Daniel Tennant

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Publications

  1. 2020
  2. Published

    Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction

    Craig Doig, Aga Zielinska, Rachel Fletcher, Yasir Elhassan, Antje Garten, David Cartwright, Daniel Tennant & Gareth Lavery, 19 Feb 2020, In: Skeletal Muscle. 10, 1, 13 p., 5.

    Research output: Contribution to journal › Article › peer-review

  3. Published

    Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function

    Katarina Kluckova, Alpesh Thakker, Gareth Lavery & Daniel Tennant, Jan 2020, In: FASEB Journal. 34, 1, p. 303-315

    Research output: Contribution to journal › Article › peer-review

  4. 2019
  5. Published

    Development and validation of a combined hypoxia and immune prognostic classifier for head and neck cancer

    Jill Brooks, Albert Menezes Antao Nobre De Menezes, Lucinda Archer, Neeraj Lal, Rachel Spruce, Nikos Batis, Jennifer Bryant, Gordon Ryan, Steve Lee, Gary Middleton, Daniel Tennant & 7 others, Andrew Beggs, Jon Deeks, Jean-Baptiste Cazier, Benjamin Willcox & Hisham Mehanna, Sep 2019, In: Clinical Cancer Research. 25, 17, p. 5315-5328 15 p.

    Research output: Contribution to journal › Article › peer-review

  6. Published

    Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures

    Yasir Elhassan, Katarina Kluckova, Rachel Fletcher, Antje Garten, Craig Doig, David Cartwright, Claire Burley, Ned Jenkinson, Martin Wilson, Sam Lucas, Ildem Akerman, Alex Seabright, Yu-Chiang Lai, Daniel Tennant, Peter Nightingale, Gareth Wallis, Konstantinos Manolopoulos & 2 others, Andrew Philp & Gareth Lavery, 13 Aug 2019, In: Cell Reports. 28, 7, p. 1717-1728.e6 19 p.

    Research output: Contribution to journal › Article › peer-review

  7. Published

    Ex vivo metabolite profiling of paediatric central nervous system tumours reveals prognostic markers

    Sarah Kohe, Martin Wilson, Theodoros Arvanitis, Daniel Tennant & Andrew Peet, 19 Jul 2019, In: Scientific Reports. 9, 1, 10473.

    Research output: Contribution to journal › Article › peer-review

  8. 2018
  9. Published

    Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion

    Rachel Fletcher, Yasir Elhassan, David Cartwright, Craig Doig, Antje Garten, Alpesh Thakker, Daniel Tennant, Christian Ludwig & Gareth Lavery, 15 Nov 2018, In: Wellcome Open Research.

    Research output: Contribution to journal › Article › peer-review

  10. Published

    Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species

    Katherine Eales, Garth Cruickshank, Jim Tucker & Daniel Tennant, 25 Sep 2018, In: Scientific Reports. 8, 1, 14358.

    Research output: Contribution to journal › Article › peer-review

  11. Published

    Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours

    Sarah Kohe, Martin Wilson, Daniel Tennant & Andrew Peet, 10 Aug 2018, In: Scientific Reports. 8, 1, 11992.

    Research output: Contribution to journal › Article › peer-review

  12. E-pub ahead of print

    Development and validation of a combined metabolic and immune prognostic classifier for head and neck cancer

    Jill Brooks, Lucinda Archer, Rachel Spruce, Nikos Batis, Jennifer Bryant, Andrew Beggs, Daniel Tennant, Gary Middleton, Jean-Baptiste Cazier, Benjamin Willcox, 1 Jun 2018, In: Journal of Clinical Oncology. 36, 15 Suppl, p. 6049-6049

    Research output: Contribution to journal › Abstract › peer-review

  13. Published

    Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma

    Katarina Kluckova & Daniel Tennant, 1 May 2018, In: Cell and tissue research. 372, 2, p. 367-378

    Research output: Contribution to journal › Article › peer-review

  14. Published

    Oncogenic IDH1 mutations promote enhanced proline synthesis through PYCR1 to support the maintenance of mitochondrial redox homeostasis

    Katherine Eales, Chiara Bardella, Cristina Escribano Gonzalez, Alpesh Thakker, Katarina Kluckova, Mark Jeeves, Federica Cuozzo, David Hodson, Ian Tomlinson, Christian Ludwig & 2 others, & Daniel Tennant, 20 Mar 2018, In: Cell Reports. 22, 12, p. 3107–3114 8 p.

