Metabolism and Systems Research

Organisational unit: School

Publications

  1. 2021
  2. E-pub ahead of print

    Impact of the new NICE guidance 2021 on management of early onset neonatal sepsis

    Andrew Ewer & , 11 Sep 2021, (E-pub ahead of print) In: Archives of disease in childhood. Fetal and neonatal edition.

    Research output: Contribution to journalLetterpeer-review

  3. Published
  4. Published
  5. Published

    Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

    Fiona Ashford, , David Hodson, Alejandra Tomas, , , , , , & , Sep 2021, In: Molecular metabolism. 51, 101242.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Prolyl-4-hydroxylase 3 maintains β-cell glucose metabolism during fatty acid excess in mice

    Daniela Nasteska, , Katrina Viloria, , Alpesh Thakker, , , , , , Gareth Lavery, Ildem Akerman, , , Daniel Tennant & David Hodson, 23 Aug 2021, In: JCI Insight. 6, 16, 21 p., e140288.

    Research output: Contribution to journalArticlepeer-review

  7. E-pub ahead of print
  8. Published

    Novel insights into the molecular regulation of ribonucleotide reductase in adrenocortical carcinoma treatment

    Cristina Ronchi, & , 20 Aug 2021, In: Cancers. 13, 16, 20 p., 4200.

    Research output: Contribution to journalArticlepeer-review

  9. E-pub ahead of print

    Fetal exome sequencing for isolated increased nuchal translucency: should we be doing it?

    Mark Kilby, , , , , , & , 19 Aug 2021, (E-pub ahead of print) In: BJOG: An International Journal of Obstetrics & Gynaecology.

    Research output: Contribution to journalArticlepeer-review

  10. E-pub ahead of print
  11. Accepted/In press
  12. Published
  13. E-pub ahead of print
  14. E-pub ahead of print
  15. Published

    Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

    David Hodson, , , , , Alejandra Tomas & , Aug 2021, In: Biochemical Pharmacology. 190, 12 p., 114656.

    Research output: Contribution to journalArticlepeer-review

  16. Published

    Heterogeneity of G-protein activation by the calcium-sensing receptor

    Caroline M Gorvin, Aug 2021, In: Journal of Molecular Endocrinology. 67, 2, p. 41-53 13 p.

    Research output: Contribution to journalArticlepeer-review

  17. E-pub ahead of print

    Review on marine sponge alkaloid, aaptamine: a potential antibacterial and anticancer drug

    Selvambigai Manivannan, , & , 31 Jul 2021, (E-pub ahead of print) In: Chem Biol Drug Design.

    Research output: Contribution to journalReview articlepeer-review

  18. Published
  19. Published

    The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell-lines

    Caroline M Gorvin, 26 Jul 2021, In: Journal of Molecular Endocrinology. 67, 3, p. 83-94 12 p.

    Research output: Contribution to journalArticlepeer-review

  20. Published

    Heads and tails: requirements for informative and robust computational measures of sperm motility

    Gemma Cupples, Meurig Thomas Gallagher, David Smith & Jackson Kirkman-Brown, 23 Jul 2021, XIIIth International Symposium on Spermatology. Björndahl, L., Flanagan, J., Holmberg, R. & Kvist, U. (eds.). Springer, Cham, p. 135-150

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  21. Published
  22. E-pub ahead of print
  23. Accepted/In press
  24. E-pub ahead of print
  25. Accepted/In press

    Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking

    David Hodson, , , , , , & , 12 Jul 2021, (Accepted/In press) In: Molecular Pharmacology.

    Research output: Contribution to journalArticlepeer-review

  26. E-pub ahead of print

    30-Day morbidity and mortality of bariatric metabolic surgery in adolescence during the COVID-19 pandemic - The GENEVA study

    Christian Ludwig, Abd Tahrani & , 8 Jul 2021, (E-pub ahead of print) In: Pediatric Obesity. e12832.

    Research output: Contribution to journalArticlepeer-review

  27. E-pub ahead of print

    SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells

    Julia Ast, , , , , , , David Hodson & , 2 Jul 2021, (E-pub ahead of print) In: Molecular metabolism. 53, 14 p., 101285.

    Research output: Contribution to journalArticlepeer-review

  28. Published
  29. Published

    The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging

    Janet Lord, Gareth Lavery & Leigh Breen, 1 Jul 2021, In: AJP: Cell Physiology. 321, 1, p. C26-C37 12 p.

