Helen McGettrick

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Publications

  1. Published

    Prostaglandin D-2 Regulates CD4(+) Memory T Cell Trafficking across Blood Vascular Endothelium and Primes These Cells for Clearance across Lymphatic Endothelium

    Helen McGettrick, Clara Yates, Christopher Buckley, Gerard Nash & Ed Rainger, 1 Aug 2011, In: Journal of Immunology. 187, 3, p. 1432-1439 8 p.

    Research output: Contribution to journal › Article › peer-review

  2. Published

    Comparative adhesive and migratory properties of mesenchymal stem cells from different tissues

    Helen McGettrick & Gerard Nash, 10 May 2019, In: Biorheology. 56, 1, p. 15-30 16 p.

    Research output: Contribution to journal › Article › peer-review

  3. E-pub ahead of print

    Endocrine Regulation of Lymphocyte Trafficking In Vitro

    Bonita Apta, Myriam Chimen & Helen McGettrick, 28 Mar 2017, In: Methods in molecular biology. 1591, p. 101-119 19 p.

    Research output: Contribution to journal › Article › peer-review

  4. Published

    The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

    Rachel Bayley, Helen McGettrick, Jacqueline Smith, Christopher Buckley & Stephen Young, 2015, In: Annals of the Rheumatic Diseases. 74, 8, p. 1588-95

    Research output: Contribution to journal › Article › peer-review

  5. Published

    Adhesion of tumour cells to matrices and endothelium

    Clara Yates, Helen McGettrick, Gerard Nash & Ed Rainger, 1 Jan 2010, Methods in Molecular Medicine: Metastasis Research Protocols. 2nd Edition.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  6. Published

    Leukocyte trafficking between stromal compartments: lessons from rheumatoid arthritis

    Christopher Buckley & Helen McGettrick, 1 Aug 2018, In: Nature Reviews Rheumatology. 14, 8, p. 476-487 12 p.

    Research output: Contribution to journal › Review article › peer-review

  7. Published

    Identification of phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration

    Christopher Buckley, Ewan Ross, Helen McGettrick, Chloe Osborne, Caroline Schmutz, Mike Salmon, Nicholas Matharu, Gerard Nash & Ed Rainger, 19 Dec 2005, In: Journal of Leukocyte Biology. 79, 2, p. 303-11 9 p.

    Research output: Contribution to journal › Article › peer-review

  8. Published

    Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture.

    Lynn Butler, Helen McGettrick, Hannah Jeffery, Caroline Savage, Ed Rainger & Gerard Nash, 1 Feb 2011, In: Experimental Cell Research. 317, 3, p. 276-92 17 p.

    Research output: Contribution to journal › Article

  9. Published

    Static and dynamic assays of cell adhesion relevant to the vasculature

    Lynn Butler, Helen McGettrick & Gerard Nash, 1 Jan 2009, In: Methods in molecular biology. 467, p. 211-28 18 p.

    Research output: Contribution to journal › Article › peer-review

  10. Published

    Static and Dynamic Assays of Cell Adhesion Relevant to the Vasculature

    Helen McGettrick & Gerard Nash, 13 May 2016, Angiogenesis Protocols. Springer, Vol. 1430. p. 231-48 18 p. (Methods in Molecular Biology; vol. 1430).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  11. Published

    An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31

    Helen McGettrick, Lynn Butler, Christopher Buckley, Ed Rainger & Gerard Nash, 1 Apr 2006, In: Biorheology. 43, 1, p. 71-82 12 p.

    Research output: Contribution to journal › Article

  12. Published

    Monocyte subsets coregulate inflammatory responses by integrated signaling through TNF and IL-6 at the endothelial cell interface.

    Myriam Chimen, Clara Yates, Helen McGettrick, Matt Harrison, Bonita Apta, Lea Dib, Paul Harrison, Gerard Nash & Ed Rainger, 1 Apr 2017, In: Journal of Immunology. 198, 7, p. 2834-2843

    Research output: Contribution to journal › Article › peer-review

  13. E-pub ahead of print

    Introduction: T cell trafficking in inflammation and immunity

    Myriam Chimen, Bonita Apta & Helen McGettrick, 28 Mar 2017, T-Cell Trafficking: Methods and Protocols. Springer, Vol. 1591. p. 73-84 12 p. (Methods in Molecular Biology (MIMB)).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  14. E-pub ahead of print

