Lawrence Young

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Publications

  1. 2016
  2. Published

    Evidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women

    Sarah Leonard, Sally Roberts, Lawrence Young, 15 Feb 2016, In: Scientific Reports. 6, 20847.

    Research output: Contribution to journal › Article › peer-review

  3. Published

    The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling

    Mhairi Morris, Christopher Dawson, Louise Laverick & Lawrence Young, 2016, In: Scientific Reports. 6, p. 19533

    Research output: Contribution to journal › Article › peer-review

  4. 2015
  5. Published

    Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells

    Angela Lo, Christopher Dawson, Lawrence Young, 15 Jun 2015, In: Journal of Pathology. 237, 2, p. 238-248

    Research output: Contribution to journal › Article › peer-review

  6. Published

    Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection

    John Arrand, Paul Murray, Alan Rickinson, Lawrence Young, May 2015, In: Journal of virology. 89, 10, p. 5222-37 16 p.

    Research output: Contribution to journal › Article › peer-review

  7. 2014
  8. Published

    Epstein-Barr virus and nasopharyngeal carcinoma

    Lawrence Young & Christopher Dawson, Dec 2014, In: Chinese Journal of Cancer. 33, 12, p. 581-90 10 p.

    Research output: Contribution to journal › Article › peer-review

  9. 2013
  10. Published

    Epstein-Barr virus induction of the Hedgehog signalling pathway imposes a stem cell phenotype on human epithelial cells

    John Arrand, Wenbin Wei, Lawrence Young & Christopher Dawson, 12 Aug 2013, In: Journal of Pathology.

    Research output: Contribution to journal › Article › peer-review

  11. Published

    Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells

    Angela Lo, Lawrence Young & Christopher Dawson, Jul 2013, In: Journal of Pathology. 230, 3, p. 336-46 11 p.

    Research output: Contribution to journal › Article › peer-review

  12. 2012
  13. Published

    A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels

    Wenbin Wei, Stephanie Maloney, Andrew Bell, Paul Murray, Christopher Dawson, Lawrence Young & John Arrand, 17 Jul 2012, In: PLoS ONE. 7, 7, p. e41055

    Research output: Contribution to journal › Article › peer-review

  14. Published

    The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).

    Christopher Dawson & Lawrence Young, 12 Jan 2012, In: Seminars in Cancer Biology.

    Research output: Contribution to journal › Article

  15. Published

    Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma

    Christopher Dawson, Lawrence Young, 1 Jan 2012, In: Journal of virology. 86, 1, p. 60-68 9 p.

    Research output: Contribution to journal › Article

  16. 2011
  17. Published

    Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study.

    Yuk Ting Ma, Stuart Collins, Lawrence Young, Paul Murray, 26 Apr 2011, In: British Journal of Cancer. 104, 9, p. 1500-4 5 p.

    Research output: Contribution to journal › Article

  18. Published

    Phase I/II trial of a dendritic cell vaccine transfected with DNA encoding melan A and gp100 for patients with metastatic melanoma.

    Jane Steele, Ankit Rao, Sarah Berhane, Lucinda Billingham, Gordon Ryan, Lawrence Young & Neil Steven, 10 Feb 2011, In: Gene Therapy. 18, p. 584-593

    Research output: Contribution to journal › Article

  19. 2010
  20. Published

    Smoking-induced p16 methylation in young women

    Yuk Ting Ma, Stuart Collins, Lawrence Young, Paul Murray, 1 Oct 2010, p. Abstract B48.

    Research output: Contribution to conference (unpublished) › Abstract

  21. Published

    The contribution of the Epstein-Barr virus to the pathogenesis of childhood lymphomas

    Zumla Cader, Pamela Kearns, Lawrence Young, Paul Murray & Martina Vockerodt, 1 Jun 2010, In: Cancer Treatment Reviews. 36, 4, p. 348-353 6 p.

    Research output: Contribution to journal › Article › peer-review

  22. Published

    Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGF beta-mediated growth inhibition

    Angela Lo, Christopher Dawson & Lawrence Young, 1 Jun 2010, In: Molecular Cancer. 9, p. 155 1 p.

    Research output: Contribution to journal › Article

  23. Published

    CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus

    Peter Searle, Lawrence Young & Daniel Palmer, 1 Mar 2010, In: Molecular Cancer. 9, p. 52 1 p.

    Research output: Contribution to journal › Article

  24. Published

    Is Human Papillomavirus Viral Load a Clinically Useful Predictive Marker? A Longitudinal Study

    Christothea Constandinou-Williams, Stuart Collins, Sally Roberts, Lawrence Young & Paul Murray, 1 Mar 2010, In: Cancer Epidemiology Biomarkers &amp Prevention. 19, 3, p. 832-837 6 p.

    Research output: Contribution to journal › Article

  25. Published

    CD40 ligand-induced carcinoma cell death: a balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals.

    Lawrence Young & Daniel Palmer, 15 Jan 2010, In: Journal of Immunology. 184, 2, p. 1111-20 10 p.