    Research output: Contribution to journal › Article › peer-review

  15. E-pub ahead of print

    High-Speed Tracer Analysis of Metabolism (HS-TrAM)

    Andrew Peet, Daniel Tennant, Mark Jeeves & Christian Ludwig, 12 Jan 2018, In: Wellcome Open Research. 11 p.

    Research output: Contribution to journal › Article

  16. 2017
  17. Published

    Combined analysis of NMR and MS spectra (CANMS)

    Daniel Tennant, Ulrich Guenther & Christian Ludwig, 3 Apr 2017, In: Angewandte Chemie (International Edition) . 56, 15, p. 4140-4144 5 p.

    Research output: Contribution to journal › Article › peer-review

  18. Published

    Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma

    Katherine Eales, Wenbin Wei, Sarah Essex, Andrew Filer, Paul Moss, Dickens Pratt, Clare Davies & Daniel Tennant, Feb 2017, In: Leukemia. 31, 2, p. 373-381

    Research output: Contribution to journal › Article › peer-review

  19. 2016
  20. E-pub ahead of print

    Metabolic differences between cold stored and machine perfused porcine kidneys: A 1H NMR based study

    Daniel Tennant, Christian Ludwig, 3 Dec 2016, In: Cryobiology.

    Research output: Contribution to journal › Article › peer-review

  21. Published

    Cooperative co-evolutionary module identification with application to cancer disease module discovery

    Shan He, Daniel Tennant, Mirco Musolesi, John Heath & Xin Yao, 1 Dec 2016, In: IEEE Transactions on Evolutionary Computation. 20, 6, p. 874-891 18 p.

    Research output: Contribution to journal › Article › peer-review

  22. Published

    Isocitrate dehydrogenase (IDH), Succinate dehydrogenase (SDH), Fumarate hydratase (FH): three players for one phenotype in cancer?

    Giulio Laurenti & Daniel Tennant, 15 Aug 2016, In: Biochemical Society Transactions. 44, 4, p. 1111-1116

    Research output: Contribution to journal › Article › peer-review

  23. Published

    13C glucose labelling studies using 2D NMR are a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys

    Daniel Tennant & Christian Ludwig, 5 Aug 2016, In: Transplantation Research. 5, 1, 7.

    Research output: Contribution to journal › Article › peer-review

  24. Published

    Mitochondrial metabolic remodelling in response to genetic and environmental perturbations

    Daniel Tennant, Jul 2016, In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 8, 4, p. 272-285

    Research output: Contribution to journal › Review article › peer-review

  25. Published

    Hypoxia and metabolic adaptation of cancer cells

    Katherine Eales & Daniel Tennant, 25 Jan 2016, In: Oncogenesis. 5, e190.

    Research output: Contribution to journal › Article › peer-review

  26. Published

    Metabolic plasticity in CLL: adaptation to the hypoxic niche

    Katarzyna Koczula, Christian Ludwig, Leroy Cronin, Dickens Pratt, Helen Parry, Daniel Tennant, Mark Drayson, Christopher Bunce, Farhat Khanim & Ulrich Guenther, Jan 2016, In: Leukemia. 30, 1, p. 65–73 9 p.

    Research output: Contribution to journal › Article › peer-review

  27. Published

    Probing cancer cell metabolism using NMR spectroscopy

    Daniel Tennant & Christian Ludwig, 2016, Tumor Microenvironment: Study Protocols. Springer, p. 89-111 23 p. (Advances in Experimental Medicine and Biology; vol. 899).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  28. 2015
  29. Published

    Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

    Christian Ludwig & Daniel Tennant, 2 Nov 2015, In: Nature Communications. 6, 8784.

    Research output: Contribution to journal › Article › peer-review

  30. Published

    Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

    Christian Ludwig, David Bartlett, Sarah Essex, Will Allwood, Helen Parry, Pip Nicolson, Warwick Dunn, Paul Moss, Dickens Pratt & Daniel Tennant, 16 Oct 2015, In: Blood Cancer Journal. 5, e359.

    Research output: Contribution to journal › Letter › peer-review

  31. Published

    A roadmap for interpreting 13C metabolite labeling patterns from cells

    & 17 others, , Daniel Tennant, 1 Aug 2015, In: Current Opinion in Biotechnology. 34, p. 189-201 13 p.

