Alex Conner
Publications
- 2018
- Published
Aquaporins and Their Regulation after Spinal Cord Injury
Halsey, A. M., Alex Conner, Bill, R. M., Ann Logan & Zubair Ahmed, 18 Oct 2018, In : Cells. 7, 10, 174.Research output: Contribution to journal › Review article
- 2017
- E-pub ahead of print
Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs
Mike Woolley, Reynolds, C. A., Simms, J., Walker, C. S., Mobarec, J. C., Garelja, M. L., Alex Conner, Poyner, D. R. & Hay, D. L., 11 Jul 2017, In : Biochemical Pharmacology.Research output: Contribution to journal › Article
- E-pub ahead of print
Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach
Mike Woolley, Simms, J., Mobarec, J. C., Reynolds, C. A., Poyner, D. R. & Alex Conner, 30 May 2017, In : Molecular and Cellular Endocrinology.Research output: Contribution to journal › Article
- 2016
- E-pub ahead of print
Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family
Mike Woolley & Alex Conner, 27 Nov 2016, In : Molecular and Cellular Endocrinology.Research output: Contribution to journal › Article
- Published
Structural Determinants of Oligomerization of the Aquaporin-4 Channel
Philip Kitchen, Matthew Conner, Bill, R. M. & Alex Conner, 25 Mar 2016, In : Journal of Biological Chemistry. 291, 13, p. 6858-6871 14 p.Research output: Contribution to journal › Article
- E-pub ahead of print
Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties
Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M., Pardamwar, M., McElhinney, J. M. W. R., Lathbridge, A., Constantine, A., Harris, P. W. R., Yuen, T-Y., Brimble, M. A., Barwell, J., Poyner, D. R., Mike Woolley, Alex Conner, Pioszak, A. A., Reynolds, C. A. & Hay, D. L., 24 Mar 2016, In : Journal of Biological Chemistry.Research output: Contribution to journal › Article
- 2015
- Published
Beyond water homeostasis: diverse functional roles of mammalian aquaporins
Philip Kitchen, Day, R. E., Salman, M. M., Matthew Conner, Bill, R. M. & Alex Conner, Dec 2015, In : Biochimica et Biophysica Acta (BBA) - General Subjects. 1850, 12, p. 2410-2421Research output: Contribution to journal › Article
- Published
Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways
Philip Kitchen, Öberg, F., Sjöhamn, J., Hedfalk, K., Bill, R. M., Alex Conner, Matthew Conner & Törnroth-Horsefield, S., 2015, In : PLoS ONE. 10, 11, p. e0143027Research output: Contribution to journal › Article
- 2014
- Published
Human aquaporins : regulators of transcellular water flow
Day, R. E., Kitchen, P., Owen, D. S., Bland, C., Marshall, L., Alex Conner, Bill, R. M. & Conner, M. T., 1 May 2014, In : Biochimica et Biophysica Acta (BBA) - General Subjects. 1840, 5, p. 1492-1506Research output: Contribution to journal › Article
- 2010
- Published
Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin.
Brown, JE., Alex Conner, Digby, JE., Ward, KL., Ramanjaneya, M., Randeva, HS. & Dunmore, SJ., 1 May 2010, In : Peptides. 31, 5, p. 944-9 6 p.Research output: Contribution to journal › Article
- Published
Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells.
Brown, JE., Onyango, DJ., Ramanjaneya, M., Alex Conner, Patel, ST., Dunmore, SJ. & Randeva, HS., 1 Mar 2010, In : Journal of Molecular Endocrinology. 44, 3, p. 171-8 8 p.Research output: Contribution to journal › Article
- Published
Membrane trafficking of aquaporin 1 is mediated by protein kinase C via microtubules and regulated by tonicity.