    Research output: Contribution to journal › Article

  26. Published

    Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors.

    John O'Neil, Christopher Dawson, Lawrence Young & John Arrand, 1 Jan 2010, In: Molecular Cancer. 9, p. 241 1 p.

    Research output: Contribution to journal › Article

  27. Published

    Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappa B pathway in carcinoma cells by inhibiting IKK phosphorylation

    Christopher Dawson, Khilan Shah, John Arrand, Lawrence Young & John O'Neil, 1 Jan 2010, In: Molecular Cancer. 9, p. 1 1 p.

    Research output: Contribution to journal › Article

  28. 2009
  29. Published

    The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation

    Khilan Shah, Wenbin Wei, John O'Neil, Christopher Dawson & Lawrence Young, 5 Nov 2009, In: Oncogene. 28, 44, p. 3903-14 12 p.

    Research output: Contribution to journal › Article

  30. Published

    Epstein-Barr virus and carcinogenesis: beyond Burkitt's lymphoma

    Lawrence Young, 1 Nov 2009, In: Clinical Microbiology and Infection. 15, 11, p. 982-988 7 p.

    Research output: Contribution to journal › Review article

  31. Published

    Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: A longitudinal study

    Stuart Collins, Lawrence Young, 9 Oct 2009, In: European Journal of Cancer.

    Research output: Contribution to journal › Article

  32. Published

    Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma

    Mhairi Morris, Christopher Dawson & Lawrence Young, 1 Aug 2009, In: Future Oncology. 5, 6, p. 811-825 15 p.

    Research output: Contribution to journal › Review article

  33. Published

    Disruption of the E2 gene is a common and early event in the natural history of cervical human papillomavirus infection: a longitudinal cohort study.

    Stuart Collins, Christothea Constandinou-Williams, Kaisheng Wen, Lawrence Young, Sally Roberts, Paul Murray, 1 May 2009, In: Cancer Research. 69, 9, p. 3828-32 5 p.

    Research output: Contribution to journal › Article

  34. Published

    A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

    Prashant Patel, Vivien Mautner, Stuart Collins, Peter Searle, Lawrence Young & Nicholas James, 14 Apr 2009, In: Molecular Therapy.

    Research output: Contribution to journal › Article

  35. Published

    Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma

    Lawrence Young, 1 Mar 2009, In: Hematological Oncology. 27, 1, p. 31-39 9 p.

    Research output: Contribution to journal › Article

  36. Published

    The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.

    Shikha Bose, Matthew Fung, Christopher Dawson, Wenbin Wei, John Arrand, Lawrence Young, Tatjana Stankovic & Paul Murray, 1 Feb 2009, In: Journal of Pathology. 217, 3, p. 345-52 8 p.

    Research output: Contribution to journal › Article

  37. Published

    A Phase II Study of Adoptive Immunotherapy Using Dendritic Cells Pulsed with Tumor Lysate in Patients with Hepatocellular Carcinoma

    Daniel Palmer, Forhad Ahmed, Jane Steele, Neil Steven, Lawrence Young & David Adams, 1 Jan 2009, In: Hepatology. 49, 1, p. 124-132 9 p.

    Research output: Contribution to journal › Article

  38. 2008
  39. Published

    Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes.

    Mhairi Morris, Christopher Dawson, Wenbin Wei, John O'Neil, Junying Jia, Andrew Bell, Lawrence Young & John Arrand, 1 Nov 2008, In: Journal of General Virology. 89, Pt 11, p. 2806-20 15 p.

    Research output: Contribution to journal › Article

  40. Published

    DNA tumour viruses promote tumour cell invasion and metastasis by deregulating the normal processes of cell adhesion and motility

    Mhairi Morris, Lawrence Young & Christopher Dawson, 1 Sep 2008, In: European Journal of Cell Biology. 87, 8-9, p. 677-97 21 p.

    Research output: Contribution to journal › Article

  41. Published

    The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype

    Martina Vockerodt, Wenbin Wei, John Arrand, Lawrence Young & Paul Murray, 1 Sep 2008, In: Journal of Pathology. 216, 1, p. 83-92 10 p.

    Research output: Contribution to journal › Article

  42. Published

    Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin's Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells

    Karl Baumforth, Wenbin Wei, Georgia Kapatai, Emma Kalk, Karen Piper, Lee Machado, Lawrence Young & 2 others, & Paul Murray, 1 Jul 2008, In: The American Journal of Pathology. 173, 1, p. 195-204

    Research output: Contribution to journal › Article › peer-review

  43. Published

    Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway

    Christopher Dawson, Louise Laverick, Mhairi Morris & Lawrence Young, 1 Apr 2008, In: Journal of virology. 82, 7, p. 3654-64 11 p.

    Research output: Contribution to journal › Article

  44. Published

    Combining gene and immunotherapy for prostate cancer

    Vivien Mautner, Peter Searle, Lawrence Young & Nicholas James, 1 Jan 2008, In: Prostate Cancer and Prostatic Diseases. 11, 2, p. 187-93 7 p.

