Colleges, School and Institutes
Willingness to take PhD students
A characteristic feature of chronic inflammatory reactions is their persistence and predilection for certain sites. Chris Buckley’s group investigates the role that tissue resident stromal cells (fibroblasts) play in determining both the switch to persistence as well as the site at which inflammation occurs. The group’s work has allowed them to propose that a stromal area post code, predominantly defined by fibroblasts, exists within tissues. Their hypothesis predicts that components of this stromal area post code become disordered during inflammation, leading to the accumulation of lymphocytes in structures that resemble lymphoid tissues. They suggest that stromal cells in general and fibroblasts in particular offer a new family of organ-specific targets to treat chronic immune-mediated inflammatory diseases such as rheumatoid arthritis.
Professor Buckley is interested in supervising doctoral research on the role of stromal cells in inflammation.