Jon Frampton
Publications
- Published
The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development
Stephanie Dumon, Jon Frampton, 1 May 2009, In: Blood. 113, 22, p. 5456-5465 10 p.Research output: Contribution to journal › Article
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Functional delivery of large genomic DNA to human cells with a peptide-lipid vector
Jon Frampton, 1 Oct 2003, In: Journal of Gene Medicine. 5, p. 883-892 10 p.Research output: Contribution to journal › Article
- Published
The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen
Steve Watson, Ben Atkinson, Oscar Berlanga & Jon Frampton, 1 Jul 2001, In: Journal of Thrombosis and Haemostasis. 86, 1, p. 276-88 13 p.Research output: Contribution to journal › Review article
- Published
Integrin a2b1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCg2
Steve Watson & Jon Frampton, 3 Mar 2003, In: Journal of Cell Biology. 160, 5, p. 769-780 12 p.Research output: Contribution to journal › Article
- Published
- Published
Thrombin-induced conversion of fibrinogen to fibrin results in rapid platelet trapping which is not dependent on platelet activation of GPIb
Steve Watson & Jon Frampton, 1 Feb 2003, In: British Journal of Pharmacology. 138, 4, p. 574-583 10 p.Research output: Contribution to journal › Article
- Published
Author Correction: High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia (Scientific Reports, (2020), 10, 1, (3505), 10.1038/s41598-020-60480-x)
Pierre Cauchy, Paloma Garcia, Jon Frampton & Giacomo Volpe, 1 Dec 2020, In: Scientific Reports. 10, 1, 13109.Research output: Contribution to journal › Comment/debate › peer-review
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High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia
Paloma Garcia, Jon Frampton, 26 Feb 2020, In: Scientific Reports. 10, 1, 3505.Research output: Contribution to journal › Article › peer-review
- Published
Fine-tuning Mybl2 is required for proper mesenchymal-to-epithelial transition during somatic reprogramming
Carl Ward, Giacomo Volpe, Pierre Cauchy, Anetta Ptasinska, Jon Frampton & Paloma Garcia, 7 Aug 2018, In: Cell Reports. 24, 6, p. 1496-1511.e8 24 p.Research output: Contribution to journal › Article › peer-review
- Published
Generation of knockout rabbits using transcription activator-like effector nucleases
Philip Newsome, Jon Frampton, 5 Feb 2014, In: Cell Regeneration . 3, 3.Research output: Contribution to journal › Article › peer-review
- Published
- Published
Regulation of the Flt3 gene in haematopoietic stem and early progenitor cells
Giacomo Volpe, Mary Clarke, Paloma Garcia, Alexandros Vegiopoulos, Walter Del Pozzo, Jon Frampton & Stephanie Dumon, 18 Sep 2015, In: PLoS ONE. 10, 9, e0138257.Research output: Contribution to journal › Article › peer-review
- Published
Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature
Giacomo Volpe, David Grainger, Carl Ward, Pierre Cauchy, Daniel Coleman, Peter Cockerill, Paloma Garcia & Jon Frampton, 11 Sep 2017, In: Scientific Reports. 7, 11148.Research output: Contribution to journal › Article › peer-review
- Published
Coordination of erythropoiesis by the transcription factor c-Myb
Alexandros Vegiopoulos, Paloma Garcia & Jon Frampton, 15 Jun 2006, In: Blood. 107, 12, p. 4703-10 8 p.Research output: Contribution to journal › Article
- Published
Transcriptional regulation by c-Myb could be a major factor distinguishing the erythroid and megakaryocytic lineages
Alexandros Vegiopoulos, Jon Frampton & Jon Frampton, 1 Jan 2003, In Myb Transcription Factors: Their Role in Growth, Differentiation and Disease.Research output: Chapter in Book/Report/Conference proceeding › Chapter
- Published
Targeting the transcription factor Myb by small-molecule inhibitors
Jon Frampton, 1 Mar 2017, In: Experimental Hematology. 47, p. 31-35Research output: Contribution to journal › Article › peer-review
- E-pub ahead of print
Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction
Emilie Dasse, Jon Frampton, 2 Dec 2015, In: Blood.Research output: Contribution to journal › Article › peer-review
- Published