    Research output: Contribution to journal › Article › peer-review

  32. Published

    Metabolomic analysis of perfusate during hypothermic machine perfusion of human cadaveric kidneys

    Mark Cobbold, Christian Ludwig, Daniel Tennant, Nicholas Inston, 1 Apr 2015, In: Transplantation. 99, 4, p. 754-759 6 p.

    Research output: Contribution to journal › Article › peer-review

  33. 2014
  34. Published

    Metabolomic perfusate analysis during kidney machine perfusion : the pig provides an appropriate model for human studies

    Nicholas Inston, Daniel Tennant, Christian Ludwig, 12 Dec 2014, In: PLoS ONE. 9, 12, e114818.

    Research output: Contribution to journal › Article › peer-review

  35. Published

    Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions

    Garrick Wilson, Daniel Tennant & Jane McKeating, Dec 2014, In: Journal of Hepatology. 61, 6, p. 1397-1406 10 p.

    Research output: Contribution to journal › Article › peer-review

  36. Published

    The role of HIFs in ischaemia-reperfusion injury

    Neil Howell & Daniel Tennant, 30 Jul 2014, In: Hypoxia. 2, p. 107-115 9 p.

    Research output: Contribution to journal › Review article › peer-review

  37. Published

    DiME : a scalable disease module identification algorithm with application to glioma progression

    Daniel Tennant, John Heath, Xin Yao & Shan He, 11 Feb 2014, In: PLoS ONE. 9, 2, e86693.

    Research output: Contribution to journal › Article › peer-review

  38. 2013
  39. Published

    A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

    Daniel Tennant & 3 others, Christian Ludwig, 30 May 2013, In: Cell Reports. 3, 5, p. 1440-1448 9 p.

    Research output: Contribution to journal › Article › peer-review

  40. 2012
  41. Published

    Community detection in social and biological networks using differential evolution

    Mirco Musolesi, Daniel Tennant, Ralf Weber, John Heath & Shan He, 30 Oct 2012, Learning and Intelligent Optimization - 6th International Conference, LION 6, Revised Selected Papers. p. 71-85 15 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 7219 LNCS).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  42. Published

    From Transcriptional Profiling to Tumor Biology in Pheochromocytoma and Paraganglioma

    Daniel Tennant, 1 Mar 2012, p. 15-20. 6 p.

    Research output: Contribution to conference (unpublished) › Paper › peer-review

  43. Published

    Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

    Jennifer Kirwan, Christian Ludwig, Daniel Tennant & 15 others, , Ulrich Guenther, Mark Viant, 1 Mar 2012, In: Cell Metabolism. 15, 3, p. 361-371 11 p.

    Research output: Contribution to journal › Article › peer-review

  44. Published

    Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

    Daniel Tennant, Ulrich Guenther, 2012, In: Cell Metabolism.

    Research output: Contribution to journal › Article › peer-review

  45. 2011
  46. Published

    Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival

    Daniel Tennant, 2 Sep 2011, In: PLoS ONE. 6, 9, p. e24411-

    Research output: Contribution to journal › Article › peer-review

  47. Published

    PK-M2 Makes Cells Sweeter on HIF1

    Daniel Tennant, 1 May 2011, In: Cell. 145, 5, p. 647-649 3 p.

    Research output: Contribution to journal › Editorial › peer-review

  48. 2010
  49. Published

    HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

    Daniel Tennant, 1 Aug 2010, In: Journal of Molecular Medicine. 88, 8, p. 839-849 11 p.

    Research output: Contribution to journal › Article › peer-review

  50. Published

    Targeting metabolic transformation for cancer therapy

    Daniel Tennant, 1 Apr 2010, In: Nature Reviews Cancer. 10, 4, p. 267-277 11 p.

    Research output: Contribution to journal › Article › peer-review

  51. Published

    IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

    Daniel Tennant, 1 Jan 2010, In: Cancer Cell. 17, 1, p. 7-9 3 p.

    Research output: Contribution to journal › Article › peer-review

  52. 2009
  53. Published

    Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death

    Daniel Tennant, 12 Nov 2009, In: Oncogene. 28, 45, p. 4009-21 13 p.

    Research output: Contribution to journal › Article › peer-review

  54. Published

    Metabolic transformation in cancer

    Daniel Tennant, 2009, In: Carcinogenesis. 30, 8, p. 1269-80 12 p.

    Research output: Contribution to journal › Article › peer-review

  55. 2007
  56. Published

    Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

    Daniel Tennant, 2007, In: Molecular and Cellular Biology. 27, 9, p. 3282-9 8 p.

    Research output: Contribution to journal › Article › peer-review