Mark Wheatley

Colleges, School and Institutes

Willingness to take PhD students


PhD projects

Mark Wheatley has an international reputation for his research into the structure and function of G-protein-coupled receptors (GPCRs). He has national and international collaborations with both academia and the pharmaceutical industry. In particular, he has maintained a longstanding interest in the receptors for the pituitary hormones vasopressin (AVP) and oxytocin (OT). These peptides have many physiological functions including regulation of blood pressure and urine volume (AVP), lactation and contraction of the uterus at birth (OT). Effects are mediated by a family of four related receptor proteins, V1aR, V1bR, V2R and OTR. Professor Wheatley's lab aims to understand how GPCRs for peptide hormones work at the molecular level, which will aid rational drug design in the future.