Kristien Boelaert
Publications
- 2020
- Published
The prevalence of thyroid dysfunction and autoimmunity in women with history of miscarriage or subfertility
Rima Smith, Aurelio Tobias Garces, Paul Smith, Lee Middleton, Justin Chu & 14 others, , 1 Aug 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 8, p. 2667–2677Research output: Contribution to journal › Article › peer-review
- Published
Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer
Martin Read, Alice Fletcher, Hannah Nieto, Holly Adcock, Liam Cox, Luke Alderwick, Kristien Boelaert, Vicki Smith & Christopher McCabe, 8 May 2020, In: Journal of the Endocrine Society. 4, Issue Supplement 1, 1 p., OR28-03.Research output: Contribution to journal › Abstract › peer-review
- 2019
- Published
A high-throughput yellow fluorescent protein (YFP) cell-based screen identifies autophagy modulators to increase the effectiveness of radioiodine therapy
Martin Read, Alice Fletcher, Luke Alderwick, Kristien Boelaert, Vicki Smith & Christopher McCabe, 13 Nov 2019, In: Endocrine Abstracts. 65, 1 p., OC4.1.Research output: Contribution to journal › Abstract › peer-review
- Published
Levothyroxine to increase live births in euthyroid women with thyroid antibodies trying to conceive: the TABLET RCT
Lee Middleton, Versha Cheed & 14 others, , 31 Oct 2019, In: Efficacy and Mechanism Evaluation. 6, 11, p. 1-102 102 p.Research output: Contribution to journal › Article › peer-review
- E-pub ahead of print
Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) enhances radioiodine uptake: Targeting NIS interactors to enhance radioiodine uptake
Alice Fletcher, Martin Read, Dean Larner, Hannah Nieto, Gareth Lavery, Kristien Boelaert, Andrew Turnell, Vicki Smith & Christopher McCabe, 31 Oct 2019, In: Cancer Research.Research output: Contribution to journal › Article › peer-review
- Published
Patients treated for hyperthyroidism are at increased risk of becoming obese: findings from a large prospective secondary care cohort
Barbara Torlinska, Linda Nichols, Christopher McCabe & Kristien Boelaert, 15 Oct 2019, In: Thyroid. 29, 10, p. 1380-1389 10 p.Research output: Contribution to journal › Article › peer-review
- Published
- Published
Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study
Rasiah Thayakaran, Nicola Adderley, Barbara Torlinska, Kristien Boelaert, Dana Sumilo, Malcolm Price, G Neil Thomas & Krishnarajah Nirantharakumar, 3 Sep 2019, In: BMJ. 366, 8 p., l4892.Research output: Contribution to journal › Article › peer-review
- Published
Risk of incident circulatory disease in patients treated for differentiated thyroid carcinoma with no history of cardiovascular disease
Kristien Boelaert & Krishnarajah Nirantharakumar, 1 Aug 2019, In: Clinical Endocrinology. 91, 2, p. 323-330 8 p.Research output: Contribution to journal › Article › peer-review
- Published
Antigen-specific immunotherapy with thyrotropin receptor peptides in Graves' hyperthyroidism: a phase I study
Kristien Boelaert, 17 Jul 2019, In: Thyroid. 29, 7, p. 1003-1011 9 p.Research output: Contribution to journal › Article › peer-review
- Published
Glucocorticoid induced adrenal insufficiency is common in steroid treated glomerular diseases - proposed strategy for screening and management
Kristien Boelaert & Lorraine Harper, 6 May 2019, In: BMC Nephrology. 20, 1, 154.Research output: Contribution to journal › Article › peer-review
- Published
Knowledge of thyroid eye disease in Graves’ Disease patients with and without orbitopathy
Matthew Edmunds & Kristien Boelaert, 9 Apr 2019, In: Thyroid. 29, 4, p. 557-562 6 p.Research output: Contribution to journal › Article › peer-review
- Published
Levothyroxine in women with thyroid peroxidase antibodies before conception
Rima Smith, Lee Middleton, Versha Cheed, Christopher McCabe & 14 others, , 4 Apr 2019, In: The New England Journal of Medicine. 380, 14, p. 1316-1325 10 p.Research output: Contribution to journal › Article › peer-review
- Published
Adjuvant rituximab, a potential treatment for the young patient with Graves' hyperthyroidism (RiGD): study protocol for a single-arm, single-stage, phase II trial
Kristien Boelaert, 21 Jan 2019, In: BMJ open. 9, 1, 10 p., e024705.Research output: Contribution to journal › Article › peer-review
- Published
Liothyronine cost and prescriptions in England
