Lawrence Young
Publications
- 2016
- Published
Evidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women
Sarah Leonard, Sally Roberts, Lawrence Young, 15 Feb 2016, In: Scientific Reports. 6, 20847.Research output: Contribution to journal › Article › peer-review
- Published
The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling
Mhairi Morris, Christopher Dawson, Louise Laverick & Lawrence Young, 2016, In: Scientific Reports. 6, p. 19533Research output: Contribution to journal › Article › peer-review
- 2015
- Published
Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells
Angela Lo, Christopher Dawson, Lawrence Young, 15 Jun 2015, In: Journal of Pathology. 237, 2, p. 238-248Research output: Contribution to journal › Article › peer-review
- Published
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection
John Arrand, Paul Murray, Alan Rickinson, Lawrence Young, May 2015, In: Journal of virology. 89, 10, p. 5222-37 16 p.Research output: Contribution to journal › Article › peer-review
- 2014
- Published
Epstein-Barr virus and nasopharyngeal carcinoma
Lawrence Young & Christopher Dawson, Dec 2014, In: Chinese Journal of Cancer. 33, 12, p. 581-90 10 p.Research output: Contribution to journal › Article › peer-review
- 2013
- Published
- Published
Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells
Angela Lo, Lawrence Young & Christopher Dawson, Jul 2013, In: Journal of Pathology. 230, 3, p. 336-46 11 p.Research output: Contribution to journal › Article › peer-review
- 2012
- Published
A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels
Wenbin Wei, Stephanie Maloney, Andrew Bell, Paul Murray, Christopher Dawson, Lawrence Young & John Arrand, 17 Jul 2012, In: PLoS ONE. 7, 7, p. e41055Research output: Contribution to journal › Article › peer-review
- Published
- Published
Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma
Christopher Dawson, Lawrence Young, 1 Jan 2012, In: Journal of virology. 86, 1, p. 60-68 9 p.Research output: Contribution to journal › Article
- 2011
- Published
- Published
Phase I/II trial of a dendritic cell vaccine transfected with DNA encoding melan A and gp100 for patients with metastatic melanoma.
Jane Steele, Ankit Rao, Sarah Berhane, Lucinda Billingham, Gordon Ryan, Lawrence Young & Neil Steven, 10 Feb 2011, In: Gene Therapy. 18, p. 584-593Research output: Contribution to journal › Article
- 2010
- Published
Smoking-induced p16 methylation in young women
Yuk Ting Ma, Stuart Collins, Lawrence Young, Paul Murray, 1 Oct 2010, p. Abstract B48.Research output: Contribution to conference (unpublished) › Abstract
- Published
- Published
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CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus
Peter Searle, Lawrence Young & Daniel Palmer, 1 Mar 2010, In: Molecular Cancer. 9, p. 52 1 p.Research output: Contribution to journal › Article
- Published
Is Human Papillomavirus Viral Load a Clinically Useful Predictive Marker? A Longitudinal Study
Christothea Constandinou-Williams, Stuart Collins, Sally Roberts, Lawrence Young & Paul Murray, 1 Mar 2010, In: Cancer Epidemiology Biomarkers & Prevention. 19, 3, p. 832-837 6 p.Research output: Contribution to journal › Article
- Published
CD40 ligand-induced carcinoma cell death: a balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals.
Lawrence Young & Daniel Palmer, 15 Jan 2010, In: Journal of Immunology. 184, 2, p. 1111-20 10 p.Research output: Contribution to journal › Article
- Published
Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors.
John O'Neil, Christopher Dawson, Lawrence Young & John Arrand, 1 Jan 2010, In: Molecular Cancer. 9, p. 241 1 p.Research output: Contribution to journal › Article
- Published
- 2009
- Published
The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation
Khilan Shah, Wenbin Wei, John O'Neil, Christopher Dawson & Lawrence Young, 5 Nov 2009, In: Oncogene. 28, 44, p. 3903-14 12 p.Research output: Contribution to journal › Article
- Published
Epstein-Barr virus and carcinogenesis: beyond Burkitt's lymphoma
Lawrence Young, 1 Nov 2009, In: Clinical Microbiology and Infection. 15, 11, p. 982-988 7 p.Research output: Contribution to journal › Review article
- Published
- Published
Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma
Mhairi Morris, Christopher Dawson & Lawrence Young, 1 Aug 2009, In: Future Oncology. 5, 6, p. 811-825 15 p.Research output: Contribution to journal › Review article
- Published
Disruption of the E2 gene is a common and early event in the natural history of cervical human papillomavirus infection: a longitudinal cohort study.
