John Curnow

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Publications

  1. 2021
  2. Published

    Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation

    Alexander Roberts, Tina Tang, Chiara Pallini, Graham Wallace, Alison Cooper, Aaron Scott, David Thickett, Sebastian Lugg, Thomas Pinkney, Graham Taylor, Kristian Brock, Zania Stamataki, John Curnow, John Gordon, Omar Qureshi, Nicholas Barnes & 7 others, , 17 Feb 2021, In: Scientific Reports. 11, 1, 4030.

    Research output: Contribution to journal › Article › peer-review

  3. 2018
  4. E-pub ahead of print

    Cerebrospinal fluid immunoglobulin light chain ratios predict disease progression in multiple sclerosis

    John Curnow, Ghaniah Hassan-Smith & Michael Douglas, 9 May 2018, In: Journal of Neurology, Neurosurgery & Psychiatry.

    Research output: Contribution to journal › Article › peer-review

  5. 2017
  6. Published

    N-glycosylation and expression in human tissues of the orphan GPR61 receptor

    Gillian Grafton, Alison Cooper, John Curnow & Nicholas Barnes, 1 Dec 2017, In: FEBS Open Bio. 7, 12, p. 1982-1993 12 p.

    Research output: Contribution to journal › Article › peer-review

  7. Published

    CCR6+ Th cells in the cerebrospinal fluid of persons with multiple sclerosis are dominated by pathogenic non-classic Th1 cells and GM-CSF-only-secreting Th cells

    Ghaniah Hassan-Smith, Michael Douglas & John Curnow, Aug 2017, In: Brain, Behaviour, and Immunity. 64, p. 71-79

    Research output: Contribution to journal › Article › peer-review

  8. Published

    Inosine Acedoben Dimepranol promotes an early and sustained increase in the natural killer cell component of circulating lymphocytes: a clinical trial supporting anti-viral indications

    Amy Newman, Gillian Grafton, John Curnow, Nicholas Barnes & John Gordon, Jan 2017, In: International Immunopharmacology. 42, p. 108-114

    Research output: Contribution to journal › Article › peer-review

  9. 2016
  10. Published

    Conjunctival neutrophils predict progressive scarring in Ocular Mucous Membrane Pemphigoid

    John Curnow & Saaeha Rauz, 1 Oct 2016, In: Investigative Ophthalmology & Visual Science (IOVS). 57, 13, p. 5457-5469

    Research output: Contribution to journal › Article › peer-review

  11. 2015
  12. E-pub ahead of print

    Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors

    Gillian Grafton, John Curnow & Nicholas Barnes, 17 Oct 2015, In: The Journal of Steroid Biochemistry and Molecular Biology.

    Research output: Contribution to journal › Article › peer-review

  13. Published

    Association analysis of TGFBR3 gene with Behçet's disease and idiopathic intermediate uveitis in a Caucasian population

    Robert Barry, Phil Murray, John Curnow & Graham Wallace, May 2015, In: British Journal of Ophthalmology. 99, 5, p. 696-9 4 p.

    Research output: Contribution to journal › Article › peer-review

  14. 2014
  15. Published

    Cytokine production and antigen recognition by human mucosal homing conjunctival effector memory CD8+ T cells

    Geraint Williams, Annette Pachnio, Heather Long, Saaeha Rauz & John Curnow, 29 Dec 2014, In: Investigative Ophthalmology & Visual Science (IOVS). 55, 12, p. 8523-8530 8 p.

    Research output: Contribution to journal › Article › peer-review

  16. Published

    High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

    Ghaniah Hassan-Smith, Lakhvir Assi, Jeffrey Faint, Michael Douglas & John Curnow, 15 Nov 2014, In: Journal of Neuroimmunology. 276, 1-2, p. 175-179 5 p.

    Research output: Contribution to journal › Article › peer-review

  17. 2013
  18. Published

    Elevation of conjunctival epithelial CD45INTCD11b⁺CD16⁺CD14⁻ neutrophils in ocular Stevens-Johnson syndrome and toxic epidermal necrolysis

    Geraint Williams, Paul Tomlins, Alastair Denniston, John Curnow & Saaeha Rauz, 10 Jul 2013, In: Investigative Ophthalmology & Visual Science (IOVS). 54, 7, p. 4578-4585

    Research output: Contribution to journal › Article › peer-review

  19. Published

    Cell-intrinsic regulation of murine dendritic cell function and survival by pre-receptor amplification of glucocorticoid

    Annelise Soulier, Elizabeth Rabbitt, Paul Stewart, Gareth Lavery, John Curnow & Ronjon Chakraverty, 2013, In: Blood.

