Kristien Boelaert
Publications
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Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism
18 Oct 2018, In: JCI Insight. 3, 20, 11 p., e99631.Research output: Contribution to journal › Abstract › peer-review
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Pro-invasive effect of proto-oncogene PBF is modulated by an interaction with cortactin
Rachel Spruce, Martin Read, Neil Sharma, Rachel Fletcher, Hisham Mehanna, Kristien Boelaert, Vicki Smith & Christopher McCabe, Dec 2016, In: The Journal of clinical endocrinology and metabolism. 101, 12, p. 4551-4563Research output: Contribution to journal › Article › peer-review
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Iodine status of UK schoolgirls: a cross-sectional survey
Roger Holder, Kristien Boelaert & Jayne Franklyn, 1 Jun 2011, In: Lancet. 377, 9782, p. 2007-2012 6 p.Research output: Contribution to journal › Article
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Risk of incident circulatory disease in patients treated for differentiated thyroid carcinoma with no history of cardiovascular disease
Kristien Boelaert & Krishnarajah Nirantharakumar, 1 Aug 2019, In: Clinical Endocrinology. 91, 2, p. 323-330 8 p.Research output: Contribution to journal › Article › peer-review
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Patients treated for hyperthyroidism are at increased risk of becoming obese: findings from a large prospective secondary care cohort
Barbara Torlinska, Linda Nichols, Christopher McCabe & Kristien Boelaert, 15 Oct 2019, In: Thyroid. 29, 10, p. 1380-1389 10 p.Research output: Contribution to journal › Article › peer-review
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Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
Barbara Torlinska, Kristien Boelaert, 1 Mar 2018, In: Nutrients. 10, 3, 291.Research output: Contribution to journal › Article › peer-review
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Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study
Rasiah Thayakaran, Nicola Adderley, Barbara Torlinska, Kristien Boelaert, Dana Sumilo, Malcolm Price, G Neil Thomas & Krishnarajah Nirantharakumar, 3 Sep 2019, In: BMJ. 366, 8 p., l4892.Research output: Contribution to journal › Article › peer-review
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Controlled Antenatal Thyroid Study: Obstetric Outcomes
Kristien Boelaert, Shiaoyng Chan, 13 Feb 2017, In: Thyroid Research. 10(Suppl 1), 2, p. 2 1 p., O1.Research output: Contribution to journal › Abstract › peer-review
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Liothyronine cost and prescriptions in England
Kristien Boelaert, Jan 2019, In: The Lancet Diabetes and Endocrinology. 7, 1, p. 11-12 2 p.Research output: Contribution to journal › Letter › peer-review
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Iodothyronine deiodinase enzyme mRNA expression in normal pituitary and pituitary adenomas
Lesley Tannahill, Christopher McCabe, Kachilele-Linjewile Kachilele, Kristien Boelaert, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001.Research output: Contribution to conference (unpublished) › Paper
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Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours
Lesley Tannahill, Christopher McCabe, Kachilele-Linjewile Kachilele, Kristien Boelaert, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jun 2002, In: Clinical Endocrinology. 56, 6, p. 735-743 9 p.Research output: Contribution to journal › Article
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PTTG binding factor (PBF) - A novel transforming gene in thyroid tumorigenesis which represses iodide uptake
Kristien Boelaert, Lesley Tannahill, Margaret Eggo, Jayne Franklyn, Neil Gittoes & Christopher McCabe, 1 Jan 2004, p. OR 37-3.Research output: Contribution to conference (unpublished) › Abstract
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PTTG Binding Factor (PBF) - a Novel Transforming Gene in Thyroid Tumorigenesis
Kristien Boelaert, Lesley Tannahill, Dae Kim, Margaret Eggo, Neil Gittoes, Lawrence Young, Jayne Franklyn & Christopher McCabe, 5 Apr 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4341-4349 9 p.Research output: Contribution to journal › Article
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PTTG binding factor in thyroid cancer
Kristien Boelaert, Farhat Khanim, Dae Kim & Jayne Franklyn, 1 Jan 2003, p. 93. 1 p.Research output: Contribution to conference (unpublished) › Abstract
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PBF predicts recurrence in thyroid cancer and potentiates the actions of PTTG in vitro
Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 1 Jan 2004, p. OC19.Research output: Contribution to conference (unpublished) › Abstract
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Pituitary Tumor Transforming Gene Binding Factor: A New Gene in Breast Cancer
Rachel Spruce, Martin Read, Vicki Smith, Neil Sharma, Laura Buckley, Margaret Eggo, Laurence Loubiere, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 May 2010, In: Cancer Research. 70, 9, p. 3739-3749 11 p.Research output: Contribution to journal › Article
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A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer
Vicki Smith, Martin Read, Andrew Turnell, Rachel Spruce, Jim Fong, Margaret Eggo, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 1 Sep 2009, In: Journal of Cell Science. 122, 18, p. 3393-3402 10 p.Research output: Contribution to journal › Article › peer-review
