Jon Frampton

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Publications

  1. 2019
  2. Published

    CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex

    Giacomo Volpe, Jon Frampton, 24 Jan 2019, In : Leukemia. 33, p. 1608-1619 12 p.

    Research output: Contribution to journal › Article

  3. 2018
  4. Published

    Fine-tuning Mybl2 is required for proper mesenchymal-to-epithelial transition during somatic reprogramming

    Carl Ward, Giacomo Volpe, Pierre Cauchy, Anetta Ptasinska, Jon Frampton & Paloma Garcia, 7 Aug 2018, In : Cell Reports. 24, 6, p. 1496-1511

    Research output: Contribution to journal › Article

  5. Published

    Inducible disruption of the c-myb gene allows allogeneic bone marrow transplantation without irradiation

    Jon Frampton, 1 Jun 2018, In : Journal of Immunological Methods. 457, p. 66-72

    Research output: Contribution to journal › Article

  6. Published

    Harnessing genomics to improve outcomes for women with cancer in India: key priorities for research

    Sudha Sundar, Jean-Baptiste Cazier & Jon Frampton, 15 Feb 2018, In : The Lancet Oncology. 19, 2, p. e102–e112

    Research output: Contribution to journal › Article

  7. 2017
  8. Published

    Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature

    Giacomo Volpe, David Grainger, Carl Ward, Pierre Cauchy, Daniel Coleman, Peter Cockerill, Paloma Garcia & Jon Frampton, 11 Sep 2017, In : Scientific Reports. 7, 11148.

    Research output: Contribution to journal › Article

  9. Published

    Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1

    Philip Newsome, Jon Frampton & 4 others, , 17 Mar 2017, In : Journal of Biological Chemistry. 292, 11, p. 4755-4763 9 p.

    Research output: Contribution to journal › Article

  10. Published

    Targeting the transcription factor Myb by small-molecule inhibitors

    Jon Frampton, 1 Mar 2017, In : Experimental Hematology. 47, p. 31-35

    Research output: Contribution to journal › Article

  11. 2016
  12. E-pub ahead of print

    Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3

    Mary Clarke, Giacomo Volpe, Lozan Sheriff, Carl Ward, Wenbin Wei, Stephanie Dumon, Paloma Garcia & Jon Frampton, 8 Nov 2016, In : Leukemia.

    Research output: Contribution to journal › Article

  13. 2015
  14. E-pub ahead of print

    Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

    Emilie Dasse, Jon Frampton, 2 Dec 2015, In : Blood.

    Research output: Contribution to journal › Article

  15. Published

    Fibrin activates GPVI in human and mouse platelets

    Craig Hughes, Jon Frampton & Steve Watson, 24 Sep 2015, In : Blood. 126, 13, p. 1601-1608 8 p.

    Research output: Contribution to journal › Article

  16. Published

    Regulation of the Flt3 gene in haematopoietic stem and early progenitor cells

    Giacomo Volpe, Mary Clarke, Paloma Garcia, Alexandros Vegiopoulos, Walter Del Pozzo, Jon Frampton & Stephanie Dumon, 18 Sep 2015, In : PLoS ONE. 10, 9, e0138257.

    Research output: Contribution to journal › Article

  17. Published

    Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut

    Dean Kavanagh, Philip Newsome, Jon Frampton & Neena Kalia, 24 Aug 2015, In : Stem Cells. 33, 9, p. 2785-97 13 p.

    Research output: Contribution to journal › Article

  18. Published

    Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

    Kate Lowe, Brenda Finney, Jon Frampton, Christopher Buckley & Steve Watson, 11 Jun 2015, In : Blood. 125, 24, p. 3769-3777 9 p.

    Research output: Contribution to journal › Article

  19. Published

    Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

    Paloma Garcia, Jon Frampton, Feb 2015, In : Stem Cells. 33, 2, p. 479-490 12 p.

    Research output: Contribution to journal › Article

  20. Published

    The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters

    Jon Frampton & 1 others, , Jan 2015, In : Cell Research. 25, 1, p. 80-92 13 p.

    Research output: Contribution to journal › Article

  21. 2014
  22. Published

    Transcriptional pause release is a rate-limiting step for somatic cell reprogramming

    Yuan Li & 12 others, , Jon Frampton, 6 Nov 2014, In : Cell stem cell. 15, 5, p. 574-88 15 p.

    Research output: Contribution to journal › Article

  23. Published

    RAG1/2 knockout pigs with severe combined immunodeficiency

    Jon Frampton, 1 Aug 2014, In : Journal of Immunology. 193, 3, p. 1496-503 8 p.

    Research output: Contribution to journal › Article

  24. Published

    Generation of knockout rabbits using transcription activator-like effector nucleases

    Philip Newsome, Jon Frampton, 5 Feb 2014, In : Cell Regeneration . 3, 3.

