Jon Frampton

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Publications

  1. Published

    The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development

    Stephanie Dumon, Jon Frampton, 1 May 2009, In: Blood. 113, 22, p. 5456-5465 10 p.

    Research output: Contribution to journal › Article

  2. Published

    Functional delivery of large genomic DNA to human cells with a peptide-lipid vector

    Jon Frampton, 1 Oct 2003, In: Journal of Gene Medicine. 5, p. 883-892 10 p.

    Research output: Contribution to journal › Article

  3. Published

    The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

    Steve Watson, Ben Atkinson, Oscar Berlanga & Jon Frampton, 1 Jul 2001, In: Journal of Thrombosis and Haemostasis. 86, 1, p. 276-88 13 p.

    Research output: Contribution to journal › Review article

  4. Published

    Integrin a2b1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCg2

    Steve Watson & Jon Frampton, 3 Mar 2003, In: Journal of Cell Biology. 160, 5, p. 769-780 12 p.

    Research output: Contribution to journal › Article

  5. Published

    Evaluation of the role of platelet integrins in fibronectindependent spreading and adhesion

    Steve Watson, Owen McCarty, Laura Machesky & Jon Frampton, 1 Oct 2004, In: Journal of Thrombosis and Haemostasis. 2, 10, p. 1823-1833 11 p.

    Research output: Contribution to journal › Article

  6. Published

    Thrombin-induced conversion of fibrinogen to fibrin results in rapid platelet trapping which is not dependent on platelet activation of GPIb

    Steve Watson & Jon Frampton, 1 Feb 2003, In: British Journal of Pharmacology. 138, 4, p. 574-583 10 p.

    Research output: Contribution to journal › Article

  7. Published

    Author Correction: High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia (Scientific Reports, (2020), 10, 1, (3505), 10.1038/s41598-020-60480-x)

    Pierre Cauchy, Paloma Garcia, Jon Frampton & Giacomo Volpe, 1 Dec 2020, In: Scientific Reports. 10, 1, 13109.

    Research output: Contribution to journal › Comment/debate › peer-review

  8. Published

    High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia

    Paloma Garcia, Jon Frampton, 26 Feb 2020, In: Scientific Reports. 10, 1, 3505.

    Research output: Contribution to journal › Article › peer-review

  9. Published

    Fine-tuning Mybl2 is required for proper mesenchymal-to-epithelial transition during somatic reprogramming

    Carl Ward, Giacomo Volpe, Pierre Cauchy, Anetta Ptasinska, Jon Frampton & Paloma Garcia, 7 Aug 2018, In: Cell Reports. 24, 6, p. 1496-1511.e8 24 p.

    Research output: Contribution to journal › Article › peer-review

  10. Published

    Generation of knockout rabbits using transcription activator-like effector nucleases

    Philip Newsome, Jon Frampton, 5 Feb 2014, In: Cell Regeneration . 3, 3.

    Research output: Contribution to journal › Article › peer-review

  11. Published

    C/EBPα and MYB regulate FLT3 expression in AML

    Giacomo Volpe, Paloma Garcia, Emilie Dasse, Laura O'Neill, Jon Frampton & Stephanie Dumon, 23 Jan 2013, In: Leukemia. 27, 7, p. 1487-1496 10 p.

    Research output: Contribution to journal › Article › peer-review

  12. Published

    Regulation of the Flt3 gene in haematopoietic stem and early progenitor cells

    Giacomo Volpe, Mary Clarke, Paloma Garcia, Alexandros Vegiopoulos, Walter Del Pozzo, Jon Frampton & Stephanie Dumon, 18 Sep 2015, In: PLoS ONE. 10, 9, e0138257.

    Research output: Contribution to journal › Article › peer-review

  13. Published

    Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature

    Giacomo Volpe, David Grainger, Carl Ward, Pierre Cauchy, Daniel Coleman, Peter Cockerill, Paloma Garcia & Jon Frampton, 11 Sep 2017, In: Scientific Reports. 7, 11148.

    Research output: Contribution to journal › Article › peer-review

  14. Published

    Coordination of erythropoiesis by the transcription factor c-Myb

    Alexandros Vegiopoulos, Paloma Garcia & Jon Frampton, 15 Jun 2006, In: Blood. 107, 12, p. 4703-10 8 p.

    Research output: Contribution to journal › Article

  15. Published

    Transcriptional regulation by c-Myb could be a major factor distinguishing the erythroid and megakaryocytic lineages

    Alexandros Vegiopoulos, Jon Frampton & Jon Frampton, 1 Jan 2003, In Myb Transcription Factors: Their Role in Growth, Differentiation and Disease.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  16. Published

    Targeting the transcription factor Myb by small-molecule inhibitors

    Jon Frampton, 1 Mar 2017, In: Experimental Hematology. 47, p. 31-35

    Research output: Contribution to journal › Article › peer-review

  17. E-pub ahead of print

    Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

    Emilie Dasse, Jon Frampton, 2 Dec 2015, In: Blood.