    Research output: Contribution to journal › Article

  45. Published

    Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells

    Joanne Gough, Karl Baumforth, Wenbin Wei, Gemma Kelly, Lawrence Young & Paul Murray, 1 Jan 2008, In: Blood. 111, 1, p. 292-301 10 p.

    Research output: Contribution to journal › Article

  46. 2007
  47. Published

    CD154 tone sets the signaling pathways and transcriptome generated in model CD40-pluricompetent L3055 Burkitt's lymphoma cells

    Wenbin Wei, John Arrand, Martin Rowe, Lawrence Young & John Gordon, 1 Sep 2007, In: Journal of Immunology. 179, 5, p. 2705-2712 8 p.

    Research output: Contribution to journal › Article

  48. Published

    Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFβ signaling pathways

    Victoria Wood, John O'Neil, Wenbin Wei, Suzanne Stewart, Christopher Dawson & Lawrence Young, 7 May 2007, In: Oncogene. 26, p. 4135-4147 13 p.

    Research output: Contribution to journal › Article

  49. Published

    BMI-1 is induced by the Epstein-Barr virus oncogene LMP1, and regulates the expression of viral target genes in Hodgkin's lymphoma cells

    Amanda Dutton, James Last, Wenbin Wei, Martina Vockerodt, Karl Baumforth, Joanne Gough, Martin Rowe, Malcolm Taylor, Lawrence Young & Paul Murray, 15 Mar 2007, In: Blood. 109, 6, p. 2597-2603 7 p.

    Research output: Contribution to journal › Article

  50. Published

    C4b binding protein binds to CD154 and preventing CD40 mediated cholangiocyte apoptosis: A novel link between complement system and epithelial cell survival

    Kevin Williams, Stephen Young, Lawrence Young, David Adams & Simon Afford, 17 Jan 2007, In: PLoS ONE. 2, p. e159

    Research output: Contribution to journal › Article › peer-review

  51. Published

    EBV latent membrane protein-1 imposes a Hodgkin's lymphoma-like gene expression signature in germinal center B cells

    Martina Vockerodt, Susan Morgan, Michael Kuo, Karl Baumforth, Wenbin Wei, John Arrand, John Gordon, Lawrence Young & Paul Murray, 1 Jan 2007, In: Blood.

    Research output: Contribution to journal › Article

  52. Published

    Smoking-induced epigenetic changes in young women

    Yuk Ting Ma, Stuart Collins, Lawrence Young, Paul Murray, 1 Jan 2007.

    Research output: Contribution to conference (unpublished) › Abstract

  53. Published

    The natural history of cervical HPV infection: unresolved issues

    Stuart Collins & Lawrence Young, 1 Jan 2007, In: Nature Reviews Cancer. 7, 1, p. 11-22 12 p.

    Research output: Contribution to journal › Article

  54. 2006
  55. Published

    The polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens

    Jane Steele, Emma Kalk, Paul Moss, Stefan Hubscher, David Adams & Lawrence Young, 3 Oct 2006, In: British Journal of Cancer. 95, p. 1202-1211 10 p.

    Research output: Contribution to journal › Article

  56. Published

    Epstein-Barr virus induces cellular transcription factors to stimulate expression of EBER genes by RNA polymerase III

    Christopher Dawson, John Arrand, Lawrence Young, 7 Aug 2006, In: Journal of Biological Chemistry. 281, p. 33871-33880 10 p.

    Research output: Contribution to journal › Article

  57. Published

    Targeting cellular FLICE-like inhibitory protein as a novel approach to the treatment of Hodgkin's lymphoma

    Amanda Dutton, Lawrence Young & Paul Murray, 1 Jun 2006, In: Expert Review of Anticancer Therapy. 6, p. 911-919 9 p.

    Research output: Contribution to journal › Review article

  58. Published

    CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2

    Jalal Ahmed-Choudhury, Kevin Williams, Lawrence Young, David Adams & Simon Afford, Apr 2006, In: Cellular Signalling. 18, 4, p. 456-68 13 p.

    Research output: Contribution to journal › Article › peer-review

  59. Published

    Cancer gene therapy: Clinical trials

    Daniel Palmer, Lawrence Young & Vivien Mautner, 1 Feb 2006, In: Trends in Biotechnology. 24, p. 76-82 7 p.

    Research output: Contribution to journal › Review article

  60. Published

    The role of cellular flice inhibitory protecin (c-FLIP) in the pathogenesis and treatment of cancer

    Amanda Dutton, Lawrence Young & Paul Murray, 1 Feb 2006, In: Expert Opinion on Therapeutic Targets. 10, p. 27-35 9 p.

    Research output: Contribution to journal › Review article

  61. Published

    Epstein-Barr virus (EBV) and its associated human cancers-genetics, epigenetics, pathobiology and novel therapeutics

    Lawrence Young & Paul Murray, 1 Jan 2006, In: Frontiers in Bioscience. 11, p. 2672-2713 42 p.

    Research output: Contribution to journal › Review article

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