Lee Middleton

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Research Projects

  1. Calcium Supplementation for Prevention of Pre-eclampsia in High Risk Women: CaPE Trial

    Lee Middleton, Andrew Ewer, Patrick Moore & Peter Brocklehurst

    NIHR

    1/09/20 → 1/02/25

    Project: Other Government Departments

  2. Early detection and treatment of post-partum hemorrhage using the MOTIVE bundle : a World Health Organization cluster randomized trial with health economic analysis (the E-MOTIVE study)

    Adam Devall, Karla Hemming, Tracy Roberts, Lee Middleton, Peter Brocklehurst, Arri Coomarasamy, Ioannis Gallos & James Martin

    THE BILL & MELINDA GATES FOUNDATION

    1/11/19 → 1/01/23

    Project: Research

  3. Letrozole for improving fertility in women with polycystic ovary syndrome

    Tracy Roberts, Wiebke Arlt, Lee Middleton, Arri Coomarasamy, Ioannis Gallos, Adam Devall & Rima Smith

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/04/19 → 28/02/23

    Project: Other Government Departments

  4. Rescue Cervical Cerclage to prevent miscarriage and preterm birth a Randomised Controlled Trial (C-STICH2)

    Peter Brocklehurst, Victoria Ann Morton, Lee Middleton, Arri Coomarasamy, R. Katie Morris & Laura Jones

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/07/18 → 30/06/25

    Project: Other Government Departments

  5. A Randomised Controlled Trial to investigate the clinical and cost-effectiveness of Paravertebral Blockade compared with Thoracic Epidural Blockade in reducing Chronic Post-Thoractomy Pain (TOPIC 2)

    Louise Jackson, Babu Naidu, Fang Gao Smith, & Lee Middleton

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/05/18 → 31/10/22

    Project: Other Government Departments

  6. A randomised controlled trial of a Sythetic Osmotic cervical dilator for induction of Labour in comparison to dinoprostone Vaginal insErt (SOLVE)

    Lee Middleton & Janesh Gupta

    MEDICEM INTERNATIONAL CR

    1/06/17 → 31/05/19

    Project: EU

  7. Vaginal Preparation at caesarean section to Reduce Endometriosis and Prevent Sepsis (PREPS)

    Victoria Ann Morton, R. Katie Morris, David Lissauer & Lee Middleton

    NIHR CENTRAL COMMISSIONING FACILITY

    1/06/17 → 31/08/18

    Project: Other Government Departments

  8. A randomised trial of mifepristone and misoprostol alone in the medical management of missed miscarriage: The MIFEMISO Trial

    Adam Devall, Lee Middleton, Arri Coomarasamy, Tracy Roberts & Laura Jones

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/02/17 → 31/07/20

    Project: Other Government Departments

  9. GEM3: A multi-centre double-blind placebo-controlled randomised trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy

    Lee Middleton & Arri Coomarasamy

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/04/16 → 30/09/19

    Project: Other Government Departments

  10. High Or Low Dose Syntocinon for delay in labour (HOLDS)

    Andrew Ewer, Lee Middleton, Sara Kenyon & Beck Taylor

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/03/16 → 31/05/19

    Project: Other Government Departments

  11. GaPP2:A multi-centre randomised controlled trial of the efficacy and mechanism of action of gabapentin for the management of chronic pelvic pain in women

    Lee Middleton &

    NIHR

    1/09/15 → 31/10/19

    Project: Other Government Departments

  12. Local Oestrogen Treatment in postmenopausal women Undergoing pelvic organ prolapse Surgery (LOTUS) - Feasibility Study

    Lee Middleton &

    NIHR

    1/04/15 → 31/08/17

    Project: Other Government Departments

  13. A randomised controlled trial to investigate the effectiveness of thoracic eqidural and paravertebral blockade in reducing chronic post-thoracotomy pian -TOPIC pilot study

    Fang Gao Smith, Babu Naidu, Lee Middleton, , Jane Daniels & Joyce Yeung

    NIHR CENTRAL COMMISSIONING FACILITY

    1/12/14 → 30/11/16

    Project: Other Government Departments

  14. C-STICH: Cerclage Suture Type for Incompetent Cervix and effect on Health outcomes

    Lee Middleton, Andrew Ewer &

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/12/14 → 31/08/21

    Project: Other Government Departments

  15. Effectiveness of progesterone to prevent miscarriage in women with early pregnancy bleeding: A placebo-controlled randomised trial (PRISM Study: Progesterone In Spontaneous Miscarriage)

    Tracy Roberts, Adam Devall, Arri Coomarasamy & Lee Middleton

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/10/14 → 14/10/18

    Project: Other Government Departments

  16. Ulipristal acetate versus conventional management of heavy menstrual bleeding (HMB including uterine fibroids): a randomised controlled trial and exploration of mechanism of action (UCON trial)

    Lee Middleton

    NIHR

    1/10/14 → 31/05/21

    Project: Other Government Departments

  17. Preventing Recurrence of Endometriosis by Means of long acting Protestogen Therapy (Pre-empt)

    Lee Middleton, Tracy Roberts &

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/12/13 → 30/04/23

    Project: Other Government Departments

  18. Effectiveness of Antibiotic Prophylaxis During Surgical Evacuation of the Uterus for Miscarriage Management in Low Income Countries (AIMS Trial)

    Arri Coomarasamy, David Lissauer & Lee Middleton

    MEDICAL RESEARCH COUNCIL

    10/06/13 → 9/08/17

    Project: Research Councils

  19. The Relationship Between Refluxing Pelvic Veins and Chronic Pelvic Pain in Women

    Jane Daniels, Janesh Gupta, Rita Solanki & Lee Middleton

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/08/12 → 31/07/14

    Project: Other Government Departments

  20. Anti Epileptic drug monitoring in Pregnancy: an evaluation of effectiveness, cost effectiveness and acceptability of monitoring strategies

    Lee Middleton & Jamie Coleman

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/10/11 → 30/09/15

    Project: Other Government Departments

  21. MEDAL - Can magnetic resonance imaging (MRI) scan replace or triage the use of laparoscopy in establishing a diagnosis among women presenting in secondary care with chronic pelvic pain (CPP)

    Jane Daniels, Jon Deeks, Lee Middleton & Tracy Roberts

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/10/11 → 30/11/15

    Project: Other Government Departments

  22. Efficacy and Mechanism of Thyroxine Treatment on Pregnancy and Neonatal Outcomes in Women with Thyroid Antibodies: A Randomised, Placebo-Controlled, Double-Blind, Multi-Centre Trial

    Mark Kilby, Lee Middleton, Arri Coomarasamy & Kristien Boelaert

    NIHR

    1/06/11 → 31/03/18

    Project: Other Government Departments

  23. NIHR HTA - A Randomised Trial of Treating Fibroids with either Embolisation or Myomectomy to Measure the Effect on Quality of Life Among Women Wishing to Avoid Hysterectomy (FEMME)

    Lee Middleton &

    NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

    1/06/11 → 31/12/19

    Project: Other Government Departments

  24. The PLUTO Trial: Percutaneous Shunting in Lower Urinary Tract Obstruction

    Mark Kilby, R. Katie Morris, Jane Daniels, Khalid Khan, Lee Middleton, Stirling Bryan, Tracy Roberts, Celia Taylor, Richard Gray, Richard Lilford &

    THE NHS HEALTH TECHNOLOGY ASSESMENT PROGRAMME (HTA)

    1/09/08 → 30/06/12

    Project: Research