Kristien Boelaert, 1 Jan 2019, In: The Lancet Diabetes and Endocrinology. 7, 1, p. 11-12 2 p.Research output: Contribution to journal › Letter › peer-review
- 2018
- Published
- Published
Oncogenic action of pituitary-tumor transforming gene (PBF) in head and neck cancer is associated with poorer overall survival
Martin Read, Alice Fletcher, Hannah Nieto, Moray Campbell, Kristien Boelaert, Andrew Turnell, Vicki Smith, Hisham Mehanna & Christopher McCabe, 1 Nov 2018, In: Endocrine Abstracts. 59, 1 p., P119.Research output: Contribution to journal › Abstract › peer-review
- Published
Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism
Hakan Cangul, Kristien Boelaert & 7 others, , 18 Oct 2018, In: JCI Insight. 3, 20, 11 p., e99631.Research output: Contribution to journal › Abstract › peer-review
- E-pub ahead of print
PTTG and PBF functionally interact with p53 and predict overall survival in head and neck cancer
Martin Read, Alice Fletcher, Peter Rae, Hannah Nieto, Sally Roberts, Moray Campbell, Kristien Boelaert, Andrew Turnell, Vicki Smith, Hisham Mehanna & Christopher McCabe, 28 Aug 2018, In: Cancer Research. 25 p.Research output: Contribution to journal › Article › peer-review
- Published
PO-124 PTTG and PBF functionally interact with P53 and predict overall survival in head and neck cancer
Martin Read, Alice Fletcher, Kristien Boelaert, Andrew Turnell, Vicki Smith, Hisham Mehanna & Christopher McCabe, 1 Jul 2018, In: ESMO Open. 3, Suppl. 2, p. A69-A69 1 p.Research output: Contribution to journal › Abstract › peer-review
- Published
- Published
The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review
Jennifer Bryant, Nikos Batis, Rachel Spruce, Christopher McCabe, Kristien Boelaert, Neil Sharma & Hisham Mehanna, 30 Apr 2018, In: Frontiers in Oncology. 8, APR, 132.Research output: Contribution to journal › Article › peer-review
- Published
The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review.
Nikos Batis, Rachel Spruce, Anne Hartley, Christopher McCabe, Kristien Boelaert & Hisham Mehanna, 30 Apr 2018, In: Frontiers in Oncology.Research output: Contribution to journal › Article › peer-review
- Published
Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
Barbara Torlinska, Kristien Boelaert, 1 Mar 2018, In: Nutrients. 10, 3, 291.Research output: Contribution to journal › Article › peer-review
- 2017
- Published
Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF
Alice Fletcher, Wenqi Lu, Hannah Nieto, Kristien Boelaert, Martin Read, Vicki Smith & Christopher McCabe, Sep 2017, In: Endocrine-related cancer. 24, 9, p. 459-474Research output: Contribution to journal › Article › peer-review
- Published
MANAGEMENT OF ENDOCRINE DISEASE: Subclinical thyrotoxicosis: prevalence, causes and choice of therapy
Kristien Boelaert, Jun 2017, In: European Journal of Endocrinology. 176, 6, p. R325-R337Research output: Contribution to journal › Review article › peer-review
- E-pub ahead of print
Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer
Martin Read, Alice Fletcher, Hannah Nieto, John Reynolds, Kristien Boelaert, Andrew Turnell, Vicki Smith & Christopher McCabe, 15 May 2017, In: Oncogene. 72326.Research output: Contribution to journal › Article › peer-review
- Published
- Published
Comparative analysis of human and mouse expression data identifies proto-oncogene PTTG- and PBF-associated genes in thyroid cancer
Martin Read, Hannah Nieto, Alice Fletcher, Neil Sharma, Andrew Turnell, Kristien Boelaert, Vicki Smith & Christopher McCabe, 13 Feb 2017, In: Thyroid Research. 10(Suppl 1), 2Research output: Contribution to journal › Abstract › peer-review
- Published
Controlled Antenatal Thyroid Study: Obstetric Outcomes
Kristien Boelaert, Shiaoyng Chan, 13 Feb 2017, In: Thyroid Research. 10(Suppl 1), 2, p. 2 1 p., O1.Research output: Contribution to journal › Abstract › peer-review
- Published
Pharmacological enhancement of radioiodine uptake using Src kinase inhibitors
Alice Fletcher, Neil Sharma, Martin Read, Kristien Boelaert, Christopher McCabe & Vicki Smith, 13 Feb 2017, In: Thyroid Research. 10(Suppl 1), 2, p. 2 1 p., O2.Research output: Contribution to journal › Abstract › peer-review
- 2016
- Published
Pro-invasive effect of proto-oncogene PBF is modulated by an interaction with cortactin
