Microbiology and Infection

Organisational unit: School

Publications

  1. 1984
  2. Published

    Clostridium difficile enterotoxin (toxin A): new results

    John Stephen, , Timothy Mitchell, , David Candy, & , Apr 1984, In: Biochemical Society Transactions. 12, 2, p. 194-5 2 p.

    Research output: Contribution to journalArticle

  3. Published

    Production and release of toxins A and B by Clostridium difficile

    Timothy Mitchell, John Stephen, David Candy & , Dec 1984, In: Journal of Medical Microbiology. 18, 3, p. 385-91 7 p.

    Research output: Contribution to journalArticlepeer-review

  4. 1986
  5. Published

    Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

    Timothy Mitchell, , , John Stephen, , David Candy & , Jan 1986, In: Gut. 27, 1, p. 78-85 8 p.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Growth of Clostridium difficile and production of toxins A and B in complex and defined media

    Timothy Mitchell, John Stephen, & David Candy, Jun 1986, In: Journal of Medical Microbiology. 21, 4, p. 293-7 5 p.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Sporogenesis and toxin A production by Clostridium difficile

    Timothy Mitchell, , John Stephen, David Candy & , Aug 1986, In: Journal of Medical Microbiology. 22, 1, p. 33-8 6 p.

    Research output: Contribution to journalArticlepeer-review

  8. 1987
  9. Published

    Biological mode of action of Clostridium difficile toxin A: a novel enterotoxin

    Timothy Mitchell, , , David Candy & John Stephen, May 1987, In: Journal of Medical Microbiology. 23, 3, p. 211-9 9 p.

    Research output: Contribution to journalArticlepeer-review

  10. Published
  11. Published
  12. Published
  13. Published
  14. 1989
  15. Published

    Expression of the pneumolysin gene in Escherichia coli: rapid purification and biological properties

    Timothy Mitchell, , , & , 23 Jan 1989, In: Biochimica et Biophysica Acta. 1007, 1, p. 67-72 6 p.

    Research output: Contribution to journalArticlepeer-review

  16. Published

    Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity

    Timothy Mitchell, , & , Aug 1989, In: Infection and Immunity. 57, 8, p. 2547-52 6 p.

    Research output: Contribution to journalArticlepeer-review

  17. 1990
  18. Published

    Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2

    Timothy Mitchell, , , & , 11 Jul 1990, In: Nucleic Acids Research. 18, 13, p. 4010

    Research output: Contribution to journalArticlepeer-review

  19. Published

    The effect of Streptococcus pneumoniae pneumolysin on human respiratory epithelium in vitro

    Timothy Mitchell, , , , , & , Oct 1990, In: Microbial Pathogenesis. 9, 4, p. 275-84 10 p.

    Research output: Contribution to journalArticlepeer-review

  20. 1991
  21. Published
  22. Published
  23. Published
  24. Published
  25. Published

    Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pneumoniae

    Timothy Mitchell & , Nov 1991, In: Molecular Microbiology. 5, 11, p. 2611-6 6 p.

    Research output: Contribution to journalArticlepeer-review

  26. 1992
  27. Published

    The interaction of Streptococcus pneumoniae with intact human respiratory mucosa in vitro

    Timothy Mitchell, , & , May 1992, In: The European respiratory journal. 5, 5, p. 576-83 8 p.

    Research output: Contribution to journalArticlepeer-review

  28. Published

    Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo

    Timothy Mitchell, , , , & , Nov 1992, In: Infection and Immunity. 60, 11, p. 4969-72 4 p.

    Research output: Contribution to journalArticlepeer-review

  29. 1993
  30. Published
  31. Published

    Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins

    Timothy Mitchell, 1993, In: Annual Review of Microbiology. 47, p. 89-115 27 p.

    Research output: Contribution to journalArticlepeer-review

  32. Published
  33. Published

    Characterization of the solution properties and conformation of pneumolysin, the membrane-damaging toxin of Streptococcus pneumoniae

    Paul Morgan, , , & Timothy Mitchell, 15 Dec 1993, In: Biochemical Journal. 296 ( Pt 3), p. 671-4 4 p.

    Research output: Contribution to journalArticlepeer-review

  34. 1994
  35. Published

    Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis

    Timothy Mitchell, Feb 1994, In: Infection and Immunity. 62, 2, p. 757-8 2 p.

