Angelo Agathanggelou

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Publications

  1. Published

    Targeting the ataxia telangiectasia mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

    Angelo Agathanggelou, Victoria Weston, Tracey Perry, Nick Davies, John Fossey, Ceri Oldreive, Wenbin Wei, Dickens Pratt, Paul Moss, Grant Stewart, Malcolm Taylor & 1 others, Tatjana Stankovic, 31 Aug 2015, In: Haematologica. 100, 8, p. 1076-1085 10 p.

    Research output: Contribution to journal › Article › peer-review

  2. Published

    Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours

    Angelo Agathanggelou, Donia MaCartney, Ashraf Dallol, Paul Fullwood, Eamonn Maher & Farida Latif, 22 Mar 2001, In: Oncogene. 20, 12, p. 1509-1518 10 p.

    Research output: Contribution to journal › Article

  3. Published

    CLL Progression Is Associated with Increased Clonal Diversity and Replication Stress

    Angelo Agathanggelou, Anna Skowronska, Nick Davies, Marwan Cheng Kuang Kwok, Malcolm Taylor & Tatjana Stankovic, 6 Dec 2014, Blood. Vol. 124. p. 1977 (Blood).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  4. Published

    Role of the RAS association domain family 1 (RASSF1) tumor suppresor gene in human cancers

    Angelo Agathanggelou, Wendy Cooper & Farida Latif, 1 May 2005, In: Cancer Research. 65, p. 3497-3508 12 p.

    Research output: Contribution to journal › Article

  5. Published

    Identification of Novel Gene Expression Targets for the Ras Association Domain Family 1 (RASSF1A) Tumor Suppressor Gene in Non-Small Cell Lung Cancer and Neuroblastoma

    Angelo Agathanggelou, Jalal Ahmed-Choudhury, Eamonn Maher & Farida Latif, 1 Jan 2003, In: Cancer Research. 63, p. 5344-5351 8 p.

    Research output: Contribution to journal › Article

  6. Published

    Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers

    Angelo Agathanggelou, Ashraf Dallol, Eamonn Maher & Farida Latif, 13 Mar 2003, In: Oncogene. 22, 10, p. 1580-1588 9 p.

    Research output: Contribution to journal › Article

  7. Published

    USP7 inhibition alters homologous recombination repair and targets CLL cells independent of ATM/p53 functional status

    Angelo Agathanggelou, Nick Davies, Marwan Cheng Kuang Kwok, Anastasia Zlatanou, Ceri Oldreive, Tracey Perry, Pamela Kearns, Anna Skowronska, Helen Parry, Dickens Pratt, Paul Moss & 3 others, Malcolm Taylor, Grant Stewart & Tatjana Stankovic, 11 May 2017, In: Blood.

    Research output: Contribution to journal › Article › peer-review

  8. Published

    Transcriptional regulation of Cyclin A2 by RASSF1A through the enhanced binding of p120E4F to the Cyclin A2 promotor

    Jalal Ahmed-Choudhury, Angelo Agathanggelou, Sarah Fenton, Christopher Ricketts, Eamonn Maher & Farida Latif, 1 Apr 2005, In: Cancer Research. 65, p. 2690-2697 8 p.

    Research output: Contribution to journal › Article

  9. Published

    RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastomas

    Dewi Astuti, Angelo Agathanggelou, Ashraf Dallol, Carole Cummins, Farida Latif & Eamonn Maher, 8 Nov 2001, In: Oncogene. 20, 51, p. 7573-7577 5 p.

    Research output: Contribution to journal › Article

  10. E-pub ahead of print

    Degradation of a novel DNA damage response protein, tankyrase 1 binding protein 1, following adenovirus infection

    Nafiseh Chalabi Hagkarim, Philip Byrd, Neil Shimwell, Angelo Agathanggelou, Grant Stewart & Roger Grand, 28 Mar 2018, In: Journal of virology. 24 p., JVI.02034-17.

    Research output: Contribution to journal › Article › peer-review

  11. Published

    BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia

    Angelo Agathanggelou, Victoria Weston, Eva Petermann, Anastasia Zlatanou, Ceri Oldreive, Wenbin Wei, Grant Stewart, Emma Smith, Pamela Kearns & Tatjana Stankovic, Jul 2013, In: Blood Cancer Journal. 3, 7, e126.

    Research output: Contribution to journal › Article › peer-review

  12. Published

    Involvement of the RASSF1A tumor suppressor gene in controlling cell migration

    Ashraf Dallol, Angelo Agathanggelou, Eamonn Maher & Farida Latif, 1 Jan 2005, In: Cancer Research. 65, 17, p. 7653-7659 7 p.

