John Curnow
Publications
- 2021
- Published
Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation
Alexander Roberts, Tina Tang, Chiara Pallini, Graham Wallace, Alison Cooper, Aaron Scott, David Thickett, Sebastian Lugg, Thomas Pinkney, Graham Taylor, Kristian Brock, Zania Stamataki, John Curnow, John Gordon, Omar Qureshi, Nicholas Barnes & 7 others, , 17 Feb 2021, In: Scientific Reports. 11, 1, 4030.Research output: Contribution to journal › Article › peer-review
- 2018
- E-pub ahead of print
- 2017
- Published
N-glycosylation and expression in human tissues of the orphan GPR61 receptor
Gillian Grafton, Alison Cooper, John Curnow & Nicholas Barnes, 1 Dec 2017, In: FEBS Open Bio. 7, 12, p. 1982-1993 12 p.Research output: Contribution to journal › Article › peer-review
- Published
CCR6+ Th cells in the cerebrospinal fluid of persons with multiple sclerosis are dominated by pathogenic non-classic Th1 cells and GM-CSF-only-secreting Th cells
Ghaniah Hassan-Smith, Michael Douglas & John Curnow, Aug 2017, In: Brain, Behaviour, and Immunity. 64, p. 71-79Research output: Contribution to journal › Article › peer-review
- Published
Inosine Acedoben Dimepranol promotes an early and sustained increase in the natural killer cell component of circulating lymphocytes: a clinical trial supporting anti-viral indications
Amy Newman, Gillian Grafton, John Curnow, Nicholas Barnes & John Gordon, Jan 2017, In: International Immunopharmacology. 42, p. 108-114Research output: Contribution to journal › Article › peer-review
- 2016
- Published
Conjunctival neutrophils predict progressive scarring in Ocular Mucous Membrane Pemphigoid
John Curnow & Saaeha Rauz, 1 Oct 2016, In: Investigative Ophthalmology & Visual Science (IOVS). 57, 13, p. 5457-5469Research output: Contribution to journal › Article › peer-review
- 2015
- E-pub ahead of print
Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors
Gillian Grafton, John Curnow & Nicholas Barnes, 17 Oct 2015, In: The Journal of Steroid Biochemistry and Molecular Biology.Research output: Contribution to journal › Article › peer-review
- Published
Association analysis of TGFBR3 gene with Behçet's disease and idiopathic intermediate uveitis in a Caucasian population
Robert Barry, Phil Murray, John Curnow & Graham Wallace, May 2015, In: British Journal of Ophthalmology. 99, 5, p. 696-9 4 p.Research output: Contribution to journal › Article › peer-review
- 2014
- Published
Cytokine production and antigen recognition by human mucosal homing conjunctival effector memory CD8+ T cells
Geraint Williams, Annette Pachnio, Heather Long, Saaeha Rauz & John Curnow, 29 Dec 2014, In: Investigative Ophthalmology & Visual Science (IOVS). 55, 12, p. 8523-8530 8 p.Research output: Contribution to journal › Article › peer-review
- Published
High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis
Ghaniah Hassan-Smith, Lakhvir Assi, Jeffrey Faint, Michael Douglas & John Curnow, 15 Nov 2014, In: Journal of Neuroimmunology. 276, 1-2, p. 175-179 5 p.Research output: Contribution to journal › Article › peer-review
- 2013
- Published
Elevation of conjunctival epithelial CD45INTCD11b⁺CD16⁺CD14⁻ neutrophils in ocular Stevens-Johnson syndrome and toxic epidermal necrolysis
Geraint Williams, Paul Tomlins, Alastair Denniston, John Curnow & Saaeha Rauz, 10 Jul 2013, In: Investigative Ophthalmology & Visual Science (IOVS). 54, 7, p. 4578-4585Research output: Contribution to journal › Article › peer-review
- Published
Cell-intrinsic regulation of murine dendritic cell function and survival by pre-receptor amplification of glucocorticoid
Annelise Soulier, Elizabeth Rabbitt, Paul Stewart, Gareth Lavery, John Curnow & Ronjon Chakraverty, 2013, In: Blood.Research output: Contribution to journal › Article › peer-review
- 2012
- Published
The dominant human conjunctival epithelial CD8αβ+ T cell population is maintained with age but the number of CD4+ T cells increases
Geraint Williams, Alastair Denniston, Paul Tomlins, Robert Barry, Saaeha Rauz & John Curnow, 1 Dec 2012, In: Age (Dordrecht, Netherlands). 34, 6, p. 1517-1528Research output: Contribution to journal › Article › peer-review
- Published
Aqueous Humor Suppression of Dendritic Cell Function Helps Maintain Immune Regulation in the Eye during Human Uveitis.