    Research output: Contribution to journalArticlepeer-review

  36. Published

    Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes

    Timothy Mitchell, Apr 1994, In: Infection and Immunity. 62, 4, p. 1501-3 3 p.

    Research output: Contribution to journalArticlepeer-review

  37. Published

    Characterisation of an oxidative response inhibitor produced by Streptococcus pneumoniae

    Timothy Mitchell, & , Jul 1994, In: Thorax. 49, 7, p. 676-83 8 p.

    Research output: Contribution to journalArticlepeer-review

  38. Published
  39. Published

    A role in cell-binding for the C-terminus of pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae

    Timothy Mitchell, 15 Aug 1994, In: FEMS Microbiology Letters. 121, 2, p. 217-21 5 p.

    Research output: Contribution to journalArticlepeer-review

  40. Published

    A neuraminidase from Streptococcus pneumoniae has the features of a surface protein

    Timothy Mitchell, Sep 1994, In: Infection and Immunity. 62, 9, p. 3688-95 8 p.

    Research output: Contribution to journalArticlepeer-review

  41. Published

    Pneumolysin activates phospholipase A in pulmonary artery endothelial cells

    Timothy Mitchell, & , Sep 1994, In: Infection and Immunity. 62, 9, p. 3829-36 8 p.

    Research output: Contribution to journalArticlepeer-review

  42. Published

    Modeling the bacterial protein toxin, pneumolysin, in its monomeric and oligomeric form

    Paul Morgan, , , , Timothy Mitchell & , 14 Oct 1994, In: Journal of Biological Chemistry. 269, 41, p. 25315-20 6 p.

    Research output: Contribution to journalArticlepeer-review

  43. Published
  44. 1995
  45. Published

    Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia

    Timothy Mitchell, & , Jan 1995, In: Journal of Clinical Investigation. 95, 1, p. 142-50 9 p.

    Research output: Contribution to journalArticlepeer-review

  46. Published
  47. Published

    Growth and virulence of a complement-activation-negative mutant of Streptococcus pneumoniae in the rabbit cornea

    Timothy Mitchell, Apr 1995, In: Current eye research. 14, 4, p. 281-4 4 p.

    Research output: Contribution to journalArticlepeer-review

  48. Published

    Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae

    Timothy Mitchell, , & , May 1995, In: Infection and Immunity. 63, 5, p. 1969-74 6 p.

    Research output: Contribution to journalArticlepeer-review

  49. Published
  50. Published

    Subunit organisation and symmetry of pore-forming, oligomeric pneumolysin

    Paul Morgan, , , Timothy Mitchell, & , 28 Aug 1995, In: FEBS Letters. 371, 1, p. 77-80 4 p.

    Research output: Contribution to journalArticlepeer-review

  51. 1996
  52. Published

    Functional analysis of pneumolysin by use of monoclonal antibodies

    Paul Morgan, & Timothy Mitchell, Feb 1996, In: Infection and Immunity. 64, 2, p. 480-4 5 p.

    Research output: Contribution to journalArticlepeer-review

  53. Published
  54. 1997
  55. Published

    Biological properties of pneumolysin

    Timothy Mitchell & , 1997, In: Microbial Drug Resistance. 3, 1, p. 19-26 8 p.

    Research output: Contribution to journalArticlepeer-review

  56. Published
  57. Published

    Relationship of structure to function in pneumolysin

    Timothy Mitchell & Paul Morgan, 1997, In: Microbial Drug Resistance. 3, 1, p. 11-7 7 p.

    Research output: Contribution to journalArticlepeer-review

  58. Published

    Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

    Timothy Mitchell, Mar 1997, In: Microbial Pathogenesis. 22, 3, p. 129-32 4 p.

    Research output: Contribution to journalArticlepeer-review

  59. Published

    Structural and functional analogy between pneumolysin and proaerolysin

    Timothy Mitchell, & Paul Morgan, Mar 1997, In: Protein Engineering. 10, 3, p. 207-15 9 p.

    Research output: Contribution to journalArticlepeer-review

  60. Published

    Structural and functional characterisation of two proteolytic fragments of the bacterial protein toxin, pneumolysin

    Paul Morgan, , , , , Timothy Mitchell, & , 4 Aug 1997, In: FEBS Letters. 412, 3, p. 563-7 5 p.

