Elizabeth Sapey

Dr.

Accepting PhD Students

PhD projects

Liz’s research interests focus on understanding why chronic inflammatory diseases are so heterogeneous in their presentation and course. The research includes two interrelated themes:

1. The role of innate immunity in disease pathogenesis, especially its role in tissue damage during ageing, chronic lung disease (COPD) and acute lung infections (primarily pneumonia). Aberrant neutrophil functions have been implicated in the tissue damage and poor bacterial clearance seen in each of these areas. She has focused on how neutrophil behaviour (and cell signalling) in the presence of inflammation alters in health and disease, in particular, how inaccurate migration and reduced phagocytosis lead to increased inflammatory burden and poorer clinical outcomes.

2. The need to characterise clinical and inflammatory phenotypes in frailty ageing, and chronic disease to better inform therapeutic targeting. This work includes studying how disease manifests in its most early stages, assessing physiological techniques that better diagnose both disease and decline, understanding the shared risk from other chronic inflammatory co-morbidities and utilising outcome measures that reflect pathology.

20002024

Research activity per year

Personal profile

Research interests

Professor Liz Sapey is the Director of the Institute of Inflammation and Ageing, a multidisciplinary research institute which brings together fundamental scientists and clinicians to translate understanding of the process of inflammation in to new treatments for chronic age-related inflammatory disease and the consequences of major trauma. She is an Honorary Acute Medicine and Respiratory Consultant Physician at the University Hospitals Birmingham NHS Foundation Trust. Her research interests focus on  inflammatory and infectious diseases associated with ageing, and the impact of inflammation in an ageing host during hospitalization.  As Director of PIONEER, the Health Data Hub in Acute Care, Liz supports the transparent, ethical and publicly endorsed use of health data for research and innovation, working with the NHS  and reserachers to link health and health-related data from different organisations.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 1 - No Poverty
  • SDG 3 - Good Health and Well-being

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