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Manipulation of PBF/PTTG1IP phosphorylation status ; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors
Vicki Smith, Neil Sharma, Rachel Spruce, Martin Read, Ashley Martin, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Jul 2013, In: The Journal of clinical endocrinology and metabolism. 98, 7, p. 2876-2886 11 p.Research output: Contribution to journal › Article › peer-review
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The prevalence of thyroid dysfunction and autoimmunity in women with history of miscarriage or subfertility
Rima Smith, Aurelio Tobias Garces, Paul Smith, Lee Middleton, Justin Chu & 14 others, , 1 Aug 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 8, p. 2667–2677Research output: Contribution to journal › Article › peer-review
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Levothyroxine in women with thyroid peroxidase antibodies before conception
Rima Smith, Lee Middleton, Versha Cheed, Christopher McCabe & 14 others, , 4 Apr 2019, In: The New England Journal of Medicine. 380, 14, p. 1316-1325 10 p.Research output: Contribution to journal › Article › peer-review
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PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8
Vicki Smith, Martin Read, Andrew Turnell, Jim Fong, Shiaoyng Chan, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 2012, In: Endocrinology. 153, 7, p. 3526-36 11 p.Research output: Contribution to journal › Article › peer-review
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Who Should Treat Thyroid Cancer? A UK Surgical Perspective
Neil Sharma, Kristien Boelaert, 1 Aug 2010, In: Clinical Oncology. 22, 6, p. 413-418 6 p.Research output: Contribution to journal › Article
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Thyroid hyperplasia in a transgenic mouse model of PTTG-Binding Factor (PBF) overexpression
Martin Read, Neil Sharma, Jim Fong, Vicki Smith, Wendy Leadbeater, Margaret Eggo, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Sep 2010.Research output: Contribution to conference (unpublished) › Abstract
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Enlargement of the thyroid gland in a heterozygous PBF knock-in transgenic mouse model
Martin Read, Jim Fong, Vicki Smith, Andrew Turnell, Wendy Leadbeater, Dae Kim, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Jan 2009, p. 371. 1 p.Research output: Contribution to conference (unpublished) › Paper
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Comparative analysis of human and mouse expression data identifies proto-oncogene PTTG- and PBF-associated genes in thyroid cancer
Martin Read, Hannah Nieto, Alice Fletcher, Neil Sharma, Andrew Turnell, Kristien Boelaert, Vicki Smith & Christopher McCabe, 13 Feb 2017, In: Thyroid Research. 10(Suppl 1), 2Research output: Contribution to journal › Abstract › peer-review
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Dietary factors augment the ability of the proto-oncogene PBF to induce goitrogenesis and hyperplasia in vivo
Martin Read, Vicki Smith, Jim Fong, Wendy Leadbeater, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Mar 2012, In: Endocrine Abstracts. 28, OC3.8.Research output: Contribution to journal › Abstract › peer-review
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Proto-oncogene PBF/PTTG1IP Regulates Thyroid Cell Growth and Represses Radioiodide Treatment
Martin Read, Jim Fong, Neil Sharma, Vicki Smith, Margaret Eggo, Wendy Leadbeater, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Oct 2011, In: Cancer Research. 71, 19, p. 6153-64 12 p.Research output: Contribution to journal › Article
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Comparative analysis of human and mouse expression data identifies distinct proto-oncogene PBF- and PTTG-associated genes in thyroid cancer
Martin Read, Jim Fong, Hannah Nieto, Kristien Boelaert, Vicki Smith, Andrew Turnell & Christopher McCabe, 1 Jul 2016, In: European Journal of Cancer. 61, Suppl 1, p. S36 1 p., 202.Research output: Contribution to journal › Abstract › peer-review
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Elevated genetic instability is associated with repressed DNA repair gene expression in a bi-transgenic murine model of PTTG and PBF
Martin Read, Jim Fong, Vicki Smith, Rachel Spruce, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 2 Dec 2013.Research output: Contribution to conference (unpublished) › Poster
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A novel mechansim of thyroid tumourigenesis based on inactivation of p53 by the PTTG-binding factor PBF
Martin Read, Rachel Spruce, Andrew Turnell, Dae Kim, Vicki Smith, Jim Fong, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 12 Apr 2008, In: Cancer Research. 68, p. 1855Research output: Contribution to journal › Abstract
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Examination of PTTG-Binding Factor (PBF) mRNA reveals functional miRNA target sites and exon-skipping splice variants in thyroid cells
Martin Read, Alice Fletcher, Vicki Smith, Rachel Spruce, Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Mar 2014, In: Endocrine Abstracts. 34, P397.Research output: Contribution to journal › Abstract › peer-review
