Alex Conner

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Publications

  1. 2020
  2. Published

    Targeting aquaporin-4 subcellular localization as a novel approach to treat CNS edema

    Ann Logan, Zubair Ahmed, Alex Conner, 14 May 2020, In: Cell. 181, 4, p. 784-799.e19

    Research output: Contribution to journal › Article › peer-review

  3. 2018
  4. Published

    Aquaporins and Their Regulation after Spinal Cord Injury

    Alex Conner, Ann Logan & Zubair Ahmed, 18 Oct 2018, In: Cells. 7, 10, 174.

    Research output: Contribution to journal › Review article › peer-review

  5. 2017
  6. E-pub ahead of print

    Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

    Mike Woolley, Alex Conner, 11 Jul 2017, In: Biochemical Pharmacology.

    Research output: Contribution to journal › Article › peer-review

  7. E-pub ahead of print

    Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach

    Mike Woolley & Alex Conner, 30 May 2017, In: Molecular and Cellular Endocrinology.

    Research output: Contribution to journal › Article › peer-review

  8. 2016
  9. E-pub ahead of print

    Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family

    Mike Woolley & Alex Conner, 27 Nov 2016, In: Molecular and Cellular Endocrinology.

    Research output: Contribution to journal › Article › peer-review

  10. Published

    Structural Determinants of Oligomerization of the Aquaporin-4 Channel

    Philip Kitchen, Matthew Conner & Alex Conner, 25 Mar 2016, In: Journal of Biological Chemistry. 291, 13, p. 6858-6871 14 p.

    Research output: Contribution to journal › Article › peer-review

  11. E-pub ahead of print

    Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties

    Mike Woolley, Alex Conner, 24 Mar 2016, In: Journal of Biological Chemistry.

    Research output: Contribution to journal › Article › peer-review

  12. 2015
  13. Published

    Beyond water homeostasis: diverse functional roles of mammalian aquaporins

    Philip Kitchen, Matthew Conner & Alex Conner, Dec 2015, In: Biochimica et Biophysica Acta (BBA) - General Subjects. 1850, 12, p. 2410-2421

    Research output: Contribution to journal › Article › peer-review

  14. Published

    Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways

    Philip Kitchen, Alex Conner, Matthew Conner, 2015, In: PLoS ONE. 10, 11, p. e0143027

    Research output: Contribution to journal › Article › peer-review

  15. 2014
  16. Published

    Human aquaporins : regulators of transcellular water flow

    Alex Conner, 1 May 2014, In: Biochimica et Biophysica Acta (BBA) - General Subjects. 1840, 5, p. 1492-1506

    Research output: Contribution to journal › Article › peer-review

  17. 2010
  18. Published

    Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin.

    Alex Conner, 1 May 2010, In: Peptides. 31, 5, p. 944-9 6 p.

    Research output: Contribution to journal › Article

  19. Published

    Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells.

    Alex Conner, 1 Mar 2010, In: Journal of Molecular Endocrinology. 44, 3, p. 171-8 8 p.

    Research output: Contribution to journal › Article

  20. Published

    Membrane trafficking of aquaporin 1 is mediated by protein kinase C via microtubules and regulated by tonicity.

    Matthew Conner, Alex Conner, 9 Feb 2010, In: Biochemistry. 49, 5, p. 821-3 3 p.

    Research output: Contribution to journal › Article

  21. 2008
  22. Published

    Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR

    Tim Dafforn, Tim Knowles, Christian Ludwig, Michael Overduin, Ulrich Gunther, Mark Wheatley & Alex Conner, 12 Aug 2008, In: Biochemistry. 47, 32, p. 8434-44 11 p.

    Research output: Contribution to journal › Article

  23. 2006
  24. Published

    Diverse funtional motifs within the three intracellular loops of the CGRPI receptor

    Alex Conner, Matthew Conner, Mark Wheatley, 31 Oct 2006, In: Biochemistry. 45, p. 12976-12985 10 p.