Matthew Conner, Alex Conner, Brown, JE. & Bill, RM., 9 Feb 2010, In : Biochemistry. 49, 5, p. 821-3 3 p.Research output: Contribution to journal › Article
- 2008
- Published
Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR
Conner, M., Hicks, MR., Tim Dafforn, Tim Knowles, Christian Ludwig, Staddon, S., Michael Overduin, Ulrich Gunther, Thome, J., Mark Wheatley, Poyner, DR. & Alex Conner, 12 Aug 2008, In : Biochemistry. 47, 32, p. 8434-44 11 p.Research output: Contribution to journal › Article
- 2006
- Published
Diverse funtional motifs within the three intracellular loops of the CGRPI receptor
Alex Conner, Simms, J., Matthew Conner, Wootten, DL., Mark Wheatley & Poyner, DR., 31 Oct 2006, In : Biochemistry. 45, p. 12976-12985 10 p.Research output: Contribution to journal › Article
- Published
The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression
Alex Conner, Simms, J., Howitt, SG., Mark Wheatley & Poyner, DR., 20 Jan 2006, In : Journal of Biological Chemistry. 281, 3, p. 1644-1651 8 p.Research output: Contribution to journal › Article
- Published
Binding and activation of the CGRP1 receptor: a Family B GPCR heteromer
Alex Conner, Simms, J., Mark Wheatley & Poyner, DR., 1 Jan 2006.Research output: Contribution to conference (unpublished) › Paper
- Published
Definition of residues within the second extracellular loop of the cl receptor required for receptor activaton by CGRP
Alex Conner, Simms, J., Ioannidou, A., Mark Wheatley & Poyner, DR., 1 Jan 2006.Research output: Contribution to conference (unpublished) › Paper
- 2005
- Published
A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors
Alex Conner, Hay, DL., Simms, J., Howitt, SG., Schindler, M., Smith, DM., Mark Wheatley & Poyner, DR., 1 Jan 2005, In : Molecular Pharmacology. 67, 1, p. 20-31 12 p.Research output: Contribution to journal › Article
- Published
An histidine within the second intracellular loop of CL receptor is required for the formation of an active CGRP-receptor
Alex Conner, Simms, J., Howitt, E., Mark Wheatley & Poyner, DR., 1 Jan 2005.Research output: Contribution to conference (unpublished) › Paper
- Published
Characterisation of a C-terminal deletion mutant of the calcitonin receptor-like receptor
Staddon, S., Mark Wheatley, Poyner, DR. & Alex Conner, 1 Jan 2005.Research output: Contribution to conference (unpublished) › Paper
- Published
Determinants of RAMP1 needed to induce high affinity binding for CGRP in calcitonin receptor-like receptor
Simms, J., Hay, DL., Alex Conner, Mark Wheatley & Poyner, DR., 1 Jan 2005.Research output: Contribution to conference (unpublished) › Paper
- Published
Multiple residues within the second extracellular loop of the CL receptor are required for receptor activation by CGRP
Alex Conner, Simms, J., Howitt, SG., Mark Wheatley & Poyner, DR., 1 Jan 2005.Research output: Contribution to conference (unpublished) › Paper
- 2004
- Published
Heterodimers and Family B GPCRs, CGRP and adrenomedullin
Alex Conner, Simms, JH., Hay, DL., Mahmoud, K., Mark Wheatley & Poyner, DR., 1 Jan 2004, In : Biochemical Society Transactions. 32, p. 843-846 4 p.Research output: Contribution to journal › Article
- Published
Heterodimers and family B GPCRS; RAMPs, CGRP and adrenomedullin
Alex Conner, Simms, J., Howitt, SG., Mahmoud, K., Hay, DL., Mark Wheatley & Poyner, DR., 1 Jan 2004.Research output: Contribution to conference (unpublished) › Abstract
- Published
the effect on CGRP-affinity and signalling of mutations to proline residues within the transmembrane regions of human calcitonin receptor-like receptor (CL)
Alex Conner, Hay, DL., Simms, J., Howitt, SG., Mark Wheatley, Smith, DM. & Poyner, DR., 1 Jan 2004, In : CGRP Meeting, Zurich, Switzerland.Research output: Contribution to journal › Abstract
- 2003
- Published
CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS.
Hay, DL., Howitt, SG., Alex Conner, Schindler, M., Smith, DM. & Poyner, DR., 1 Oct 2003, In : British Journal of Pharmacology. 140, 3, p. 477-86 10 p.Research output: Contribution to journal › Article
- Published
The role of hydrophilic residues in transmembrane helix 2 of the CGRP1 receptor (CL/RAMP1) in signal transduction
Alex Conner, Hay, DL., Howitt, SG., Smith, DM., Mark Wheatley & Poyner, DR., 1 Jan 2003, In : Pharmacol. Soc. Meeting, London.Research output: Contribution to journal › Abstract
- 2001
- Published
The interaction of calcitonin-gene related peptide with its receptors
Alex Conner, Hay, DL., Howitt, SG., Langel, U., Kilk, K., Mark Wheatley, Smith, DM. & Poyner, DR., 1 Aug 2001, In : Biochemical Society Transactions. 30, p. 451-455 5 p.Research output: Contribution to journal › Article
- Published
The effect on CGRP-binding of mutations to the hydrophilic residues within the first transmembrane region of human calcitonin receptor-like receptor (CRLR)
Alex Conner, Howitt, SG., Mark Wheatley, Smith, DM. & Poyner, DR., 1 Jan 2001.Research output: Contribution to conference (unpublished) › Paper
- Published
The effect on CGRP-binding of mutations to the hydrophilic residues within the second transmembrane region of human calcitonin receptor-like receptor (CRLR)
Alex Conner, Howitt, SG., Mark Wheatley, Smith, DM. & Poyner, DR., 1 Jan 2001.Research output: Contribution to conference (unpublished) › Paper