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The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells
Martin Read, Jim Fong, Rachel Spruce, Vicki Smith, Neil Sharma, Kristien Boelaert, Jayne Franklyn, Andrew Turnell & Christopher McCabe, 1 Apr 2014, In: Endocrinology. 155, 4, p. 1222-34 13 p.Research output: Contribution to journal › Article › peer-review
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A high-throughput yellow fluorescent protein (YFP) cell-based screen identifies autophagy modulators to increase the effectiveness of radioiodine therapy
Martin Read, Alice Fletcher, Luke Alderwick, Kristien Boelaert, Vicki Smith & Christopher McCabe, 13 Nov 2019, In: Endocrine Abstracts. 65, 1 p., OC4.1.Research output: Contribution to journal › Abstract › peer-review
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PO-124 PTTG and PBF functionally interact with P53 and predict overall survival in head and neck cancer
Martin Read, Alice Fletcher, Kristien Boelaert, Andrew Turnell, Vicki Smith, Hisham Mehanna & Christopher McCabe, 1 Jul 2018, In: ESMO Open. 3, Suppl. 2, p. A69-A69 1 p.Research output: Contribution to journal › Abstract › peer-review
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Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer
Martin Read, Alice Fletcher, Hannah Nieto, John Reynolds, Kristien Boelaert, Andrew Turnell, Vicki Smith & Christopher McCabe, 14 Sep 2017, In: Oncogene. 36, p. 5296–5308Research output: Contribution to journal › Article › peer-review
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Elevated genetic instability is associated with repressed DNA repair gene expression in a bi-transgenic murine model of PTTG and PBF
Martin Read, Jim Fong, Vicki Smith, Rachel Spruce, Kristien Boelaert, Jayne Franklyn & Christopher McCabe, 2013, p. A24.Research output: Contribution to conference (unpublished) › Abstract
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Comparative analysis of human and mouse expression data identifies proto-oncogene PTTG- and PBF-associated genes in thyroid cancer
Martin Read, Hannah Nieto, Alice Fletcher, Neil Sharma, Andrew Turnell, Kristien Boelaert, Vicki Smith & Christopher McCabe, 13 May 2016.Research output: Contribution to conference (unpublished) › Abstract › peer-review
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PTTG and PBF functionally interact with p53 and predict overall survival in head and neck cancer
Martin Read, Alice Fletcher, Peter Rae, Hannah Nieto, Sally Roberts, Moray Campbell, Kristien Boelaert, Andrew Turnell, Vicki Smith, Hisham Mehanna & Christopher McCabe, Oct 2018, In: Cancer Research. 78, 20, p. 5863-5876 14 p.Research output: Contribution to journal › Article › peer-review
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Oncogenic action of pituitary-tumor transforming gene (PBF) in head and neck cancer is associated with poorer overall survival
Martin Read, Alice Fletcher, Hannah Nieto, Moray Campbell, Kristien Boelaert, Andrew Turnell, Vicki Smith, Hisham Mehanna & Christopher McCabe, 1 Nov 2018, In: Endocrine Abstracts. 59, 1 p., P119.Research output: Contribution to journal › Abstract › peer-review
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The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer
Martin Read, Vicki Smith, Rachel Spruce, Dae Kim, Stephen Ward, Kristien Boelaert, Jayne Franklyn, Andrew Turnell & Christopher McCabe, Jan 2016, In: Molecular Carcinogenesis. 55, 1, p. 15-26Research output: Contribution to journal › Article › peer-review
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Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer
Martin Read, Alice Fletcher, Hannah Nieto, Holly Adcock, Liam Cox, Luke Alderwick, Kristien Boelaert, Vicki Smith & Christopher McCabe, 8 May 2020, In: Journal of the Endocrine Society. 4, Issue Supplement 1, 1 p., OR28-03.Research output: Contribution to journal › Abstract › peer-review
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High tumoral expression of PBF and PTTG modulates the DNA damage response and is associated with poor survival in thyroid cancer
Martin Read, Jim Fong, Alice Fletcher, Neil Sharma, Kristien Boelaert, Andrew Turnell, Vicki Smith & Christopher McCabe, 4 Nov 2016, In: Endocrine Abstracts. 44, P246.Research output: Contribution to journal › Abstract › peer-review
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Abnormal expression of 11beta-HSD type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation
Elizabeth Rabbitt, John Ayuk, Kristien Boelaert, Michael Sheppard, Martin Hewison, Paul Stewart & Neil Gittoes, 20 Mar 2003, In: Oncogene. 22(11), 11, p. 1663-1667 5 p.Research output: Contribution to journal › Article
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Pharmacological enhancement of radioiodine uptake using Src kinase inhibitors
Alice Fletcher, Neil Sharma, Martin Read, Kristien Boelaert, Christopher McCabe & Vicki Smith, 13 Feb 2017, In: Thyroid Research. 10(Suppl 1), 2, p. 2 1 p., O2.Research output: Contribution to journal › Abstract › peer-review
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Antigen-specific immunotherapy with thyrotropin receptor peptides in Graves' hyperthyroidism: a phase I study
Kristien Boelaert, 17 Jul 2019, In: Thyroid. 29, 7, p. 1003-1011 9 p.Research output: Contribution to journal › Article › peer-review
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Thyroid stimulating hormone in thyroid cancer: does it matter?