    Research output: Contribution to journal › Article

  25. Published

    The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression

    Alex Conner, Mark Wheatley, 20 Jan 2006, In: Journal of Biological Chemistry. 281, 3, p. 1644-1651 8 p.

    Research output: Contribution to journal › Article

  26. Published

    Binding and activation of the CGRP1 receptor: a Family B GPCR heteromer

    Alex Conner, Mark Wheatley, 1 Jan 2006.

    Research output: Contribution to conference (unpublished) › Paper

  27. Published

    Definition of residues within the second extracellular loop of the cl receptor required for receptor activaton by CGRP

    Alex Conner, Mark Wheatley, 1 Jan 2006.

    Research output: Contribution to conference (unpublished) › Paper

  28. 2005
  29. Published

    A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors

    Alex Conner, Mark Wheatley, 1 Jan 2005, In: Molecular Pharmacology. 67, 1, p. 20-31 12 p.

    Research output: Contribution to journal › Article

  30. Published

    An histidine within the second intracellular loop of CL receptor is required for the formation of an active CGRP-receptor

    Alex Conner, Mark Wheatley, 1 Jan 2005.

    Research output: Contribution to conference (unpublished) › Paper

  31. Published

    Characterisation of a C-terminal deletion mutant of the calcitonin receptor-like receptor

    Mark Wheatley & Alex Conner, 1 Jan 2005.

    Research output: Contribution to conference (unpublished) › Paper

  32. Published

    Determinants of RAMP1 needed to induce high affinity binding for CGRP in calcitonin receptor-like receptor

    Alex Conner, Mark Wheatley, 1 Jan 2005.

    Research output: Contribution to conference (unpublished) › Paper

  33. Published

    Multiple residues within the second extracellular loop of the CL receptor are required for receptor activation by CGRP

    Alex Conner, Mark Wheatley, 1 Jan 2005.

    Research output: Contribution to conference (unpublished) › Paper

  34. 2004
  35. Published

    Heterodimers and Family B GPCRs, CGRP and adrenomedullin

    Alex Conner, Mark Wheatley, 1 Jan 2004, In: Biochemical Society Transactions. 32, p. 843-846 4 p.

    Research output: Contribution to journal › Article

  36. Published

    Heterodimers and family B GPCRS; RAMPs, CGRP and adrenomedullin

    Alex Conner, Mark Wheatley, 1 Jan 2004.

    Research output: Contribution to conference (unpublished) › Abstract

  37. Published

    the effect on CGRP-affinity and signalling of mutations to proline residues within the transmembrane regions of human calcitonin receptor-like receptor (CL)

    Alex Conner, Mark Wheatley, 1 Jan 2004, In: CGRP Meeting, Zurich, Switzerland.

    Research output: Contribution to journal › Abstract

  38. 2003
  39. Published

    CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS.

    Alex Conner, 1 Oct 2003, In: British Journal of Pharmacology. 140, 3, p. 477-86 10 p.

    Research output: Contribution to journal › Article

  40. Published

    The role of hydrophilic residues in transmembrane helix 2 of the CGRP1 receptor (CL/RAMP1) in signal transduction

    Alex Conner, Mark Wheatley, 1 Jan 2003, In: Pharmacol. Soc. Meeting, London.

    Research output: Contribution to journal › Abstract

  41. 2001
  42. Published

    The interaction of calcitonin-gene related peptide with its receptors

    Alex Conner, Mark Wheatley, 1 Aug 2001, In: Biochemical Society Transactions. 30, p. 451-455 5 p.

    Research output: Contribution to journal › Article

  43. Published

    The effect on CGRP-binding of mutations to the hydrophilic residues within the first transmembrane region of human calcitonin receptor-like receptor (CRLR)

    Alex Conner, Mark Wheatley, 1 Jan 2001.

    Research output: Contribution to conference (unpublished) › Paper

  44. Published

    The effect on CGRP-binding of mutations to the hydrophilic residues within the second transmembrane region of human calcitonin receptor-like receptor (CRLR)

    Alex Conner, Mark Wheatley, 1 Jan 2001.

    Research output: Contribution to conference (unpublished) › Paper