Jon Frampton

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Publications

  1. Published

    c-Myb-Dependent Smooth Muscle Cell Differentiation

    Jon Frampton, 14 Mar 2008, In: Circulation Research. 102, 5, p. 554-561 8 p.

    Research output: Contribution to journal › Article

  2. Published

    c-Myb is required for progenitor cell homeostasis in colonic crypts

    John Heath, Jon Frampton, 6 Mar 2007, In: National Academy of Sciences. Proceedings. 104, 10, p. 3829-34 6 p.

    Research output: Contribution to journal › Article

  3. Published

    c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells

    Jon Frampton, 1 Jul 2006, In: Blood. 108, 1, p. 297-304 8 p.

    Research output: Contribution to journal › Article

  4. Published

    c-Myb is a key regulator of hematopoietic progenitor expansion and commitment

    Jon Frampton & Jon Frampton, 1 Jan 2003, In Myb Transcription Factors: Their Role in Growth, Differentiation and Disease.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  5. Published

    c-Myb and GATA-1 alternate dominant roles during megakaryocyte differentiation

    Paloma Garcia & Jon Frampton, 1 Aug 2011, In: Journal of Thrombosis and Haemostasis. 9, 8, p. 1572-1581 10 p.

    Research output: Contribution to journal › Article › peer-review

  6. Published

    c-Myb and CREB function in adult neurogenesis

    Jon Frampton & Jon Frampton, 1 Jan 2004, Myb Transcription Factors: Their Role in Growth, Differentiation and Disease.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  7. Published

    c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain

    Jon Frampton, 29 Nov 2007, In: Stem Cells. 26, 1, p. 173-81 9 p.

    Research output: Contribution to journal › Article

  8. Published

    Using retroviruses to express genes in primary megakaryocyte lineage cells

    George Murphy, Jon Frampton, 1 Jan 2003, In Platelets and Megakaryocytes: Methods and Protocols.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  9. E-pub ahead of print

    Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3

    Mary Clarke, Giacomo Volpe, Lozan Sheriff, Carl Ward, Wenbin Wei, Stephanie Dumon, Paloma Garcia & Jon Frampton, 8 Nov 2016, In: Leukemia.

    Research output: Contribution to journal › Article › peer-review

  10. Published

    Transcriptional regulation by c-Myb could be a major factor distinguishing the erythroid and megakaryocytic lineages

    Alexandros Vegiopoulos, Jon Frampton & Jon Frampton, 1 Jan 2003, In Myb Transcription Factors: Their Role in Growth, Differentiation and Disease.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  11. Published

    Transcriptional pause release is a rate-limiting step for somatic cell reprogramming

    Yuan Li & 12 others, , Jon Frampton, 6 Nov 2014, In: Cell stem cell. 15, 5, p. 574-88 15 p.

    Research output: Contribution to journal › Article › peer-review

  12. Published

    Thrombin-induced conversion of fibrinogen to fibrin results in rapid platelet trapping which is not dependent on platelet activation of GPIb

    Steve Watson & Jon Frampton, 1 Feb 2003, In: British Journal of Pharmacology. 138, 4, p. 574-583 10 p.

    Research output: Contribution to journal › Article

  13. Published

    The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development

    Stephanie Dumon, Jon Frampton, 1 May 2009, In: Blood. 113, 22, p. 5456-5465 10 p.

    Research output: Contribution to journal › Article

  14. Published

    The transcription factor B-Myb is essential for S phase progression and genomic stability in both diploid and polyploid megakaryocytes

    Paloma Garcia & Jon Frampton, 15 Apr 2006, In: Journal of Cell Science. 119, p. 1483-1493 11 p.

    Research output: Contribution to journal › Article

  15. Published

    The scl+19 cell enhancer is not required for haematopoiesis: identification of a second bifunctional hematopoietic/endothelial enhancer regulated by Fil-1 and Elf-1

    George Murphy, Jon Frampton, 1 Jan 2004, In: Molecular and Cellular Biology. 24, p. 1870-1883 14 p.

    Research output: Contribution to journal › Article

  16. Published

    The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

    Steve Watson, Ben Atkinson, Oscar Berlanga & Jon Frampton, 1 Jul 2001, In: Journal of Thrombosis and Haemostasis. 86, 1, p. 276-88 13 p.

    Research output: Contribution to journal › Review article

  17. Published

    The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters

    Jon Frampton & 1 others, , Jan 2015, In: Cell Research. 25, 1, p. 80-92 13 p.

    Research output: Contribution to journal › Article › peer-review

  18. Published

    The homeodomain protein PRH influences the differentiation of haematopoietic cells

    Padma-Sheela Jayaraman, Jon Frampton, Dec 2000, In: Leukaemia Research. 24, 12, p. 1023-31 9 p.

