Lawrence Young

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Publications

  1. 2016
  2. Published

    Evidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women

    Sarah Leonard, Sally Roberts, Lawrence Young, 15 Feb 2016, In: Scientific Reports. 6, 20847.

    Research output: Contribution to journal › Article › peer-review

  3. Published

    The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling

    Mhairi Morris, Christopher Dawson, Louise Laverick & Lawrence Young, 2016, In: Scientific Reports. 6, p. 19533

    Research output: Contribution to journal › Article › peer-review

  4. 2015
  5. Published

    Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells

    Angela Lo, Christopher Dawson, Lawrence Young, 15 Jun 2015, In: Journal of Pathology. 237, 2, p. 238-248

    Research output: Contribution to journal › Article › peer-review

  6. Published

    Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection

    John Arrand, Paul Murray, Alan Rickinson, Lawrence Young, May 2015, In: Journal of virology. 89, 10, p. 5222-37 16 p.

    Research output: Contribution to journal › Article › peer-review

  7. 2014
  8. Published

    Epstein-Barr virus and nasopharyngeal carcinoma

    Lawrence Young & Christopher Dawson, Dec 2014, In: Chinese Journal of Cancer. 33, 12, p. 581-90 10 p.

    Research output: Contribution to journal › Article › peer-review

  9. 2013
  10. Published

    Epstein-Barr virus induction of the Hedgehog signalling pathway imposes a stem cell phenotype on human epithelial cells

    John Arrand, Wenbin Wei, Lawrence Young & Christopher Dawson, 12 Aug 2013, In: Journal of Pathology.

    Research output: Contribution to journal › Article › peer-review

  11. Published

    Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells

    Angela Lo, Lawrence Young & Christopher Dawson, Jul 2013, In: Journal of Pathology. 230, 3, p. 336-46 11 p.

    Research output: Contribution to journal › Article › peer-review

  12. 2012
  13. Published

    A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels

    Wenbin Wei, Stephanie Maloney, Andrew Bell, Paul Murray, Christopher Dawson, Lawrence Young & John Arrand, 17 Jul 2012, In: PLoS ONE. 7, 7, p. e41055

    Research output: Contribution to journal › Article › peer-review

  14. Published

    The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).

    Christopher Dawson & Lawrence Young, 12 Jan 2012, In: Seminars in Cancer Biology.

    Research output: Contribution to journal › Article

  15. Published

    Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma

    Christopher Dawson, Lawrence Young, 1 Jan 2012, In: Journal of virology. 86, 1, p. 60-68 9 p.

    Research output: Contribution to journal › Article

  16. 2011
  17. Published

    Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study.

    Yuk Ting Ma, Stuart Collins, Lawrence Young, Paul Murray, 26 Apr 2011, In: British Journal of Cancer. 104, 9, p. 1500-4 5 p.

    Research output: Contribution to journal › Article

  18. Published

    Phase I/II trial of a dendritic cell vaccine transfected with DNA encoding melan A and gp100 for patients with metastatic melanoma.

    Jane Steele, Ankit Rao, Sarah Berhane, Lucinda Billingham, Gordon Ryan, Lawrence Young & Neil Steven, 10 Feb 2011, In: Gene Therapy. 18, p. 584-593

    Research output: Contribution to journal › Article

  19. 2010
  20. Published

    Smoking-induced p16 methylation in young women

    Yuk Ting Ma, Stuart Collins, Lawrence Young, Paul Murray, 1 Oct 2010, p. Abstract B48.

    Research output: Contribution to conference (unpublished) › Abstract

  21. Published

    The contribution of the Epstein-Barr virus to the pathogenesis of childhood lymphomas

    Zumla Cader, Pamela Kearns, Lawrence Young, Paul Murray & Martina Vockerodt, 1 Jun 2010, In: Cancer Treatment Reviews. 36, 4, p. 348-353 6 p.