Rachel Spruce, Martin Read, Neil Sharma, Rachel Fletcher, Hisham Mehanna, Kristien Boelaert, Vicki Smith & Christopher McCabe, Dec 2016, In: The Journal of clinical endocrinology and metabolism. 101, 12, p. 4551-4563Research output: Contribution to journal › Article › peer-review
- Published
High tumoral expression of PBF and PTTG modulates the DNA damage response and is associated with poor survival in thyroid cancer
Martin Read, Jim Fong, Alice Fletcher, Neil Sharma, Kristien Boelaert, Andrew Turnell, Vicki Smith & Christopher McCabe, 4 Nov 2016, In: Endocrine Abstracts. 44, P246.Research output: Contribution to journal › Abstract › peer-review
- Published
Thyroid stimulating hormone in thyroid cancer: does it matter?
Hannah Nieto & Kristien Boelaert, 1 Nov 2016, In: Endocrine-related cancer. 23, 11, ERC-16-0328.Research output: Contribution to journal › Article › peer-review
- Published
Multifocality in Sporadic Medullary Thyroid Carcinoma: An International Multicenter Study
Kristien Boelaert, Neil Sharma & 2 others, , Nov 2016, In: Thyroid. 26, 11, p. 1563-1572 10 p.Research output: Contribution to journal › Article › peer-review
- Published
WOMEN IN CANCER PROFILE: From bedside to bench and back: my journey in thyroid disease
Kristien Boelaert, Nov 2016, In: Endocrine-related cancer. 23, 11, p. 9-13Research output: Contribution to journal › Special issue › peer-review
- Published
Comparative analysis of human and mouse expression data identifies distinct proto-oncogene PBF- and PTTG-associated genes in thyroid cancer
Martin Read, Jim Fong, Hannah Nieto, Kristien Boelaert, Vicki Smith, Andrew Turnell & Christopher McCabe, 1 Jul 2016, In: European Journal of Cancer. 61, Suppl 1, p. S36 1 p., 202.Research output: Contribution to journal › Abstract › peer-review
- Published
Comparative analysis of human and mouse expression data identifies proto-oncogene PTTG- and PBF-associated genes in thyroid cancer
Martin Read, Hannah Nieto, Alice Fletcher, Neil Sharma, Andrew Turnell, Kristien Boelaert, Vicki Smith & Christopher McCabe, 13 May 2016.Research output: Contribution to conference (unpublished) › Abstract › peer-review
- Published
The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer
Martin Read, Vicki Smith, Rachel Spruce, Dae Kim, Stephen Ward, Kristien Boelaert, Jayne Franklyn, Andrew Turnell & Christopher McCabe, Jan 2016, In: Molecular Carcinogenesis. 55, 1, p. 15-26Research output: Contribution to journal › Article › peer-review
- 2015
- Published
- E-pub ahead of print
Effectiveness of metyrapone in treating Cushing's Syndrome: a retrospective multicenter study in 195 patients
Kristien Boelaert, Niki Karavitaki & 8 others, , 9 Sep 2015, In: The Journal of clinical endocrinology and metabolism. 100, 11, jc20152616.Research output: Contribution to journal › Article › peer-review
- Published
Costs and benefits of iodine supplementation for pregnant women in a mildly to moderately iodine-deficient population: a modelling analysis
Mark Monahan, Kristien Boelaert, Kate Jolly, Shiaoyng Chan, Pelham Barton & Tracy Roberts, Sep 2015, In: The Lancet Diabetes and Endocrinology. 3, 9, p. 715-722 8 p.Research output: Contribution to journal › Article
- Published
- Published
Clinical challenges of thyroid eye disease in HIV-positive patients on highly active antiretroviral therapy
Matthew Edmunds, Barbara Torlinska & Kristien Boelaert, Mar 2015, In: The Journal of clinical endocrinology and metabolism. 100, 3, p. 779-787 9 p.Research output: Contribution to journal › Article › peer-review
- Published
Miscellaneous Hormones
Vasileios Chortis & Kristien Boelaert, 2015, Side Effects of Drugs. Elsevier, Vol. 37. p. 539-558Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
- 2014
- Published
Autoimmune encephalopathy in the context of Graves' disease with ophthalmopathy
Vasileios Chortis, Matthew Edmunds & Kristien Boelaert, Dec 2014, In: Clinical Endocrinology. 81, 6, p. 936-7 2 p.Research output: Contribution to journal › Article › peer-review
- Published
One Base Deletion (c.2422delT) in the TPO Gene Causes Severe Congenital Hypothyroidism
Kristien Boelaert, Timothy Barrett, 5 Sep 2014, In: J Clin res Pediatr Endocrinol. 6, 3, p. 169-73Research output: Contribution to journal › Article › peer-review
- Published
Differences in the recurrence and mortality outcomes rates of incidental and nonincidental papillary thyroid microcarcinoma: a systematic review and meta-analysis of 21 329 person-years of follow-up