    Research output: Contribution to journalArticlepeer-review

  30. Published
  31. Published
  32. Published
  33. Published

    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

    & 31 others, , , , , , , , , , , , , , , , , , Davide Calebiro, , , , , , , , , , , , & , 24 Jun 2021, In: Cell. 184, 13, p. 3502-3518.e33 51 p.

    Research output: Contribution to journalArticlepeer-review

  34. E-pub ahead of print

    Interim data monitoring in cluster randomised trials: practical issues and a case study

    Karla Hemming, James Martin, Ioannis Gallos, Arri Coomarasamy, Lee Middleton & , 22 Jun 2021, (E-pub ahead of print) In: Clinical Trials.

    Research output: Contribution to journalArticlepeer-review

  35. E-pub ahead of print

    Adaptation and use of media in an innovative simulation-based clinician training programme

    Eka Melson, , , , , , & Punith Kempegowda, 21 Jun 2021, (E-pub ahead of print) In: BMJ Simulation and Technology Enhanced Learning.

    Research output: Contribution to journalArticlepeer-review

  36. Published

    Angiography-based 4-dimensional superficial wall strain and stress: a new diagnostic tool in the catheterization laboratory

    Atif Shahzad, , , , , , , , , & , 18 Jun 2021, In: Frontiers in cardiovascular medicine. 8, 13 p., 667310.

    Research output: Contribution to journalReview articlepeer-review

  37. E-pub ahead of print

    Diagnosis and management of migraine in ten steps: consensus statement

    Alex Sinclair & 7 others, , , , , , & , 18 Jun 2021, (E-pub ahead of print) In: Nature Reviews Neurology.

    Research output: Contribution to journalReview articlepeer-review

  38. E-pub ahead of print
  39. Published

    The UPTAKE study: a cross-sectional survey examining the insights and beliefs of the UK population on COVID-19 vaccine uptake and hesitancy

    Anandadeep Mandal, , , , Paul Moss, & , 15 Jun 2021, In: British Medical Journal. 11, 6, p. 1-11 11 p., e048856.

    Research output: Contribution to journalArticlepeer-review

  40. E-pub ahead of print

    Loss of SDHB promotes dysregulated iron homeostasis, oxidative stress, and sensitivity to ascorbate

    Katarina Kluckova, , , , , Alpesh Thakker, , Jennie Roberts, , , , , Daniel Tennant & , 14 Jun 2021, (E-pub ahead of print) In: Cancer Research.

    Research output: Contribution to journalArticlepeer-review

  41. E-pub ahead of print

    Headache attributed to idiopathic intracranial hypertension (IIH) and persistent post-IIH headache: a narrative review

    Alex Sinclair, 9 Jun 2021, (E-pub ahead of print) In: Headache.

    Research output: Contribution to journalReview articlepeer-review

  42. Published
  43. Published
  44. Published

    Methods for managing miscarriage: a network meta-analysis

    Adam Devall, Hannah Jeffery, , , Malcolm Price, Aurelio Tobias Garces, , , , Arri Coomarasamy & Ioannis Gallos, 1 Jun 2021, In: Cochrane Database of Systematic Reviews. 2021, 6, 238 p., CD012602.

    Research output: Contribution to journalReview articlepeer-review

  45. Published

    Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis

    Shakila Thangaratinam, , , , & , Jun 2021, In: Lancet Global Health. 9, 6, p. e759-e772 14 p.

    Research output: Contribution to journalArticlepeer-review

  46. Published

    Maternal medicine in the COVID era

    Shakila Thangaratinam, Jun 2021, In: Best Practice & Research: Clinical Obstetrics & Gynaecology. 73, p. 113-124

    Research output: Contribution to journalReview articlepeer-review

  47. Published
  48. Published
  49. Published
  50. E-pub ahead of print

    Monitoring response to conventional treatment in children with XLH: value of ALP and Rickets Severity Score (RSS) in a real world setting

    Oct 2021, In: Bone. 151, 116025.

    Research output: Contribution to journalArticlepeer-review

  51. E-pub ahead of print

    Outcomes measures in idiopathic intracranial hypertension

    Alex Sinclair, 28 May 2021, (E-pub ahead of print) In: Expert Review of Neurotherapeutics.

    Research output: Contribution to journalArticlepeer-review

  52. Published
  53. Published

    Current perspectives on idiopathic intracranial hypertension without papilloedema

    Alex Sinclair & , 24 May 2021, In: Life. 11, 472.

