Lawrence Young
Publications
- 2016
- Published
Evidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women
Sarah Leonard, Sally Roberts, Lawrence Young, 15 Feb 2016, In: Scientific Reports. 6, 20847.Research output: Contribution to journal › Article › peer-review
- Published
The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling
Mhairi Morris, Christopher Dawson, Louise Laverick & Lawrence Young, 2016, In: Scientific Reports. 6, p. 19533Research output: Contribution to journal › Article › peer-review
- 2015
- Published
Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells
Angela Lo, Christopher Dawson, Lawrence Young, 15 Jun 2015, In: Journal of Pathology. 237, 2, p. 238-248Research output: Contribution to journal › Article › peer-review
- Published
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection
John Arrand, Paul Murray, Alan Rickinson, Lawrence Young, May 2015, In: Journal of virology. 89, 10, p. 5222-37 16 p.Research output: Contribution to journal › Article › peer-review
- 2014
- Published
Epstein-Barr virus and nasopharyngeal carcinoma
Lawrence Young & Christopher Dawson, Dec 2014, In: Chinese Journal of Cancer. 33, 12, p. 581-90 10 p.Research output: Contribution to journal › Article › peer-review
- 2013
- Published
- Published
Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells
Angela Lo, Lawrence Young & Christopher Dawson, Jul 2013, In: Journal of Pathology. 230, 3, p. 336-46 11 p.Research output: Contribution to journal › Article › peer-review
- 2012
- Published
A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels
Wenbin Wei, Stephanie Maloney, Andrew Bell, Paul Murray, Christopher Dawson, Lawrence Young & John Arrand, 17 Jul 2012, In: PLoS ONE. 7, 7, p. e41055Research output: Contribution to journal › Article › peer-review
- Published
- Published
Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma
Christopher Dawson, Lawrence Young, 1 Jan 2012, In: Journal of virology. 86, 1, p. 60-68 9 p.Research output: Contribution to journal › Article
- 2011
- Published
- Published
Phase I/II trial of a dendritic cell vaccine transfected with DNA encoding melan A and gp100 for patients with metastatic melanoma.
Jane Steele, Ankit Rao, Sarah Berhane, Lucinda Billingham, Gordon Ryan, Lawrence Young & Neil Steven, 10 Feb 2011, In: Gene Therapy. 18, p. 584-593Research output: Contribution to journal › Article
- 2010
- Published
Smoking-induced p16 methylation in young women
Yuk Ting Ma, Stuart Collins, Lawrence Young, Paul Murray, 1 Oct 2010, p. Abstract B48.Research output: Contribution to conference (unpublished) › Abstract
- Published
- Published
- Published
CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus
Peter Searle, Lawrence Young & Daniel Palmer, 1 Mar 2010, In: Molecular Cancer. 9, p. 52 1 p.Research output: Contribution to journal › Article
- Published
Is Human Papillomavirus Viral Load a Clinically Useful Predictive Marker? A Longitudinal Study
Christothea Constandinou-Williams, Stuart Collins, Sally Roberts, Lawrence Young & Paul Murray, 1 Mar 2010, In: Cancer Epidemiology Biomarkers & Prevention. 19, 3, p. 832-837 6 p.Research output: Contribution to journal › Article
- Published
CD40 ligand-induced carcinoma cell death: a balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals.
Lawrence Young & Daniel Palmer, 15 Jan 2010, In: Journal of Immunology. 184, 2, p. 1111-20 10 p.Research output: Contribution to journal › Article
- Published
Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors.
John O'Neil, Christopher Dawson, Lawrence Young & John Arrand, 1 Jan 2010, In: Molecular Cancer. 9, p. 241 1 p.Research output: Contribution to journal › Article
- Published
- 2009
- Published
The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation
Khilan Shah, Wenbin Wei, John O'Neil, Christopher Dawson & Lawrence Young, 5 Nov 2009, In: Oncogene. 28, 44, p. 3903-14 12 p.Research output: Contribution to journal › Article
- Published
Epstein-Barr virus and carcinogenesis: beyond Burkitt's lymphoma
Lawrence Young, 1 Nov 2009, In: Clinical Microbiology and Infection. 15, 11, p. 982-988 7 p.Research output: Contribution to journal › Review article
- Published
- Published
Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma
Mhairi Morris, Christopher Dawson & Lawrence Young, 1 Aug 2009, In: Future Oncology. 5, 6, p. 811-825 15 p.Research output: Contribution to journal › Review article
- Published
Disruption of the E2 gene is a common and early event in the natural history of cervical human papillomavirus infection: a longitudinal cohort study.
Stuart Collins, Christothea Constandinou-Williams, Kaisheng Wen, Lawrence Young, Sally Roberts, Paul Murray, 1 May 2009, In: Cancer Research. 69, 9, p. 3828-32 5 p.Research output: Contribution to journal › Article
- Published
- Published
Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma
Lawrence Young, 1 Mar 2009, In: Hematological Oncology. 27, 1, p. 31-39 9 p.Research output: Contribution to journal › Article
- Published
The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.
Shikha Bose, Matthew Fung, Christopher Dawson, Wenbin Wei, John Arrand, Lawrence Young, Tatjana Stankovic & Paul Murray, 1 Feb 2009, In: Journal of Pathology. 217, 3, p. 345-52 8 p.Research output: Contribution to journal › Article
- Published
A Phase II Study of Adoptive Immunotherapy Using Dendritic Cells Pulsed with Tumor Lysate in Patients with Hepatocellular Carcinoma
Daniel Palmer, Forhad Ahmed, Jane Steele, Neil Steven, Lawrence Young & David Adams, 1 Jan 2009, In: Hepatology. 49, 1, p. 124-132 9 p.Research output: Contribution to journal › Article
- 2008
- Published
Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes.