    Research output: Contribution to journal › Article

  13. Published

    Depletion of the Ras association domain family 1, isoform A-associated novel mitochondrial associated protein, C19)RF5/MAP1S, causes mitotic abnormalities

    Ashraf Dallol, Wendy Cooper, Angelo Agathanggelou, Eamonn Maher & Farida Latif, 15 Jan 2007, In: Cancer Research. 67, 2, p. 492-500 9 p.

    Research output: Contribution to journal › Article

  14. Published

    RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics

    Ashraf Dallol, Angelo Agathanggelou, Sarah Fenton, Jalal Ahmed-Choudhury, Luke Hesson, Eamonn Maher & Farida Latif, 1 Jan 2004, In: Cancer Research. 64, 12, p. 4112-4116 5 p.

    Research output: Contribution to journal › Article

  15. Published

    Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts

    Nick Davies, Marwan Cheng Kuang Kwok, Ceri Oldreive, Helen Parry, Angelo Agathanggelou, Dickens Pratt, Malcolm Taylor, Paul Moss & Tatjana Stankovic, 26 Apr 2017, In: OncoTarget. 8, 27, p. 44749-44760

    Research output: Contribution to journal › Article › peer-review

  16. Published

    Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppresor gene

    Sarah Fenton, Ashraf Dallol, Angelo Agathanggelou, Luke Hesson, Jalal Ahmed-Choudhury, Eamonn Maher & Farida Latif, 1 Jan 2004, In: Cancer Research. 64, 1, p. 102-107 6 p.

    Research output: Contribution to journal › Article

  17. Published

    CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis and cytokine secretion

    Neil Gallagher, Aris Eliopoulos, Angelo Agathanggelou & Lawrence Young, 1 Apr 2002, In: Molecular Pathology. 55, 2, p. 110-120 11 p.

    Research output: Contribution to journal › Article

  18. Published

    Induction of a CD8(+) T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia

    Oliver Goodyear, Angelo Agathanggelou, Igor Novitzky Basso, Gordon Ryan, Tatjana Stankovic, Paul Moss & Charles Craddock, 1 Sep 2010, In: Blood. 116, 11, p. 1908-1918 11 p.

    Research output: Contribution to journal › Article

  19. Published

    Frequent 3p allele loss and epigenetic inactivation of RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma

    Richard Hogg, Angelo Agathanggelou, Ashraf Dallol, Paul Fullwood, Michael Kuo, Eamonn Maher & Farida Latif, 1 Aug 2002, In: European Journal of Cancer. 38, 12, p. 1585-1592 8 p.

    Research output: Contribution to journal › Article

  20. Published

    Identification of a single nucleotide polymorphism in the human Alpha 2 Delta 2 calcium channel subunit gene

    Donia MaCartney, Angelo Agathanggelou & Farida Latif, 1 Dec 2001, In: Molecular and Cellular Probes. 15, 6, p. 391-393 3 p.

    Research output: Contribution to journal › Article

  21. Published

    Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients

    Angelo Agathanggelou, Eamonn Maher & Farida Latif, 9 Jan 2003, In: Oncogene. 22, 1, p. 147-150 4 p.

    Research output: Contribution to journal › Article

  22. Published

    Non-Hodgkin's lymphoma, coeliac disease, and Epstein-Barr virus: a study of 13 cases of enteropathy-associated T- and B-cell lymphoma

    Gerald Niedobitek, Angelo Agathanggelou, Andrew Read, Rosemary Tierney, Lawrence Young, Oct 1995, In: Journal of Pathology. 177, 2, p. 115-22 8 p.

    Research output: Contribution to journal › Article › peer-review

  23. Published

    ATR Inhibition Exacerbates Replication Stress in TP53 or ATM Deficient CLL Cells and Enhances Sensitivity to Chemotherapy and Targeted Therapy

    Marwan Cheng Kuang Kwok, Nick Davies, Angelo Agathanggelou, Eva Petermann & Tatjana Stankovic, 6 Dec 2014, Blood. Vol. 124. p. 3340 (Blood).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  24. Published

    ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 or ATM defective chronic lymphocytic leukemia cells

    Marwan Cheng Kuang Kwok, Nick Davies, Angelo Agathanggelou, Ceri Oldreive, Eva Petermann, Grant Stewart, Dickens Pratt, Helen Parry, Malcolm Taylor, Paul Moss & Tatjana Stankovic, 4 Feb 2016, In: Blood. 127, 5, p. 582-595