Hannah Nieto & Kristien Boelaert, 1 Nov 2016, In: Endocrine-related cancer. 23, 11, ERC-16-0328.Research output: Contribution to journal › Article › peer-review
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Costs and benefits of iodine supplementation for pregnant women in a mildly to moderately iodine-deficient population: a modelling analysis
Mark Monahan, Kristien Boelaert, Kate Jolly, Shiaoyng Chan, Pelham Barton & Tracy Roberts, Sep 2015, In: The Lancet Diabetes and Endocrinology. 3, 9, p. 715-722 8 p.Research output: Contribution to journal › Article
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Differences in the recurrence and mortality outcomes rates of incidental and nonincidental papillary thyroid microcarcinoma: a systematic review and meta-analysis of 21 329 person-years of follow-up
Hisham Mehanna, Ben Carter, Kristien Boelaert & Jayne Franklyn, Aug 2014, In: The Journal of clinical endocrinology and metabolism. 99, 8, p. 2834-43 10 p.Research output: Contribution to journal › Article › peer-review
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Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour.
Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Shakir Hussain, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Feb 2003, In: Clinical Endocrinology. 58, 2, p. 141-50 10 p.Research output: Contribution to journal › Article
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The destruction box of pituitary tumor transforming gene (PTTG) mediates cell transformation in vitro
Christopher McCabe, Jattinder Khaira, Kristien Boelaert, Lesley Tannahill, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001, p. OR37-2.Research output: Contribution to conference (unpublished) › Paper
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Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors
Christopher McCabe, Kristien Boelaert, Lesley Tannahill, Jattinder Khaira, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Sep 2002, In: Journal of Clinical Endocrinology and Metabolism. 87, 9, p. 4238-4244 7 p.Research output: Contribution to journal › Article
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Pituitary tumor transforming gene (PTTG), PTTG binding factor (PBF) and related growth factor expression in sporadic pituitary tumours
Christopher McCabe, Jattinder Khaira, Kristien Boelaert, Lesley Tannahill, Michael Sheppard, Jayne Franklyn & Neil Gittoes, 1 Jan 2001, p. OC18.Research output: Contribution to conference (unpublished) › Abstract
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Influence of family history on the age of presentation of AITD - the UK AITD consortium
Kristien Boelaert, Stephen Gough & Jayne Franklyn, 1 Jan 2006, p. P878.Research output: Contribution to conference (unpublished) › Abstract
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The pituitary tumor transforming gene in thyroid cancer
Neil Sharma, Vicki Smith, Kristien Boelaert & Christopher McCabe, 5 Apr 2012, In: Journal of endocrinological investigation. 35, 4, p. 425-433Research output: Contribution to journal › Review article › peer-review
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Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a VEGF/KDR/ID3 autocrine pathway
Dae Kim, Jayne Franklyn, Kristien Boelaert, Margaret Eggo & Christopher McCabe, 5 Sep 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4603-4611 9 p.Research output: Contribution to journal › Article
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Pituitary tumor transforming gene (PTTG) regulates multiple downstream angiogenic genes in thyroid cancer
Dae Kim, Jayne Franklyn, Kristien Boelaert, Margaret Eggo & Christopher McCabe, 29 Dec 2005, In: Journal of Clinical Endocrinology and Metabolism. 91, 3, p. 1119-1128 10 p.Research output: Contribution to journal › Article
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Glucocorticoid induced adrenal insufficiency is common in steroid treated glomerular diseases - proposed strategy for screening and management
Kristien Boelaert & Lorraine Harper, 6 May 2019, In: BMC Nephrology. 20, 1, 154.Research output: Contribution to journal › Article › peer-review
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