Francis Mussai

Colleges, School and Institutes

External positions

, Birmingham Children's Hospital NHS Foundation Trust

1 Jul 2012 → …

Research interests

Francis’ research group is centred on understanding how paediatric solid tumours and haematological malignancies interact with the immune system and suppress the immune response.  The laboratory is co-supervised with Dr Carmela De Santo. Research studies are carried out in collaboration with a number of local, national and international research collaborators. Clinical trials based on this laboratory’s research are being established in partnership with pharmaceutical companies to try and improve patient outcomes.

Adult Cancers

Research projects investigating how adult cancers (such as colon, mesothelioma, renal, and melanoma) escape from the immune system are underway in the laboratory. New drugs which can re-activate the immune response against cancer are being tested, alongside national clinical trials. The research is co-supervised with Professor Gary Middleton.

Neuroblastoma

Neuroblastoma is the most common extra-cranial solid malignancy of childhood. Although the prognosis for low stage neuroblastoma has improved, patients with Stage IV neuroblastoma have an extremely poor survival despite treatment with high chemotherapy, radiotherapy, surgery and immunotherapy.

Myeloid-derived suppressor cells (MDSCs) are a population of immature myeloid cells found in increased numbers in adults with solid tumours and they inactivate a patient’s anti-tumour immune response. The project aims to understand the role of MDSCs in the immunobiology of neuroblastoma and target their activity, to restore anti-cancer immunity. The project is being carried out in collaboration with Professor John Anderson at Great Ormond Street Hospital, Professor  Louis Chesler at the Institute for Cancer Research, and Dr Kate Wheeler at the Children’s Hospital, Oxford.

Acute Myeloid Leukaemia

Acute Myeloid Leukaemia (AML) is the most frequent leukaemia in adults and the second most common leukaemia of childhood. Despite intensification of chemotherapy treatment, a significant number of patients will relapse and succumb to their disease. The mechanisms in which AML blasts create an immunosuppressive niche and halt normal haematopoiesis are currently under study in the Mussai group. Development of prognostic biomarkers and identification of therapies to overcome the immunosuppressive microenvironment in AML are the subject of ongoing research. The study is being carried out in collaboration with Dr Pam Kearns. 

The research has been generously funded by the Amber Phillpott Trust Birmingham Children's Hospital Research Fund, Children with Cancer, the Stiliyan Petrov Foundation, Niayah’s Fund, Cancer Research UK and other local charities.

Education/Academic qualification

  • ROYAL COLLEGE OF PHYSICIANS

    FRCP(Edin)

Professional Qualifications

  • DPhil in Clinical Medicine, Magdalen College, University of Oxford, DPhil

    2012 -
  • Educational Commission for Foreign Medical Graduates (USMLE), USA, USMLE

    2007 -
  • Membership of the Royal College of Paediatrics and Child Health, MRCPCH

    2007 -
  • BM BCh, Christ Church College, University of Oxford, BM BCh

    2004 -
  • MA (Oxon) in Physiological Sciences, St. Anne’s College, University of Oxford, MA (Oxon)

    2001 -

Willingness to take PhD students

Yes

PhD projects

Francis supervises doctoral researchers who are interested in the immunology of paediatric and adult cancers or investigating the activity of novel targeted therapies. The group welcomes applications from prospective doctoral candidates who wish to apply for fellowship/grant programs to join the team.