    Introduction: T-cell trafficking during inflammation. T-cell trafficking

    Myriam Chimen, Bonita Apta & Helen McGettrick, 28 Mar 2017, Methods in Molecular Biology. Springer, Vol. 1591. p. 73-84

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  15. Published

    Peptide Receptor

    Myriam Chimen, Helen McGettrick, Parth Narendran & Ed Rainger, 8 Jan 2015, Patent No. WO2015/001356

    Research output: Patent

  16. Published

    PEPTIDE AND USES THEREOF

    Myriam Chimen, Helen McGettrick, Parth Narendran & Ed Rainger, 18 Jul 2013, Patent No. WO2013/104928

    Research output: Patent

  17. Published

    Assay method

    Myriam Chimen, Parth Narendran, Helen McGettrick & Ed Rainger, 30 May 2014, Patent No. WO2014/080204

    Research output: Patent

  18. Published

    A novel immune regulatory peptide, PEPITEM (peptide inhibitor of trans-endothelial migration), controls T-cell trafficking during inflammation, a tonic inhibitory pathway that is lost in Type 1 diabetes

    Myriam Chimen, Helen McGettrick, Francesca Barone, Gerard Nash, Ed Rainger & Parth Narendran, Mar 2014, In: Diabetic Medicine. 31, Supp 1, p. 46-46 1 p.

    Research output: Contribution to journal › Article

  19. Published

    Distinct fibroblast subsets drive inflammation and damage in arthritis

    Adam Croft, Joana Campos, Jason Turner, Jennifer Marshall, Amy Naylor, Sam Kemble, Francesca Barone, Helen McGettrick & 4 others, , Andrew Filer & Christopher Buckley, 13 Jun 2019, In: Nature. 570, 7760, p. 246–251

    Research output: Contribution to journal › Article › peer-review

  20. Published

    C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37

    Helen McGettrick, Michael Tomlinson, 1 Oct 2018, In: Journal of Cell Science. 131, 19, 15 p., jcs214551.

    Research output: Contribution to journal › Article › peer-review

  21. Published

    Identification of a transitional fibroblast functional phenotype in very early rheumatoid arthritis

    Andrew Filer, Sam Kemble, Karim Raza, Christopher Buckley, Gerard Nash & Helen McGettrick, 13 Nov 2017, In: Annals of the Rheumatic Diseases. 76, 12, p. 2105-2112

    Research output: Contribution to journal › Article › peer-review

  22. Published

    The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue

    Esther Hidalgo, Sarah Essex, Lorraine Yeo, John Curnow, Andrew Filer, Mark Cooper, Helen McGettrick, Mike Salmon, Christopher Buckley, Karim Raza & Dagmar Scheel-Toellner, 1 Nov 2011, In: Arthritis & Rheumatism. 63, 11, p. 3284-93 10 p.

    Research output: Contribution to journal › Article › peer-review

  23. Published

    Triggering the resolution of immune mediated inflammatory diseases: can targeting leukocyte migration be the answer?

    Myriam Chimen & Helen McGettrick, 1 Mar 2019, In: Frontiers in Pharmacology. 10, 9 p., 184.

    Research output: Contribution to journal › Article › peer-review

  24. Accepted/In press

    Shared mechanisms of multi-morbidity in COPD: the neutrophil as a potential inflammatory target

    Helen McGettrick & Elizabeth Sapey, 2 Nov 2019, (Accepted/In press) In: European Respiratory Review.

    Research output: Contribution to journal › Review article › peer-review

  25. Published

    Importance of validating antibody panels: Anti-PD-L1 clone binds AF700 fluorophore

    Helen McGettrick & Elizabeth Sapey, Aug 2020, In: Journal of Immunological Methods. 483, p. 112795

    Research output: Contribution to journal › Article › peer-review

  26. Published

    Analysis of the effects of stromal cells on the migration of lymphocytes into and through inflamed tissue using 3-D culture models

    Hannah Jeffery, Christopher Buckley, Paul Moss, Ed Rainger, Gerard Nash & Helen McGettrick, 31 Dec 2013, In: Journal of Immunological Methods. 400-401, p. 45-57 13 p.

    Research output: Contribution to journal › Article › peer-review

  27. Published

    DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system

    Maria Juarez, Helen McGettrick, Dagmar Scheel-Toellner, Lorraine Yeo, Rowan Hardy, Karim Raza, Christopher Buckley & Andrew Filer, 19 Jan 2016, In: Arthritis Research & Therapy. 18, 1, 14.