    Research output: Contribution to journal › Article › peer-review

  20. 2012
  21. Published

    The dominant human conjunctival epithelial CD8αβ+ T cell population is maintained with age but the number of CD4+ T cells increases

    Geraint Williams, Alastair Denniston, Paul Tomlins, Robert Barry, Saaeha Rauz & John Curnow, 1 Dec 2012, In: Age (Dordrecht, Netherlands). 34, 6, p. 1517-1528

    Research output: Contribution to journal › Article › peer-review

  22. Published

    Aqueous Humor Suppression of Dendritic Cell Function Helps Maintain Immune Regulation in the Eye during Human Uveitis.

    Alastair Denniston, Paul Tomlins, Geraint Williams, Graham Wallace, Saaeha Rauz, Phil Murray & John Curnow, 1 Jan 2012, In: Investigative Ophthalmology & Visual Science (IOVS). 53, 2, p. 888-96 9 p.

    Research output: Contribution to journal › Article

  23. 2011
  24. Published

    The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue

    Esther Hidalgo, Sarah Essex, Lorraine Yeo, John Curnow, Andrew Filer, Mark Cooper, Helen McGettrick, Mike Salmon, Christopher Buckley, Karim Raza & Dagmar Scheel-Toellner, 1 Nov 2011, In: Arthritis & Rheumatism. 63, 11, p. 3284-93 10 p.

    Research output: Contribution to journal › Article › peer-review

  25. Published

    A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease

    John Curnow, Laura O'Neill, Stuart Egginton & Francesco Falciani, 1 Sep 2011, In: PLoS Computational Biology. 7, 9, p. e1002129

    Research output: Contribution to journal › Article

  26. Published

    Bridging innate and adaptive immunity: removing the toll

    John Curnow & Graham Wallace, 1 Aug 2011, In: Current Opinion in Pharmacology. 11, 4, p. 395-396 2 p.

    Research output: Contribution to journal › Editorial

  27. Published

    Intraocular immune mechanisms in Uveitis

    John Curnow, Alastair Denniston, Phil Murray & Graham Wallace, 1 Aug 2011, In: Current Immunology Reviews. 7, 3, p. 350-359 10 p.

    Research output: Contribution to journal › Review article › peer-review

  28. Published

    The stromal cell antigen CD248 (endosialin) is expressed on naive CD8(+) human T cells and regulates proliferation.

    Debbie Hardie, Amy Naylor, Tiezheng Hou, Sian Lax, John Curnow & Christopher Buckley, Jul 2011, In: Immunology. 133, 3, p. 288-295 8.

    Research output: Contribution to journal › Article › peer-review

  29. Published

    Validation of a fornix depth measurer : a putative tool for the assessment of progressive cicatrising conjunctivitis

    Geraint Williams, John Curnow, Peter Nightingale & Saaeha Rauz, Jun 2011, In: British Journal of Ophthalmology. 95, 6, p. 842-847 6 p.

    Research output: Contribution to journal › Article › peer-review

  30. 2010
  31. Published

    Endogenous Cortisol and TGF-  in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell Function

    Alastair Denniston, Geraint Williams, Saaeha Rauz, Phil Murray & John Curnow, 24 Nov 2010, In: Journal of Immunology.

    Research output: Contribution to journal › Article

  32. Published

    Expression of 5-HT3A receptors by human immune cells: impact of physiological activation

    Amy Newman, John Curnow, John Gordon & Nicholas Barnes, 1 Jul 2010.

    Research output: Contribution to conference (unpublished) › Paper

  33. Published

    Dynamic regulation of spinal pro-inflammatory cytokine release in the rat in vivo following peripheral nerve injury.

    Kevin Whitehead, John Curnow, 1 May 2010, In: Brain, Behaviour, and Immunity. 24, 4, p. 569-576 8 p.

    Research output: Contribution to journal › Article

  34. Published

    Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum

    John Curnow, Caroline Schmutz, Alastair Denniston, Christopher Buckley, Janet Lord, 18 Mar 2010, In: PLoS ONE. 5, 3, p. e9730

    Research output: Contribution to journal › Article › peer-review

  35. 2009
  36. Published

    The Role of 11ss-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy

    Jeremy Tomlinson, Iwona Bujalska, Laura Gathercole, Paul Tomlins, John Curnow, Paul Stewart, Elizabeth Walker & Saaeha Rauz, 30 Oct 2009, In: Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 398-406 9 p.

