Andrew Bell

Colleges, School and Institutes

Research interests

Dr Andrew Bell is a Research Fellow in the Institute of Cancer and Genomics. His research aims to understand how Epstein-Barr virus, a common herpesvirus with oncogenic properties, contributes to the development of several human malignancies. This work is funded by Cancer Research UK and involves collaborations with other members of the Centre for Human Virology.

EBV infection in healthy individuals

EBV establishes a persistent asymptomatic infection in the B cell system. I am interested in understanding how EBV exploits the natural process of B cell differentiation to gain access to the long-lived memory B cell pool while evading the host immune system.

EBV-driven B cell transformation

A clue to EBV’s role in lymphoma development comes from the observation that EBV can transform normal B lymphocytes in vitro into continuously growing lymphoblastoid cells. My work aims to understand how different viral genes contribute to this growth transformation process and identify virus-induced cellular changes that might be relevant to EBV-associated diseases.

EBV-associated B cell lymphomas

EBV is linked to a remarkable range of malignancies of B cell and epithelial cell origin. I am particularly interested in how EBV contributes to the development of four B cell lymphomas: post- transplant lymphoproliferative disease, diffuse large B cell lymphoma, Hodgkin lymphoma and Burkitt lymphoma.

Education/Academic qualification

  • PhD Biochemistry

  • BSc (Hons) Biochemistry

Willingness to take PhD students

Yes

PhD projects

Andrew Bell is a member of a research team interested in the biology of EBV and its role in lymphomagenesis. His work addresses the following areas:

EBV persistence in normal healthy individuals
The effects of EBV infection on cellular phenotype
Virus gene expression in different cell types
The role of EBV in lymphomagenesis

Dr Bell supervises a number of PhD researchers studying the biology of Epstein Barr virus (EBV) and the pathogenesis of EBV-associated lymphomas

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