    Research output: Contribution to journal › Article › peer-review

  25. Published

    Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL: natural history and mechanism of spontaneous CLL regression

    Marwan Cheng Kuang Kwok, Ceri Oldreive, Anshita Goel, Grigorios Papatzikas, Samantha Drennan, Angelo Agathanggelou, Archana Sharma-Oates, Robert Hollows, Nick Davies, Helen Parry, Andrew Beggs & 10 others, , Malcolm Taylor, Jean-Baptiste Cazier, Paul Moss & Tatjana Stankovic, 6 Feb 2020, In: Blood. 135, 6, p. 411-428 18 p.

    Research output: Contribution to journal › Article › peer-review

  26. Published

    Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway

    Marwan Cheng Kuang Kwok, Nick Davies, Angelo Agathanggelou, Eva Petermann & Tatjana Stankovic, 26 Feb 2015, In: The Lancet. 385 Suppl 1, p. S58

    Research output: Contribution to journal › Abstract › peer-review

  27. Published

    Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia

    Ruth Roberts & 4 others, Tatjana Stankovic, John Fossey & Angelo Agathanggelou, 1 Aug 2019, In: Medchemcomm. 10, 8, p. 1379-1390 12 p.

    Research output: Contribution to journal › Article › peer-review

  28. Published

    Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response.

    Victoria Weston, Esther Maina, Carmel McConville, Angelo Agathanggelou, Anna Skowronska, Judy Powell, Pamela Kearns, Francesco Falciani, Malcolm Taylor & Tatjana Stankovic, 1 Jan 2009, In: Blood. 113, 1, p. 117-26 10 p.

    Research output: Contribution to journal › Article › peer-review

  29. Published

    Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma.

    Malgosia Zatyka, Angelo Agathanggelou, Dewi Astuti, Neil Morgan, Frances Richards, Farida Latif & Eamonn Maher, 1 Oct 2001, In: Cancer Research. 61, 19, p. 7277-81 5 p.

    Research output: Contribution to journal › Article

  30. Published

    Frequent epigenetic inactivation of the RASSF1A tumor suppresor gene in Hodgkin's lymphoma

    Paul Murray, Angelo Agathanggelou, Farida Latif, Richard Grundy, Lawrence Young, 1 Jan 2004, In: Oncogene. 23, 6, p. 1326-1331 6 p.

    Research output: Contribution to journal › Article

  31. Published

    Latent Epstein-Barr virus infection in cottontop tamarins. A possible model for Epstein-Barr virus infection in humans

    Gerald Niedobitek, Angelo Agathanggelou, Rosemary Tierney, Peter Watkins, Andrea Morgan, Lawrence Young, Oct 1994, In: The American Journal of Pathology. 145, 4, p. 969-78 10 p.

    Research output: Contribution to journal › Article › peer-review

  32. Published

    T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice

    Ceri Oldreive, Nick Davies, Helen Parry, Angelo Agathanggelou, Laura Cronin, Katerina Vrzalikova, Elena Odintsova, Dickens Pratt, Malcolm Taylor, Paul Moss & Tatjana Stankovic, 28 Oct 2015, In: Disease Models and Mechanisms. 8, p. 1401-1412 12 p.

    Research output: Contribution to journal › Article › peer-review

  33. Published

    Aniline-containing derivatives of parthenolide: Synthesis and anti-chronic lymphocytic leukaemia activity

    Tatjana Stankovic, Angelo Agathanggelou & John Fossey, 27 Nov 2020, In: Tetrahedron. 76, 48, 131631.

    Research output: Contribution to journal › Article › peer-review

  34. Published

    Synthetic Lethality In CLL With DNA Damage Response Defect By Targeting ATR Pathway

    Tatjana Stankovic, Nick Davies, Marwan Cheng Kuang Kwok, Angelo Agathanggelou, 15 Nov 2013, Blood. Vol. 122. p. 120 (Blood).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  35. Published

    CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

    Angelo Agathanggelou, Paul Moss & 4 others, , Tatjana Stankovic, 4 Jul 2018, In: Nature. 559, 7713, p. 285-289 5 p.

    Research output: Contribution to journal › Article › peer-review

  36. Published

    USP7 is essential for maintaining Rad18 stability and DNA damage tolerance

    Anastasia Zlatanou, Grant Stewart, Angelo Agathanggelou, Tatjana Stankovic, 2015, In: Oncogene.

    Research output: Contribution to journal › Article › peer-review