Clare Ray

Accepting PhD Students

PhD projects

The main theme of Clare Ray’s research and doctoral supervision is the regulation of skeletal muscle blood flow. Her focus has been on the role of the local mediators adenosine and nitric oxide in matching oxygen delivery to oxygen consumption during hypoxia when oxygen delivery is compromised and during exercise when oxygen consumption is increased. More recently, Dr Ray has been interested in the role of reactive oxygen species in the vasodilator responses of skeletal muscle and the influence of adaptive and maladaptive changes induced by chronic hypoxia. She is also involved in research investigating the skeletal muscle vasodilatation evoked by insulin with a focus on the role of nitric oxide and the endothelium as a barrier to insulin action in models of type 2 diabetes.

Research activity per year

25 Article
5 Abstract
2 Paper
2 Review article
More
- 1 Conference contribution
- 1 Chapter (peer-reviewed)

36 results

2023
Analyzing Angiotensin II Receptor Type 1 Clustering in PC12 Cells in Response to Hypoxia Using Direct Stochastic Optical Reconstruction Microscopy (dSTORM)
Aldossary, H. S., Nieves, D. J., Kavanagh, D. M., Owen, D., Ray, C. J., Kumar, P., Coney, A. M. & Holmes, A. P., 16 Jun 2023, Arterial Chemoreceptors: Mal(adaptive) Responses: O2 Dependent and Independent Mechanisms. Conde, S. V., Iturriaga, R., del Rio, R., Gauda, E. & Monteiro, E. C. (eds.). 1 ed. Springer, p. 175-184 10 p. (Advances in Experimental Medicine and Biology; vol. 1427).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Cultural adaptation and development of an educational intervention ‘Meri Sehat, Mere Rules’ relating to cardiovascular disease associated with rheumatoid arthritis for South Asian people.
Tiwana, R., Kamal, A., Singh, D., Misra, D., Usman, F., John, H., Kitas, G. D., Greenfield, S., Kumar, P., Ray, C., Bosworth, A., Ahmad, A., Reehal, J. & Kumar, K., 25 Oct 2023, (E-pub ahead of print) In: Mediterranean Journal of Rheumatology. 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
53 Downloads (Pure)
2022
Are multiple mitochondrial related signalling pathways involved in carotid body oxygen sensing?
Holmes, A. P., Swiderska, A., Nathanael, D., Aldossary, H. S., Ray, C. J., Coney, A. M. & Kumar, P., 31 May 2022, In: Frontiers in Physiology. 13, 12 p., 908617.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
27 Downloads (Pure)
Risk of incident obstructive sleep apnoea in patients with type 1 diabetes: a population-based retrospective cohort study
Alshehri, Z., Subramanian, A., Adderley, N., Gokhale, K., Karamat, M. A., Ray, C., Kumar, P., Nirantharakumar, K. & Tahrani, A., Aug 2022, In: Diabetologia. 65, 8, p. 1353-1363 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
51 Downloads (Pure)
2021
Barriers to access, transition and progression of widening participation students in UK medical schools: the students’ perspective
Sartania, N., Alldridge, L. & Ray, C., 18 Jun 2021, In: MedEdPublish. 10, 6 p., 132.
Research output: Contribution to journal › Article › peer-review

Open Access
File
22 Downloads (Pure)
Mitochondrial succinate metabolism and reactive oxygen species are important but not essential for eliciting carotid body and ventilatory responses to hypoxia in the rat
Swiderska, A., Coney, A. M., Alzahrani, A. A., Aldossary, H. S., Batis, N., Ray, C. J., Kumar, P. & Holmes, A. P., 25 May 2021, In: Antioxidants. 10, 6, 20 p., 840.
Research output: Contribution to journal › Article › peer-review

Open Access
File
126 Downloads (Pure)
β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia
Alzahrani, A. A., Cao, L. L., Aldossary, H. S., Nathanael, D., Fu, J., Ray, C. J., Brain, K. L., Kumar, P., Coney, A. M. & Holmes, A. P., Jan 2021, In: Pfluegers Archiv: European journal of physiology . 473, 1, p. 37-51 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Citations (Scopus)

179 Downloads (Pure)
2020

A student practical to conceptualize the importance of Poiseuille’s law and flow control in the cardiovascular system
Holmes, A. P., Ray, C. J., Kumar, P. & Coney, A. M., 1 Sept 2020, In: Advances in Physiology Education.
Research output: Contribution to journal › Article › peer-review
G-protein-coupled receptor (GPCR) signaling in the carotid body: roles in hypoxia and cardiovascular and respiratory disease
Aldossary, H. S., Alzahrani, A. A., Nathanael, D., Alhuthail, E. A., Ray, C. J., Batis, N., Kumar, P., Coney, A. M. & Holmes, A. P., 1 Sept 2020, In: International Journal of Molecular Sciences. 21, 17, 20 p., 6012.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
3 Citations (Scopus)

