Alex Conner

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Publications

  1. 2018
  2. Published

    Aquaporins and Their Regulation after Spinal Cord Injury

    Halsey, A. M., Alex Conner, Bill, R. M., Ann Logan & Zubair Ahmed, 18 Oct 2018, In : Cells. 7, 10, 174.

    Research output: Contribution to journal › Review article

  3. 2017
  4. E-pub ahead of print

    Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

    Mike Woolley, Reynolds, C. A., Simms, J., Walker, C. S., Mobarec, J. C., Garelja, M. L., Alex Conner, Poyner, D. R. & Hay, D. L., 11 Jul 2017, In : Biochemical Pharmacology.

    Research output: Contribution to journal › Article

  5. E-pub ahead of print

    Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach

    Mike Woolley, Simms, J., Mobarec, J. C., Reynolds, C. A., Poyner, D. R. & Alex Conner, 30 May 2017, In : Molecular and Cellular Endocrinology.

    Research output: Contribution to journal › Article

  6. 2016
  7. E-pub ahead of print

    Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family

    Mike Woolley & Alex Conner, 27 Nov 2016, In : Molecular and Cellular Endocrinology.

    Research output: Contribution to journal › Article

  8. Published

    Structural Determinants of Oligomerization of the Aquaporin-4 Channel

    Philip Kitchen, Matthew Conner, Bill, R. M. & Alex Conner, 25 Mar 2016, In : Journal of Biological Chemistry. 291, 13, p. 6858-6871 14 p.

    Research output: Contribution to journal › Article

  9. E-pub ahead of print

    Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties

    Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M., Pardamwar, M., McElhinney, J. M. W. R., Lathbridge, A., Constantine, A., Harris, P. W. R., Yuen, T-Y., Brimble, M. A., Barwell, J., Poyner, D. R., Mike Woolley, Alex Conner, Pioszak, A. A., Reynolds, C. A. & Hay, D. L., 24 Mar 2016, In : Journal of Biological Chemistry.

    Research output: Contribution to journal › Article

  10. 2015
  11. Published

    Beyond water homeostasis: diverse functional roles of mammalian aquaporins

    Philip Kitchen, Day, R. E., Salman, M. M., Matthew Conner, Bill, R. M. & Alex Conner, Dec 2015, In : Biochimica et Biophysica Acta (BBA) - General Subjects. 1850, 12, p. 2410-2421

    Research output: Contribution to journal › Article

  12. Published

    Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways

    Philip Kitchen, Öberg, F., Sjöhamn, J., Hedfalk, K., Bill, R. M., Alex Conner, Matthew Conner & Törnroth-Horsefield, S., 2015, In : PLoS ONE. 10, 11, p. e0143027

    Research output: Contribution to journal › Article

  13. 2014
  14. Published

    Human aquaporins : regulators of transcellular water flow

    Day, R. E., Kitchen, P., Owen, D. S., Bland, C., Marshall, L., Alex Conner, Bill, R. M. & Conner, M. T., 1 May 2014, In : Biochimica et Biophysica Acta (BBA) - General Subjects. 1840, 5, p. 1492-1506

    Research output: Contribution to journal › Article

  15. 2010
  16. Published

    Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin.

    Brown, JE., Alex Conner, Digby, JE., Ward, KL., Ramanjaneya, M., Randeva, HS. & Dunmore, SJ., 1 May 2010, In : Peptides. 31, 5, p. 944-9 6 p.

    Research output: Contribution to journal › Article

  17. Published

    Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells.

    Brown, JE., Onyango, DJ., Ramanjaneya, M., Alex Conner, Patel, ST., Dunmore, SJ. & Randeva, HS., 1 Mar 2010, In : Journal of Molecular Endocrinology. 44, 3, p. 171-8 8 p.

    Research output: Contribution to journal › Article

  18. Published

    Membrane trafficking of aquaporin 1 is mediated by protein kinase C via microtubules and regulated by tonicity.

    Matthew Conner, Alex Conner, Brown, JE. & Bill, RM., 9 Feb 2010, In : Biochemistry. 49, 5, p. 821-3 3 p.

    Research output: Contribution to journal › Article

  19. 2008
  20. Published

    Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR

    Conner, M., Hicks, MR., Tim Dafforn, Tim Knowles, Christian Ludwig, Staddon, S., Michael Overduin, Ulrich Gunther, Thome, J., Mark Wheatley, Poyner, DR. & Alex Conner, 12 Aug 2008, In : Biochemistry. 47, 32, p. 8434-44 11 p.

    Research output: Contribution to journal › Article

  21. 2006
  22. Published

    Diverse funtional motifs within the three intracellular loops of the CGRPI receptor

    Alex Conner, Simms, J., Matthew Conner, Wootten, DL., Mark Wheatley & Poyner, DR., 31 Oct 2006, In : Biochemistry. 45, p. 12976-12985 10 p.

    Research output: Contribution to journal › Article

  23. Published

    The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression

    Alex Conner, Simms, J., Howitt, SG., Mark Wheatley & Poyner, DR., 20 Jan 2006, In : Journal of Biological Chemistry. 281, 3, p. 1644-1651 8 p.