    Research output: Contribution to journal › Article

  25. 2013
  26. Published

    Crosstalk between mesenchymal stem cells and endothelial cells leads to down-regulation of cytokine-induced leukocyte recruitment

    Nguyet -Thin Luu, Helen McGettrick, Christopher Buckley, Philip Newsome, Ed Rainger, Jon Frampton & Gerard Nash, Dec 2013, In : Stem Cells. 31, 12, p. 2690-2702

    Research output: Contribution to journal › Article

  27. Published

    Multi-modal molecular diffuse optical tomography system for small animal imaging

    Hector Basevi, Jon Frampton, Iain Styles & Hamid Dehghani, 10 Sep 2013, In : Measurement Science and Technology. 24, 10, 22 p., 105405.

    Research output: Contribution to journal › Article

  28. Published

    Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging

    Hector Basevi, Hamid Dehghani, Iain Styles & Jon Frampton, 25 Jun 2013, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8799.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  29. Published

    C/EBPα and MYB regulate FLT3 expression in AML

    Giacomo Volpe, Paloma Garcia, Emilie Dasse, Laura O'Neill, Jon Frampton & Stephanie Dumon, 23 Jan 2013, In : Leukemia. 27, 7, p. 1487-1496 10 p.

    Research output: Contribution to journal › Article

  30. Published

    Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

    Jon Frampton, 2013, In : Nature Communications. 4, p. 2924

    Research output: Contribution to journal › Article

  31. Published

    Enhancing the adhesion of haematopoietic precursor cell integrins with hydrogen peroxide increases recruitment within murine gut

    Dean Kavanagh, Adrian Yemm, Jon Frampton & Neena Kalia, 2013, In : Cell transplantation. 22, 8, p. 1485-1499 15 p.

    Research output: Contribution to journal › Article

  32. Published

    Mechanisms of adhesion and subsequent actions of a haematopoietic stem cell line, HPC-7, in the injured murine intestinal microcirculation in vivo

    Dean Kavanagh, Adrian Yemm, Yan Zhao, Jon Frampton & Neena Kalia, 2013, In : PLoS ONE. 8, 3, p. e59150

    Research output: Contribution to journal › Article

  33. 2012
  34. Published

    The TspanC8 subgroup of tetraspanins interacts with a disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

    Elizabeth Haining, Steve Watson, Jon Frampton, Paloma Garcia & Michael Tomlinson, 16 Nov 2012, In : Journal of Biological Chemistry. 287, 47, p. 39753-39765 13 p.

    Research output: Contribution to journal › Article

  35. Published

    Human mesenchymal stem cells are recruited to injured liver in a β1-integrin and CD44 dependent manner

    Victoria Day, Abhilok Garg, Nick Davies, David Bartlett, Heather Beard, Dean Kavanagh, Neena Kalia, Jon Frampton, Trish Lalor & Philip Newsome, 1 Sep 2012, In : Hepatology. 56, 3, p. 1063-1073 11 p.

    Research output: Contribution to journal › Article

  36. Published

    Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells

    Emilie Dasse, Giacomo Volpe, Doug Walton, Neil Wilson, Walter Del Pozzo, Laura O'Neill, Jon Frampton & Stephanie Dumon, Jun 2012, In : Blood Cancer Journal. 2, 6, p. e76

    Research output: Contribution to journal › Article

  37. Published

    A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

    Jon Frampton, 1 Apr 2012, In : Science. 336, 6077, p. 86-90 5 p.

    Research output: Contribution to journal › Article

  38. Published

    Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation

    Stephanie Dumon, Emilie Dasse, Walter Del Pozzo, Bryan Turner, Laura O'Neill & Jon Frampton, 2012, In : PLoS ONE. 7, 8, p. e43300

    Research output: Contribution to journal › Article

  39. Published

    MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia

    Stephanie Dumon, Sylvie Freeman, Ban Dawood, Lozan Sheriff, Maelle Lorvellec, Jon Frampton & Paloma Garcia, 2012, In : Leukemia. 27, 3, p. 661-670 10 p.

    Research output: Contribution to journal › Article

  40. 2011
  41. Published

    Mesenchymal stem cells inhibit recruitment of flowing neutrophils and lymphocytes by endothelial cells: roles of interleukin-6 and transforming growth factor-{beta}

    Christopher Buckley, Nguyet -Thin Luu, Philip Newsome, Jon Frampton & Gerard Nash, Oct 2011.

    Research output: Contribution to conference (unpublished) › Poster

  42. Published

    c-Myb and GATA-1 alternate dominant roles during megakaryocyte differentiation

    Paloma Garcia & Jon Frampton, 1 Aug 2011, In : Journal of Thrombosis and Haemostasis. 9, 8, p. 1572-1581 10 p.

    Research output: Contribution to journal › Article

  43. Published

    Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region

    Jon Frampton, 1 Jun 2011, In : The Journal of Experimental Medicine. 208, 6, p. 1305-1315 11 p.