    Research output: Contribution to journal › Article › peer-review

  28. Published

    Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6–mediated crosstalk

    Sahithi Kuravi, Helen McGettrick, Lorraine Harper, Ed Rainger & Caroline Savage, 2014, In: Journal of Immunology.

    Research output: Contribution to journal › Article › peer-review

  29. Published

    Clinical potential of targeting fibroblast growth factor‐23 and αKlotho in the treatment of uremic cardiomyopathy

    Christopher Weston, Alan M Jones, Helen McGettrick, Winnie Wei Ling Chua, Larissa Fabritz, Paulus Kirchhof, Davor Pavlovic, Jon Townend, 9 Apr 2020, In: Journal of the American Heart Association. 9, 7, 15 p., e016041.

    Research output: Contribution to journal › Article › peer-review

  30. Published

    Adiponectin signalling in bone homeostasis, with age and in disease

    Amy Naylor & Helen McGettrick, 7 Jan 2021, In: Bone Research. 9, 1.

    Research output: Contribution to journal › Review article › peer-review

  31. Published

    The roles of integrins in function of human neutrophils after their migration through endothelium into interstitial matrix

    Ding Luo, Helen McGettrick, Ed Rainger & Gerard Nash, 23 Feb 2015, In: PLoS ONE. 10, 2, e0118593.

    Research output: Contribution to journal › Article › peer-review

  32. Published

    Crosstalk between mesenchymal stem cells and endothelial cells leads to down-regulation of cytokine-induced leukocyte recruitment

    Nguyet -Thin Luu, Helen McGettrick, Christopher Buckley, Philip Newsome, Ed Rainger, Jon Frampton & Gerard Nash, Dec 2013, In: Stem Cells. 31, 12, p. 2690-2702

    Research output: Contribution to journal › Article › peer-review

  33. Published

    Insights Into Leukocyte Trafficking in Inflammatory Arthritis - Imaging the Joint

    Helen McGettrick, 9 Mar 2021, In: Frontiers in cell and developmental biology. 9, 635102.

    Research output: Contribution to journal › Review article › peer-review

  34. Published

    Go with the flow: Studying regulation of inflammatory T cell recruitment

    Myriam Chimen & Helen McGettrick, 6 Mar 2018

    Research output: Other contribution

  35. Published

    Inflammatory responses of endothelial cells experiencing reduction in flow after conditioning by shear stress

    Helen McGettrick, Mike Salmon, Ed Rainger & Gerard Nash, 1 Sep 2008, In: Journal of Cellular Physiology. 216, 3, p. 732-41 10 p.

    Research output: Contribution to journal › Article

  36. Published

    Analysis of leukocyte migration through monolayers of cultured endothelial cells.

    Helen McGettrick, Lynn Butler & Gerard Nash, 1 Jan 2007, In: Methods in molecular biology. 370, p. 37-54 18 p.

    Research output: Contribution to journal › Article

  37. Published

    Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target

    Helen McGettrick & Elizabeth Sapey, 31 Mar 2020, In: European Respiratory Review. 29, 155

    Research output: Contribution to journal › Review article › peer-review

  38. Published

    Tissue stroma as a regulator of leukocyte recruitment in inflammation

    Helen McGettrick, Christopher Buckley, Ed Rainger & Gerard Nash, 1 Mar 2012, In: Journal of Leukocyte Biology. 91, 3, p. 385-400 16 p.

    Research output: Contribution to journal › Article › peer-review

  39. Published

    Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment

    Helen McGettrick, Andrew Filer, Ed Rainger, Christopher Buckley & Gerard Nash, 1 Oct 2007, In: Biochemical Society Transactions. 35, 5, p. 1161-1162 2 p.

    Research output: Contribution to journal › Article › peer-review

  40. Published

    Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine?

    Helen McGettrick, 8 Apr 2019, In: Arthritis Research & Therapy. 21, 90.

    Research output: Contribution to journal › Editorial › peer-review

  41. Published

    Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells

    Helen McGettrick, Andrew Filer, Mike Salmon, Christopher Buckley, Ed Rainger & Gerard Nash, 1 Jan 2009, In: European Journal of Immunology. 39, 1, p. 113-25 13 p.

    Research output: Contribution to journal › Article › peer-review

  42. Published

    Bridging the gap-Immune cells that can repair nerves

    Helen McGettrick, 12 Feb 2021, In: Cellular and Molecular Immunology.