    Research output: Contribution to journal › Article

  24. Published

    Binding and activation of the CGRP1 receptor: a Family B GPCR heteromer

    Alex Conner, Simms, J., Mark Wheatley & Poyner, DR., 1 Jan 2006.

    Research output: Contribution to conference (unpublished) › Paper

  25. Published

    Definition of residues within the second extracellular loop of the cl receptor required for receptor activaton by CGRP

    Alex Conner, Simms, J., Ioannidou, A., Mark Wheatley & Poyner, DR., 1 Jan 2006.

    Research output: Contribution to conference (unpublished) › Paper

  26. 2005
  27. Published

    A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors

    Alex Conner, Hay, DL., Simms, J., Howitt, SG., Schindler, M., Smith, DM., Mark Wheatley & Poyner, DR., 1 Jan 2005, In : Molecular Pharmacology. 67, 1, p. 20-31 12 p.

    Research output: Contribution to journal › Article

  28. Published

    An histidine within the second intracellular loop of CL receptor is required for the formation of an active CGRP-receptor

    Alex Conner, Simms, J., Howitt, E., Mark Wheatley & Poyner, DR., 1 Jan 2005.

    Research output: Contribution to conference (unpublished) › Paper

  29. Published

    Characterisation of a C-terminal deletion mutant of the calcitonin receptor-like receptor

    Staddon, S., Mark Wheatley, Poyner, DR. & Alex Conner, 1 Jan 2005.

    Research output: Contribution to conference (unpublished) › Paper

  30. Published

    Determinants of RAMP1 needed to induce high affinity binding for CGRP in calcitonin receptor-like receptor

    Simms, J., Hay, DL., Alex Conner, Mark Wheatley & Poyner, DR., 1 Jan 2005.

    Research output: Contribution to conference (unpublished) › Paper

  31. Published

    Multiple residues within the second extracellular loop of the CL receptor are required for receptor activation by CGRP

    Alex Conner, Simms, J., Howitt, SG., Mark Wheatley & Poyner, DR., 1 Jan 2005.

    Research output: Contribution to conference (unpublished) › Paper

  32. 2004
  33. Published

    Heterodimers and Family B GPCRs, CGRP and adrenomedullin

    Alex Conner, Simms, JH., Hay, DL., Mahmoud, K., Mark Wheatley & Poyner, DR., 1 Jan 2004, In : Biochemical Society Transactions. 32, p. 843-846 4 p.

    Research output: Contribution to journal › Article

  34. Published

    Heterodimers and family B GPCRS; RAMPs, CGRP and adrenomedullin

    Alex Conner, Simms, J., Howitt, SG., Mahmoud, K., Hay, DL., Mark Wheatley & Poyner, DR., 1 Jan 2004.

    Research output: Contribution to conference (unpublished) › Abstract

  35. Published

    the effect on CGRP-affinity and signalling of mutations to proline residues within the transmembrane regions of human calcitonin receptor-like receptor (CL)

    Alex Conner, Hay, DL., Simms, J., Howitt, SG., Mark Wheatley, Smith, DM. & Poyner, DR., 1 Jan 2004, In : CGRP Meeting, Zurich, Switzerland.

    Research output: Contribution to journal › Abstract

  36. 2003
  37. Published

    CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS.

    Hay, DL., Howitt, SG., Alex Conner, Schindler, M., Smith, DM. & Poyner, DR., 1 Oct 2003, In : British Journal of Pharmacology. 140, 3, p. 477-86 10 p.

    Research output: Contribution to journal › Article

  38. Published

    The role of hydrophilic residues in transmembrane helix 2 of the CGRP1 receptor (CL/RAMP1) in signal transduction

    Alex Conner, Hay, DL., Howitt, SG., Smith, DM., Mark Wheatley & Poyner, DR., 1 Jan 2003, In : Pharmacol. Soc. Meeting, London.

    Research output: Contribution to journal › Abstract

  39. 2001
  40. Published

    The interaction of calcitonin-gene related peptide with its receptors

    Alex Conner, Hay, DL., Howitt, SG., Langel, U., Kilk, K., Mark Wheatley, Smith, DM. & Poyner, DR., 1 Aug 2001, In : Biochemical Society Transactions. 30, p. 451-455 5 p.

    Research output: Contribution to journal › Article

  41. Published

    The effect on CGRP-binding of mutations to the hydrophilic residues within the first transmembrane region of human calcitonin receptor-like receptor (CRLR)

    Alex Conner, Howitt, SG., Mark Wheatley, Smith, DM. & Poyner, DR., 1 Jan 2001.

    Research output: Contribution to conference (unpublished) › Paper

  42. Published

    The effect on CGRP-binding of mutations to the hydrophilic residues within the second transmembrane region of human calcitonin receptor-like receptor (CRLR)

    Alex Conner, Howitt, SG., Mark Wheatley, Smith, DM. & Poyner, DR., 1 Jan 2001.

    Research output: Contribution to conference (unpublished) › Paper