    Research output: Contribution to journal › Article › peer-review

  22. Published

    Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGF beta-mediated growth inhibition

    Angela Lo, Christopher Dawson & Lawrence Young, 1 Jun 2010, In: Molecular Cancer. 9, p. 155 1 p.

    Research output: Contribution to journal › Article

  23. Published

    CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus

    Peter Searle, Lawrence Young & Daniel Palmer, 1 Mar 2010, In: Molecular Cancer. 9, p. 52 1 p.

    Research output: Contribution to journal › Article

  24. Published

    Is Human Papillomavirus Viral Load a Clinically Useful Predictive Marker? A Longitudinal Study

    Christothea Constandinou-Williams, Stuart Collins, Sally Roberts, Lawrence Young & Paul Murray, 1 Mar 2010, In: Cancer Epidemiology Biomarkers &amp Prevention. 19, 3, p. 832-837 6 p.

    Research output: Contribution to journal › Article

  25. Published

    CD40 ligand-induced carcinoma cell death: a balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals.

    Lawrence Young & Daniel Palmer, 15 Jan 2010, In: Journal of Immunology. 184, 2, p. 1111-20 10 p.

    Research output: Contribution to journal › Article

  26. Published

    Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors.

    John O'Neil, Christopher Dawson, Lawrence Young & John Arrand, 1 Jan 2010, In: Molecular Cancer. 9, p. 241 1 p.

    Research output: Contribution to journal › Article

  27. Published

    Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappa B pathway in carcinoma cells by inhibiting IKK phosphorylation

    Christopher Dawson, Khilan Shah, John Arrand, Lawrence Young & John O'Neil, 1 Jan 2010, In: Molecular Cancer. 9, p. 1 1 p.

    Research output: Contribution to journal › Article

  28. 2009
  29. Published

    The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation

    Khilan Shah, Wenbin Wei, John O'Neil, Christopher Dawson & Lawrence Young, 5 Nov 2009, In: Oncogene. 28, 44, p. 3903-14 12 p.

    Research output: Contribution to journal › Article

  30. Published

    Epstein-Barr virus and carcinogenesis: beyond Burkitt's lymphoma

    Lawrence Young, 1 Nov 2009, In: Clinical Microbiology and Infection. 15, 11, p. 982-988 7 p.

    Research output: Contribution to journal › Review article

  31. Published

    Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: A longitudinal study

    Stuart Collins, Lawrence Young, 9 Oct 2009, In: European Journal of Cancer.

    Research output: Contribution to journal › Article

  32. Published

    Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma

    Mhairi Morris, Christopher Dawson & Lawrence Young, 1 Aug 2009, In: Future Oncology. 5, 6, p. 811-825 15 p.

    Research output: Contribution to journal › Review article

  33. Published

    Disruption of the E2 gene is a common and early event in the natural history of cervical human papillomavirus infection: a longitudinal cohort study.

    Stuart Collins, Christothea Constandinou-Williams, Kaisheng Wen, Lawrence Young, Sally Roberts, Paul Murray, 1 May 2009, In: Cancer Research. 69, 9, p. 3828-32 5 p.

    Research output: Contribution to journal › Article

  34. Published

    A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

    Prashant Patel, Vivien Mautner, Stuart Collins, Peter Searle, Lawrence Young & Nicholas James, 14 Apr 2009, In: Molecular Therapy.

    Research output: Contribution to journal › Article

  35. Published

    Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma

    Lawrence Young, 1 Mar 2009, In: Hematological Oncology. 27, 1, p. 31-39 9 p.

    Research output: Contribution to journal › Article

  36. Published

    The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.

    Shikha Bose, Matthew Fung, Christopher Dawson, Wenbin Wei, John Arrand, Lawrence Young, Tatjana Stankovic & Paul Murray, 1 Feb 2009, In: Journal of Pathology. 217, 3, p. 345-52 8 p.

