Conny Bonifer

Publications

  1. 2021
  2. Published

    Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1

    Salam Assi, Paulynn Suyin Chin, Daniel Coleman, Anna Pickin, , , , Peter Cockerill & Conny Bonifer, 20 Apr 2021, In: Cell Reports. 35, 3, 26 p., 109010.

    Research output: Contribution to journalArticlepeer-review

  3. Published
  4. E-pub ahead of print

    The transcriptional regulation of normal and malignant blood cell development

    Conny Bonifer, 29 Jan 2021, (E-pub ahead of print) In: The FEBS journal.

    Research output: Contribution to journalReview articlepeer-review

  5. Published

    RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

    Salam Assi, , Conny Bonifer & , 22 Jan 2021, In: Nature Communications. 12, 1, 520.

    Research output: Contribution to journalArticlepeer-review

  6. 2020
  7. Published

    Dissecting Clonal Heterogeneity in AML

    Conny Bonifer, 14 Dec 2020, In: Cancer Cell. 38, 6, p. 782-784 3 p.

    Research output: Contribution to journalArticle

  8. Published
  9. E-pub ahead of print
  10. Published
  11. Published

    Modelling t(8;21) acute myeloid leukaemia ‐ What have we learned?

    Paulynn Suyin Chin & Conny Bonifer, 24 Sep 2020, In: MedComm.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

    Peter Keane, , , & Conny Bonifer, 26 May 2020, In: Cell Reports. 31, 8, 107691.

    Research output: Contribution to journalArticlepeer-review

  13. Published
  14. 2019
  15. Published
  16. Published

    Standing at odds: mutated RAS and hematopoietic stem cells

    Conny Bonifer, Nov 2019, In: Haematologica. 104, 11, p. 2125-2128 4 p.

    Research output: Contribution to journalArticle

  17. Published
  18. Published

    Rewiring of the transcription factor network in acute myeloid leukemia

    Salam Assi, Conny Bonifer & Peter Cockerill, 25 Jun 2019, In: Cancer Informatics. 18

    Research output: Contribution to journalComment/debatepeer-review

  19. Published
  20. Published
  21. 2018
  22. Published
  23. Published

    Prospective isolation and characterization of genetically and functionally distinct AML subclones

    Peter Keane, Maria Imperato, , , , , , , , , , Peter Cockerill, , , , Conny Bonifer & , 8 Oct 2018, In: Cancer Cell. 34, 4, p. 674-689.e8 24 p.

    Research output: Contribution to journalArticlepeer-review

  24. Published
  25. Published
  26. Published
  27. Published
  28. 2017
  29. Published
  30. Published

    A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program

    Anetta Ptasinska, , , Salam Assi, Paulynn Suyin Chin, Maria Imperato, , , , Conny Bonifer & , 7 Sep 2017, In: Blood. 130, 10, p. 1213-1222 10 p.

    Research output: Contribution to journalArticlepeer-review

  31. Published
  32. Published

    Chromatin priming of genes in development: concepts, mechanisms and consequences

    Conny Bonifer & Peter Cockerill, May 2017, In: Experimental Hematology. 49, p. 1-8

    Research output: Contribution to journalReview articlepeer-review

  33. Published

    Runx1 Structure and Function in Blood Cell Development

    Conny Bonifer, , & , 16 Mar 2017, RUNX Proteins in Development and Cancer. Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. & van Wijnen, A. (eds.). Springer, p. 65-81 17 p. (Advances in Experimental Medicine and Biology; vol. 962, no. Book Part III).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  34. 2016
  35. E-pub ahead of print

    The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease

    Jane Gilmour & Conny Bonifer, 23 Dec 2016, (E-pub ahead of print) In: Yale Journal of Biology and Medicine. 89, 4, p. 513-525

    Research output: Contribution to journalArticlepeer-review

  36. Published

    Instructive role of MLL-fusion proteins revealed by a model of t(4;11) pro-B acute lymphoblastic leukemia

    Anetta Ptasinska, , Salam Assi, , , , , , , , , , Conny Bonifer, & , 14 Nov 2016, In: Cancer Cell. 30, 5, p. 737–749 13 p.

    Research output: Contribution to journalArticlepeer-review

  37. E-pub ahead of print
  38. Published

    Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

    Jane Gilmour, Anna Pickin & 3 others, , Conny Bonifer & , Jun 2016, In: EBioMedicine. 8, June 2016, p. 117-131

    Research output: Contribution to journalArticlepeer-review

  39. Published
  40. Published

    Inducible chromatin priming is associated with the establishment of immunological memory in T cells

    Sarah Bevington, Pierre Cauchy, , , , , Niall Gilding, , Conny Bonifer & Peter Cockerill, Mar 2016, In: The EMBO journal. 35, 5, p. 515-535 21 p.