    Research output: Contribution to journal › Article

  37. Published

    107 Neurone-Glia Signalling Underlies Spinal Pro-Inflammatory Cytokine Release Evoked By Primary Afferent Stimulation in the Neuropathic Rat

    Kevin Whitehead, John Curnow, 1 Sep 2009, In: European Journal of Pain. 13, p. S40-S40

    Research output: Contribution to journal › Article

  38. Published

    Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging

    John Curnow, Christopher Buckley, 1 Aug 2009, In: The Journal of Experimental Medicine. 206, 9, p. 1929-1940 12 p.

    Research output: Contribution to journal › Article › peer-review

  39. Published

    Cytokine and chemokine levels in tears and in corneal fibroblast cultures before and after excimer laser treatment

    John Curnow, 1 Feb 2009, In: Journal of cataract and refractive surgery. 35, 2, p. 240-247 8 p.

    Research output: Contribution to journal › Article

  40. Published

    A threshold level of TLR9 mRNA predicts cellular responsiveness to CpG-ODN in haematological and non-haematological tumour cell lines

    John Curnow, 1 Jan 2009, In: Cellular Immunology. 259, 1, p. 90-99 10 p.

    Research output: Contribution to journal › Article

  41. 2008
  42. Published

    Serum cytokine profiles in Behçet's disease: is there a role for IL-15 in pathogenesis?

    John Curnow, Phil Murray & Graham Wallace, 16 Nov 2008, In: Immunology Letters. 121, 1, p. 7-12 6 p.

    Research output: Contribution to journal › Article

  43. Published

    Exploring the pathogenesis of idiopathic intracranial hypertension:: An inflammatory perspective

    Alex Sinclair, Alexandra Ball, Carl E Clarke, Paul Stewart, John Curnow & Saaeha Rauz, 15 Sep 2008, In: Journal of Neuroimmunology. 201-202, p. 212-220 9 p.

    Research output: Contribution to journal › Article

  44. Published

    Elevated CSF leptin in idiopathic intracranial hypertension: evidence for hypothalamic leptin resistance?

    Alexandra Ball, Alex Sinclair, John Curnow, Jeremy Tomlinson, Elizabeth Walker, Paul Stewart, Peter Nightingale, Carl E Clarke & Saaeha Rauz, 1 Sep 2008, In: Clinical Endocrinology. 70, p. 863-869 7 p.

    Research output: Contribution to journal › Article

  45. Published

    Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis

    Dagmar Scheel-Toellner, Karim Raza, Darrell Pilling, John Curnow, Christopher Buckley, Janet Lord & Mike Salmon, 1 Jan 2008, In: Apoptosis. 23, 1, p. 109-17 9 p.

    Research output: Contribution to journal › Article › peer-review

  46. Published

    Phenotypic and functional differentiation of KG-1 into dendritic-like cells

    John Curnow, 1 Jan 2008, In: Immunobiology. 213, 1, p. 75-86 12 p.

    Research output: Contribution to journal › Article

  47. Published

    Soluble gp130, an antagonist of IL-6 transsignaling, is elevated in uveitis aqueous humor

    John Curnow, Alastair Denniston, Paul Tomlins, Graham Wallace, Saaeha Rauz, Mike Salmon & Phil Murray, 1 Jan 2008, In: Investigative Ophthalmology & Visual Science (IOVS). 49, 9, p. 3988-3991 4 p.

    Research output: Contribution to journal › Article

  48. 2007
  49. Published

    CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation

    Karen Piper, John Curnow, Charles Craddock & Paul Moss, 1 Dec 2007, In: Blood. 110, 12, p. 3827-32 6 p.

    Research output: Contribution to journal › Article

  50. Published

    Multiplex bead analysis of vitreous humor of patients with vitreoretinal disorders

    John Curnow, Graham Wallace & Phil Murray, 1 May 2007, In: Investigative Ophthalmology & Visual Science (IOVS). 48, 5, p. 2203-2207 5 p.

    Research output: Contribution to journal › Article

  51. Published

    Cytokine profiles in idiopathic intracranial hypertension

    Alexandra Ball, John Curnow, Jeremy Tomlinson, Elizabeth Walker, Paul Stewart, Peter Nightingale, Carl E Clarke & Saaeha Rauz, 1 Jan 2007.