    Research output: Contribution to journal › Article

  37. Published

    A Phase II Study of Adoptive Immunotherapy Using Dendritic Cells Pulsed with Tumor Lysate in Patients with Hepatocellular Carcinoma

    Daniel Palmer, Forhad Ahmed, Jane Steele, Neil Steven, Lawrence Young & David Adams, 1 Jan 2009, In: Hepatology. 49, 1, p. 124-132 9 p.

    Research output: Contribution to journal › Article

  38. 2008
  39. Published

    Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes.

    Mhairi Morris, Christopher Dawson, Wenbin Wei, John O'Neil, Junying Jia, Andrew Bell, Lawrence Young & John Arrand, 1 Nov 2008, In: Journal of General Virology. 89, Pt 11, p. 2806-20 15 p.

    Research output: Contribution to journal › Article

  40. Published

    DNA tumour viruses promote tumour cell invasion and metastasis by deregulating the normal processes of cell adhesion and motility

    Mhairi Morris, Lawrence Young & Christopher Dawson, 1 Sep 2008, In: European Journal of Cell Biology. 87, 8-9, p. 677-97 21 p.

    Research output: Contribution to journal › Article

  41. Published

    The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype

    Martina Vockerodt, Wenbin Wei, John Arrand, Lawrence Young & Paul Murray, 1 Sep 2008, In: Journal of Pathology. 216, 1, p. 83-92 10 p.

    Research output: Contribution to journal › Article

  42. Published

    Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin's Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells

    Karl Baumforth, Wenbin Wei, Georgia Kapatai, Emma Kalk, Karen Piper, Lee Machado, Lawrence Young & 2 others, & Paul Murray, 1 Jul 2008, In: The American Journal of Pathology. 173, 1, p. 195-204

    Research output: Contribution to journal › Article › peer-review

  43. Published

    Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway

    Christopher Dawson, Louise Laverick, Mhairi Morris & Lawrence Young, 1 Apr 2008, In: Journal of virology. 82, 7, p. 3654-64 11 p.

    Research output: Contribution to journal › Article

  44. Published

    Combining gene and immunotherapy for prostate cancer

    Vivien Mautner, Peter Searle, Lawrence Young & Nicholas James, 1 Jan 2008, In: Prostate Cancer and Prostatic Diseases. 11, 2, p. 187-93 7 p.

    Research output: Contribution to journal › Article

  45. Published

    Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells

    Joanne Gough, Karl Baumforth, Wenbin Wei, Gemma Kelly, Lawrence Young & Paul Murray, 1 Jan 2008, In: Blood. 111, 1, p. 292-301 10 p.

    Research output: Contribution to journal › Article

  46. 2007
  47. Published

    CD154 tone sets the signaling pathways and transcriptome generated in model CD40-pluricompetent L3055 Burkitt's lymphoma cells

    Wenbin Wei, John Arrand, Martin Rowe, Lawrence Young & John Gordon, 1 Sep 2007, In: Journal of Immunology. 179, 5, p. 2705-2712 8 p.

    Research output: Contribution to journal › Article

  48. Published

    Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFβ signaling pathways

    Victoria Wood, John O'Neil, Wenbin Wei, Suzanne Stewart, Christopher Dawson & Lawrence Young, 7 May 2007, In: Oncogene. 26, p. 4135-4147 13 p.

    Research output: Contribution to journal › Article

  49. Published

    BMI-1 is induced by the Epstein-Barr virus oncogene LMP1, and regulates the expression of viral target genes in Hodgkin's lymphoma cells

    Amanda Dutton, James Last, Wenbin Wei, Martina Vockerodt, Karl Baumforth, Joanne Gough, Martin Rowe, Malcolm Taylor, Lawrence Young & Paul Murray, 15 Mar 2007, In: Blood. 109, 6, p. 2597-2603 7 p.