Stuart Collins, Christothea Constandinou-Williams, Kaisheng Wen, Lawrence Young, Sally Roberts, Paul Murray, 1 May 2009, In: Cancer Research. 69, 9, p. 3828-32 5 p.Research output: Contribution to journal › Article
- Published
- Published
Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma
Lawrence Young, 1 Mar 2009, In: Hematological Oncology. 27, 1, p. 31-39 9 p.Research output: Contribution to journal › Article
- Published
The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.
Shikha Bose, Matthew Fung, Christopher Dawson, Wenbin Wei, John Arrand, Lawrence Young, Tatjana Stankovic & Paul Murray, 1 Feb 2009, In: Journal of Pathology. 217, 3, p. 345-52 8 p.Research output: Contribution to journal › Article
- Published
A Phase II Study of Adoptive Immunotherapy Using Dendritic Cells Pulsed with Tumor Lysate in Patients with Hepatocellular Carcinoma
Daniel Palmer, Forhad Ahmed, Jane Steele, Neil Steven, Lawrence Young & David Adams, 1 Jan 2009, In: Hepatology. 49, 1, p. 124-132 9 p.Research output: Contribution to journal › Article
- 2008
- Published
Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes.
Mhairi Morris, Christopher Dawson, Wenbin Wei, John O'Neil, Junying Jia, Andrew Bell, Lawrence Young & John Arrand, 1 Nov 2008, In: Journal of General Virology. 89, Pt 11, p. 2806-20 15 p.Research output: Contribution to journal › Article
- Published
DNA tumour viruses promote tumour cell invasion and metastasis by deregulating the normal processes of cell adhesion and motility
Mhairi Morris, Lawrence Young & Christopher Dawson, 1 Sep 2008, In: European Journal of Cell Biology. 87, 8-9, p. 677-97 21 p.Research output: Contribution to journal › Article
- Published
The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype
Martina Vockerodt, Wenbin Wei, John Arrand, Lawrence Young & Paul Murray, 1 Sep 2008, In: Journal of Pathology. 216, 1, p. 83-92 10 p.Research output: Contribution to journal › Article
- Published
Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin's Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells
Karl Baumforth, Wenbin Wei, Georgia Kapatai, Emma Kalk, Karen Piper, Lee Machado, Lawrence Young & 2 others, , 1 Jul 2008, In: The American Journal of Pathology. 173, 1, p. 195-204Research output: Contribution to journal › Article › peer-review
- Published
- Published
- Published
Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells
Joanne Gough, Karl Baumforth, Wenbin Wei, Gemma Kelly, Lawrence Young & Paul Murray, 1 Jan 2008, In: Blood. 111, 1, p. 292-301 10 p.Research output: Contribution to journal › Article
- 2007
- Published
CD154 tone sets the signaling pathways and transcriptome generated in model CD40-pluricompetent L3055 Burkitt's lymphoma cells
Wenbin Wei, John Arrand, Martin Rowe, Lawrence Young & John Gordon, 1 Sep 2007, In: Journal of Immunology. 179, 5, p. 2705-2712 8 p.Research output: Contribution to journal › Article
- Published
Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFβ signaling pathways
Victoria Wood, John O'Neil, Wenbin Wei, Suzanne Stewart, Christopher Dawson & Lawrence Young, 7 May 2007, In: Oncogene. 26, p. 4135-4147 13 p.Research output: Contribution to journal › Article
- Published
BMI-1 is induced by the Epstein-Barr virus oncogene LMP1, and regulates the expression of viral target genes in Hodgkin's lymphoma cells
Amanda Dutton, James Last, Wenbin Wei, Martina Vockerodt, Karl Baumforth, Joanne Gough, Martin Rowe, Malcolm Taylor, Lawrence Young & Paul Murray, 15 Mar 2007, In: Blood. 109, 6, p. 2597-2603 7 p.Research output: Contribution to journal › Article
- Published
C4b binding protein binds to CD154 and preventing CD40 mediated cholangiocyte apoptosis: A novel link between complement system and epithelial cell survival
Kevin Williams, Stephen Young, Lawrence Young, David Adams & Simon Afford, 17 Jan 2007, In: PLoS ONE. 2, p. e159Research output: Contribution to journal › Article › peer-review
- Published
EBV latent membrane protein-1 imposes a Hodgkin's lymphoma-like gene expression signature in germinal center B cells