    Research output: Contribution to journal › Article › peer-review

  18. Published

    A dual role for integrin-linked kinase in platelets: regulating integrin function and  -granule secretion

    Jon Frampton, 1 Dec 2008, In: Blood. 112, 12, p. 4523-4531 9 p.

    Research output: Contribution to journal › Article

  19. Published

    Targeting an E2F site in the mouse genome prevents promoter silencing in quiescent and post-mitotic cells

    Fiona Tavner, Jon Frampton, 30 Oct 2006, In: Oncogene. 26, 19, p. 2727-35 9 p.

    Research output: Contribution to journal › Article

  20. Published

    Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

    Jon Frampton, 2013, In: Nature Communications. 4, p. 2924

    Research output: Contribution to journal › Article › peer-review

  21. Published

    Phospholipase Cg2-independent activation of integrins by GPVI in murine platelets: involvement of phospholipase Cg1 and PI3-kinase. (In Press)

    Jon Frampton, 1 Jan 2002, In: Blood.

    Research output: Contribution to journal › Article

  22. Published

    Murine GPVI stimulates weak integrin activation in PLC gamma 2-/- platelets: involvement of PLC gamma 1 and PI3-kinase

    Jon Frampton & Steve Watson, 1 Aug 2003, In: Blood. 102, 4, p. 1367-1373 7 p.

    Research output: Contribution to journal › Article

  23. Published

    Harnessing genomics to improve outcomes for women with cancer in India: key priorities for research

    Sudha Sundar, Jean-Baptiste Cazier & Jon Frampton, 15 Feb 2018, In: The Lancet Oncology. 19, 2, p. e102–e112

    Research output: Contribution to journal › Article › peer-review

  24. Published

    Inducible disruption of the c-myb gene allows allogeneic bone marrow transplantation without irradiation

    Jon Frampton, 1 Jun 2018, In: Journal of Immunological Methods. 457, p. 66-72

    Research output: Contribution to journal › Article › peer-review

  25. Published

    Origin-specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence their Behaviour After Infusion.

    Julie Rayes, Stephen Watson, Philip Newsome, Neena Kalia, Jon Frampton, Helen McGettrick & Gerard Nash, Feb 2018, In: Stem cells (Dayton, Ohio).

    Research output: Contribution to journal › Article › peer-review

  26. Published

    A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein

    Yotis Senis, Michael Tomlinson, Stephanie Dumon, Victoria Heath, Jennifer Spalton, Roy Bicknell, Jon Frampton, Ashley Martin, Mike Wakelam & Steve Watson, 27 Dec 2006, In: Molecular and Cellular Proteomics. 6, p. 548-564 17 p.

    Research output: Contribution to journal › Article

  27. Published

    EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wall

    Jon Frampton, 1 May 2011, In: Journal of Thrombosis and Haemostasis. 9, 5, p. 1007-1019 13 p.

    Research output: Contribution to journal › Article › peer-review

  28. Published

    A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

    Jon Frampton, 1 Apr 2012, In: Science. 336, 6077, p. 86-90 5 p.

    Research output: Contribution to journal › Article › peer-review

  29. Published

    CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex

    Giacomo Volpe, Jon Frampton, Jul 2019, In: Leukemia. 33, p. 1608-1619 12 p.

    Research output: Contribution to journal › Article › peer-review

  30. Published

    RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors In vivo and Results in Hemangioma Development

    Jon Frampton, 15 Jun 2008, In: Clinical Cancer Research. 14, 12, p. 3948-3955 8 p.

    Research output: Contribution to journal › Article

  31. Published

    Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development

    Jon Frampton, 1 Aug 2006, In: Blood. 108, 3, p. 896-903 8 p.

    Research output: Contribution to journal › Article

  32. Published

    Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

    Paloma Garcia, Jon Frampton, Feb 2015, In: Stem Cells. 33, 2, p. 479-490 12 p.

    Research output: Contribution to journal › Article › peer-review

  33. Published

    Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region

    Jon Frampton, 1 Jun 2011, In: The Journal of Experimental Medicine. 208, 6, p. 1305-1315 11 p.

    Research output: Contribution to journal › Article › peer-review

  34. Published

    Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 modulates SDF-1alpha/CXCR4 responses of hematopoietic stem cells

    Ewan Ross, Sian Lax, Tiezheng Hou, Sylvie Freeman, Stuart Egginton, Tarvinder Dhanjal, Mike Salmon, Steve Watson, Gerard Nash, Jon Frampton & Christopher Buckley, 1 Jan 2006.