Hisham Mehanna, Ben Carter, Kristien Boelaert & Jayne Franklyn, Aug 2014, In: The Journal of clinical endocrinology and metabolism. 99, 8, p. 2834-43 10 p.Research output: Contribution to journal › Article › peer-review
- Published
The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells
Martin Read, Jim Fong, Rachel Spruce, Vicki Smith, Neil Sharma, Kristien Boelaert, Jayne Franklyn, Andrew Turnell & Christopher McCabe, Apr 2014, In: Endocrinology. 155, 4, p. 1222-34 13 p.Research output: Contribution to journal › Article › peer-review
- Published
Examination of PTTG-Binding Factor (PBF) mRNA reveals functional miRNA target sites and exon-skipping splice variants in thyroid cells
Martin Read, Alice Fletcher, Vicki Smith, Rachel Spruce, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Mar 2014, In: Endocrine Abstracts. 34, P397.Research output: Contribution to journal › Abstract › peer-review
- Published
Patient information in Graves' disease and thyroid-associated ophthalmopathy: readability assessment of online resources
Matthew Edmunds, Alastair Denniston, Kristien Boelaert, Jayne Franklyn & Omar Durrani, Jan 2014, In: Thyroid. 24, 1, p. 67-72 6 p.Research output: Contribution to journal › Article › peer-review
- 2013
- Published
Elevated genetic instability is associated with repressed DNA repair gene expression in a bi-transgenic murine model of PTTG and PBF
Martin Read, Jim Fong, Vicki Smith, Rachel Spruce, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 2 Dec 2013.Research output: Contribution to conference (unpublished) › Poster
- Published
Fine needle aspiration and medulla
Kristien Boelaert, Neil Sharma & 2 others, , 1 Nov 2013, In: Endocrine Practice. 19, 6, p. 920-927 8 p.Research output: Contribution to journal › Article › peer-review
- Published
Thyroid dyshormonogenesis is mainly caused by TPO mutations in consanguineous community
Kristien Boelaert, Timothy Barrett & Eamonn Maher, Aug 2013, In: Clinical Endocrinology. 79, 2, p. 275-81 7 p.Research output: Contribution to journal › Article › peer-review
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- Published
Manipulation of PBF/PTTG1IP phosphorylation status ; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors
Vicki Smith, Neil Sharma, Rachel Spruce, Martin Read, Ashley Martin, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Jul 2013, In: The Journal of clinical endocrinology and metabolism. 98, 7, p. 2876-2886 11 p.Research output: Contribution to journal › Article › peer-review
- Published
Comparison of mortality in hyperthyroidism during periods of treatment with thionamides and after radioiodine
Kristien Boelaert, Barbara Torlinska & Jayne Franklyn, May 2013, In: The Journal of clinical endocrinology and metabolism. 98, 5, p. 1869-82 14 p.Research output: Contribution to journal › Article › peer-review
- Published
Elevated genetic instability is associated with repressed DNA repair gene expression in a bi-transgenic murine model of PTTG and PBF
Martin Read, Jim Fong, Vicki Smith, Rachel Spruce, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 2013, p. A24.Research output: Contribution to conference (unpublished) › Abstract
- 2012
- Published
TSHR is the main causative locus in autosomal recessively inherited thyroid dysgenesis
Hakan Cangul, Kristien Boelaert & 3 others, , Jun 2012, In: Journal of pediatric endocrinology & metabolism. 25, 5-6, p. 419-426 8 p.Research output: Contribution to journal › Article › peer-review
- Published
The pituitary tumor transforming gene in thyroid cancer
Neil Sharma, Vicki Smith, Kristien Boelaert & Christopher McCabe, 5 Apr 2012, In: Journal of endocrinological investigation. 35, 4, p. 425-433Research output: Contribution to journal › Review article › peer-review
- Published
Dietary factors augment the ability of the proto-oncogene PBF to induce goitrogenesis and hyperplasia in vivo
Martin Read, Vicki Smith, Jim Fong, Wendy Leadbeater, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Mar 2012, In: Endocrine Abstracts. 28, OC3.8.Research output: Contribution to journal › Abstract › peer-review
- Published
Thyrotoxicosis
Jayne Franklyn & Kristien Boelaert, 1 Mar 2012, In: Lancet. 379, 9821, p. 1155-1166 12 p.Research output: Contribution to journal › Article
- Published
PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8
Vicki Smith, Martin Read, Andrew Turnell, Jim Fong, Shiaoyng Chan, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 2012, In: Endocrinology. 153, 7, p. 3526-36 11 p.Research output: Contribution to journal › Article › peer-review
- 2011
- Published
Choice of Antithythroid Drugs in Pregnancy Response
Kristien Boelaert, 1 Oct 2011, In: Thyroid. 21, 10, p. 1160-1161 2 p.Research output: Contribution to journal › Article
- Published
Finding the malignant thyroid nodule in the haystack
Kristien Boelaert & Christopher McCabe, 1 Oct 2011, In: Nature Reviews Endocrinology. 7, 10, p. 563-564 2 p.Research output: Contribution to journal › Editorial
- Published
Proto-oncogene PBF/PTTG1IP Regulates Thyroid Cell Growth and Represses Radioiodide Treatment
Martin Read, Jim Fong, Neil Sharma, Vicki Smith, Margaret Eggo, Wendy Leadbeater, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Oct 2011, In: Cancer Research. 71, 19, p. 6153-64 12 p.Research output: Contribution to journal › Article
- Published
Iodine status of UK schoolgirls: a cross-sectional survey
Roger Holder, Kristien Boelaert & Jayne Franklyn, 1 Jun 2011, In: Lancet. 377, 9782, p. 2007-2012 6 p.Research output: Contribution to journal › Article
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- 2010
- Published
Presence of Other Autoimmune Diseases in Subjects with Autoimmune Thyroid Disease Reply
Kristien Boelaert & Jayne Franklyn, 1 Oct 2010, In: The American Journal of Medicine. 123, 10, p. E25-E25Research output: Contribution to journal › Article
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Thyroid hyperplasia in a transgenic mouse model of PTTG-Binding Factor (PBF) overexpression
Martin Read, Neil Sharma, Jim Fong, Vicki Smith, Wendy Leadbeater, Margaret Eggo, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Sep 2010.Research output: Contribution to conference (unpublished) › Abstract
- Published
Treatment of Graves' Disease with Antithyroid Drugs: Current Perspectives
Kristien Boelaert, 1 Sep 2010, In: Thyroid. 20, 9, p. 943-946 4 p.Research output: Contribution to journal › Editorial
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Who Should Treat Thyroid Cancer? A UK Surgical Perspective
Neil Sharma, Kristien Boelaert, 1 Aug 2010, In: Clinical Oncology. 22, 6, p. 413-418 6 p.Research output: Contribution to journal › Article
- Published
Pituitary Tumor Transforming Gene Binding Factor: A New Gene in Breast Cancer
Rachel Spruce, Martin Read, Vicki Smith, Neil Sharma, Laura Buckley, Margaret Eggo, Laurence Loubiere, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 May 2010, In: Cancer Research. 70, 9, p. 3739-3749 11 p.Research output: Contribution to journal › Article
- Published
Older Subjects with Hyperthyroidism Present with a Paucity of Symptoms and Signs: A Large Cross-Sectional Study
Kristien Boelaert, Barbara Torlinska, Roger Holder & Jayne Franklyn, 14 Apr 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 6, p. 2715-2726 12 p.Research output: Contribution to journal › Article
- Published
Thyroid Gland: Revised Guidelines for the Management of Thyroid Cancer
Kristien Boelaert, 1 Apr 2010, In: Nature Reviews Endocrinology. 6, 4, p. 185-186 2 p.Research output: Contribution to journal › Editorial
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Prevalence and Relative Risk of Other Autoimmune Diseases in Subjects with Autoimmune Thyroid Disease
Kristien Boelaert, Paul Newby, Matthew Simmonds, Roger Holder, Stephen Gough & Jayne Franklyn, 1 Feb 2010, In: The American Journal of Medicine. 123, 2, p. 183.e1 1 p.Research output: Contribution to journal › Article
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- 2009
- Published
A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer
Vicki Smith, Martin Read, Andrew Turnell, Rachel Spruce, Jim Fong, Margaret Eggo, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 1 Sep 2009, In: Journal of Cell Science. 122, 18, p. 3393-3402 10 p.Research output: Contribution to journal › Article › peer-review
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The association between serum TSH concentration and thyroid cancer
Kristien Boelaert, 20 Jul 2009, In: Endocrine-related cancer.Research output: Contribution to journal › Article
