thyroid, 9th edition. Vol. Ch 40.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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The Skeletal System in Hypothyroidism
Neil Gittoes & Michael Sheppard, 1 Jan 2005, The Thyroid, 9th edition. Vol. Ch 62.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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The assessment of thyroid neoplasia
Kristien Boelaert, Jayne Franklyn, Michael Sheppard, 1 Jan 2007, Clinical Endocrine Oncology.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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The critical parameters in GH excess
Michael Sheppard, 1 Jan 2005, In: Journal of endocrinological investigation. 28, 5 Suppl, p. 92-5 4 p.Research output: Contribution to journal › Review article
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The destruction box of pituitary tumor transforming gene (PTTG) mediates cell transformation in vitro
Christopher McCabe, Jattinder Khaira, Kristien Boelaert, Lesley Tannahill, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001, p. OR37-2.Research output: Contribution to conference (unpublished) › Paper
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The role of growth hormone-receptor antagonism in relation to acromegaly
John Ayuk & Michael Sheppard, 1 Nov 2004, In: Expert Opinion on Pharmacotherapy. 5(11), p. 2279-2285 7 p.Research output: Contribution to journal › Review article
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Thyroid Function Tests
Neil Gittoes, Jayne Franklyn, Michael Sheppard, 1 Jan 2001, Endocrinology (4th Edition). Vol. 2 Ch 97.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Thyroid function and mortality in patients treated for hyperthyroidism
Jayne Franklyn, Michael Sheppard, 6 Jul 2005, In: JAMA The Journal of the American Medical Association. 294, 1, p. 71-80 10 p.Research output: Contribution to journal › Article
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Thyroid-stimulating hormone rapidly stimulates inositol polyphosphate formation in FRTL-5 thyrocytes without activating phosphoinositidase C
Philip Hunt, Margaret Eggo, Michael Sheppard, Chris Kirk & Bob Michell, 15 May 1996, In: Biochemical Journal. 316, 1, p. 175-182 8 p.Research output: Contribution to journal › Article › peer-review
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Tie-2 is expressed on thyroid follicular cells, is increased in goiter, and is regulated by thryotropin through cyclic adenosine 3',5'-monophosphate
James Ramsden, Helen Cocks, Munjiba Shams, Michael Sheppard, Asif Ahmed & Margaret Eggo, 1 Jun 2001, In: Journal of Clinical Endocrinology and Metabolism. 86, 6, p. 2709-2716 8 p.Research output: Contribution to journal › Article
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Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors
Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Jattinder Khaira, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Sep 2002, In: Journal of Clinical Endocrinology and Metabolism. 87, 9, p. 4238-4244 7 p.Research output: Contribution to journal › Article
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Weight gain following treatment of hyperthyroidism
Roger Holder, Michael Sheppard & Jayne Franklyn, 1 Aug 2001, In: Clinical Endocrinology. 55, 2, p. 233-239 7 p.Research output: Contribution to journal › Article