    Research output: Contribution to conference (unpublished) › Abstract

  35. Published

    A Novel Role for PECAM-1 (CD31) in Regulating Haematopoietic Progenitor Cell Compartmentalization between the Peripheral Blood and Bone Marrow

    Ewan Ross, Sylvie Freeman, Yan Zhao, Tarvinder Dhanjal, Sian Lax, Zubair Ahmed, Neena Kalia, Stuart Egginton, Gerard Nash, Steve Watson, Jon Frampton & Christopher Buckley, 4 Jun 2008, In: PLoS ONE. 3, 6, 10 p., e2338.

    Research output: Contribution to journal › Article › peer-review

  36. Published

    Platelet endothelial cell adhesion molecule (PECAM)-1 modulates SDF-1a/CXCR4 responses of hematopoietic stem cells

    Ewan Ross, Sylvie Freeman, Tarvinder Dhanjal, Sian Lax, Zubair Ahmed, Tiezheng Hou, Stuart Egginton, Gerard Nash, Steve Watson, Jon Frampton & Christopher Buckley, 1 Jan 2009, p. 450. 1 p.

    Research output: Contribution to conference (unpublished) › Abstract

  37. Published

    Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code

    Jon Frampton, 1 Dec 2008, In: Blood. 112, 12, p. 4512-4522 11 p.

    Research output: Contribution to journal › Article

  38. Published

    The heptapeptide LSARLAF mediates platelet activation through phospholipase Cy 2 independently of glycoprotein 11b-111a

    Andrew Pearce, Steve Watson & Jon Frampton, 15 Feb 2004, In: Biochemical Journal. 378, 1, p. 193-199 7 p.

    Research output: Contribution to journal › Article

  39. Published

    Evidence That Integrin alpha IIb beta 3-dependent Interaction of Mast Cells with Fibrinogen Exacerbates Chronic Inflammation

    Jon Frampton, 1 Nov 2009, In: Journal of Biological Chemistry. 284, 45, p. 31463-31472 10 p.

    Research output: Contribution to journal › Article

  40. Published

    Manipulation of mouse hematopoietic progenitors by specific retroviral infection

    George Murphy, Alexandros Vegiopoulos, Steve Watson & Jon Frampton, 1 Oct 2003, In: Journal of Biological Chemistry. 278, 44, p. 43556-43563 8 p.

    Research output: Contribution to journal › Article

  41. Published

    Platelets secrete stromal cell-derived factor 1  and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo

    & 1 others, Jon Frampton, 17 Apr 2006, In: The Journal of Experimental Medicine. 203, 5, p. 1221-33 13 p.

    Research output: Contribution to journal › Article

  42. Published

    Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb

    Jon Frampton, 23 Aug 2005, In: Circulation. 112, p. 1180-8 9 p.

    Research output: Contribution to journal › Article

  43. Published

    c-Myb and CREB function in adult neurogenesis

    Jon Frampton & Jon Frampton, 1 Jan 2004, Myb Transcription Factors: Their Role in Growth, Differentiation and Disease.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  44. Published

    c-Myb is required for progenitor cell homeostasis in colonic crypts

    John Heath, Jon Frampton, 6 Mar 2007, In: National Academy of Sciences. Proceedings. 104, 10, p. 3829-34 6 p.

    Research output: Contribution to journal › Article

  45. Published

    c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain

    Jon Frampton, 29 Nov 2007, In: Stem Cells. 26, 1, p. 173-81 9 p.

    Research output: Contribution to journal › Article

  46. Published

    Crosstalk between mesenchymal stem cells and endothelial cells leads to down-regulation of cytokine-induced leukocyte recruitment

    Nguyet -Thin Luu, Helen McGettrick, Christopher Buckley, Philip Newsome, Ed Rainger, Jon Frampton & Gerard Nash, Dec 2013, In: Stem Cells. 31, 12, p. 2690-2702

    Research output: Contribution to journal › Article › peer-review

  47. Published

    Characterization of the c-Myb-responsive Region and Regulation of the Human Type I Collagen alpha 2 Chain Gene by c-Myb

    Jon Frampton, 10 Jan 2003, In: Journal of Biological Chemistry. 278, 3, p. 1533-1541 9 p.

    Research output: Contribution to journal › Article

  48. Published

    Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

    Kate Lowe, Brenda Finney, Jon Frampton, Christopher Buckley & Steve Watson, 11 Jun 2015, In: Blood. 125, 24, p. 3769-3777 9 p.

    Research output: Contribution to journal › Article › peer-review

  49. Published

    B-Myb is Critical for Proper Duplication During an Unperturbed s Phase in Mouse Embryonic Stem Cells.

    Maelle Lorvellec, Stephanie Dumon, Jon Frampton & Paloma Garcia, 16 Aug 2010, In: Stem Cells. 28, 10, p. 1751-1759 9 p.

    Research output: Contribution to journal › Article › peer-review

  50. Published

    Transcriptional pause release is a rate-limiting step for somatic cell reprogramming

    Yuan Li & 12 others, , Jon Frampton, 6 Nov 2014, In: Cell stem cell. 15, 5, p. 574-88 15 p.

    Research output: Contribution to journal › Article › peer-review

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