Martina Vockerodt, Susan Morgan, Michael Kuo, Karl Baumforth, Wenbin Wei, John Arrand, John Gordon, Lawrence Young & Paul Murray, 1 Jan 2007, In: Blood.Research output: Contribution to journal › Article
- Published
- Published
The natural history of cervical HPV infection: unresolved issues
Stuart Collins & Lawrence Young, 1 Jan 2007, In: Nature Reviews Cancer. 7, 1, p. 11-22 12 p.Research output: Contribution to journal › Article
- 2006
- Published
- Published
- Published
Targeting cellular FLICE-like inhibitory protein as a novel approach to the treatment of Hodgkin's lymphoma
Amanda Dutton, Lawrence Young & Paul Murray, 1 Jun 2006, In: Expert Review of Anticancer Therapy. 6, p. 911-919 9 p.Research output: Contribution to journal › Review article
- Published
CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2
Jalal Ahmed-Choudhury, Kevin Williams, Lawrence Young, David Adams & Simon Afford, Apr 2006, In: Cellular Signalling. 18, 4, p. 456-68 13 p.Research output: Contribution to journal › Article › peer-review
- Published
Cancer gene therapy: Clinical trials
Daniel Palmer, Lawrence Young & Vivien Mautner, 1 Feb 2006, In: Trends in Biotechnology. 24, p. 76-82 7 p.Research output: Contribution to journal › Review article
- Published
The role of cellular flice inhibitory protecin (c-FLIP) in the pathogenesis and treatment of cancer
Amanda Dutton, Lawrence Young & Paul Murray, 1 Feb 2006, In: Expert Opinion on Therapeutic Targets. 10, p. 27-35 9 p.Research output: Contribution to journal › Review article
- Published
Epstein-Barr virus (EBV) and its associated human cancers-genetics, epigenetics, pathobiology and novel therapeutics
Lawrence Young & Paul Murray, 1 Jan 2006, In: Frontiers in Bioscience. 11, p. 2672-2713 42 p.Research output: Contribution to journal › Review article
- Published
- 2005
- Published
TRAF6 is required for TRAF2-dependent CD40 signal transduction in non-haemopoietic cells
Clare Davies, Lawrence Young & Aris Eliopoulos, 15 Nov 2005, In: Molecular and Cellular Biology. 25, p. 9806-9819 14 p.Research output: Contribution to journal › Article
- Published
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells
Karl Baumforth, Joanne Gough, Trevor Pettitt, Wenbin Wei, Susan Morgan, Tatjana Stankovic, Dickens Pratt, Mike Wakelam, Lawrence Young & Paul Murray, 15 Sep 2005, In: Blood. 106, p. 2138-2146 9 p.Research output: Contribution to journal › Article
- Published
- Published
- Published
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The role of sexual behaviour in the acquisition of asymptomatic EBV infection
Lawrence Young & Paul Murray, 1 Jun 2005, In: The Pediatric Infectious Disease Journal . 24, p. 498-502 5 p.Research output: Contribution to journal › Article
- Published
Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A
Lawrence Young, Christopher Dawson, 1 May 2005, In: Journal of virology. 79, p. 5499-5506 8 p.Research output: Contribution to journal › Article
- Published
- Published
PTTG Binding Factor (PBF) - a Novel Transforming Gene in Thyroid Tumorigenesis
Kristien Boelaert, Lesley Tannahill, Dae Kim, Margaret Eggo, Neil Gittoes, Lawrence Young, Jayne Franklyn & Christopher McCabe, 5 Apr 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4341-4349 9 p.Research output: Contribution to journal › Article
- Published
Inhibition of NF-κB enhances the cytotoxicity of virus-directed enzyme prodrug therapy and oncolytic adenovirus cancer gene therapy
Daniel Palmer, Peter Searle & Lawrence Young, 31 Mar 2005, In: Gene Therapy. 12, p. 1187-1197 11 p.Research output: Contribution to journal › Article
- Published
Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving AKT kinase and mTOR
Amanda Dutton, Christopher Dawson, Lawrence Young & Paul Murray, 1 Mar 2005, In: Journal of Pathology. 205, p. 498-506 9 p.Research output: Contribution to journal › Article
- Published
The Epstein-Barr virus encoded LMP2A and LMP2B proteins promote epithelial cell spreading and motility
Lawrence Young & Christopher Dawson, 1 Feb 2005, In: Journal of virology. 79, p. 1789-1802 14 p.Research output: Contribution to journal › Article
- Published
Activation of CD40 in cervical carcinoma cells facilitates CTL responses and augments chemotherapy-induced apoptosis
