Conny Bonifer

Publications

  1. 2021
  2. Published
  3. Published
  4. E-pub ahead of print

    The transcriptional regulation of normal and malignant blood cell development

    Conny Bonifer, 29 Jan 2021, (E-pub ahead of print) In: The FEBS journal.

    Research output: Contribution to journalReview articlepeer-review

  5. Published

    RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

    Salam Assi, Conny Bonifer, 22 Jan 2021, In: Nature Communications. 12, 1, 520.

    Research output: Contribution to journalArticlepeer-review

  6. 2020
  7. Published

    Dissecting Clonal Heterogeneity in AML

    Conny Bonifer, 14 Dec 2020, In: Cancer Cell. 38, 6, p. 782-784 3 p.

    Research output: Contribution to journalArticle

  8. Published
  9. E-pub ahead of print
  10. Published
  11. Published

    Modelling t(8;21) acute myeloid leukaemia ‐ What have we learned?

    Paulynn Suyin Chin & Conny Bonifer, 24 Sep 2020, In: MedComm.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

    Peter Keane & Conny Bonifer, 26 May 2020, In: Cell Reports. 31, 8, 107691.

    Research output: Contribution to journalArticlepeer-review

  13. Published
  14. 2019
  15. Published
  16. Published

    Standing at odds: mutated RAS and hematopoietic stem cells

    Conny Bonifer, Nov 2019, In: Haematologica. 104, 11, p. 2125-2128 4 p.

    Research output: Contribution to journalArticle

  17. Published
  18. Published

    Rewiring of the transcription factor network in acute myeloid leukemia

    Salam Assi, Conny Bonifer & Peter Cockerill, 25 Jun 2019, In: Cancer Informatics. 18

    Research output: Contribution to journalComment/debatepeer-review

  19. Published
  20. Published
  21. 2018
  22. Published
  23. Published

    Prospective isolation and characterization of genetically and functionally distinct AML subclones

    Peter Keane, Maria Imperato, Peter Cockerill, Conny Bonifer, 8 Oct 2018, In: Cancer Cell. 34, 4, p. 674-689.e8 24 p.

    Research output: Contribution to journalArticlepeer-review

  24. Published
  25. Published
  26. Published
  27. Published
  28. 2017
  29. Published
  30. Published

    A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program

    Anetta Ptasinska, Salam Assi, Paulynn Suyin Chin, Maria Imperato, Conny Bonifer, 7 Sep 2017, In: Blood. 130, 10, p. 1213-1222 10 p.

    Research output: Contribution to journalArticlepeer-review

  31. Published
  32. Published

    Chromatin priming of genes in development: concepts, mechanisms and consequences

    Conny Bonifer & Peter Cockerill, May 2017, In: Experimental Hematology. 49, p. 1-8

    Research output: Contribution to journalReview articlepeer-review

  33. Published

    Runx1 Structure and Function in Blood Cell Development

    Conny Bonifer, 16 Mar 2017, RUNX Proteins in Development and Cancer. Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. & van Wijnen, A. (eds.). Springer, p. 65-81 17 p. (Advances in Experimental Medicine and Biology; vol. 962, no. Book Part III).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  34. 2016
  35. E-pub ahead of print

    The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease

    Jane Gilmour & Conny Bonifer, 23 Dec 2016, (E-pub ahead of print) In: Yale Journal of Biology and Medicine. 89, 4, p. 513-525

    Research output: Contribution to journalArticlepeer-review

  36. Published

    Instructive role of MLL-fusion proteins revealed by a model of t(4;11) pro-B acute lymphoblastic leukemia

    Anetta Ptasinska, Salam Assi, Conny Bonifer, 14 Nov 2016, In: Cancer Cell. 30, 5, p. 737–749 13 p.

    Research output: Contribution to journalArticlepeer-review

  37. E-pub ahead of print
  38. Published

    Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

    Jane Gilmour, Anna Pickin & 3 others, , Conny Bonifer, Jun 2016, In: EBioMedicine. 8, June 2016, p. 117-131

    Research output: Contribution to journalArticlepeer-review

  39. Published
  40. Published
  41. E-pub ahead of print
  42. Published

    The leukemia-associated RUNX1/ETO oncoprotein confers a mutator phenotype

    Anetta Ptasinska, Salam Assi, Conny Bonifer & Jeffery Allan, Jan 2016, In: Leukemia. 30

    Research output: Contribution to journalArticlepeer-review

  43. Published
  44. 2015
  45. E-pub ahead of print

    UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO

    Salam Assi, Anetta Ptasinska, Conny Bonifer, 1 Dec 2015, (E-pub ahead of print) In: Leukemia.