    Research output: Contribution to journal › Article

  44. Published

    Development of a multi-view, multi-spectral bioluminescence tomography small animal imaging system

    Hamid Dehghani, Hector Basevi, Iain Styles, Jon Frampton, 22 May 2011, p. 80881K.

    Research output: Contribution to conference (unpublished) › Paper

  45. Published

    EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wall

    Jon Frampton, 1 May 2011, In : Journal of Thrombosis and Haemostasis. 9, 5, p. 1007-1019 13 p.

    Research output: Contribution to journal › Article

  46. Published

    Professor Alan M Gewirtz (1949-2010) OBITUARY

    Jon Frampton, 1 May 2011, In : Oncogene. 30, 19, p. 2187-2187 1 p.

    Research output: Contribution to journal › Article

  47. 2010
  48. Published

    B-Myb is Critical for Proper Duplication During an Unperturbed s Phase in Mouse Embryonic Stem Cells.

    Maelle Lorvellec, Stephanie Dumon, Jon Frampton & Paloma Garcia, 16 Aug 2010, In : Stem Cells. 28, 10, p. 1751-1759 9 p.

    Research output: Contribution to journal › Article

  49. Published

    Critical roles for c-Myb in lymphoid priming and early B-cell development

    Jon Frampton, 1 Apr 2010, In : Blood. 115, 14, p. 2796-2805 10 p.

    Research output: Contribution to journal › Article

  50. Published

    Platelets contribute to postnatal occlusion of the ductus arteriosus

    Jon Frampton, 1 Jan 2010, In : Nature Medicine. 16, 1, p. 75-U111

    Research output: Contribution to journal › Article

  51. 2009
  52. Published

    Evidence That Integrin alpha IIb beta 3-dependent Interaction of Mast Cells with Fibrinogen Exacerbates Chronic Inflammation

    Jon Frampton, 1 Nov 2009, In : Journal of Biological Chemistry. 284, 45, p. 31463-31472 10 p.

    Research output: Contribution to journal › Article

  53. Published

    Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors

    Jon Frampton, 1 Jun 2009, In : Blood. 113, 23, p. 5783-5792 10 p.

    Research output: Contribution to journal › Article

  54. Published

    Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis.

    Paloma Garcia, Mary Clarke, Oscar Berlanga, Maelle Lorvellec & Jon Frampton, 20 May 2009, In : The EMBO journal. 28, 10, p. 1492-504 13 p.

    Research output: Contribution to journal › Article

  55. Published

    The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development

    Stephanie Dumon, Jon Frampton, 1 May 2009, In : Blood. 113, 22, p. 5456-5465 10 p.

    Research output: Contribution to journal › Article

  56. Published

    Haematopoietic stem cell recruitment to injured murine liver sinusoids depends on alpha(4)beta(1) integrin/VCAM-1 interactions

    Dean Kavanagh, Heather Beard, Trish Lalor, Jon Frampton, David Adams & Neena Kalia, 1 Jan 2009, In : Gut. 59, 1, p. 79-87 9 p.

    Research output: Contribution to journal › Article

  57. Published

    Platelet endothelial cell adhesion molecule (PECAM)-1 modulates SDF-1a/CXCR4 responses of hematopoietic stem cells

    Ewan Ross, Sylvie Freeman, Tarvinder Dhanjal, Sian Lax, Zubair Ahmed, Tiezheng Hou, Stuart Egginton, Gerard Nash, Steve Watson, Jon Frampton & Christopher Buckley, 1 Jan 2009, p. 450. 1 p.

    Research output: Contribution to conference (unpublished) › Abstract

  58. 2008
  59. Published

    A dual role for integrin-linked kinase in platelets: regulating integrin function and  -granule secretion

    Jon Frampton, 1 Dec 2008, In : Blood. 112, 12, p. 4523-4531 9 p.

    Research output: Contribution to journal › Article

  60. Published

    Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code

    Jon Frampton, 1 Dec 2008, In : Blood. 112, 12, p. 4512-4522 11 p.

    Research output: Contribution to journal › Article

  61. Published

    RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors In vivo and Results in Hemangioma Development

    Jon Frampton, 15 Jun 2008, In : Clinical Cancer Research. 14, 12, p. 3948-3955 8 p.

    Research output: Contribution to journal › Article

  62. Published

    A Novel Role for PECAM-1 (CD31) in Regulating Haematopoietic Progenitor Cell Compartmentalization between the Peripheral Blood and Bone Marrow

    Ewan Ross, Sylvie Freeman, Yan Zhao, Tarvinder Dhanjal, Sian Lax, Zubair Ahmed, Neena Kalia, Stuart Egginton, Gerard Nash, Steve Watson, Jon Frampton & Christopher Buckley, 4 Jun 2008, In : PLoS ONE. 3, 6, 10 p., e2338.

    Research output: Contribution to journal › Article

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