    Research output: Contribution to journal › Article

  50. Published

    C4b binding protein binds to CD154 and preventing CD40 mediated cholangiocyte apoptosis: A novel link between complement system and epithelial cell survival

    Kevin Williams, Stephen Young, Lawrence Young, David Adams & Simon Afford, 17 Jan 2007, In: PLoS ONE. 2, p. e159

    Research output: Contribution to journal › Article › peer-review

  51. Published

    EBV latent membrane protein-1 imposes a Hodgkin's lymphoma-like gene expression signature in germinal center B cells

    Martina Vockerodt, Susan Morgan, Michael Kuo, Karl Baumforth, Wenbin Wei, John Arrand, John Gordon, Lawrence Young & Paul Murray, 1 Jan 2007, In: Blood.

    Research output: Contribution to journal › Article

  52. Published

    Smoking-induced epigenetic changes in young women

    Yuk Ting Ma, Stuart Collins, Lawrence Young, Paul Murray, 1 Jan 2007.

    Research output: Contribution to conference (unpublished) › Abstract

  53. Published

    The natural history of cervical HPV infection: unresolved issues

    Stuart Collins & Lawrence Young, 1 Jan 2007, In: Nature Reviews Cancer. 7, 1, p. 11-22 12 p.

    Research output: Contribution to journal › Article

  54. 2006
  55. Published

    The polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens

    Jane Steele, Emma Kalk, Paul Moss, Stefan Hubscher, David Adams & Lawrence Young, 3 Oct 2006, In: British Journal of Cancer. 95, p. 1202-1211 10 p.

    Research output: Contribution to journal › Article

  56. Published

    Epstein-Barr virus induces cellular transcription factors to stimulate expression of EBER genes by RNA polymerase III

    Christopher Dawson, John Arrand, Lawrence Young, 7 Aug 2006, In: Journal of Biological Chemistry. 281, p. 33871-33880 10 p.

    Research output: Contribution to journal › Article

  57. Published

    Targeting cellular FLICE-like inhibitory protein as a novel approach to the treatment of Hodgkin's lymphoma

    Amanda Dutton, Lawrence Young & Paul Murray, 1 Jun 2006, In: Expert Review of Anticancer Therapy. 6, p. 911-919 9 p.

    Research output: Contribution to journal › Review article

  58. Published

    CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2

    Jalal Ahmed-Choudhury, Kevin Williams, Lawrence Young, David Adams & Simon Afford, Apr 2006, In: Cellular Signalling. 18, 4, p. 456-68 13 p.

    Research output: Contribution to journal › Article › peer-review

  59. Published

    Cancer gene therapy: Clinical trials

    Daniel Palmer, Lawrence Young & Vivien Mautner, 1 Feb 2006, In: Trends in Biotechnology. 24, p. 76-82 7 p.

    Research output: Contribution to journal › Review article

  60. Published

    The role of cellular flice inhibitory protecin (c-FLIP) in the pathogenesis and treatment of cancer

    Amanda Dutton, Lawrence Young & Paul Murray, 1 Feb 2006, In: Expert Opinion on Therapeutic Targets. 10, p. 27-35 9 p.

    Research output: Contribution to journal › Review article

  61. Published

    Epstein-Barr virus (EBV) and its associated human cancers-genetics, epigenetics, pathobiology and novel therapeutics

    Lawrence Young & Paul Murray, 1 Jan 2006, In: Frontiers in Bioscience. 11, p. 2672-2713 42 p.

    Research output: Contribution to journal › Review article

  62. Published

    Viral gene therapy strategies: From basic science to clinical application

    Lawrence Young, Peter Searle, David Onion & Vivien Mautner, 1 Jan 2006, In: Journal of Pathology. 208, p. 299-318 20 p.

    Research output: Contribution to journal › Article

  63. 2005
  64. Published

    TRAF6 is required for TRAF2-dependent CD40 signal transduction in non-haemopoietic cells

    Clare Davies, Lawrence Young & Aris Eliopoulos, 15 Nov 2005, In: Molecular and Cellular Biology. 25, p. 9806-9819 14 p.