Alastair Denniston, Paul Tomlins, Geraint Williams, Graham Wallace, Saaeha Rauz, Phil Murray & John Curnow, 1 Jan 2012, In: Investigative Ophthalmology & Visual Science (IOVS). 53, 2, p. 888-96 9 p.Research output: Contribution to journal › Article
- 2011
- Published
The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue
Esther Hidalgo, Sarah Essex, Lorraine Yeo, John Curnow, Andrew Filer, Mark Cooper, Helen McGettrick, Mike Salmon, Christopher Buckley, Karim Raza & Dagmar Scheel-Toellner, 1 Nov 2011, In: Arthritis & Rheumatism. 63, 11, p. 3284-93 10 p.Research output: Contribution to journal › Article › peer-review
- Published
A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease
John Curnow, Laura O'Neill, Stuart Egginton & Francesco Falciani, 1 Sep 2011, In: PLoS Computational Biology. 7, 9, p. e1002129Research output: Contribution to journal › Article
- Published
Bridging innate and adaptive immunity: removing the toll
John Curnow & Graham Wallace, 1 Aug 2011, In: Current Opinion in Pharmacology. 11, 4, p. 395-396 2 p.Research output: Contribution to journal › Editorial
- Published
Intraocular immune mechanisms in Uveitis
John Curnow, Alastair Denniston, Phil Murray & Graham Wallace, 1 Aug 2011, In: Current Immunology Reviews. 7, 3, p. 350-359 10 p.Research output: Contribution to journal › Review article › peer-review
- Published
The stromal cell antigen CD248 (endosialin) is expressed on naive CD8(+) human T cells and regulates proliferation.
Debbie Hardie, Amy Naylor, Tiezheng Hou, Sian Lax, John Curnow & Christopher Buckley, Jul 2011, In: Immunology. 133, 3, p. 288-295 8.Research output: Contribution to journal › Article › peer-review
- Published
Validation of a fornix depth measurer : a putative tool for the assessment of progressive cicatrising conjunctivitis
Geraint Williams, John Curnow, Peter Nightingale & Saaeha Rauz, Jun 2011, In: British Journal of Ophthalmology. 95, 6, p. 842-847 6 p.Research output: Contribution to journal › Article › peer-review
- 2010
- Published
- Published
- Published
Dynamic regulation of spinal pro-inflammatory cytokine release in the rat in vivo following peripheral nerve injury.
Kevin Whitehead, John Curnow, 1 May 2010, In: Brain, Behaviour, and Immunity. 24, 4, p. 569-576 8 p.Research output: Contribution to journal › Article
- Published
- 2009
- Published
The Role of 11ss-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy
Jeremy Tomlinson, Iwona Bujalska, Laura Gathercole, Paul Tomlins, John Curnow, Paul Stewart, Elizabeth Walker & Saaeha Rauz, 30 Oct 2009, In: Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 398-406 9 p.Research output: Contribution to journal › Article
- Published
107 Neurone-Glia Signalling Underlies Spinal Pro-Inflammatory Cytokine Release Evoked By Primary Afferent Stimulation in the Neuropathic Rat
Kevin Whitehead, John Curnow, 1 Sep 2009, In: European Journal of Pain. 13, p. S40-S40Research output: Contribution to journal › Article
- Published
Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging
John Curnow, Christopher Buckley, 1 Aug 2009, In: The Journal of Experimental Medicine. 206, 9, p. 1929-1940 12 p.Research output: Contribution to journal › Article › peer-review
- Published
Cytokine and chemokine levels in tears and in corneal fibroblast cultures before and after excimer laser treatment
John Curnow, 1 Feb 2009, In: Journal of cataract and refractive surgery. 35, 2, p. 240-247 8 p.Research output: Contribution to journal › Article
- Published
A threshold level of TLR9 mRNA predicts cellular responsiveness to CpG-ODN in haematological and non-haematological tumour cell lines
John Curnow, 1 Jan 2009, In: Cellular Immunology. 259, 1, p. 90-99 10 p.Research output: Contribution to journal › Article
- 2008
- Published
Serum cytokine profiles in Behçet's disease: is there a role for IL-15 in pathogenesis?
John Curnow, Phil Murray & Graham Wallace, 16 Nov 2008, In: Immunology Letters. 121, 1, p. 7-12 6 p.Research output: Contribution to journal › Article
- Published
Exploring the pathogenesis of idiopathic intracranial hypertension:: An inflammatory perspective
Alex Sinclair, Alexandra Ball, Carl E Clarke, Paul Stewart, John Curnow & Saaeha Rauz, 15 Sep 2008, In: Journal of Neuroimmunology. 201-202, p. 212-220 9 p.Research output: Contribution to journal › Article
- Published
Elevated CSF leptin in idiopathic intracranial hypertension: evidence for hypothalamic leptin resistance?