    Research output: Contribution to journalReview articlepeer-review

  54. Published
  55. Published

    A sensitivity analysis of biophysiological responses of stress for wearable sensors in connected health

    Atif Shahzad, 21 May 2021, In: IEEE Access. 9, p. 93567-93579 13 p.

    Research output: Contribution to journalArticlepeer-review

  56. Accepted/In press

    Cerebrospinal fluid shunting protocol for Idiopathic Intracranial Hypertension improves revision rate

    Alex Sinclair, & , 21 May 2021, (Accepted/In press) In: Journal of Neurosurgery.

    Research output: Contribution to journalArticlepeer-review

  57. Published
  58. E-pub ahead of print

    WFS1 protein expression correlates with clinical progression of optic atrophy in patients with Wolfram syndrome

    Malgosia Zatyka, Dewi Astuti, , Renuka Dias, , , , , , & Timothy Barrett, 18 May 2021, (E-pub ahead of print) In: Journal of Medical Genetics.

    Research output: Contribution to journalArticlepeer-review

  59. Published

    Genetic causes of neonatal and infantile hypercalcaemia

    Caroline M Gorvin, 14 May 2021, In: Pediatric Nephrology.

    Research output: Contribution to journalReview articlepeer-review

  60. Published

    Steroid sulphatase and its inhibitors: past, present and future

    Paul Foster, 11 May 2021, In: Molecules. 26, 10, 21 p., 2852.

    Research output: Contribution to journalReview articlepeer-review

  61. E-pub ahead of print
  62. E-pub ahead of print

    Congenital adrenal hyperplasia – current insights in pathophysiology, diagnostics and management

    Wiebke Arlt & 1 others, , 7 May 2021, (E-pub ahead of print) In: Endocrine Reviews.

    Research output: Contribution to journalReview articlepeer-review

  63. Published
  64. E-pub ahead of print

    Identification and management of fetal anaemia: a practical guide

    Mark Kilby & R. Katie Morris, 3 May 2021, (E-pub ahead of print) In: The Obstetrician and Gynaecologist.

    Research output: Contribution to journalArticlepeer-review

  65. Published
  66. Published
  67. Published

    Miscarriage matters: the epidemiological, physical, psychological and economic burden of early pregnancy loss

    Ioannis Gallos & 5 others, , Adam Devall, , & Arri Coomarasamy, 1 May 2021, In: The Lancet. 397, p. 1658–1667

    Research output: Contribution to journalArticlepeer-review

  68. Published

    Recurrent miscarriage: evidence to accelerate action

    Arri Coomarasamy, Debra Bick, Raj Kaur & 5 others, Oonagh Pickering, , Adam Devall, Ioannis Gallos & , 1 May 2021, In: The Lancet. 397, 10285, p. 1675-1682 8 p.

    Research output: Contribution to journalArticlepeer-review

  69. Published

    The role of metabolism in migraine pathophysiology and susceptibility

    Daniel Fulton, Gareth Lavery & Alex Sinclair, 1 May 2021, In: Life: Physiology and Pathology. 11, 5, 415.

    Research output: Contribution to journalReview articlepeer-review

  70. Published
  71. Published
  72. Published

    Fetal ultrasound diagnosis allows effective early postnatal treatment of hematometrocolpos

    Andrew Ewer & , May 2021, In: Clinical Case Reports. 9, 5, 3 p., e04088.

    Research output: Contribution to journalArticlepeer-review

  73. Published
  74. Published

    Sporadic miscarriage: evidence to provide effective care

    Arri Coomarasamy, Ioannis Gallos, , , , , , , , , , , , , Adam Devall, , & , May 2021, In: The Lancet. 397, 10285, p. 1668-1674

    Research output: Contribution to journalArticlepeer-review

  75. Published
  76. Published

    Tocolytics for delaying preterm birth: a network meta-analysis

    Amie Wilson, Victoria Ann Morton, , , , , Arri Coomarasamy, , , , Malcolm Price, R. Katie Morris & Ioannis Gallos, 22 Apr 2021, In: Cochrane Database of Systematic Reviews. 2021, 4, 16 p., CD014978.

    Research output: Contribution to journalArticlepeer-review

  77. E-pub ahead of print

    The prenatal exome - a door to prenatal diagnostics?

    Mark Kilby, 20 Apr 2021, (E-pub ahead of print) In: Expert review of molecular diagnostics.