    Research output: Contribution to journal › Article

  65. Published

    Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

    Karl Baumforth, Joanne Gough, Trevor Pettitt, Wenbin Wei, Susan Morgan, Tatjana Stankovic, Dickens Pratt, Mike Wakelam, Lawrence Young & Paul Murray, 15 Sep 2005, In: Blood. 106, p. 2138-2146 9 p.

    Research output: Contribution to journal › Article

  66. Published

    Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth

    Christopher Dawson, Suzanne Stewart, John Gordon, Paul Murray, Lawrence Young & Aris Eliopoulos, 8 Aug 2005, In: Oncogene. 24, p. 7913-7923 11 p.

    Research output: Contribution to journal › Article

  67. Published

    NF-κB overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells

    Clare Davies, Danai Bem, Lawrence Young & Aris Eliopoulos, 1 Jun 2005, In: Cellular Signalling. 17, p. 729-738 10 p.

    Research output: Contribution to journal › Article

  68. Published

    Role of sexual behavior in the acquisition of asymptomatic Epstein-Barr virus infection: a longitudinal study.

    Stuart Collins, Ankit Rao, Lawrence Young & Paul Murray, 1 Jun 2005, In: The Pediatric Infectious Disease Journal . 24, 6, p. 498-502 5 p.

    Research output: Contribution to journal › Article

  69. Published

    The role of sexual behaviour in the acquisition of asymptomatic EBV infection

    Lawrence Young & Paul Murray, 1 Jun 2005, In: The Pediatric Infectious Disease Journal . 24, p. 498-502 5 p.

    Research output: Contribution to journal › Article

  70. Published

    Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A

    Lawrence Young, Christopher Dawson, 1 May 2005, In: Journal of virology. 79, p. 5499-5506 8 p.

    Research output: Contribution to journal › Article

  71. Published

    Proximity of first intercourse to menarche and the risk of human papillomavirus infection: A longitudinal study

    Stuart Collins, Heather Winter, Lawrence Young, 10 Apr 2005, In: International Journal of Cancer. 114, 3, p. 498-500 3 p.

    Research output: Contribution to journal › Article

  72. Published

    PTTG Binding Factor (PBF) - a Novel Transforming Gene in Thyroid Tumorigenesis

    Kristien Boelaert, Lesley Tannahill, Dae Kim, Margaret Eggo, Neil Gittoes, Lawrence Young, Jayne Franklyn & Christopher McCabe, 5 Apr 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4341-4349 9 p.

    Research output: Contribution to journal › Article

  73. Published

    Inhibition of NF-κB enhances the cytotoxicity of virus-directed enzyme prodrug therapy and oncolytic adenovirus cancer gene therapy

    Daniel Palmer, Peter Searle & Lawrence Young, 31 Mar 2005, In: Gene Therapy. 12, p. 1187-1197 11 p.

    Research output: Contribution to journal › Article

  74. Published

    Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving AKT kinase and mTOR

    Amanda Dutton, Christopher Dawson, Lawrence Young & Paul Murray, 1 Mar 2005, In: Journal of Pathology. 205, p. 498-506 9 p.

    Research output: Contribution to journal › Article

  75. Published

    The Epstein-Barr virus encoded LMP2A and LMP2B proteins promote epithelial cell spreading and motility

    Lawrence Young & Christopher Dawson, 1 Feb 2005, In: Journal of virology. 79, p. 1789-1802 14 p.

    Research output: Contribution to journal › Article

  76. Published

    Activation of CD40 in cervical carcinoma cells facilitates CTL responses and augments chemotherapy-induced apoptosis

    Seran Hill, Andrew Hislop, Clare Davies, David Luesley, Alan Rickinson, Lawrence Young & Aris Eliopoulos, 1 Jan 2005, In: Journal of Immunology. 174, p. 41-50 10 p.