    Research output: Contribution to journalArticlepeer-review

  46. Published
  47. Published

    Chromatin Structure Profiling Identifies Crucial Regulators of Tumor Maintenance

    Conny Bonifer & Peter Cockerill, 1 Nov 2015, In: Trends in Cancer. 1, 3, p. 157-160 4 p.

    Research output: Contribution to journalShort surveypeer-review

  48. Published
  49. Published
  50. Published

    Developmental-stage-dependent transcriptional response to leukaemic oncogene expression

    Salam Assi, Jane Gilmour & Conny Bonifer, 28 May 2015, In: Nature Communications. 6, 7203.

    Research output: Contribution to journalArticlepeer-review

  51. Published

    The RUNX1-PU.1 axis in the control of hematopoiesis

    Maria Imperato, Pierre Cauchy, Nadine Obier & Conny Bonifer, Apr 2015, In: International journal of hematology. 101, 4, p. 319-329

    Research output: Contribution to journalArticlepeer-review

  52. Published

    Cytokine and proinflammatory gene expression in classical Hodgkin lymphoma: Its more than NF-κB!

    Pierre Cauchy, Conny Bonifer, Mar 2015, In: Cytokine. 72, 1, p. 115–117

    Research output: Contribution to journalArticle

  53. Published

    Aberrant transcriptional programming in blood cancers

    Conny Bonifer, Peter Cockerill & Anetta Ptasinska, 2015, Chromosomal Translocations and Genome Rearrangements in Cancer. Rowley, J., Le Beau, M. & Rabbitts, T. H. (eds.).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  54. Published

    Polynucleotides for Use in Medicine

    Conny Bonifer, 2015, IPC No. European patent application, Patent No. 10735185.0

    Research output: Patent

  55. Published

    RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1

    Anetta Ptasinska, Salam Assi, Conny Bonifer, 2015, In: Oncogenesis. 4, e146.

    Research output: Contribution to journalArticlepeer-review

  56. 2014
  57. Published
  58. Published
  59. Published

    RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence

    Conny Bonifer, 11 Sep 2014, In: Blood. 124, 11, p. e11-e20

    Research output: Contribution to journalArticlepeer-review

  60. Published
  61. Published

    Delineating MEIS1 cis-regulatory elements active in hematopoietic cells

    Conny Bonifer, Peter Cockerill, Feb 2014, In: Leukemia. 28, 2, p. 433-436 4 p.

    Research output: Contribution to journalLetterpeer-review

  62. Published
  63. 2013
  64. Published

    Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia

    Maarten Hoogenkamp, Conny Bonifer & 2 others, , 11 Nov 2013, In: Cancer Cell. 24, 5, p. 575-588 14 p.

    Research output: Contribution to journalArticlepeer-review

  65. Published
  66. Published
  67. Published
  68. Published

    Why detailed model gene studies in higher eukaryotes are still necessary

    Conny Bonifer, Jun 2013, In: Immunology. 139, 2, p. 158-60 3 p.

    Research output: Contribution to journalArticlepeer-review

  69. Published
  70. Published
  71. Published

    The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus

    Conny Bonifer, 2013, In: PLoS ONE. 8, 1, p. e54935

    Research output: Contribution to journalArticlepeer-review

  72. 2012
  73. Published

    RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

    Monika Lichtinger & Conny Bonifer, 14 Nov 2012, In: The EMBO journal. 31, 22, p. 4318-4333 16 p.

    Research output: Contribution to journalArticlepeer-review

  74. Published
  75. Published
  76. Published

    GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

    Monika Lichtinger, Conny Bonifer, 2012, In: Blood. 120, 2, p. 314-22 9 p.

    Research output: Contribution to journalArticlepeer-review

  77. 2011
  78. Published
  79. Published

    Macrophage development from HSCs requires PU.1-coordinated microRNA expression

    Maarten Hoogenkamp, Conny Bonifer, 25 Aug 2011, In: Blood. 118, 8, p. 2275-2284 10 p.

    Research output: Contribution to journalArticlepeer-review

  80. Published
  81. Published

    Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

    Maarten Hoogenkamp, Conny Bonifer, 10 Mar 2011, In: Blood. 117, 10, p. 2827-2838 12 p.