Seran Hill, Andrew Hislop, Clare Davies, David Luesley, Alan Rickinson, Lawrence Young & Aris Eliopoulos, 1 Jan 2005, In: Journal of Immunology. 174, p. 41-50 10 p.Research output: Contribution to journal › Article
- 2004
- Published
Nitroreductase: A prodrug-activating enzyme for cancer gene therapy
Peter Searle, Andrew Lovering, Jane Grove, Chris Guise, Nicholas James, Vivien Mautner, Lawrence Young, David Kerr, Scott White & Eva Hyde, 1 Nov 2004, In: Clinical and Experimental Pharmacology and Physiology. 31, 11, p. 811-816 6 p.Research output: Contribution to journal › Article › peer-review
- Published
Epstein-Barr virus encoded LMP2A regulates viral and cellular gene expression via modulation of the NF-κB transcription factor pathway
Suzanne Stewart, Christopher Dawson, John Curnow & Lawrence Young, 25 Oct 2004, In: National Academy of Sciences. Proceedings. 101, p. 15730-15735 6 p.Research output: Contribution to journal › Article › peer-review
- Published
Expression of the cellular FLICE inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death
Amanda Dutton, John O'Neil, Anne Milner, Lawrence Young & Paul Murray, 19 Apr 2004, In: National Academy of Sciences. Proceedings. 101, p. 6611-6616 6 p.Research output: Contribution to journal › Article
- Published
Epstein-Barr virus latent membrane protein 1 (LMP1) up-regulates Id1 expression in nasopharyngeal epithelial cells
Aris Eliopoulos, Lawrence Young, 5 Apr 2004, In: Oncogene. 23, p. 4488-4494 7 p.Research output: Contribution to journal › Article
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Virus directed enzyme prodrug therapy: Intratumoural administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer
Daniel Palmer, Vivien Mautner, Stefan Hubscher, Seran Hill, Peter Searle, Lawrence Young, Nicholas James, 29 Mar 2004, In: Journal of Clinical Oncology. 22, p. 1546-1552 7 p.Research output: Contribution to journal › Article
- Published
An interferon-γ ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies
Jane Steele, Caroline Savage, John Winer & Lawrence Young, 1 Jan 2004, In: Journal of Neuroimmunology. 150, p. 98-106 9 p.Research output: Contribution to journal › Article
- Published
- Published
Carbonic anhydrase IX, a marker of hypoxia: Correlation with clinical outcome in transitional cell carcinoma of the bladder
Syed Hussain, Daniel Palmer, Louise Hiller, Paul Murray, Lawrence Young & Nicholas James, 1 Jan 2004, In: Oncology reports. 11, p. 1005-1010 6 p.Research output: Contribution to journal › Article
- Published
Cytokine mediated modulation of the myc network in barrett's metaplasia
Lawrence Young, Moray Campbell & Chris Tselepis, 1 Jan 2004.Research output: Contribution to conference (unpublished) › Abstract
- Published
Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector
Joanne Gough, Vivien Mautner, Lawrence Young & Peter Searle, 1 Jan 2004, In: Gene Therapy. 11, p. 1126-1236 111 p.Research output: Contribution to journal › Article
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Epstein-Barr virus associated cancers: Aetiology and treatment
Victor Lopes, Lawrence Young & Paul Murray, 1 Jan 2004, In: Herpes. 10, p. 78-82 5 p.Research output: Contribution to journal › Article
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Epstein-Barr virus: 40 years on
Lawrence Young & Alan Rickinson, 1 Jan 2004, In: Nature Reviews Cancer. 4, p. 757-768 12 p.Research output: Contribution to journal › Review article
- Published
Expression of tumour necrosis factor receptor-associated factor 1 (TRAF1) in nasopharyngeal carcinoma: Possible up-regulation by Epstein-Barr virus latent membrane protein 1
Christopher Dawson, Lawrence Young, 1 Jan 2004, In: International Journal of Cancer. 112, p. 265-272 8 p.Research output: Contribution to journal › Article
- Published
- Published
Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells
Clare Davies, Mike Wakelam, Lawrence Young & Aris Eliopoulos, 1 Jan 2004, In: Journal of Biological Chemistry. 279, p. 1010-1019 10 p.Research output: Contribution to journal › Article
- Published
PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro
Kristien Boelaert, Lesley Tannahill, Farhat Khanim, Margaret Eggo, Jasbir Moore, Lawrence Young, Neil Gittoes, Jayne Franklyn & Christopher McCabe, 1 Jan 2004, In: Journal of Molecular Endocrinology. 33, p. 663-677 15 p.Research output: Contribution to journal › Article
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TNF receptors and their ligands: in sickness and in health, in life and death
Lawrence Young & Aris Eliopoulos, 1 Jan 2004, In: Current Opinion in Pharmacology. 4, p. 311-313 3 p.Research output: Contribution to journal › Review article
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The role of CD40 in the pathogenesis and treatment of cancer
Aris Eliopoulos & Lawrence Young, 1 Jan 2004, In: Current Opinion in Pharmacology. 4, p. 360-367 8 p.Research output: Contribution to journal › Review article
- 2003
- Published
The Epstein-Barr virus encoded latent infection membrane protein 1 (LMP1) regulates the processing of p100 NK-κB2 to p52 via an IKKγ/NEMO-independent signaling pathway
Aris Eliopoulos, Jorge Caamano, Joanne Gough, Paul Murray & Lawrence Young, 23 Oct 2003, In: Oncogene. 22, 48, p. 7557-7569 13 p.Research output: Contribution to journal › Article
- Published
- Published
Epstein-Barr virus nuclear antigen 1 (EBNA1) induced cytotoxicity in epithelial cells is associated with EBNA1 degradation and processing.
Christopher Dawson & Lawrence Young, 1 Sep 2003, In: Virology. 313, 2, p. 663-76 14 p.Research output: Contribution to journal › Article
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Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil
Daniel Palmer, Anne Milner & Lawrence Young, 1 Sep 2003, In: British Journal of Cancer. 89, 5, p. 944-950 7 p.Research output: Contribution to journal › Article
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Epstein-Barr virus and oncogenesis: From latent genes to tumours
Lawrence Young & Paul Murray, 11 Aug 2003, In: Oncogene. 22, 33, p. 5108-5121 14 p.Research output: Contribution to journal › Article
- Published
Differential induction of nuclear factor-κB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation
Jalal Ahmed-Choudhury, Lawrence Young, David Adams & Simon Afford, 1 Apr 2003, In: Molecular Biology of the Cell. 14, 4, p. 1334-1345 12 p.Research output: Contribution to journal › Article
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The effect of Epstein-Barr virus status on survival in age and sex defined subgroups of patients with advanced Hodgkin's disease
Lucinda Billingham, Joanne Gough, Lawrence Young & Paul Murray, 1 Feb 2003, In: Annals of Oncology. 14, 2, p. 282-290 9 p.Research output: Contribution to journal › Article
- Published
Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling
Christopher Dawson, Aris Eliopoulos & Lawrence Young, 31 Jan 2003, In: Journal of Biological Chemistry. 278, 6, p. 3694-3704 11 p.Research output: Contribution to journal › Article
- Published
Human papillomavirus type 18 and rapidly progressing cervical intraepithelial neoplasia
Stuart Collins, Heather Winter & Lawrence Young, 4 Jan 2003, In: Lancet. 361, 9351, p. 40-43 4 p.Research output: Contribution to journal › Article
- Published
BCL2 expression predicts survival in patients receiving synchronous chemoradiotherapy in advanced transitional cell carcinoma of the bladder
Syed Hussain, Louise Hiller, Paul Murray, Lawrence Young & Nicholas James, 1 Jan 2003, In: Oncology reports. 10, p. 571-576 6 p.Research output: Contribution to journal › Article
- Published
- Published
- Published
Reactivity with a monoclonal antibody to Epstein-Barr virus (EBV) nuclear antigen 1 defines a subset of aggressive breast cancers in the absence of the EBV genome
Paul Murray, Andrew Bell, Judith Timms, David Rowlands, Christopher McConkey & Lawrence Young, 1 Jan 2003, In: Cancer Research. 63, p. 2338-2343 6 p.Research output: Contribution to journal › Article
- 2002
- Published
TRAF1 is a critical regulator of JNK signalling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 (LMP1) but not CD40