    Research output: Contribution to journal › Article

  77. 2004
  78. Published

    Nitroreductase: A prodrug-activating enzyme for cancer gene therapy

    Peter Searle, Andrew Lovering, Jane Grove, Chris Guise, Nicholas James, Vivien Mautner, Lawrence Young, David Kerr, Scott White & Eva Hyde, 1 Nov 2004, In: Clinical and Experimental Pharmacology and Physiology. 31, 11, p. 811-816 6 p.

    Research output: Contribution to journal › Article › peer-review

  79. Published

    Epstein-Barr virus encoded LMP2A regulates viral and cellular gene expression via modulation of the NF-κB transcription factor pathway

    Suzanne Stewart, Christopher Dawson, John Curnow & Lawrence Young, 25 Oct 2004, In: National Academy of Sciences. Proceedings. 101, p. 15730-15735 6 p.

    Research output: Contribution to journal › Article › peer-review

  80. Published

    Expression of the cellular FLICE inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

    Amanda Dutton, John O'Neil, Anne Milner, Lawrence Young & Paul Murray, 19 Apr 2004, In: National Academy of Sciences. Proceedings. 101, p. 6611-6616 6 p.

    Research output: Contribution to journal › Article

  81. Published

    Epstein-Barr virus latent membrane protein 1 (LMP1) up-regulates Id1 expression in nasopharyngeal epithelial cells

    Aris Eliopoulos, Lawrence Young, 5 Apr 2004, In: Oncogene. 23, p. 4488-4494 7 p.

    Research output: Contribution to journal › Article

  82. Published

    Virus directed enzyme prodrug therapy: Intratumoural administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer

    Daniel Palmer, Vivien Mautner, Stefan Hubscher, Seran Hill, Peter Searle, Lawrence Young, Nicholas James, 29 Mar 2004, In: Journal of Clinical Oncology. 22, p. 1546-1552 7 p.

    Research output: Contribution to journal › Article

  83. Published

    An interferon-γ ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies

    Jane Steele, Caroline Savage, John Winer & Lawrence Young, 1 Jan 2004, In: Journal of Neuroimmunology. 150, p. 98-106 9 p.

    Research output: Contribution to journal › Article

  84. Published

    CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule

    Daniel Palmer, Syed Hussain, Peter Cooke, Lawrence Young & Nicholas James, 1 Jan 2004, In: Oncology reports. 12, p. 679-682 4 p.

    Research output: Contribution to journal › Article

  85. Published

    Carbonic anhydrase IX, a marker of hypoxia: Correlation with clinical outcome in transitional cell carcinoma of the bladder

    Syed Hussain, Daniel Palmer, Louise Hiller, Paul Murray, Lawrence Young & Nicholas James, 1 Jan 2004, In: Oncology reports. 11, p. 1005-1010 6 p.

    Research output: Contribution to journal › Article

  86. Published

    Cytokine mediated modulation of the myc network in barrett's metaplasia

    Lawrence Young, Moray Campbell & Chris Tselepis, 1 Jan 2004.

    Research output: Contribution to conference (unpublished) › Abstract

  87. Published

    Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector

    Joanne Gough, Vivien Mautner, Lawrence Young & Peter Searle, 1 Jan 2004, In: Gene Therapy. 11, p. 1126-1236 111 p.

    Research output: Contribution to journal › Article

  88. Published

    Epstein-Barr virus associated cancers: Aetiology and treatment

    Victor Lopes, Lawrence Young & Paul Murray, 1 Jan 2004, In: Herpes. 10, p. 78-82 5 p.

    Research output: Contribution to journal › Article

  89. Published

    Epstein-Barr virus: 40 years on

    Lawrence Young & Alan Rickinson, 1 Jan 2004, In: Nature Reviews Cancer. 4, p. 757-768 12 p.

    Research output: Contribution to journal › Review article

  90. Published

    Expression of tumour necrosis factor receptor-associated factor 1 (TRAF1) in nasopharyngeal carcinoma: Possible up-regulation by Epstein-Barr virus latent membrane protein 1

    Christopher Dawson, Lawrence Young, 1 Jan 2004, In: International Journal of Cancer. 112, p. 265-272 8 p.