    Research output: Contribution to journalArticlepeer-review

  41. E-pub ahead of print
  42. Published

    The leukemia-associated RUNX1/ETO oncoprotein confers a mutator phenotype

    Anetta Ptasinska, Salam Assi, , , Conny Bonifer, & Jeffery Allan, Jan 2016, In: Leukemia. 30

    Research output: Contribution to journalArticlepeer-review

  43. Published
  44. 2015
  45. E-pub ahead of print

    UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO

    Salam Assi, Anetta Ptasinska, , Conny Bonifer, , & , 1 Dec 2015, (E-pub ahead of print) In: Leukemia.

    Research output: Contribution to journalArticlepeer-review

  46. Published
  47. Published

    Chromatin Structure Profiling Identifies Crucial Regulators of Tumor Maintenance

    Conny Bonifer & Peter Cockerill, 1 Nov 2015, In: Trends in Cancer. 1, 3, p. 157-160 4 p.

    Research output: Contribution to journalShort surveypeer-review

  48. Published

    C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis

    Maarten Hoogenkamp, , , , , , , , Conny Bonifer & , 11 Aug 2015, In: Stem Cell Reports. 5, 2, p. 232-247

    Research output: Contribution to journalArticlepeer-review

  49. Published
  50. Published

    Developmental-stage-dependent transcriptional response to leukaemic oncogene expression

    Salam Assi, , Jane Gilmour, & Conny Bonifer, 28 May 2015, In: Nature Communications. 6, 7203.

    Research output: Contribution to journalArticlepeer-review

  51. Published

    The RUNX1-PU.1 axis in the control of hematopoiesis

    Maria Imperato, Pierre Cauchy, Nadine Obier & Conny Bonifer, Apr 2015, In: International journal of hematology. 101, 4, p. 319-329

    Research output: Contribution to journalArticlepeer-review

  52. Published

    Cytokine and proinflammatory gene expression in classical Hodgkin lymphoma: Its more than NF-κB!

    Pierre Cauchy, Conny Bonifer & , Mar 2015, In: Cytokine. 72, 1, p. 115–117

    Research output: Contribution to journalArticle

  53. Published

    Aberrant transcriptional programming in blood cancers

    Conny Bonifer, Peter Cockerill & Anetta Ptasinska, 2015, Chromosomal Translocations and Genome Rearrangements in Cancer. Rowley, J., Le Beau, M. & Rabbitts, T. H. (eds.).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  54. Published

    Polynucleotides for Use in Medicine

    Conny Bonifer, 2015, IPC No. European patent application, Patent No. 10735185.0

    Research output: Patent

  55. Published

    RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1

    Anetta Ptasinska, Salam Assi, , , , Conny Bonifer, & , 2015, In: Oncogenesis. 4, e146.

    Research output: Contribution to journalArticlepeer-review

  56. 2014
  57. Published
  58. Published
  59. Published

    RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence

    Conny Bonifer, , & , 11 Sep 2014, In: Blood. 124, 11, p. e11-e20

    Research output: Contribution to journalArticlepeer-review

  60. Published

    A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification

    Jane Gilmour, Salam Assi, , , , , , & Conny Bonifer, Jun 2014, In: Development (Cambridge). 141, 12, p. 2391-2401

    Research output: Contribution to journalArticlepeer-review

  61. Published

    Delineating MEIS1 cis-regulatory elements active in hematopoietic cells

    Conny Bonifer, Peter Cockerill, , , & , Feb 2014, In: Leukemia. 28, 2, p. 433-436 4 p.

    Research output: Contribution to journalLetterpeer-review

  62. Published
  63. 2013
  64. Published

    Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia

    Maarten Hoogenkamp, Conny Bonifer & 2 others, & , 11 Nov 2013, In: Cancer Cell. 24, 5, p. 575-588 14 p.

    Research output: Contribution to journalArticlepeer-review

  65. Published
  66. Published
  67. Published
  68. Published

    Why detailed model gene studies in higher eukaryotes are still necessary

    Conny Bonifer, Jun 2013, In: Immunology. 139, 2, p. 158-60 3 p.

    Research output: Contribution to journalArticlepeer-review

  69. Published
  70. Published
  71. Published

    The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus

    Conny Bonifer & , 2013, In: PLoS ONE. 8, 1, p. e54935

    Research output: Contribution to journalArticlepeer-review

  72. 2012
  73. Published

    RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

    Monika Lichtinger, , , , , , , , , , , , , , & Conny Bonifer, 14 Nov 2012, In: The EMBO journal. 31, 22, p. 4318-4333 16 p.

    Research output: Contribution to journalArticlepeer-review

  74. Published
  75. Published
  76. Published

    GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

    Monika Lichtinger, , , , , Conny Bonifer, , & , 2012, In: Blood. 120, 2, p. 314-22 9 p.

    Research output: Contribution to journalArticlepeer-review

  77. 2011
  78. Published

    RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

    Conny Bonifer, , & , 1 Oct 2011, In: The EMBO journal. 30, 19, p. 4059-4070 12 p.

    Research output: Contribution to journalArticle

  79. Published

    Macrophage development from HSCs requires PU.1-coordinated microRNA expression

    Maarten Hoogenkamp, , , Conny Bonifer, , , & , 25 Aug 2011, In: Blood. 118, 8, p. 2275-2284 10 p.