Mhairi Morris, Christopher Dawson, Wenbin Wei, John O'Neil, Junying Jia, Andrew Bell, Lawrence Young & John Arrand, 1 Nov 2008, In: Journal of General Virology. 89, Pt 11, p. 2806-20 15 p.Research output: Contribution to journal › Article
- Published
DNA tumour viruses promote tumour cell invasion and metastasis by deregulating the normal processes of cell adhesion and motility
Mhairi Morris, Lawrence Young & Christopher Dawson, 1 Sep 2008, In: European Journal of Cell Biology. 87, 8-9, p. 677-97 21 p.Research output: Contribution to journal › Article
- Published
The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype
Martina Vockerodt, Wenbin Wei, John Arrand, Lawrence Young & Paul Murray, 1 Sep 2008, In: Journal of Pathology. 216, 1, p. 83-92 10 p.Research output: Contribution to journal › Article
- Published
Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin's Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells
Karl Baumforth, Wenbin Wei, Georgia Kapatai, Emma Kalk, Karen Piper, Lee Machado, Lawrence Young & 2 others, , 1 Jul 2008, In: The American Journal of Pathology. 173, 1, p. 195-204Research output: Contribution to journal › Article › peer-review
- Published
- Published
- Published
Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells
Joanne Gough, Karl Baumforth, Wenbin Wei, Gemma Kelly, Lawrence Young & Paul Murray, 1 Jan 2008, In: Blood. 111, 1, p. 292-301 10 p.Research output: Contribution to journal › Article
- 2007
- Published
CD154 tone sets the signaling pathways and transcriptome generated in model CD40-pluricompetent L3055 Burkitt's lymphoma cells
Wenbin Wei, John Arrand, Martin Rowe, Lawrence Young & John Gordon, 1 Sep 2007, In: Journal of Immunology. 179, 5, p. 2705-2712 8 p.Research output: Contribution to journal › Article
- Published
Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFβ signaling pathways
Victoria Wood, John O'Neil, Wenbin Wei, Suzanne Stewart, Christopher Dawson & Lawrence Young, 7 May 2007, In: Oncogene. 26, p. 4135-4147 13 p.Research output: Contribution to journal › Article
- Published
BMI-1 is induced by the Epstein-Barr virus oncogene LMP1, and regulates the expression of viral target genes in Hodgkin's lymphoma cells
Amanda Dutton, James Last, Wenbin Wei, Martina Vockerodt, Karl Baumforth, Joanne Gough, Martin Rowe, Malcolm Taylor, Lawrence Young & Paul Murray, 15 Mar 2007, In: Blood. 109, 6, p. 2597-2603 7 p.Research output: Contribution to journal › Article
- Published
C4b binding protein binds to CD154 and preventing CD40 mediated cholangiocyte apoptosis: A novel link between complement system and epithelial cell survival
Kevin Williams, Stephen Young, Lawrence Young, David Adams & Simon Afford, 17 Jan 2007, In: PLoS ONE. 2, p. e159Research output: Contribution to journal › Article › peer-review
- Published
EBV latent membrane protein-1 imposes a Hodgkin's lymphoma-like gene expression signature in germinal center B cells
Martina Vockerodt, Susan Morgan, Michael Kuo, Karl Baumforth, Wenbin Wei, John Arrand, John Gordon, Lawrence Young & Paul Murray, 1 Jan 2007, In: Blood.Research output: Contribution to journal › Article
- Published
- Published
The natural history of cervical HPV infection: unresolved issues
Stuart Collins & Lawrence Young, 1 Jan 2007, In: Nature Reviews Cancer. 7, 1, p. 11-22 12 p.Research output: Contribution to journal › Article
- 2006
- Published
- Published
- Published
Targeting cellular FLICE-like inhibitory protein as a novel approach to the treatment of Hodgkin's lymphoma
Amanda Dutton, Lawrence Young & Paul Murray, 1 Jun 2006, In: Expert Review of Anticancer Therapy. 6, p. 911-919 9 p.Research output: Contribution to journal › Review article
- Published
CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2
Jalal Ahmed-Choudhury, Kevin Williams, Lawrence Young, David Adams & Simon Afford, Apr 2006, In: Cellular Signalling. 18, 4, p. 456-68 13 p.Research output: Contribution to journal › Article › peer-review
- Published
Cancer gene therapy: Clinical trials
Daniel Palmer, Lawrence Young & Vivien Mautner, 1 Feb 2006, In: Trends in Biotechnology. 24, p. 76-82 7 p.Research output: Contribution to journal › Review article
- Published
The role of cellular flice inhibitory protecin (c-FLIP) in the pathogenesis and treatment of cancer
Amanda Dutton, Lawrence Young & Paul Murray, 1 Feb 2006, In: Expert Opinion on Therapeutic Targets. 10, p. 27-35 9 p.Research output: Contribution to journal › Review article
- Published
Epstein-Barr virus (EBV) and its associated human cancers-genetics, epigenetics, pathobiology and novel therapeutics
Lawrence Young & Paul Murray, 1 Jan 2006, In: Frontiers in Bioscience. 11, p. 2672-2713 42 p.Research output: Contribution to journal › Review article