202 Downloads (Pure)
Prostaglandin contribution to postexercise hyperemia is dependent on tissue oxygenation during rhythmic and isometric contractions
Junejo, R., Ray, C. & Marshall, J., Jun 2020, In: Physiological reports. 8, 12, e14471.
Research output: Contribution to journal › Article › peer-review

Open Access
File
174 Downloads (Pure)
2019
Cuff inflation time significantly affects blood flow recorded with venous occlusion plethysmography: rapid cuff inflation improves estimations of hyperemic flow
Junejo, R., Ray, C. & Marshall, J., 1 Mar 2019, In: European Journal of Applied Physiology. 119, 3, p. 665–674 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
6 Citations (Scopus)

277 Downloads (Pure)
2018
Adrenaline activation of the carotid body: key to CO2 and pH homeostasis in hypoglycaemia and potential pathological implications in cardiovascular disease
Holmes, A., Ray, C., Thompson, E., Alshehri, Z., Coney, A. & Kumar, P., 25 May 2018, (E-pub ahead of print) In: Respiratory physiology & neurobiology.
Research output: Contribution to journal › Article › peer-review

Open Access
File
7 Citations (Scopus)

277 Downloads (Pure)
Caffeine, gravity, and baroreceptor function: the integration diet and cardiovascular control
Hauton, D. & Ray, C., Sept 2018, In: American Journal of Physiology - Advances in Physiology Education. 42, p. 454-461 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
137 Downloads (Pure)
Ecto-5′-nucleotidase (CD73) regulates peripheral chemoreceptor activity and cardiorespiratory responses to hypoxia: Ecto-5′-nucleotidase and carotid body chemosensitivity
Holmes, A. P., Ray, C. J., Pearson, S. A., Coney, A. M. & Kumar, P., 9 Aug 2018, In: The Journal of Physiology.
Research output: Contribution to journal › Article › peer-review

Open Access
File
13 Citations (Scopus)

204 Downloads (Pure)
Is carotid body physiological O₂ sensitivity determined by a unique mitochondrial phenotype?
Holmes, A., Ray, C., Coney, A. & Kumar, P., 16 May 2018, In: Frontiers in Physiology. 9, 562.
Research output: Contribution to journal › Article › peer-review

Open Access
File
7 Citations (Scopus)

173 Downloads (Pure)
2016
Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2 sensitivity during hypoglycaemia: a role for the carotid body
Thompson, E. L., Ray, C. J., Holmes, A. P., Pye, R. L., Wyatt, C. N., Coney, A. M. & Kumar, P., 1 Aug 2016, In: The Journal of Physiology. 594, 15, p. 4439-52 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
21 Citations (Scopus)

236 Downloads (Pure)
Investigation into effects of supplementary O-2 on tissue oxygenation during isometric handgrip in the ipsilateral and contralateral limb in young (Y) and older (O) men using Near Infra Red Spectroscopy (NIRS)
Junejo, R. T., Ray, C. J., Lucas, S. J. E. & Marshall, J. M., 1 Apr 2016, In: FASEB Journal. 30, 1_supplement
Research output: Contribution to journal › Abstract › peer-review
2015

Does Adenosine make an O-2 Dependent Contribution to Exercise Hyperaemia?
Ray, C., Junejo, R. & Marshall, J., 2015, In: FASEB Journal.
Research output: Contribution to journal › Article › peer-review
Effects of Breathing O-2 at different Concentrations on Reactive Oxygen Species (ROS) and Endothelium Dependent Dilatation
Marshall, J., Junejo, R., D'Souza, F. & Ray, C., 2015, In: FASEB Journal.
Research output: Contribution to journal › Abstract › peer-review
Mild chronic intermittent hypoxia in wistar rats evokes significant cardiovascular pathophysiology but no overt changes in carotid body-mediated respiratory responses
Ray, C. J., Dow, B., Kumar, P. & Coney, A. M., 2015, Arterial Chemoreceptors in Physiology and Pathophysiology. Peers, C., Kumar, P., Wyatt, C., Gauda, E., Nurse, C. A. & Prabhakar, N. (eds.). Springer, Vol. 860. p. 245-254 10 p. (Advances in Experimental Medicine and Biology; vol. 860).
Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
4 Citations (Scopus)
O-2 Dependent Contributions of Prostaglandins (PGI(2) PGE(2)) to Exercise Hyperaemia in Young (Y) and Older (O) Men
Junejo, R., Ray, C. & Marshall, J., 2015, In: FASEB Journal.
Research output: Contribution to journal › Article › peer-review
Prostaglandins (PGs) Contribute in an O-2 Dependent Manner to Reflex Vasoconstriction in Exercise
Junejo, R., Ray, C. & Marshall, J., 2015, In: FASEB Journal.
Research output: Contribution to journal › Abstract › peer-review
2014
Glycogen metabolism protects against metabolic insult to preserve carotid body function during glucose deprivation
Holmes, A. P., Turner, P. J., Carter, P., Leadbeater, W., Ray, C. J., Hauton, D., Buckler, K. J. & Kumar, P., 15 Oct 2014, In: The Journal of Physiology. 592, 20, p. 4493-4506
Research output: Contribution to journal › Article › peer-review