    Research output: Contribution to journalArticle

  82. Published

    Chromatin mechanisms regulating gene expression in health and disease

    Conny Bonifer & Peter Cockerill, 1 Jan 2011, In: Advances in Experimental Medicine and Biology. 711, p. 12-25 14 p.

    Research output: Contribution to journalReview article

  83. Published
  84. 2010
  85. Published

    cis-Regulatory Remodeling of the SCL Locus during Vertebrate Evolution

    Maarten Hoogenkamp, Conny Bonifer, 1 Dec 2010, In: Molecular and Cellular Biology. 30, 24, p. 5741-5751 11 p.

    Research output: Contribution to journalArticle

  86. Published

    Repeat-element driven activation of proto-oncogenes in human malignancies

    Conny Bonifer, 1 Nov 2010, In: Cell Cycle. 9, 21, p. 4276-4281 6 p.

    Research output: Contribution to journalArticle

  87. Published

    An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression

    Conny Bonifer, 1 Sep 2010, In: Nucleic Acids Research. 38, 16, p. 5336-50 15 p.

    Research output: Contribution to journalArticle

  88. Published

    Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5

    Peter Cockerill, Maarten Hoogenkamp, Conny Bonifer, 20 May 2010, In: Oncogene. 29, 20, p. 2927-37 11 p.

    Research output: Contribution to journalArticle

  89. Published

    Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

    & 5 others, Peter Cockerill, Conny Bonifer, 1 May 2010, In: Nature Medicine. 16, 5, p. 571-9, 1p following 579

    Research output: Contribution to journalArticlepeer-review

  90. Published

    Chromatin regulation by RUNX1

    Monika Lichtinger, Maarten Hoogenkamp & Conny Bonifer, 15 Apr 2010, In: Blood Cells, Molecules & Diseases. 44, 4, p. 287-90 4 p.

    Research output: Contribution to journalArticle

  91. Published
  92. 2009
  93. Published

    Characterization of RNA aptamers that disrupt the RUNX1-CBFbeta/DNA complex

    Conny Bonifer, 1 Nov 2009, In: Nucleic Acids Research. 37, 20, p. 6818-30 13 p.

    Research output: Contribution to journalArticle

  94. Published

    Runx proteins regulate Foxp3 expression

    Maarten Hoogenkamp, Conny Bonifer, 1 Oct 2009, In: The Journal of Experimental Medicine. 206, 11, p. 2329-2337 9 p.

    Research output: Contribution to journalArticle

  95. Published
  96. Published

    Stepwise Activation of Enhancer and Promoter Regions of the B Cell Commitment Gene Pax5 in Early Lymphopoiesis

    Conny Bonifer, 1 Apr 2009, In: Immunity. 30, 4, p. 508-520 13 p.

    Research output: Contribution to journalArticle

  97. Published
  98. Published
  99. 2008
  100. Published
  101. Published

    Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus

    Conny Bonifer, 1 Sep 2008, In: Blood. 112, 5, p. 1673-1682 10 p.

    Research output: Contribution to journalArticlepeer-review

  102. Published
  103. Published
  104. Published

    C/EBP beta induces chromatin opening at a cell-type-specific enhancer

    Conny Bonifer, 1 Mar 2008, In: Molecular and Cellular Biology. 28, 6, p. 2102-2112 11 p.

    Research output: Contribution to journalArticle

  105. Published
  106. Published

    The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis

    Conny Bonifer, 1 Jan 2008, In: Frontiers in Bioscience. 1, 13, p. 549-560 12 p.

    Research output: Contribution to journalArticlepeer-review

  107. 2007
  108. Published
  109. Published

    Transcription factor PU.1 controls transcription start site positioning and alternative TLR4 promoter usage

    Monika Lichtinger, Conny Bonifer, 14 Sep 2007, In: Journal of Biological Chemistry. 282, 37, p. 26874-83 10 p.

    Research output: Contribution to journalArticlepeer-review

  110. Published
  111. Published

    Reduced c-myb expression levels affect hematopoietic development in vitro

    Conny Bonifer, 1 May 2007, In: International journal of hematology. 85, 4, p. 312-6 5 p.

    Research output: Contribution to journalArticle

  112. Published
  113. Published
  114. 2006
  115. Published

    The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction

    Conny Bonifer, 8 Mar 2006, In: The EMBO journal. 25, 5, p. 1070-80 11 p.

    Research output: Contribution to journalArticle

  116. Published

    Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis

    Conny Bonifer, 1 Mar 2006, In: Carcinogenesis. 27, 3, p. 382-91 10 p.

    Research output: Contribution to journalArticlepeer-review

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