    Research output: Contribution to journal › Article › peer-review

  19. Published

    The heptapeptide LSARLAF mediates platelet activation through phospholipase Cy 2 independently of glycoprotein 11b-111a

    Andrew Pearce, Steve Watson & Jon Frampton, 15 Feb 2004, In: Biochemical Journal. 378, 1, p. 193-199 7 p.

    Research output: Contribution to journal › Article

  20. Published

    The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis

    Jon Frampton, 1 Jul 2003, In: Immunity. 19, p. 33-45 13 p.

    Research output: Contribution to journal › Article

  21. Published

    The TspanC8 subgroup of tetraspanins interacts with a disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

    Elizabeth Haining, Steve Watson, Jon Frampton, Paloma Garcia & Michael Tomlinson, 16 Nov 2012, In: Journal of Biological Chemistry. 287, 47, p. 39753-39765 13 p.

    Research output: Contribution to journal › Article › peer-review

  22. Published

    The Fc receptor gamma-chain is necessary and sufficient to initiate signalling through glycoprotein VI

    Oscar Berlanga, Jon Frampton, 1 Jun 2002, In: European Journal of Biochemistry. 269, 12, p. 2951-2960 10 p.

    Research output: Contribution to journal › Article

  23. Published

    The Evi-1 proto-oncoprotein blocks endomitosis in megakaryocytes by inhibiting sustained cyclin-dependent kinase 2 catalytic activity

    Jon Frampton, 1 Sep 2005, In: British Journal of Haematology. 130, p. 902-11 10 p.

    Research output: Contribution to journal › Article

  24. Published

    Targeting the transcription factor Myb by small-molecule inhibitors

    Jon Frampton, 1 Mar 2017, In: Experimental Hematology. 47, p. 31-35

    Research output: Contribution to journal › Article › peer-review

  25. Published

    Targeting an E2F site in the mouse genome prevents promoter silencing in quiescent and post-mitotic cells

    Fiona Tavner, Jon Frampton, 30 Oct 2006, In: Oncogene. 26, 19, p. 2727-35 9 p.

    Research output: Contribution to journal › Article

  26. E-pub ahead of print

    Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

    Emilie Dasse, Jon Frampton, 2 Dec 2015, In: Blood.

    Research output: Contribution to journal › Article › peer-review

  27. Published

    Selective impairment of platelet activation to collagen in the absence of GATA1

    Sascha Hughan, Yotis Senis, Jon Frampton & Steve Watson, 1 Jun 2005, In: Blood. 105, p. 4369-76 8 p.

    Research output: Contribution to journal › Article

  28. Published

    Regulation of the Flt3 gene in haematopoietic stem and early progenitor cells

    Giacomo Volpe, Mary Clarke, Paloma Garcia, Alexandros Vegiopoulos, Walter Del Pozzo, Jon Frampton & Stephanie Dumon, 18 Sep 2015, In: PLoS ONE. 10, 9, e0138257.

    Research output: Contribution to journal › Article › peer-review

  29. Published

    Regulation of erythropoiesis by the neuronal transmembrane protein Lrfn2

    Jon Frampton, 1 Jan 2007, In: Experimental Hematology. 35, 5, p. 724-734 11 p.

    Research output: Contribution to journal › Article

  30. Published

    Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis.

    Paloma Garcia, Mary Clarke, Oscar Berlanga, Maelle Lorvellec & Jon Frampton, 20 May 2009, In: The EMBO journal. 28, 10, p. 1492-504 13 p.

    Research output: Contribution to journal › Article › peer-review

  31. Published

    RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors In vivo and Results in Hemangioma Development

    Jon Frampton, 15 Jun 2008, In: Clinical Cancer Research. 14, 12, p. 3948-3955 8 p.

    Research output: Contribution to journal › Article

  32. Published

    RAG1/2 knockout pigs with severe combined immunodeficiency

    Jon Frampton, 1 Aug 2014, In: Journal of Immunology. 193, 3, p. 1496-503 8 p.

    Research output: Contribution to journal › Article › peer-review

  33. Published

    Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development

    Jon Frampton, 1 Aug 2006, In: Blood. 108, 3, p. 896-903 8 p.

    Research output: Contribution to journal › Article

  34. Published

    Progression through key stages of the haemopoiesis is dependent on distinct threshold levels of c-Myb

    Alexandros Vegiopoulos, Ben Harman, Eric Jenkinson, Graham Anderson & Jon Frampton, 1 Sep 2003, In: The EMBO journal. 22, p. 4478-4488 11 p.