A dual role for integrin-linked kinase in platelets: regulating integrin function and -granule secretion
Jon Frampton, 1 Dec 2008, In: Blood. 112, 12, p. 4523-4531 9 p.Research output: Contribution to journal › Article
- Published
Targeting an E2F site in the mouse genome prevents promoter silencing in quiescent and post-mitotic cells
Fiona Tavner, Jon Frampton, 30 Oct 2006, In: Oncogene. 26, 19, p. 2727-35 9 p.Research output: Contribution to journal › Article
- Published
Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level
Jon Frampton, 2013, In: Nature Communications. 4, p. 2924Research output: Contribution to journal › Article › peer-review
- Published
Phospholipase Cg2-independent activation of integrins by GPVI in murine platelets: involvement of phospholipase Cg1 and PI3-kinase. (In Press)
Jon Frampton, 1 Jan 2002, In: Blood.Research output: Contribution to journal › Article
- Published
Murine GPVI stimulates weak integrin activation in PLC gamma 2-/- platelets: involvement of PLC gamma 1 and PI3-kinase
Jon Frampton & Steve Watson, 1 Aug 2003, In: Blood. 102, 4, p. 1367-1373 7 p.Research output: Contribution to journal › Article
- Published
Harnessing genomics to improve outcomes for women with cancer in India: key priorities for research
Sudha Sundar, Jean-Baptiste Cazier & Jon Frampton, 15 Feb 2018, In: The Lancet Oncology. 19, 2, p. e102–e112Research output: Contribution to journal › Article › peer-review
- Published
Inducible disruption of the c-myb gene allows allogeneic bone marrow transplantation without irradiation
Jon Frampton, 1 Jun 2018, In: Journal of Immunological Methods. 457, p. 66-72Research output: Contribution to journal › Article › peer-review
- Published
Origin-specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence their Behaviour After Infusion.
Julie Rayes, Stephen Watson, Philip Newsome, Neena Kalia, Jon Frampton, Helen McGettrick & Gerard Nash, Feb 2018, In: Stem cells (Dayton, Ohio).Research output: Contribution to journal › Article › peer-review
- Published
A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein
Yotis Senis, Michael Tomlinson, Stephanie Dumon, Victoria Heath, Jennifer Spalton, Roy Bicknell, Jon Frampton, Ashley Martin, Mike Wakelam & Steve Watson, 27 Dec 2006, In: Molecular and Cellular Proteomics. 6, p. 548-564 17 p.Research output: Contribution to journal › Article
- Published
EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wall
Jon Frampton, 1 May 2011, In: Journal of Thrombosis and Haemostasis. 9, 5, p. 1007-1019 13 p.Research output: Contribution to journal › Article › peer-review
- Published
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Jon Frampton, 1 Apr 2012, In: Science. 336, 6077, p. 86-90 5 p.Research output: Contribution to journal › Article › peer-review
- Published
CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex
Giacomo Volpe, Jon Frampton, Jul 2019, In: Leukemia. 33, p. 1608-1619 12 p.Research output: Contribution to journal › Article › peer-review
- Published
RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors In vivo and Results in Hemangioma Development
Jon Frampton, 15 Jun 2008, In: Clinical Cancer Research. 14, 12, p. 3948-3955 8 p.Research output: Contribution to journal › Article
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Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development
Jon Frampton, 1 Aug 2006, In: Blood. 108, 3, p. 896-903 8 p.Research output: Contribution to journal › Article
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Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes
Paloma Garcia, Jon Frampton, Feb 2015, In: Stem Cells. 33, 2, p. 479-490 12 p.Research output: Contribution to journal › Article › peer-review
- Published
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region
Jon Frampton, 1 Jun 2011, In: The Journal of Experimental Medicine. 208, 6, p. 1305-1315 11 p.Research output: Contribution to journal › Article › peer-review
- Published
Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 modulates SDF-1alpha/CXCR4 responses of hematopoietic stem cells
