Lee Middleton

Colleges, School and Institutes

Research interests

Through his work on over 20 successfully funded NIHR grants, Lee had developed a wealth of practical experience in various clinical trial designs including: pilot and feasibility studies, surgical trials including expertise-based designs, factorial trials, non-inferiority approaches, cluster-randomised trials, comprehensive cohort designs, and trials of tests. He also has an interest in diagnostic studies and individual patient data meta-analysis.


  • MSc in Statistics, University of Kent, 2001
  • BSc (Hons) in Mathematics, University of Manchester, 1998


Lee qualified with a BSc (Hons) in Mathematics from the University of Manchester in 1998 and later and went on to study for an MSc in Statistics at the University of Kent which was awarded in 2001.

Following his Masters award, Lee’s first role was in industry as a Statistician for Syngenta (formerly Zeneca Agrochemicals) where he provided statistical support on the design, analysis and interpretation of toxicological and pre-clinical studies.

Lee then joined BCTU as Medical Statistician in 2007 and progressed to Senior Statistician and later Statistics Lead. He is now responsible for the trial design, statistical conduct, presentation and dissemination of a diverse portfolio of high quality late phase RCTs.