Aris Eliopoulos, Sarah Blake, Clare Davies, Paul Murray & Lawrence Young, 20 Dec 2002, In: Journal of virology. 77, 2, p. 1316-1328 13 p.Research output: Contribution to journal › Article
- Published
Reactivity and isotype profiling of monoclonal antibodies using multiple antigenic peptides
Paul Murray, Lawrence Young, Karl Baumforth, 1 Oct 2002, In: Hybrid Hybridomics. 21, 5, p. 393-398 6 p.Research output: Contribution to journal › Article
- Published
Epstein-Barr virus and human cancer [Book Review]
Lawrence Young, 1 Jul 2002, In: British Journal of Cancer. 87, 1, p. 127-128 2 p.Research output: Contribution to journal › Article
- Published
Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease
Lucinda Billingham, Joanne Gough, Lawrence Young & Paul Murray, 1 Jul 2002, In: British Journal of Haematology. 118, 1, p. 195-201 7 p.Research output: Contribution to journal › Article
- Published
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The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NFκB signaling downstream of TRAF2
Aris Eliopoulos, Sarah Blake, Paul Murray & Lawrence Young, 27 Mar 2002, In: Journal of virology. 76, 9, p. 4567-4579 13 p.Research output: Contribution to journal › Article
- Published
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Induction of apoptosis by chemotherapeutic drugs: the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian carcinoma cells
Anne Milner, Daniel Palmer, Aris Eliopoulos, Pauline Knox, Christopher Poole, David Kerr & Lawrence Young, 1 Mar 2002, In: Cell Death & Differentiation . 9, 3, p. 287-300 14 p.Research output: Contribution to journal › Article
- Published
Disruption of the SH3 domain of PTTG reveals distinct mechanisms of FGF-induction and cell transformation
Kristien Boelaert, Lesley Tannahill, Jasbir Moore, Lawrence Young, Michael Sheppard, Jayne Franklyn, Neil Gittoes & Christopher McCabe, 1 Jan 2002.Research output: Contribution to conference (unpublished) › Abstract
- Published
High incidence of cervical human papillomavirus infection in women during their first sexual relationship
Heather Winter, Lawrence Young, 1 Jan 2002, In: BJOG. 109, 1, p. 96-98 3 p.Research output: Contribution to journal › Article
- Published
The SH3 domain of PTTG differentially mediates FGF-2 transactivation and cell transformation
Kristien Boelaert, Lesley Tannahill, Jasbir Moore, Lawrence Young, Michael Sheppard, Neil Gittoes, Jayne Franklyn & Christopher McCabe, 1 Jan 2002, p. OR 40-42.Research output: Contribution to conference (unpublished) › Paper
- Published
The role of the Epstein-Barr virus in human disease
Paul Murray & Lawrence Young, 1 Jan 2002, In: Frontiers in Bioscience. 7, 1-3, p. 519-540 22 p.Research output: Contribution to journal › Article
- Published
Virus interaction with host immunity
Lawrence Young, 1 Jan 2002, Critical Care Focus - Inflammation and Immunity. Vol. 10.Research output: Chapter in Book/Report/Conference proceeding › Chapter
- 2001
- Published
LMP1 structure and signal transduction
Aris Eliopoulos & Lawrence Young, 1 Dec 2001, In: Seminars in Cancer Biology. 11, 6, p. 435-444 10 p.Research output: Contribution to journal › Article
- Published
CD40 activation-induced, Fas-dependent apoptosis and NF-κB/AP-1 signalling in human intrahepatic biliary epithelial cells
Simon Afford, Jalal Ahmed-Choudhury, Heather Beard, Aris Eliopoulos, Stefan Hubscher, Lawrence Young & David Adams, 1 Nov 2001, In: FASEB Journal. 15, 13, p. 2345-2354 10 p.Research output: Contribution to journal › Article
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The Epstein-Barr virus encoded latent membrane protein 2A augments signaling from latent membrane protein 1
Christopher Dawson, Sarah Blake & Lawrence Young, 25 Oct 2001, In: Virology. 289, 2, p. 192-207 16 p.Research output: Contribution to journal › Article
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High-level β-catenin/TCF-dependent transgene expression in secondary colorectal cancer tissue
Lawrence Young, 1 Oct 2001, In: Molecular Therapy. 4, 4, p. 365-371 7 p.Research output: Contribution to journal › Article
- Published