    Research output: Contribution to journalArticlepeer-review

  80. Published
  81. Published

    Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

    Maarten Hoogenkamp, , , , , , , , , , , , , Conny Bonifer & , 10 Mar 2011, In: Blood. 117, 10, p. 2827-2838 12 p.

    Research output: Contribution to journalArticle

  82. Published

    Chromatin mechanisms regulating gene expression in health and disease

    Conny Bonifer & Peter Cockerill, 1 Jan 2011, In: Advances in Experimental Medicine and Biology. 711, p. 12-25 14 p.

    Research output: Contribution to journalReview article

  83. Published
  84. 2010
  85. Published

    cis-Regulatory Remodeling of the SCL Locus during Vertebrate Evolution

    Maarten Hoogenkamp, , Conny Bonifer, & , 1 Dec 2010, In: Molecular and Cellular Biology. 30, 24, p. 5741-5751 11 p.

    Research output: Contribution to journalArticle

  86. Published

    Repeat-element driven activation of proto-oncogenes in human malignancies

    Conny Bonifer & , 1 Nov 2010, In: Cell Cycle. 9, 21, p. 4276-4281 6 p.

    Research output: Contribution to journalArticle

  87. Published

    An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression

    Conny Bonifer, & , 1 Sep 2010, In: Nucleic Acids Research. 38, 16, p. 5336-50 15 p.

    Research output: Contribution to journalArticle

  88. Published

    Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5

    Peter Cockerill, , , Maarten Hoogenkamp, , , , Conny Bonifer & , 20 May 2010, In: Oncogene. 29, 20, p. 2927-37 11 p.

    Research output: Contribution to journalArticle

  89. Published

    Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

    & 5 others, Peter Cockerill, , , Conny Bonifer & , 1 May 2010, In: Nature Medicine. 16, 5, p. 571-9, 1p following 579

    Research output: Contribution to journalArticlepeer-review

  90. Published

    Chromatin regulation by RUNX1

    Monika Lichtinger, Maarten Hoogenkamp, , & Conny Bonifer, 15 Apr 2010, In: Blood Cells, Molecules & Diseases. 44, 4, p. 287-90 4 p.

    Research output: Contribution to journalArticle

  91. Published
  92. 2009
  93. Published

    Characterization of RNA aptamers that disrupt the RUNX1-CBFbeta/DNA complex

    Conny Bonifer & , 1 Nov 2009, In: Nucleic Acids Research. 37, 20, p. 6818-30 13 p.

    Research output: Contribution to journalArticle

  94. Published

    Runx proteins regulate Foxp3 expression

    Maarten Hoogenkamp, , , , , , , , Conny Bonifer, , & , 1 Oct 2009, In: The Journal of Experimental Medicine. 206, 11, p. 2329-2337 9 p.

    Research output: Contribution to journalArticle

  95. Published
  96. Published

    Stepwise Activation of Enhancer and Promoter Regions of the B Cell Commitment Gene Pax5 in Early Lymphopoiesis

    Conny Bonifer, & , 1 Apr 2009, In: Immunity. 30, 4, p. 508-520 13 p.

    Research output: Contribution to journalArticle

  97. Published
  98. Published
  99. 2008
  100. Published
  101. Published

    Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus

    Conny Bonifer & , 1 Sep 2008, In: Blood. 112, 5, p. 1673-1682 10 p.

    Research output: Contribution to journalArticlepeer-review

  102. Published
  103. Published
  104. Published

    C/EBP beta induces chromatin opening at a cell-type-specific enhancer

    Conny Bonifer & , 1 Mar 2008, In: Molecular and Cellular Biology. 28, 6, p. 2102-2112 11 p.

    Research output: Contribution to journalArticle

  105. Published
  106. Published

    The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis

    Conny Bonifer & , 1 Jan 2008, In: Frontiers in Bioscience. 1, 13, p. 549-560 12 p.

    Research output: Contribution to journalArticlepeer-review

  107. 2007
  108. Published
  109. Published

    Transcription factor PU.1 controls transcription start site positioning and alternative TLR4 promoter usage

    Monika Lichtinger, , , Conny Bonifer & , 14 Sep 2007, In: Journal of Biological Chemistry. 282, 37, p. 26874-83 10 p.

    Research output: Contribution to journalArticlepeer-review

  110. Published
  111. Published

    Reduced c-myb expression levels affect hematopoietic development in vitro

    Conny Bonifer, 1 May 2007, In: International journal of hematology. 85, 4, p. 312-6 5 p.

    Research output: Contribution to journalArticle

  112. Published
  113. Published
  114. 2006
  115. Published

    The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction

    Conny Bonifer, 8 Mar 2006, In: The EMBO journal. 25, 5, p. 1070-80 11 p.

    Research output: Contribution to journalArticle

  116. Published

    Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis

    Conny Bonifer, & , 1 Mar 2006, In: Carcinogenesis. 27, 3, p. 382-91 10 p.

    Research output: Contribution to journalArticlepeer-review

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