Open Access
File
15 Citations (Scopus)

167 Downloads (Pure)
Prostaglandins contribute in an O2‐dependent manner to exercise hyperaemia following rhythmic and isometric handgrip exercise in young and older healthy subjects
Junejo, R., Ray, C. & Marshall, J., 1 Apr 2014, In: FASEB Journal. 28, S1
Research output: Contribution to journal › Article › peer-review
2012
Contribution of non-endothelium-dependent substances to exercise hyperaemia: are they O(2) dependent?
Marshall, J. M. & Ray, C. J., 2012, In: The Journal of Physiology. 590, Pt 24, p. 6307-20 14 p.
Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus)
2009
Elucidation in the rat of the role of adenosine and A2A-receptors in the hyperaemia of twitch and tetanic contractions.
Ray, C. & Marshall, J., 1 Apr 2009, In: The Journal of Physiology. 587, Pt 7, p. 1565-78 14 p.
Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus)
Nitric oxide (NO) does not contribute to the generation or action of adenosine during exercise hyperaemia in rat hindlimb.
Ray, C. & Marshall, J., 1 Apr 2009, In: The Journal of Physiology. 587, Pt 7, p. 1579-91 13 p.
Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus)
2005

Endothelial adenosine release during hypoxia: a role for nitric oxide?
Ray, C., Dale, N. & Marshall, J., 1 Jan 2005, p. 937.2. 1 p.
Research output: Contribution to conference (unpublished) › Abstract
Inhibition of cortisol production with metyrapone prevents mental stress-induced endothelial dysfunction and baroreflex impairment
Broadley, AJ., Korszun, A., Abdelaal, E., Moskvina, V., Jones, C., Nash, G., Ray, C., Deanfield, J. & Frenneaux, M., 19 Jul 2005, In: Journal of the American College of Cardiology. 46, p. 344-350 7 p.
Research output: Contribution to journal › Article › peer-review
106 Citations (Scopus)
Measurement of nitric oxide release evoked by systemic hypoxia and adenosine from rat skeletal muscle in vivo
Ray, C. & Marshall, J., 7 Jul 2005, In: The Journal of Physiology. 568, p. 967-978 12 p.
Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus)
Sphingomyelinase as a link between inflammation and atherosclerosis
Church, LD., Ray, C., Coney, A., Shou, T., Goodall, JE., Marshall, J., Young, S. & Bacon, P., 2005, In: Immunology. 116, p. 59-60
Research output: Contribution to journal › Article › peer-review
The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium
Ray, C. & Marshall, J., 15 Sept 2005, In: The Journal of Physiology. 570, p. 85-96 12 p.
Research output: Contribution to journal › Article › peer-review
79 Citations (Scopus)
2004

Release of nitric oxide (NO) from the hindlimb of the anaesthetized rat in response to systemic hypoxia and adenosine infusion
Ray, C. & Marshall, J., 1 Jan 2004, p. C34.
Research output: Contribution to conference (unpublished) › Paper
2003

Interdependence of nitric oxide and prostaglandins in adenosine-evoked vasodilatation: role in hypoxia
Ray, C. & Marshall, J., 1 Jan 2003, p. M20.
Research output: Contribution to conference (unpublished) › Abstract
Mechanisms underlying the interaction of adenosine, nitric oxide and cyclooxygenase pathways in freshly excised rat aorta
Ray, C. & Marshall, J., 1 Jan 2003, p. PC47.
Research output: Contribution to conference (unpublished) › Paper
2002
Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies
Ray, C., Abbas, MR., Coney, A. & Marshall, J., 1 Oct 2002, In: The Journal of Physiology. 544, 1, p. 195-209 15 p.
Research output: Contribution to journal › Article › peer-review
113 Citations (Scopus)

Clare Ray

Research output

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