Frequent expression of the tumour necrosis factor receptor-associated factor 1 in latent membrane protein 1-positive post-transplant lymphoproliferative disease and HIV-associated lymphomas
Paul Murray, Joanne Gough, Karl Baumforth, Lawrence Young, 1 Sep 2001, In: Human Pathology. 32, 9, p. 963-969 7 p.Research output: Contribution to journal › Article
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South Asian ethnicity and material deprivation increase the risk of Epstein-Barr virus infection in childhood Hodgkin's disease
Judy Powell, Lawrence Young & Paul Murray, 3 Aug 2001, In: British Journal of Cancer. 85, p. 350-356 7 p.Research output: Contribution to journal › Article
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Gene therapy for hepatocellular carcinoma - Teaching old dogs new tricks
Simon Afford & Lawrence Young, 1 Jul 2001, In: Hepatology. 34, 1, p. 207-209 3 p.Research output: Contribution to journal › Article
- Published
Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study
Heather Winter & Lawrence Young, 9 Jun 2001, In: Lancet. 357, 9271, p. 1831-1836 6 p.Research output: Contribution to journal › Article
- Published
Expression of cytokine and chemokine genes in Epstein-Barr virus-associated nasopharyngeal carcinoma: Comparison with Hodgkin's disease
Lawrence Young, 1 Jun 2001, In: Journal of Pathology. 194, 2, p. 145-151 7 p.Research output: Contribution to journal › Article
- Published
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The promise and potential hazards of adenovirus gene therapy
Lawrence Young & Vivien Mautner, 1 May 2001, In: Gut. 48, 5, p. 733-736 4 p.Research output: Contribution to journal › Article
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Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: A well-tolerated therapy for established solid tumours
Peter Searle, Lawrence Young, David Kerr, 1 Feb 2001, In: Molecular Therapy. 3, 2, p. 233-240 8 p.Research output: Contribution to journal › Article
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Adeono-virus mediated expression of dominant negative FGF-receptor-1 reverses the effects of FGF-2 on the function of primary human thyrocytes
Emma Davies, Helen Cocks, Nicky Green, Peter Searle, Lawrence Young, Ann Logan, Jayne Franklyn & Margaret Eggo, 1 Jan 2001, p. OC7.Research output: Contribution to conference (unpublished) › Abstract
- Published
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Epstein-Barr virus infection: basis of malignancy and potential for therapy
Paul Murray & Lawrence Young, 1 Jan 2001, In: Expert Reviews in Molecular Medicine. 3, p. 1-20 20 p.Research output: Contribution to journal › Article
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Gene therapy for colorectal cancer: Therapeutic potential
Peter Searle, Lawrence Young & David Kerr, 1 Jan 2001, In: BioDrugs. 15, 6, p. 357-367 11 p.Research output: Contribution to journal › Article
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In vitro assays to study epithelial cell differentiation
Christopher Dawson & Lawrence Young, 1 Jan 2001, In: Methods in molecular biology. 174, p. 173-80 8 p.Research output: Contribution to journal › Article
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In vitro assays to study epithelial cell growth
Christopher Dawson & Lawrence Young, 1 Jan 2001, In: Methods in molecular biology. 174, p. 165-72 8 p.Research output: Contribution to journal › Article
- Published
Negation of FGF-2 effects on growth and function in primary human thyrocytes and FRTL5 cells by adenovirus-mediated expression of dominant negative FGFR-1
Emma Davies, Helen Cocks, Nicky Green, Peter Searle, Lawrence Young, Ann Logan, Jayne Franklyn & Margaret Eggo, 1 Jan 2001, p. 131. 1 p.Research output: Contribution to conference (unpublished) › Paper
- Published
- 2000
- Published
Immunotherapy in hepatocellular carcinoma
Rowan Jones, Lawrence Young & David Adams, 2 Sep 2000, In: Lancet. 356, 9232, p. 784-5 2 p.Research output: Contribution to journal › Article › peer-review
- Published
CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the TNF superfamily