    Research output: Contribution to journalArticlepeer-review

  61. Published
  62. 1998
  63. Published

    The role of streptococcal toxins in disease

    Timothy Mitchell, 1998, In: Society for Applied Microbiology. Symposium Series. 27, p. 119S-124S

    Research output: Contribution to journalArticle

  64. Published
  65. Published

    Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia

    Timothy Mitchell, Mar 1998, In: Microbial Pathogenesis. 24, 3, p. 167-74 8 p.

    Research output: Contribution to journalArticlepeer-review

  66. Published

    Molecular basis of virulence

    Timothy Mitchell, Mar 1998, In: Archives of Disease in Childhood. 78, 3, p. 197-9; discussion 199-200

    Research output: Contribution to journalArticlepeer-review

  67. Published

    The CcmE protein from Escherichia coli is a haem-binding protein

    Eleanor Reid, Deborah J Eaves & Jeff Cole, 15 Sep 1998, In: FEMS Microbiology Letters. 166, 2, p. 369-75 7 p.

    Research output: Contribution to journalArticlepeer-review

  68. Published

    The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae

    Paul Morgan, Timothy Mitchell, , , , & , 27 Nov 1998, In: Journal of Molecular Biology. 284, 2, p. 449-61 13 p.

    Research output: Contribution to journalArticlepeer-review

  69. Published

    Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae

    Paul Morgan, Timothy Mitchell, , , & , 11 Dec 1998, In: Journal of Molecular Biology. 284, 4, p. 1223-37 15 p.

    Research output: Contribution to journalArticlepeer-review

  70. 1999
  71. Published

    The effect of the pneumococcal toxin, pneumolysin on brain ependymal cilia

    Timothy Mitchell, , & , Nov 1999, In: Microbial Pathogenesis. 27, 5, p. 303-9 7 p.

    Research output: Contribution to journalArticlepeer-review

  72. Published

    Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering

    Timothy Mitchell, , , , & , 12 Nov 1999, In: Journal of Molecular Biology. 293, 5, p. 1145-60 16 p.

    Research output: Contribution to journalArticlepeer-review

  73. 2000
  74. Published

    Host cellular immune response to pneumococcal lung infection in mice

    Timothy Mitchell & , Feb 2000, In: Infection and Immunity. 68, 2, p. 492-501 10 p.

    Research output: Contribution to journalArticlepeer-review

  75. Published

    Effect of pneumolysin on rat brain ciliary function: comparison of brain slices with cultured ependymal cells

    Timothy Mitchell & , Mar 2000, In: Pediatric Research. 47, 3, p. 381-4 4 p.

    Research output: Contribution to journalArticlepeer-review

  76. Published
  77. Published

    Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae

    Timothy Mitchell & , May 2000, In: Infection and Immunity. 68, 5, p. 2819-26 8 p.

    Research output: Contribution to journalArticlepeer-review

  78. Published
  79. Published

    Virulence factors and the pathogenesis of disease caused by Streptococcus pneumoniae

    Timothy Mitchell, 29 Aug 2000, In: Research in Microbiology. 151, 6, p. 413-9 7 p.

    Research output: Contribution to journalArticlepeer-review

  80. Published

    Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide

    Timothy Mitchell, , & , Sep 2000, In: Journal of Bacteriology. 182, 17, p. 4696-703 8 p.

    Research output: Contribution to journalArticlepeer-review

  81. Published

    Delta 32 deletion of CCR5 gene and association with asthma or atopy

    Timothy Mitchell, , , , , & , 28 Oct 2000, In: The Lancet. 356, 9240, p. 1491-2 2 p.

    Research output: Contribution to journalArticlepeer-review

  82. Published

    Autotransporter proteins, evolution and redefining protein secretion: response

    Ian Henderson, & , Dec 2000, In: Trends in Microbiology. 8, 12, p. 529-532 2 p.

    Research output: Contribution to journalArticlepeer-review

  83. Published

    Enteroaggregative escherichia coli virulence factors in traveler's diarrhea strains

    Ian Henderson, & , Dec 2000, In: The Journal of Infectious Diseases. 182, 6, p. 1780-3 4 p.