    Research output: Contribution to conference (unpublished) › Paper

  52. Published

    Cytokine profiles in idiopathic intracranial hypertension: a comparison with other neuro-opthalmological conditions

    Alexandra Ball, Alex Sinclair, John Curnow, Jeremy Tomlinson, Elizabeth Walker, Carl E Clarke & Saaeha Rauz, 1 Jan 2007.

    Research output: Contribution to conference (unpublished) › Paper

  53. 2006
  54. Published

    Inflammatory mediators of uveitis: cytokines and chemokines

    John Curnow & Phil Murray, 1 Dec 2006, In: Current Opinion in Ophthalmology. 17, 6, p. 532-7 6 p.

    Research output: Contribution to journal › Article

  55. Published

    The Generation and Antigen-Specificity of CD4+CD25+ Regulatory T

    John Curnow, 1 Sep 2006, In: Inflamm Allergy Drug Targets. 5, p. 149-156 8 p.

    Research output: Contribution to journal › Review article

  56. Published

    Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye

    John Curnow, Paul Stewart, Phil Murray, Elizabeth Walker & Saaeha Rauz, Aug 2006, In: Journal of Endocrinology. 190, 2, p. 483-93 11 p.

    Research output: Contribution to journal › Article › peer-review

  57. Published

    Differential leucocyte subset survival mediated by synovial, bone marrow and skin fibroblasts in rheumatoid arthritis: site specific versus activation dependent survival of T cells and neutrophils

    Andrew Filer, Gregory Parsonage, Emily Smith, Chloe Osborne, John Curnow, Ed Rainger, Karim Raza, Gerard Nash, Janet Lord, Mike Salmon & Christopher Buckley, 1 Jul 2006, In: Arthritis & Rheumatism. 54, 7, p. 2096-2108 13 p.

    Research output: Contribution to journal › Article › peer-review

  58. Published

    EBV-associated mononucleosis leads to long-term global deficit in T cell responsiveness to IL-15

    Delphine Sauce, Martin Larsen, John Curnow, Paul Moss, Andrew Hislop, Mike Salmon & Alan Rickinson, 1 Jul 2006, In: Blood. 108, p. 11-18 8 p.

    Research output: Contribution to journal › Article

  59. Published

    Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures

    John Curnow, 1 Jun 2006, In: Clinical and Experimental Allergy . 36, p. 777-784 8 p.

    Research output: Contribution to journal › Article

  60. Published

    Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis

    Karim Raza, Dagmar Scheel-Toellner, Darrell Pilling, John Curnow, Francesco Falciani, Kanta Kumar, Janet Lord, Caroline Gordon, Christopher Buckley & Mike Salmon, 1 Jan 2006, In: Arthritis Research & Therapy. 8, 4, R120.

    Research output: Contribution to journal › Article › peer-review

  61. 2005
  62. Published

    Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis

    John Curnow, Francesco Falciani, Omar Durrani, Saaeha Rauz, Graham Wallace, Mike Salmon & Phil Murray, 1 Nov 2005, In: Investigative Ophthalmology & Visual Science (IOVS). 46, p. 4251-4259 9 p.

    Research output: Contribution to journal › Article

  63. Published

    Interaction between integrin α9β1 and Vascular Cell Adhesion Molecule-1 (VCAM-1) inhibits neutrophil apoptosis: cross-talk between integrin and cytokine signalling pathways

    Ewan Ross, Michael Douglas, See Wong, John Curnow, Gerard Nash, Ed Rainger, Dagmar Scheel-Toellner, Janet Lord, Mike Salmon & Christopher Buckley, 13 Oct 2005, In: Blood. 107, 3, p. 1178-1183 6 p.

    Research output: Contribution to journal › Article › peer-review

  64. Published

    Early rheumatoid arthritis is characterised by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

    Karim Raza, Francesco Falciani, John Curnow, Janet Lord, Caroline Gordon, Christopher Buckley & Mike Salmon, 1 Apr 2005, In: Arthritis Research & Therapy. 7, 4, p. R784-R795

    Research output: Contribution to journal › Article › peer-review

  65. Published

    Inhibition of T cell apoptosis by IL–6 at sites of inflammation: direct and trans–signalling through the IL–6R are highly regulated on human T cells

    John Curnow, Dagmar Scheel-Toellner, Mike Salmon, Phil Murray & Christopher Buckley, 1 Jan 2005, p. 3475. 1 p.

    Research output: Contribution to conference (unpublished) › Abstract

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