Ewan Ross, Sian Lax, Tiezheng Hou, Sylvie Freeman, Stuart Egginton, Tarvinder Dhanjal, Mike Salmon, Steve Watson, Gerard Nash, Jon Frampton & Christopher Buckley, 1 Jan 2006.Research output: Contribution to conference (unpublished) › Abstract
- Published
A Novel Role for PECAM-1 (CD31) in Regulating Haematopoietic Progenitor Cell Compartmentalization between the Peripheral Blood and Bone Marrow
Ewan Ross, Sylvie Freeman, Yan Zhao, Tarvinder Dhanjal, Sian Lax, Zubair Ahmed, Neena Kalia, Stuart Egginton, Gerard Nash, Steve Watson, Jon Frampton & Christopher Buckley, 4 Jun 2008, In: PLoS ONE. 3, 6, 10 p., e2338.Research output: Contribution to journal › Article › peer-review
- Published
Platelet endothelial cell adhesion molecule (PECAM)-1 modulates SDF-1a/CXCR4 responses of hematopoietic stem cells
Ewan Ross, Sylvie Freeman, Tarvinder Dhanjal, Sian Lax, Zubair Ahmed, Tiezheng Hou, Stuart Egginton, Gerard Nash, Steve Watson, Jon Frampton & Christopher Buckley, 1 Jan 2009, p. 450. 1 p.Research output: Contribution to conference (unpublished) › Abstract
- Published
Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code
Jon Frampton, 1 Dec 2008, In: Blood. 112, 12, p. 4512-4522 11 p.Research output: Contribution to journal › Article
- Published
The heptapeptide LSARLAF mediates platelet activation through phospholipase Cy 2 independently of glycoprotein 11b-111a
Andrew Pearce, Steve Watson & Jon Frampton, 15 Feb 2004, In: Biochemical Journal. 378, 1, p. 193-199 7 p.Research output: Contribution to journal › Article
- Published
Evidence That Integrin alpha IIb beta 3-dependent Interaction of Mast Cells with Fibrinogen Exacerbates Chronic Inflammation
Jon Frampton, 1 Nov 2009, In: Journal of Biological Chemistry. 284, 45, p. 31463-31472 10 p.Research output: Contribution to journal › Article
- Published
- Published
Platelets secrete stromal cell-derived factor 1 and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo
& 1 others, , 17 Apr 2006, In: The Journal of Experimental Medicine. 203, 5, p. 1221-33 13 p.Research output: Contribution to journal › Article
- Published
Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb
Jon Frampton, 23 Aug 2005, In: Circulation. 112, p. 1180-8 9 p.Research output: Contribution to journal › Article
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c-Myb and CREB function in adult neurogenesis
Jon Frampton & Jon Frampton, 1 Jan 2004, Myb Transcription Factors: Their Role in Growth, Differentiation and Disease.Research output: Chapter in Book/Report/Conference proceeding › Chapter
- Published
c-Myb is required for progenitor cell homeostasis in colonic crypts
John Heath, Jon Frampton, 6 Mar 2007, In: National Academy of Sciences. Proceedings. 104, 10, p. 3829-34 6 p.Research output: Contribution to journal › Article
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c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain
Jon Frampton, 29 Nov 2007, In: Stem Cells. 26, 1, p. 173-81 9 p.Research output: Contribution to journal › Article
- Published
Crosstalk between mesenchymal stem cells and endothelial cells leads to down-regulation of cytokine-induced leukocyte recruitment
Nguyet -Thin Luu, Helen McGettrick, Christopher Buckley, Philip Newsome, Ed Rainger, Jon Frampton & Gerard Nash, Dec 2013, In: Stem Cells. 31, 12, p. 2690-2702Research output: Contribution to journal › Article › peer-review
- Published
Characterization of the c-Myb-responsive Region and Regulation of the Human Type I Collagen alpha 2 Chain Gene by c-Myb
Jon Frampton, 10 Jan 2003, In: Journal of Biological Chemistry. 278, 3, p. 1533-1541 9 p.Research output: Contribution to journal › Article
- Published
- Published
B-Myb is Critical for Proper Duplication During an Unperturbed s Phase in Mouse Embryonic Stem Cells.
Maelle Lorvellec, Stephanie Dumon, Jon Frampton & Paloma Garcia, 16 Aug 2010, In: Stem Cells. 28, 10, p. 1751-1759 9 p.Research output: Contribution to journal › Article › peer-review
- Published
Transcriptional pause release is a rate-limiting step for somatic cell reprogramming
Yuan Li & 12 others, , 6 Nov 2014, In: Cell stem cell. 15, 5, p. 574-88 15 p.Research output: Contribution to journal › Article › peer-review