    Research output: Contribution to journal › Article › peer-review

  43. Published

    Chemokine- and adhesion-dependent survival of neutrophils after transmigration through cytokine-stimulated endothelium

    Helen McGettrick, Janet Lord, Ke-Qing Wang, Ed Rainger, Christopher Buckley & Gerard Nash, 13 Jan 2006, In: Journal of Leukocyte Biology. 79, 4, p. 779-788 10 p.

    Research output: Contribution to journal › Article › peer-review

  44. Published

    Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration

    Helen McGettrick, Paul Moss, Christopher Buckley, Ed Rainger & Gerard Nash, 1 Jan 2009, In: Journal of Leukocyte Biology. 85, 1, p. 98-107 10 p.

    Research output: Contribution to journal › Article › peer-review

  45. Published

    Influence of stromal cells on lymphocyte adhesion and migration on endothelial cells

    Helen McGettrick, Christopher Buckley, Ed Rainger & Gerard Nash, 15 Feb 2010, In: Methods in molecular biology. 616, p. 49-68 20 p.

    Research output: Contribution to journal › Article

  46. Published

    Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium.

    Helen McGettrick, Christopher Buckley, Andrew Filer, Ed Rainger & Gerard Nash, 26 May 2010, In: Immunology.

    Research output: Contribution to journal › Article › peer-review

  47. E-pub ahead of print

    Mesenchymal Stromal Cells as Active Regulators of Lymphocyte Recruitment to Blood Vascular Endothelial Cells

    Helen McGettrick, Ed Rainger & Gerard Nash, 28 Mar 2017, T-Cell Trafficking: Methods and Protocols. Rainger, G. E. & Mcgettrick, H. M. (eds.). Springer, p. 121-142 22 p. (Methods in Molecular Biology; vol. 1591).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  48. Published

    Comparative ability of mesenchymal stromal cells from different tissues to limit neutrophil recruitment to inflamed endothelium

    Nguyet -Thin Luu, Gerard Nash & Helen McGettrick, 12 May 2016, In: PLoS ONE. 11, 5, e0155161.

    Research output: Contribution to journal › Article › peer-review

  49. Published

    Analyzing the effects of stromal cells on the recruitment of leukocytes from flow

    Ed Rainger, Gerard Nash & Helen McGettrick, 7 Jan 2015, In: Journal of Visualized Experiments. 95, e52480.

    Research output: Contribution to journal › Article › peer-review

  50. Published

    Adipogenic differentiation of MSC alters their immunomodulatory properties in a tissue-specific manner

    Lozan Sheriff, Sam Kemble, Saba Nayar, Francesca Barone, Gerard Nash & Helen McGettrick, 25 May 2017, In: Stem Cells. 35, 6, p. 1636–1646

    Research output: Contribution to journal › Article › peer-review

  51. Published

    Mesenchymal stem cells as endogenous regulators of inflammation

    Helen McGettrick, 29 Aug 2018, Stromal Immunology. Springer, p. 73-98 26 p. (Advances in Experimental Medicine and Biology; vol. 1060).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  52. Published

    Mesenchymal Stem Cell Therapy for Autoimmune Disease: Risks and Rewards

    Helen McGettrick, 12 Jun 2015, In: Stem Cells and Development. 24, 18, p. 2091-2100 10 p.

    Research output: Contribution to journal › Review article › peer-review

  53. Published

    Identification and angiogenic role of the novel tumor endothelial marker CLEC14A.

    Alan Zhuang, James Beesley, John Herbert, Helen McGettrick, Philipp Antczak, Francesco Falciani, Gerard Nash, Zsuzsanna Nagy & Roy Bicknell, 27 Jun 2011, In: Oncogene. 31, 3, p. 293-305 13 p.

    Research output: Contribution to journal › Article › peer-review

  54. Published

    Bimodal expansion of the lymphatic vessels is regulated by the sequential expression of IL-7 and lymphotoxin α1β2 in newly formed tertiary lymphoid structures

    Saba Nayar, Joana Campos, Leyre Navarro-Nunez, Jorge Caamano, Helen McGettrick, Steve Watson, Christopher Buckley & Francesca Barone, 1 Sep 2016, In: Journal of Immunology. 197, 5, p. 1957-1967 11 p.

    Research output: Contribution to journal › Article › peer-review

  55. Published

    A differential role for CD248 (Endosialin) in PDGF-mediated skeletal muscle angiogenesis

    Amy Naylor, Helen McGettrick, Francesca Barone, Adam Croft, Stuart Egginton & Christopher Buckley, 22 Sep 2014, In: PLoS ONE. 9, 9, e107146.