    Research output: Contribution to journal › Article

  91. Published

    Frequent epigenetic inactivation of the RASSF1A tumor suppresor gene in Hodgkin's lymphoma

    Paul Murray, Angelo Agathanggelou, Farida Latif, Richard Grundy, Lawrence Young, 1 Jan 2004, In: Oncogene. 23, 6, p. 1326-1331 6 p.

    Research output: Contribution to journal › Article

  92. Published

    Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells

    Clare Davies, Mike Wakelam, Lawrence Young & Aris Eliopoulos, 1 Jan 2004, In: Journal of Biological Chemistry. 279, p. 1010-1019 10 p.

    Research output: Contribution to journal › Article

  93. Published

    PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro

    Kristien Boelaert, Lesley Tannahill, Farhat Khanim, Margaret Eggo, Jasbir Moore, Lawrence Young, Neil Gittoes, Jayne Franklyn & Christopher McCabe, 1 Jan 2004, In: Journal of Molecular Endocrinology. 33, p. 663-677 15 p.

    Research output: Contribution to journal › Article

  94. Published

    TNF receptors and their ligands: in sickness and in health, in life and death

    Lawrence Young & Aris Eliopoulos, 1 Jan 2004, In: Current Opinion in Pharmacology. 4, p. 311-313 3 p.

    Research output: Contribution to journal › Review article

  95. Published

    The role of CD40 in the pathogenesis and treatment of cancer

    Aris Eliopoulos & Lawrence Young, 1 Jan 2004, In: Current Opinion in Pharmacology. 4, p. 360-367 8 p.

    Research output: Contribution to journal › Review article

  96. 2003
  97. Published

    The Epstein-Barr virus encoded latent infection membrane protein 1 (LMP1) regulates the processing of p100 NK-κB2 to p52 via an IKKγ/NEMO-independent signaling pathway

    Aris Eliopoulos, Jorge Caamano, Joanne Gough, Paul Murray & Lawrence Young, 23 Oct 2003, In: Oncogene. 22, 48, p. 7557-7569 13 p.

    Research output: Contribution to journal › Article

  98. Published

    Seasonal differences in the onset of the EBV-positive and -negative forms of paediatric Hodgkin's lymphoma

    Anne Reiman, Judy Powell, Richard Grundy, Lawrence Young & Paul Murray, 6 Oct 2003, In: British Journal of Cancer. 89, 7, p. 1200-1201 2 p.

    Research output: Contribution to journal › Article

  99. Published

    Epstein-Barr virus nuclear antigen 1 (EBNA1) induced cytotoxicity in epithelial cells is associated with EBNA1 degradation and processing.

    Christopher Dawson & Lawrence Young, 1 Sep 2003, In: Virology. 313, 2, p. 663-76 14 p.

    Research output: Contribution to journal › Article

  100. Published

    Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil

    Daniel Palmer, Anne Milner & Lawrence Young, 1 Sep 2003, In: British Journal of Cancer. 89, 5, p. 944-950 7 p.

    Research output: Contribution to journal › Article

  101. Published

    Epstein-Barr virus and oncogenesis: From latent genes to tumours

    Lawrence Young & Paul Murray, 11 Aug 2003, In: Oncogene. 22, 33, p. 5108-5121 14 p.

    Research output: Contribution to journal › Article

  102. Published

    Differential induction of nuclear factor-κB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation

    Jalal Ahmed-Choudhury, Lawrence Young, David Adams & Simon Afford, 1 Apr 2003, In: Molecular Biology of the Cell. 14, 4, p. 1334-1345 12 p.

    Research output: Contribution to journal › Article

  103. Published

    Immune enhancement of nitroreductase-induced cytotoxicity: Studies using a bicistronic adenovirus vector

    Nicky Green, Peter Searle, David Kerr & Lawrence Young, 10 Mar 2003, In: International Journal of Cancer. 104, 1, p. 104-112 9 p.