    Research output: Contribution to journalArticlepeer-review

  84. 2001
  85. Published
  86. Published

    Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo

    Timothy Mitchell & , 1 Jan 2001, In: FEMS Microbiology Letters. 194, 1, p. 105-10 6 p.

    Research output: Contribution to journalArticlepeer-review

  87. Published

    Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae

    Timothy Mitchell, & , Feb 2001, In: Infection and Immunity. 69, 2, p. 845-52 8 p.

    Research output: Contribution to journalArticlepeer-review

  88. Published

    Proinflammatory interactions of pneumolysin with human neutrophils

    Timothy Mitchell, & Andy Anderson, 15 Feb 2001, In: The Journal of Infectious Diseases. 183, 4, p. 604-11 8 p.

    Research output: Contribution to journalArticlepeer-review

  89. Published
  90. Published

    Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

    Timothy Mitchell, & Andy Anderson, May 2001, In: Infection and Immunity. 69, 5, p. 3494-6 3 p.

    Research output: Contribution to journalArticlepeer-review

  91. 2002
  92. Published

    The use of microarray technology for the analysis of Streptococcus pneumoniae

    Timothy Mitchell, 2002, In: Comp Funct. Genom. 3, 4, p. 366-8 3 p.

    Research output: Contribution to journalArticle

  93. Published

    Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis

    Timothy Mitchell, , & , Jan 2002, In: Journal of Clinical Investigation. 109, 1, p. 19-27 9 p.

    Research output: Contribution to journalArticlepeer-review

  94. Published

    Sensitivities of human monocytes and epithelial cells to pneumolysin are different

    Timothy Mitchell, & , Feb 2002, In: Infection and Immunity. 70, 2, p. 1017-22 6 p.

    Research output: Contribution to journalArticlepeer-review

  95. Published

    Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection

    Timothy Mitchell, Mar 2002, In: Infection and Immunity. 70, 3, p. 1547-57 11 p.

    Research output: Contribution to journalArticlepeer-review

  96. Published
  97. Published
  98. Published

    Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro

    Timothy Mitchell & , 15 Aug 2002, In: The Journal of Infectious Diseases. 186, 4, p. 562-5 4 p.

    Research output: Contribution to journalArticlepeer-review

  99. Published

    A novel dispersin protein in enteroaggregative Escherichia coli

    Ian Henderson, , , & , Nov 2002, In: Journal of Clinical Investigation. 110, 9, p. 1329-37 9 p.

    Research output: Contribution to journalArticlepeer-review

  100. Published
  101. 2003
  102. Published
  103. Published
  104. Published
  105. Published

    Contribution of a response regulator to the virulence of Streptococcus pneumoniae is strain dependent

    Clare Blue & Timothy Mitchell, Aug 2003, In: Infection and Immunity. 71, 8, p. 4405-13 9 p.

    Research output: Contribution to journalArticlepeer-review

  106. Published
  107. Published
  108. Published

    Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization

    Timothy Mitchell & , Oct 2003, In: Infection and Immunity. 71, 10, p. 5724-32 9 p.

    Research output: Contribution to journalArticlepeer-review

  109. Published
  110. Published
  111. Published

    The pathogenesis of streptococcal infections: from tooth decay to meningitis

    Timothy Mitchell, Dec 2003, In: Nature Reviews Microbiology. 1, 3, p. 219-30 12 p.

    Research output: Contribution to journalArticlepeer-review

  112. 2004
  113. Published

    The human-specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein

    Timothy Mitchell, , , , , , , & , 2004, In: Oral Microbiology and Immunology. 48, 9, p. 677-92 16 p.

    Research output: Contribution to journalArticlepeer-review

  114. Published

    The biology of Gram-positive sortase enzymes

    Timothy Mitchell, Feb 2004, In: Trends in Microbiology. 12, 2, p. 89-95 7 p.

    Research output: Contribution to journalArticlepeer-review

  115. Published
  116. Published
  117. Published
  118. Published
  119. Published

    Nitric oxide exerts distinct effects in local and systemic infections with Streptococcus pneumoniae

    Timothy Mitchell, Jun 2004, In: Microbial Pathogenesis. 36, 6, p. 303-10 8 p.

    Research output: Contribution to journalArticlepeer-review

Previous 1 2 3 4 5 6 7 8 ...12 Next