Christopher McCabe

Colleges, School and Institutes

External positions

, SOCIETY FOR ENDOCRINOLOGY

2015 → 2019

THE WELLCOME TRUST

2013 → 2017

SOCIETY FOR ENDOCRINOLOGY

2011 → 2015

Qualifications

University
of Sheffield 1987-1990

BSc: First Class Special Honours in

Genetics

 

PhD: Genetic Aspects of Circadian Rhythmicity in Drosophila melanogaster

University of Birmingham 1990-1994

 

Professional Qualifications

  • PhD: Genetic Aspects of Circadian Rhythmicity in Drosophila melanogaster,

    1990 - 1994

  • BSc: First Class Special Honours in Genetics,

    1987 - 1990

Willingness to take PhD students

Yes

PhD projects

Chris McCabe works on mechanisms of endocrine cancers, including thyroid and breast tumour models. The McCabe group currently holds funding from the Wellcome Trust, the Medical Research Council and Cancer Research UK. Its current research focuses on:

Assessment of the role of the proto-oncogenes PTTG and PBF in thyroid, breast and colon tumours
In vitro and in vivo models exploring gene function
Gene expression in multiple tumour models
Mechanisms of aneuploidy and genetic instability in thyroid and colon cancer
The action of the sodium iodide symporter NIS in radioiodine treatment of thyroid and other tumours
Diverse mechanisms of endocrine cancer
Murine models of tumourigenesis

Professor McCabe currently supervises six doctoral researchers and is interested in supervising future projects in the areas of breast cancer invasion and thyroid cancer therapy.

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Most downloaded publications

Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF
Imruetaicharoenchoke, W., Alice Fletcher, Wenqi Lu, Watkins, RJ., Modasia, B., Poole, V., Hannah Nieto, Thompson, R., Kristien Boelaert, Martin Read, Vicki Smith & Christopher McCabe, Sep 2017, In : Endocrine-related cancer. 24, 9, p. 459-474

Research output: Contribution to journal › Article

203 downloads
The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer
Martin Read, Seed, R. I., Modasia, B., Kwan, P. P. K., Sharma, N., Vicki Smith, Rachel Spruce, Bansal, S., Gagliano, T., Stratford, A. L., Ismail, T., Wakelam, M. J. O., Dae Kim, Stephen Ward, Kristien Boelaert, Jayne Franklyn, Andrew Turnell & Christopher McCabe, Jan 2016, In : Molecular Carcinogenesis. 55, 1, p. 15-26

Research output: Contribution to journal › Article

182 downloads
Manipulation of PBF/PTTG1IP phosphorylation status ; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors
Vicki Smith, Neil Sharma, Rachel Spruce, Martin Read, Ryan, G., Kwan, P., Ashley Martin, Watkinson, J., Jayne Franklyn, Kristien Boelaert & Christopher McCabe, 1 Jul 2013, In : The Journal of clinical endocrinology and metabolism. 98, 7, p. 2876-2886 11 p.

Research output: Contribution to journal › Article

167 downloads
Vitamin D promotes human extravillous trophoblast invasion in vitro
Shiaoyng Chan, Radhika Susarla, David Canovas, Elisavet Vasilopoulou, Ohizua, O., Christopher McCabe, Martin Hewison & Mark Kilby, Apr 2015, In : Placenta. 36, 4, p. 403-9 7 p.

Research output: Contribution to journal › Article

159 downloads
Germline ESR2 mutation predisposes to medullary thyroid carcinoma and causes up-regulation of RET expression
Smith, J., Read, M., Hoffman, J., Brown, R., Bradshaw, B., Campbell, C., Cole, T., Dieguez Navas, J., Eatock, F., Gundara, J., Lian, E., McMullan, D., MacDonald, F., Morgan, N., Mulligan, L., Morrison, P. J., Robledo, M., Simpson, M., Smith, V., Stewart, S. & 10 others, Trembath, R., Sidhu, S., Togneri, F., Vialard, L., Naomi Wake, Yvonne Wallis, Watkinson, J., Eamonn Maher, Christopher McCabe & Emma Woodward, 1 May 2016, In : Human Molecular Genetics. 25, 9, p. 1836-1845

Research output: Contribution to journal › Article

67 downloads

Recent publications

A high-throughput yellow fluorescent protein (YFP) cell-based screen identifies autophagy modulators to increase the effectiveness of radioiodine therapy
Martin Read, Brookes, K., Alice Fletcher, Thornton, C., Alshahrani, M., Nieto, H., Khan, R., Webster, J., Haggie, P., Verkman, A., Luke Alderwick, Kristien Boelaert, Vicki Smith & Christopher McCabe, 13 Nov 2019, In : Endocrine Abstracts. 65, 1 p., OC4.1.

Research output: Contribution to journal › Abstract

Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) enhances radioiodine uptake: Targeting NIS interactors to enhance radioiodine uptake
Alice Fletcher, Martin Read, Thornton, C., Dean Larner, Poole, V., Brookes, K., Hannah Nieto, Alshahrani, M., Thompson, R., Gareth Lavery, Landa, I., Fagin, J. A., Campbell, M. J., Kristien Boelaert, Andrew Turnell, Vicki Smith & Christopher McCabe, 31 Oct 2019, In : Cancer Research.

Research output: Contribution to journal › Article

Dimerization of the sodium/iodide symporter
Thompson, R. J., Alice Fletcher, Brookes, K., Nieto, H., Alshahrani, M. M., Jonathan Wolf Mueller, Fine, N. H. F., David Hodson, Kristien Boelaert, Martin Read, Vicki Smith & Christopher McCabe, Oct 2019, In : Thyroid. 29, 10, p. 1485-1498 14 p.

Research output: Contribution to journal › Article

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