    Research output: Contribution to journal › Article

  35. Published

    Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature

    Giacomo Volpe, David Grainger, Carl Ward, Pierre Cauchy, Daniel Coleman, Peter Cockerill, Paloma Garcia & Jon Frampton, 11 Sep 2017, In: Scientific Reports. 7, 11148.

    Research output: Contribution to journal › Article › peer-review

  36. Published

    Professor Alan M Gewirtz (1949-2010) OBITUARY

    Jon Frampton, 1 May 2011, In: Oncogene. 30, 19, p. 2187-2187 1 p.

    Research output: Contribution to journal › Article

  37. Published

    Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut

    Dean Kavanagh, Philip Newsome, Jon Frampton & Neena Kalia, 24 Aug 2015, In: Stem Cells. 33, 9, p. 2785-97 13 p.

    Research output: Contribution to journal › Article › peer-review

  38. Published

    Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

    Kate Lowe, Brenda Finney, Jon Frampton, Christopher Buckley & Steve Watson, 11 Jun 2015, In: Blood. 125, 24, p. 3769-3777 9 p.

    Research output: Contribution to journal › Article › peer-review

  39. Published

    Platelets secrete stromal cell-derived factor 1  and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo

    & 1 others, Jon Frampton, 17 Apr 2006, In: The Journal of Experimental Medicine. 203, 5, p. 1221-33 13 p.

    Research output: Contribution to journal › Article

  40. Published

    Platelets contribute to postnatal occlusion of the ductus arteriosus

    Jon Frampton, 1 Jan 2010, In: Nature Medicine. 16, 1, p. 75-U111

    Research output: Contribution to journal › Article

  41. Published

    Platelet endothelial cell adhesion molecule (PECAM)-1 modulates SDF-1a/CXCR4 responses of hematopoietic stem cells

    Ewan Ross, Sylvie Freeman, Tarvinder Dhanjal, Sian Lax, Zubair Ahmed, Tiezheng Hou, Stuart Egginton, Gerard Nash, Steve Watson, Jon Frampton & Christopher Buckley, 1 Jan 2009, p. 450. 1 p.

    Research output: Contribution to conference (unpublished) › Abstract

  42. Published

    Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 modulates SDF-1alpha/CXCR4 responses of hematopoietic stem cells

    Ewan Ross, Sian Lax, Tiezheng Hou, Sylvie Freeman, Stuart Egginton, Tarvinder Dhanjal, Mike Salmon, Steve Watson, Gerard Nash, Jon Frampton & Christopher Buckley, 1 Jan 2006.

    Research output: Contribution to conference (unpublished) › Abstract

  43. Published

    Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb

    Jon Frampton, 23 Aug 2005, In: Circulation. 112, p. 1180-8 9 p.

    Research output: Contribution to journal › Article

  44. Published

    Phospholipase Cg2-independent activation of integrins by GPVI in murine platelets: involvement of phospholipase Cg1 and PI3-kinase. (In Press)

    Jon Frampton, 1 Jan 2002, In: Blood.

    Research output: Contribution to journal › Article

  45. Published

    Origin-specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence their Behaviour After Infusion.

    Julie Rayes, Stephen Watson, Philip Newsome, Neena Kalia, Jon Frampton, Helen McGettrick & Gerard Nash, Feb 2018, In: Stem cells (Dayton, Ohio).

    Research output: Contribution to journal › Article › peer-review

  46. Published

    Myb oncogene

    Jon Frampton, 1 Jan 2001, Encyclopedia of Genetics.

    Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

  47. Published

    Myb Transcription Factors: Their Role in Growth, Differentiation and Disease

    Jon Frampton, 1 Jan 2004, Kluwer Academic Publishers.

    Research output: Book/Report › Book

  48. Published

    Murine GPVI stimulates weak integrin activation in PLC gamma 2-/- platelets: involvement of PLC gamma 1 and PI3-kinase

    Jon Frampton & Steve Watson, 1 Aug 2003, In: Blood. 102, 4, p. 1367-1373 7 p.

    Research output: Contribution to journal › Article

  49. Published

    Multi-modal molecular diffuse optical tomography system for small animal imaging

    Hector Basevi, Jon Frampton, Iain Styles & Hamid Dehghani, 10 Sep 2013, In: Measurement Science and Technology. 24, 10, 22 p., 105405.

    Research output: Contribution to journal › Article › peer-review

  50. Published

    Mesenchymal stem cells inhibit recruitment of flowing neutrophils and lymphocytes by endothelial cells: roles of interleukin-6 and transforming growth factor-{beta}

    Christopher Buckley, Nguyet -Thin Luu, Philip Newsome, Jon Frampton & Gerard Nash, Oct 2011.

    Research output: Contribution to conference (unpublished) › Poster

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