Aris Eliopoulos, Neil Gallagher, David Adams, Simon Afford & Lawrence Young, 1 Aug 2000, In: Molecular and Cellular Biology. 20, 15, p. 5503-5515 13 p.Research output: Contribution to journal › Article
- Published
CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily
Aris Eliopoulos, Pauline Knox, Neil Gallagher, Simon Afford, Lawrence Young & David Adams, Aug 2000, In: Molecular and Cellular Biology. 20, 15, p. 5503-15 13 p.Research output: Contribution to journal › Article › peer-review
- 1999
- Published
Effect of Epstein-Barr virus infection on response to chemotherapy and survival in Hodgkin's disease
Phil Murray, Lucinda Billingham, David Kerr & Lawrence Young, 15 Jul 1999, In: Blood. 94, 2, p. 442-7 6 p.Research output: Contribution to journal › Article › peer-review
- Published
CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection
Simon Afford, Aris Eliopoulos, Stefan Hubscher, Lawrence Young & David Adams, 18 Jan 1999, In: The Journal of Experimental Medicine. 189, 2, p. 441-6 6 p.Research output: Contribution to journal › Article › peer-review
- 1996
- Published
Analysis of Epstein-Barr virus gene polymorphisms in normal donors and in virus-associated tumors from different geographic locations
Farhat Khanim, Qing-Yun Yao, Gerald Niedobitek, Alan Rickinson & Lawrence Young, 1 Nov 1996, In: Blood. 88, 9, p. 3491-3501 11 p.Research output: Contribution to journal › Article › peer-review
- Published
Human papillomavirus infection and risk of progression of epithelial abnormalities of the cervix
Rosemary Tierney & Lawrence Young, Feb 1996, In: British Journal of Cancer. 73, 4, p. 553-556 4 p.Research output: Contribution to journal › Article › peer-review
- 1995
- Published
Non-Hodgkin's lymphoma, coeliac disease, and Epstein-Barr virus: a study of 13 cases of enteropathy-associated T- and B-cell lymphoma
Gerald Niedobitek, Angelo Agathanggelou, Andrew Read, Rosemary Tierney, Lawrence Young, Oct 1995, In: Journal of Pathology. 177, 2, p. 115-22 8 p.Research output: Contribution to journal › Article › peer-review
- 1994
- Published
Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state
Rosemary Tierney, Neil Steven, Lawrence Young & Alan Rickinson, Nov 1994, In: Journal of virology. 68, 11, p. 7374-85 12 p.Research output: Contribution to journal › Article › peer-review
- Published
Latent Epstein-Barr virus infection in cottontop tamarins. A possible model for Epstein-Barr virus infection in humans
Gerald Niedobitek, Angelo Agathanggelou, Rosemary Tierney, Peter Watkins, Andrea Morgan, Lawrence Young, Oct 1994, In: The American Journal of Pathology. 145, 4, p. 969-78 10 p.Research output: Contribution to journal › Article › peer-review
- 1993
- Published
PCR for the detection of cervical HPV16 infection: the need for standardization
Rosemary Tierney, John Ellis & Lawrence Young, 19 Jun 1993, In: International Journal of Cancer. 54, 4, p. 700-1 2 p.Research output: Contribution to journal › Article › peer-review
- Published
HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2
William Thomas, Farhat Khanim, Lawrence Young, Martin Rowe & Alan Rickinson, 1993, In: Journal of virology. 67, 12, p. 7428-7435 8 p.Research output: Contribution to journal › Article › peer-review
- 1992
- Published
PCR for the detection of genital human papillomavirus infection: a mixed blessing
Lawrence Young, Rosemary Tierney, John Ellis, Jun 1992, In: Annals of Medicine. 24, 3, p. 215-9 5 p.Research output: Contribution to journal › Article › peer-review
- Published
PCR for the detection of genital HPV infection: a mixed blessing
Lawrence Young, 1992, In: Annals of Medicine. 24, p. 215-219Research output: Contribution to journal › Article
- 1990
- Published
Analysis of human papillomavirus type 16 E6-E7 transcription in cervical carcinomas and normal cervical epithelium using the polymerase chain reaction
Lawrence Young, Jul 1990, In: Journal of General Virology. 71, 7, p. 1473-1477Research output: Contribution to journal › Article › peer-review
- 1989
- Published
Subtypes of human papillomavirus 16 in cervical tissue
Lawrence Young, 2 Dec 1989, In: The Lancet. 334, 8675, p. 1342Research output: Contribution to journal › Letter › peer-review