    Research output: Contribution to journal › Article › peer-review

  56. Published

    Homeostatic regulation of T cell trafficking by a B cell derived peptide is impaired in autoimmune and chronic inflammatory disease

    Ed Rainger, Myriam Chimen, Helen McGettrick, Sahithi Kuravi, Bonita Apta, Clara Yates, Matt Harrison, Ashley Martin, Francesca Barone, Saba Nayar, Adam Cunningham, Karim Raza, Andrew Filer, Joseph Robinson, Neena Kalia & 5 others, Lucy Walker, Christopher Buckley, Gerard Nash, Parth Narendran, 15 May 2015, In: Nature Medicine. 21, 5, p. 467-475 9 p., 3842.

    Research output: Contribution to journal › Article › peer-review

  57. Published

    Origin-specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence their Behaviour After Infusion.

    Julie Rayes, Stephen Watson, Philip Newsome, Neena Kalia, Jon Frampton, Helen McGettrick & Gerard Nash, Feb 2018, In: Stem cells (Dayton, Ohio).

    Research output: Contribution to journal › Article › peer-review

  58. E-pub ahead of print

    Origin-Specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence Their Behavior After Infusion

    Lozan Sheriff, Carl Ward, Julie Rayes, Steve Watson, Ed Rainger, Neena Kalia, Helen McGettrick & Gerard Nash, 23 Mar 2018, In: Stem Cells.

    Research output: Contribution to journal › Article › peer-review

  59. Published

    Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium

    Emily Smith, Helen McGettrick, Gerard Nash, Christopher Buckley & Ed Rainger, 1 Jul 2008, In: Arthritis & Rheumatism. 58, 7, p. 1968-1973 6 p.

    Research output: Contribution to journal › Article › peer-review

  60. Published

    Neutrophils rapidly recruited by TNF-alpha stimulated endothelial cells can exit the sub endothelial environment by reverse transmigration over hours: is this a novel route for neutrophil clearance from inflamed tissue?

    Helen McGettrick, Gerard Nash & Ed Rainger, 1 Jan 2003, p. OC08.

    Research output: Contribution to conference (unpublished) › Abstract

  61. Published

    Podoplanin regulates the migration of mesenchymal stromal cells and their interaction with platelets.

    Lozan Sheriff, Jennifer Marshall, Alexander Brill, Gerard Nash & Helen McGettrick, 25 Feb 2019, In: Journal of Cell Science. 132, 5, 12 p., jcs222067.

    Research output: Contribution to journal › Article › peer-review

  62. Published

    Cerebral Hemodynamic and Neurotrophic Factor Responses Are Dependent on the Type of Exercise

    Bethany Skinner, Becky Lucas, Nigel Cable, Catarina Rendeiro, Helen McGettrick & Sam Lucas, 21 Jan 2021, In: Frontiers in Physiology. 11, 609935.

    Research output: Contribution to journal › Article › peer-review

  63. E-pub ahead of print

    Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health

    Catarina Rendeiro, Helen McGettrick & Sam Lucas, 17 Apr 2020, In: European Journal of Nutrition. 28 p.

    Research output: Contribution to journal › Article › peer-review

  64. Published

    Corrigendum: Cerebral Hemodynamic and Neurotrophic Factor Responses Are Dependent on the Type of Exercise

    Bethany Skinner, Becky Lucas, Catarina Rendeiro, Helen McGettrick & Sam Lucas, 24 Feb 2021, In: Frontiers in Physiology. 12, 659873.

    Research output: Contribution to journal › Article › peer-review

  65. Published

    Shear stress regulated gene expression and angiogenesis in vascular endothelium

    Joseph Wragg, Helen McGettrick, Stuart Egginton & Roy Bicknell, May 2014, In: Microcirculation. 21, 4, p. 290-300 11 p.

    Research output: Contribution to journal › Article › peer-review

  66. Published

    Adhesion of tumor cells to matrices and endothelium

    Clara Yates, Helen McGettrick, Gerard Nash & Ed Rainger, 2014, In: Methods in molecular biology. 1070, p. 57-75 19 p.

    Research output: Contribution to journal › Article › peer-review

  67. Published

    Targeting ß2 adrenergic receptors regulate human T cell function directly and indirectly

    Jos Bosch, Oliver Goodyear, Helen McGettrick, Phil Moss & Graham Wallace, 16 Dec 2014, In: Brain, Behaviour, and Immunity.

    Research output: Contribution to journal › Article › peer-review