    Research output: Contribution to journal › Article

  104. Published

    Pro-apoptotic genes BAX and CD40L are predictors of survival in transitional cell carcinoma of the bladder

    Syed Hussain, Louise Hiller, Paul Murray, Lawrence Young & Nicholas James, 24 Feb 2003, In: British Journal of Cancer. 88, 4, p. 586-592 7 p.

    Research output: Contribution to journal › Article

  105. Published

    Absence of Epstein-Barr virus DNA in the tumour cells of European hepatocellular carcinoma

    Andrew Bell, Judith Timms, Stefan Hubscher, Lawrence Young & Paul Murray, 15 Feb 2003, In: Virology. 306, 2, p. 236-243 8 p.

    Research output: Contribution to journal › Article

  106. Published

    The effect of Epstein-Barr virus status on survival in age and sex defined subgroups of patients with advanced Hodgkin's disease

    Lucinda Billingham, Joanne Gough, Lawrence Young & Paul Murray, 1 Feb 2003, In: Annals of Oncology. 14, 2, p. 282-290 9 p.

    Research output: Contribution to journal › Article

  107. Published

    Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling

    Christopher Dawson, Aris Eliopoulos & Lawrence Young, 31 Jan 2003, In: Journal of Biological Chemistry. 278, 6, p. 3694-3704 11 p.

    Research output: Contribution to journal › Article

  108. Published

    Human papillomavirus type 18 and rapidly progressing cervical intraepithelial neoplasia

    Stuart Collins, Heather Winter & Lawrence Young, 4 Jan 2003, In: Lancet. 361, 9351, p. 40-43 4 p.

    Research output: Contribution to journal › Article

  109. Published

    BCL2 expression predicts survival in patients receiving synchronous chemoradiotherapy in advanced transitional cell carcinoma of the bladder

    Syed Hussain, Louise Hiller, Paul Murray, Lawrence Young & Nicholas James, 1 Jan 2003, In: Oncology reports. 10, p. 571-576 6 p.

    Research output: Contribution to journal › Article

  110. Published

    Dendritic cell vaccination for hepatocellular carcinoma

    Daniel Palmer, Nazzia Mirza, Jane Steele, Neil Steven, Lawrence Young, David Adams, 1 Jan 2003, p. 280A.

    Research output: Contribution to conference (unpublished) › Abstract

  111. Published

    Inhibition of metalloproteinase cleavage enhances the cytotoxicity of Fas ligand

    Anne Milner, Nicky Green, Aris Eliopoulos & Lawrence Young, 1 Jan 2003, In: Journal of Immunology. 170, p. 677-685 9 p.

    Research output: Contribution to journal › Article

  112. Published

    Reactivity with a monoclonal antibody to Epstein-Barr virus (EBV) nuclear antigen 1 defines a subset of aggressive breast cancers in the absence of the EBV genome

    Paul Murray, Andrew Bell, Judith Timms, David Rowlands, Christopher McConkey & Lawrence Young, 1 Jan 2003, In: Cancer Research. 63, p. 2338-2343 6 p.

    Research output: Contribution to journal › Article

  113. 2002
  114. Published

    TRAF1 is a critical regulator of JNK signalling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 (LMP1) but not CD40

    Aris Eliopoulos, Sarah Blake, Clare Davies, Paul Murray & Lawrence Young, 20 Dec 2002, In: Journal of virology. 77, 2, p. 1316-1328 13 p.

    Research output: Contribution to journal › Article

  115. Published

    Reactivity and isotype profiling of monoclonal antibodies using multiple antigenic peptides

    Paul Murray, Lawrence Young, Karl Baumforth, 1 Oct 2002, In: Hybrid Hybridomics. 21, 5, p. 393-398 6 p.

    Research output: Contribution to journal › Article

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