Colleges, School and Institutes
Willingness to take PhD students
The Chromatin and Gene Expression Group headed by Bryan Turner takes on doctoral researchers with an interest in epigenetics, control of differentiation, gene expression and related areas, particularly as they relate to the growth and behaviour of cancers.
In all eukaryotic organisms, from yeast to humans, DNA is packaged into the cell nucleus by complexing with a highly conserved family of proteins, the histones, to form a DNA-protein complex called chromatin. Histone modifications strongly influence the activities of genes along the DNA with which they are complexed, and play key roles in determining patterns of gene expression in both normal cells and in the deregulated cells found in diseases such as cancer. Determining the mechanisms by which histone modifications influence gene expression and whether they have a role in the heritability of gene expression patterns remain central questions in epigenetic research and ones that Professor Turner’s research group is actively pursuing.