Alexandra Ball, Alex Sinclair, John Curnow, Jeremy Tomlinson, Elizabeth Walker, Paul Stewart, Peter Nightingale, Carl E Clarke & Saaeha Rauz, 1 Sep 2008, In: Clinical Endocrinology. 70, p. 863-869 7 p.Research output: Contribution to journal › Article
- Published
Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis
Dagmar Scheel-Toellner, Karim Raza, Darrell Pilling, John Curnow, Christopher Buckley, Janet Lord & Mike Salmon, 1 Jan 2008, In: Apoptosis. 23, 1, p. 109-17 9 p.Research output: Contribution to journal › Article › peer-review
- Published
Phenotypic and functional differentiation of KG-1 into dendritic-like cells
John Curnow, 1 Jan 2008, In: Immunobiology. 213, 1, p. 75-86 12 p.Research output: Contribution to journal › Article
- Published
Soluble gp130, an antagonist of IL-6 transsignaling, is elevated in uveitis aqueous humor
John Curnow, Alastair Denniston, Paul Tomlins, Graham Wallace, Saaeha Rauz, Mike Salmon & Phil Murray, 1 Jan 2008, In: Investigative Ophthalmology & Visual Science (IOVS). 49, 9, p. 3988-3991 4 p.Research output: Contribution to journal › Article
- 2007
- Published
CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation
Karen Piper, John Curnow, Charles Craddock & Paul Moss, 1 Dec 2007, In: Blood. 110, 12, p. 3827-32 6 p.Research output: Contribution to journal › Article
- Published
Multiplex bead analysis of vitreous humor of patients with vitreoretinal disorders
John Curnow, Graham Wallace & Phil Murray, 1 May 2007, In: Investigative Ophthalmology & Visual Science (IOVS). 48, 5, p. 2203-2207 5 p.Research output: Contribution to journal › Article
- Published
- Published
Cytokine profiles in idiopathic intracranial hypertension: a comparison with other neuro-opthalmological conditions
Alexandra Ball, Alex Sinclair, John Curnow, Jeremy Tomlinson, Elizabeth Walker, Carl E Clarke & Saaeha Rauz, 1 Jan 2007.Research output: Contribution to conference (unpublished) › Paper
- 2006
- Published
Inflammatory mediators of uveitis: cytokines and chemokines
John Curnow & Phil Murray, 1 Dec 2006, In: Current Opinion in Ophthalmology. 17, 6, p. 532-7 6 p.Research output: Contribution to journal › Article
- Published
The Generation and Antigen-Specificity of CD4+CD25+ Regulatory T
John Curnow, 1 Sep 2006, In: Inflamm Allergy Drug Targets. 5, p. 149-156 8 p.Research output: Contribution to journal › Review article
- Published
Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye
John Curnow, Paul Stewart, Phil Murray, Elizabeth Walker & Saaeha Rauz, Aug 2006, In: Journal of Endocrinology. 190, 2, p. 483-93 11 p.Research output: Contribution to journal › Article › peer-review
- Published
Differential leucocyte subset survival mediated by synovial, bone marrow and skin fibroblasts in rheumatoid arthritis: site specific versus activation dependent survival of T cells and neutrophils
Andrew Filer, Gregory Parsonage, Emily Smith, Chloe Osborne, John Curnow, Ed Rainger, Karim Raza, Gerard Nash, Janet Lord, Mike Salmon & Christopher Buckley, 1 Jul 2006, In: Arthritis & Rheumatism. 54, 7, p. 2096-2108 13 p.Research output: Contribution to journal › Article › peer-review
- Published
- Published
Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures
John Curnow, 1 Jun 2006, In: Clinical and Experimental Allergy . 36, p. 777-784 8 p.Research output: Contribution to journal › Article
- Published
Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis
Karim Raza, Dagmar Scheel-Toellner, Darrell Pilling, John Curnow, Francesco Falciani, Kanta Kumar, Janet Lord, Caroline Gordon, Christopher Buckley & Mike Salmon, 1 Jan 2006, In: Arthritis Research & Therapy. 8, 4, R120.Research output: Contribution to journal › Article › peer-review
- 2005
- Published
Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis
John Curnow, Francesco Falciani, Omar Durrani, Saaeha Rauz, Graham Wallace, Mike Salmon & Phil Murray, 1 Nov 2005, In: Investigative Ophthalmology & Visual Science (IOVS). 46, p. 4251-4259 9 p.Research output: Contribution to journal › Article
- Published
Interaction between integrin α9β1 and Vascular Cell Adhesion Molecule-1 (VCAM-1) inhibits neutrophil apoptosis: cross-talk between integrin and cytokine signalling pathways
Ewan Ross, Michael Douglas, See Wong, John Curnow, Gerard Nash, Ed Rainger, Dagmar Scheel-Toellner, Janet Lord, Mike Salmon & Christopher Buckley, 13 Oct 2005, In: Blood. 107, 3, p. 1178-1183 6 p.Research output: Contribution to journal › Article › peer-review
- Published
Early rheumatoid arthritis is characterised by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin
Karim Raza, Francesco Falciani, John Curnow, Janet Lord, Caroline Gordon, Christopher Buckley & Mike Salmon, 1 Apr 2005, In: Arthritis Research & Therapy. 7, 4, p. R784-R795Research output: Contribution to journal › Article › peer-review
- Published
Inhibition of T cell apoptosis by IL–6 at sites of inflammation: direct and trans–signalling through the IL–6R are highly regulated on human T cells
John Curnow, Dagmar Scheel-Toellner, Mike Salmon, Phil Murray & Christopher Buckley, 1 Jan 2005, p. 3475. 1 p.Research output: Contribution to conference (unpublished) › Abstract