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Enlargement of the thyroid gland in a heterozygous PBF knock-in transgenic mouse model
Martin Read, Jim Fong, Vicki Smith, Andrew Turnell, Wendy Leadbeater, Dae Kim, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Jan 2009, p. 371. 1 p.Research output: Contribution to conference (unpublished) › Paper
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- 2008
- Published
A novel mechansim of thyroid tumourigenesis based on inactivation of p53 by the PTTG-binding factor PBF
Martin Read, Rachel Spruce, Andrew Turnell, Dae Kim, Vicki Smith, Jim Fong, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 12 Apr 2008, In: Cancer Research. 68, p. 1855Research output: Contribution to journal › Abstract
- 2007
- Published
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Age and gender differences and phenotypes of patients with autoimmune thyroid disease - The UK AITD Consortium
Kristien Boelaert, Stephen Gough & Jayne Franklyn, 1 Jan 2007, p. P877.Research output: Contribution to conference (unpublished) › Abstract
- Published
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The assessment of thyroid neoplasia
Kristien Boelaert, Jayne Franklyn, Michael Sheppard, 1 Jan 2007, Clinical Endocrine Oncology.Research output: Chapter in Book/Report/Conference proceeding › Chapter
- Published
- 2006
- Published
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Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a VEGF/KDR/ID3 autocrine pathway
Dae Kim, Jayne Franklyn, Kristien Boelaert, Margaret Eggo & Christopher McCabe, 5 Sep 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4603-4611 9 p.Research output: Contribution to journal › Article
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Serum TSH concentration as a novel predictor of malignancy in thyroid nodules investigated by fine needle aspiration
Kristien Boelaert, Roger Holder, Michael Sheppard & Jayne Franklyn, 5 Sep 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4295-4301 7 p.Research output: Contribution to journal › Article
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Influence of family history on the age of presentation of AITD - the UK AITD consortium
Kristien Boelaert, Stephen Gough & Jayne Franklyn, 1 Jan 2006, p. P878.Research output: Contribution to conference (unpublished) › Abstract
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- 2005
- Published
Pituitary tumor transforming gene (PTTG) regulates multiple downstream angiogenic genes in thyroid cancer
Dae Kim, Jayne Franklyn, Kristien Boelaert, Margaret Eggo & Christopher McCabe, 29 Dec 2005, In: Journal of Clinical Endocrinology and Metabolism. 91, 3, p. 1119-1128 10 p.Research output: Contribution to journal › Article
- Published
Starling's Review: Thyroid hormone in health and disease
Kristien Boelaert & Jayne Franklyn, 1 Oct 2005, In: Journal of Endocrinology. 187, 1, p. 1-15 15 p.Research output: Contribution to journal › Review article
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PTTG Binding Factor (PBF) - a Novel Transforming Gene in Thyroid Tumorigenesis
Kristien Boelaert, Lesley Tannahill, Dae Kim, Margaret Eggo, Neil Gittoes, Lawrence Young, Jayne Franklyn & Christopher McCabe, 5 Apr 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4341-4349 9 p.Research output: Contribution to journal › Article
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- 2004
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PBF predicts recurrence in thyroid cancer and potentiates the actions of PTTG in vitro
Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 1 Jan 2004, p. OC19.Research output: Contribution to conference (unpublished) › Abstract
- Published
PTTG binding factor (PBF) - A novel transforming gene in thyroid tumorigenesis which represses iodide uptake
Kristien Boelaert, Lesley Tannahill, Margaret Eggo, Jayne Franklyn, Neil Gittoes & Christopher McCabe, 1 Jan 2004, p. OR 37-3.Research output: Contribution to conference (unpublished) › Abstract
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PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro
Kristien Boelaert, Lesley Tannahill, Farhat Khanim, Margaret Eggo, Jasbir Moore, Lawrence Young, Neil Gittoes, Jayne Franklyn & Christopher McCabe, 1 Jan 2004, In: Journal of Molecular Endocrinology. 33, p. 663-677 15 p.Research output: Contribution to journal › Article
