David Hodson, MRCVS

Colleges, School and Institutes

Biography

Dr. David Hodson completed a degree in Veterinary Science before undertaking doctoral studies in reproductive physiology and circadian biology at the University of Bristol. Subsequently, in 2008, he moved to the laboratory of Dr. Patrice Mollard at the Institut de Genomique Fonctionnelle in Montpellier (CNRS), France, where, supported by a Fellowship from the Fondation de la Recherche Medicale (FRM), he pursued postdoctoral studies focused on understanding how endocrine cells residing within the mammalian pituitary gland function as three-dimensional networks to generate hormone release in response to demand. Following award of a Diabetes UK RD Lawrence Fellowship in 2012, David moved to the Department of Medine at Imperial College London, where he set up a reserach gropup devoted to understanding how type 2 diabetes (T2D) insults target tissue- and organ-level processes to impact beta cell function and reduce insulin secretion. In 2016, David moved to the newly-formed Insitute of Metabolism and Systems Research (IMSR) at the University of Birmingham to continue his studies at the forefront of endocrinology and diabetes research.

Research interests

Research in our lab revolves around the use of sophisticated imaging modalities (e.g. high-speed multibeam, two-photon, super-resolution), combined with recombinant technologies and genetic manipulation, to interrogate and decipher the population basis for hormone secretion from endocrine tissues in situ and in vivo. Focussing predominantly upon rodent and human islets of Langerhans, these studies have demonstrated a novel mode of incretin action which boosts insulin release through coaxing beta cell cooperativity, a role for GWAS-identified genes in regulating human beta cell-beta cell interconnectedness, and dual orchestration of metabolic dynamics in a subpopulation of beta cells by glucose and incretin. Currently, we are supported by Diabetes UK, MRC and EFSD.

Qualifications

2005 Bachelor of Veterinary Science with Honours (BVSc Hons)

2005 Member of the Royal College of Veterinary Surgeons (MRCVS)

2009 Doctor of Philosophy (PhD)

Professional Qualifications

  • Member of the Royal College of Veterinary Surgeons, MRCVS

Willingness to take PhD students

Yes

PhD projects

David Hodson is currently a Senior Birmingham Fellow in Molecular Endocrinology and also holds Diabetes UK RD Lawrence and EFSD/Novo Nordisk Fellowships. David has particular interest in using multidisciplinary and innovative approaches (eg biophotonics, genetics, network biology, chemical biology) to tackle challenging research questions in endocrinology. The overall objective of his work is to identify new mechanisms through which insulin-secreting pancreatic beta cells fail during diabetes.

Research in Dr Hodson's lab revolves around the use of sophisticated imaging modalities (eg high-speed multibeam, two-photon, super-resolution), combined with chemical biology, recombinant technologies and genetic manipulation, to interrogate and decipher the population basis for hormone secretion from endocrine tissues in situ and in vivo. Focussing predominantly upon rodent and human islets of Langerhans, these studies have demonstrated a novel mode of incretin action which boosts insulin release through coaxing beta cell cooperativity, a role for GWAS-identified genes in regulating human beta cell-beta cell interconnectedness, and dual orchestration of metabolic dynamics in a subpopulation of beta cells by glucose and incretin.