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- 2003
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A potential role for PTTG/securin in the developing human fetal brain
Kristien Boelaert, Lesley Tannahill, Kachilele-Linjewile Kachilele, Shiaoyng Chan, Neil Gittoes, Jo Bradwell, Jayne Franklyn, Mark Kilby & Christopher McCabe, 1 Sep 2003, In: FASEB Journal. 17, 12, p. 1631-1639 9 p.Research output: Contribution to journal › Article
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Placental iodothyronine deiodinase expression in normal and growth restricted human pregnancies
Shiaoyng Chan, Kachilele-Linjewile Kachilele, Emma Hobbs, Kristien Boelaert, Christopher McCabe, Philip Driver, Jayne Franklyn & Mark Kilby, 1 Sep 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 9, p. 4488-4495 8 p.Research output: Contribution to journal › Article
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Pituitary tumour transforming gene and fibroblast growth factor 2 expression: potential prognostic indicators in differentiated thyroid cancer
Kristien Boelaert, Christopher McCabe, Lesley Tannahill, Neil Gittoes, Roger Holder, Jo Bradwell, Michael Sheppard & Jayne Franklyn, 1 May 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 5, p. 2341-2347 7 p.Research output: Contribution to journal › Article
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Abnormal expression of 11beta-HSD type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation
Elizabeth Rabbitt, John Ayuk, Kristien Boelaert, Michael Sheppard, Martin Hewison, Paul Stewart & Neil Gittoes, 20 Mar 2003, In: Oncogene. 22(11), 11, p. 1663-1667 5 p.Research output: Contribution to journal › Article
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Sodium iodide symporter: a novel strategy to target breast, prostate, and other cancers?
Kristien Boelaert & Jayne Franklyn, 8 Mar 2003, In: Lancet. 361, 9360, p. 796-797 2 p.Research output: Contribution to journal › Review article
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Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour.
Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Shakir Hussain, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Feb 2003, In: Clinical Endocrinology. 58, 2, p. 141-50 10 p.Research output: Contribution to journal › Article
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NIS gene expression is a potential prognostic indicator for thyroid cancer and is inhibited by PTTG
Kristien Boelaert, Lesley Tannahill, Margaret Eggo, Neil Gittoes, Michael Sheppard, Jayne Franklyn & Christopher McCabe, 1 Jan 2003, p. 28. 1 p.Research output: Contribution to conference (unpublished) › Abstract
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PTTG binding factor in thyroid cancer
Kristien Boelaert, Farhat Khanim, Dae Kim & Jayne Franklyn, 1 Jan 2003, p. 93. 1 p.Research output: Contribution to conference (unpublished) › Abstract
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- Published
Sodium iodide gene expression is a potential prognostic indicator for thyroid cancer and is inhibited by PTTG
Kristien Boelaert, Margaret Eggo, Neil Gittoes, Michael Sheppard, Jayne Franklyn & Christopher McCabe, 1 Jan 2003, p. OC37.Research output: Contribution to conference (unpublished) › Abstract
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Sodium iodide symporter (NIS) gene expression is a potential prognostic indicator for thyroid cancer and is inhibited by pituitary tumor transforming gene
Kristien Boelaert, Lesley Tannahill, Margaret Eggo, Neil Gittoes, Michael Sheppard, Jayne Franklyn & Christopher McCabe, 1 Jan 2003.Research output: Contribution to conference (unpublished) › Paper
- 2002
- Published
Early expression of thyroid hormone deiodinases and receptors in human fetal cerebral cortex
Shiaoyng Chan, Kachilele-Linjewile Kachilele, Christopher McCabe, Lesley Tannahill, Kristien Boelaert, Neil Gittoes, Jayne Franklyn & Mark Kilby, 20 Oct 2002, In: Developmental Brain Research . 138, 2, p. 109-116 8 p.Research output: Contribution to journal › Article › peer-review
- Published
Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors
Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Jattinder Khaira, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Sep 2002, In: Journal of Clinical Endocrinology and Metabolism. 87, 9, p. 4238-4244 7 p.Research output: Contribution to journal › Article
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Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours
Lesley Tannahill, Christopher McCabe, Kachilele-Linjewile Kachilele, Kristien Boelaert, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jun 2002, In: Clinical Endocrinology. 56, 6, p. 735-743 9 p.Research output: Contribution to journal › Article
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Disruption of the SH3 domain of PTTG reveals distinct mechanisms of FGF-induction and cell transformation
Kristien Boelaert, Lesley Tannahill, Jasbir Moore, Lawrence Young, Michael Sheppard, Jayne Franklyn, Neil Gittoes & Christopher McCabe, 1 Jan 2002.Research output: Contribution to conference (unpublished) › Abstract
- Published
- Published
- Published
Iodothyronine deiodinase expression in thyroid responsive fetal tissues
Shiaoyng Chan, Kachilele-Linjewile Kachilele, Christopher McCabe, Lesley Tannahill, Kristien Boelaert, Neil Gittoes, Jayne Franklyn & Mark Kilby, 1 Jan 2002, p. OC34.Research output: Contribution to conference (unpublished) › Abstract
- Published
- Published
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The SH3 domain of PTTG differentially mediates FGF-2 transactivation and cell transformation
Kristien Boelaert, Lesley Tannahill, Jasbir Moore, Lawrence Young, Michael Sheppard, Neil Gittoes, Jayne Franklyn & Christopher McCabe, 1 Jan 2002, p. OR 40-42.Research output: Contribution to conference (unpublished) › Paper
- Published
- 2001
- Published
Radiotherapy for non-functioning pituitary tumours
Kristien Boelaert & Neil Gittoes, 1 Jun 2001, In: European Journal of Endocrinology. 144, 6, p. 569-575 7 p.Research output: Contribution to journal › Review article
- Published
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Deiodinase activity and expression in the first and second trimester human fetal brain
Kachilele-Linjewile Kachilele, Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Shiaoyng Chan, Neil Gittoes, Jayne Franklyn & Mark Kilby, 1 Jan 2001, p. 3-20. 18 p.Research output: Contribution to conference (unpublished) › Paper
- Published
Deiodinase expression in human placenta as a function of gestational age: the effects of intrauterine growth restriction (IUGR)
Kachilele-Linjewile Kachilele, Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Neil Gittoes, Jayne Franklyn & Mark Kilby, 1 Jan 2001, p. 175. 1 p.Research output: Contribution to conference (unpublished) › Abstract
- Published
Deiodinase expression in human placenta as a function of gestational age: the effects of intrauterine growth restriction (IUGR)
Kachilele-Linjewile Kachilele, Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Neil Gittoes, Jayne Franklyn & Mark Kilby, 1 Jan 2001, Proceedings of the 83rd Meeting of the American Endocrine Society. p. 3-27 25 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Expression of pituitary tumor transforming gene (PTTG) in the early human fetal central nervous system
Kristien Boelaert, Christopher McCabe, Lesley Tannahill, Kachilele-Linjewile Kachilele, Jo Bradwell, Neil Gittoes, Mark Kilby & Jayne Franklyn, 1 Jan 2001, p. 177. 1 p.Research output: Contribution to conference (unpublished) › Abstract
- Published
Iodothyronine deiodinase enzyme mRNA expression in normal pituitary and pituitary adenomas
Lesley Tannahill, Christopher McCabe, Kachilele-Linjewile Kachilele, Kristien Boelaert, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001.Research output: Contribution to conference (unpublished) › Paper
- Published
- Published
Pituitary tumor transforming gene (PTTG), PTTG binding factor (PBF) and related growth factor expression in sporadic pituitary tumours
Christopher McCabe, Jattinder Khaira, Kristien Boelaert, Lesley Tannahill, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001, p. OC18.Research output: Contribution to conference (unpublished) › Abstract
- Published
- Published
The destruction box of pituitary tumor transforming gene (PTTG) mediates cell transformation in vitro
Christopher McCabe, Jattinder Khaira, Kristien Boelaert, Lesley Tannahill, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001, p. OR37-2.Research output: Contribution to conference (unpublished) › Paper