    Research output: Contribution to journalArticlepeer-review

  78. Published

    Progestogens for preventing miscarriage: a network meta-analysis (Review)

    Adam Devall, , , , Malcolm Price, Arri Coomarasamy & Ioannis Gallos, 19 Apr 2021, In: Cochrane Database of Systematic Reviews. 2021, 4, CD013792.

    Research output: Contribution to journalArticlepeer-review

  79. E-pub ahead of print

    Janus-faced EPHB4-associated disorders: novel pathogenic variants and unreported intrafamilial overlapping phenotypes

    & 11 others, , , , , Mark Kilby, , , , , & , 16 Apr 2021, (E-pub ahead of print) In: Genetics in Medicine.

    Research output: Contribution to journalArticlepeer-review

  80. Published
  81. Published

    Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene

    Ildem Akerman, , , , Sarah Flanagan, , , , , , & , 13 Apr 2021, In: Cell Reports. 35, 2, 108981.

    Research output: Contribution to journalArticlepeer-review

  82. Published

    Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China

    Mark Kilby & , 8 Apr 2021, In: BMC pregnancy and childbirth. 21, 279.

    Research output: Contribution to journalArticlepeer-review

  83. Published
  84. Published

    A feasibility study on microwave imaging of bone for osteoporosis monitoring

    Atif Shahzad, , , , & , Apr 2021, In: Medical & Biological Engineering & Computing. 59, 4, p. 925-936 12 p.

    Research output: Contribution to journalArticlepeer-review

  85. Published

    Effect of COVID-19 on the clinical course of diabetic ketoacidosis (DKA) in people with type 1 and type 2 diabetes

    Punith Kempegowda, Eka Melson, , , , , , , , , , Parth Narendran & , Apr 2021, In: Endocrine Connections. 10, 4, p. 371–377

    Research output: Contribution to journalArticlepeer-review

  86. Published

    Protein disulphide isomerase inhibition as a potential cancer therapeutic strategy

    Paul Foster, Apr 2021, In: Cancer Medicine. 10, 8, p. 2812-2825 14 p.

    Research output: Contribution to journalArticlepeer-review

  87. E-pub ahead of print

    Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtype

    David Hodson, , , , , & , 30 Mar 2021, (E-pub ahead of print) In: Cell Reports. 34, 13, 108904.

    Research output: Contribution to journalArticlepeer-review

  88. Published

    Depth perception on fundus images using a single-channel stereomicroscopy

    Edalat Radfar, , , & , 29 Mar 2021, In: Journal of Innovative Optical Health Sciences. 9 p., 2150012.

    Research output: Contribution to journalArticlepeer-review

  89. Published
  90. Published

    Migraine: disease characterisation, biomarkers, and precision medicine

    Alex Sinclair, , & , 25 Mar 2021, In: The Lancet.

    Research output: Contribution to journalArticlepeer-review

  91. Published
  92. Published
  93. E-pub ahead of print
  94. Published

    A review of biophysiological and biochemical indicators of stress for connected and preventive healthcare

    Atif Shahzad, 19 Mar 2021, In: Diagnostics. 11, 3, 30 p., 556.

    Research output: Contribution to journalArticlepeer-review

  95. Published

    Steroid sulfation in adrenal tumors

    Jonathan Wolf Mueller, , , , Cristina Ronchi, Paul Foster & , 19 Mar 2021, In: Journal of Clinical Endocrinology and Metabolism. 2021, 00, dgab182.

    Research output: Contribution to journalAbstractpeer-review

  96. Published

    Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calciumsensing receptor and adaptor protein-2

    Caroline M Gorvin, , , & , 17 Mar 2021, In: Human Molecular Genetics. 2021, 00, p. 1-36

    Research output: Contribution to journalArticlepeer-review

  97. E-pub ahead of print

    Epidemiology and mortality of Cushing’s syndrome

    Niki Karavitaki, 15 Mar 2021, (E-pub ahead of print) In: Best practice & research. Clinical endocrinology & metabolism. 101521.

    Research output: Contribution to journalArticlepeer-review

  98. Published

    Steroid disulfates - Sulfation double trouble Molecular and Cellular Endocrinology

    Jonathan Wolf Mueller, 15 Mar 2021, In: Molecular and Cellular Endocrinology. 524, 111161.

    Research output: Contribution to journalArticlepeer-review

  99. E-pub ahead of print
  100. E-pub ahead of print

    Vitamin D-binding protein/GC-globulin: a novel regulator of alpha cell function and glucagon secretion

    Katrina Viloria, Martin Hewison & David Hodson, 15 Mar 2021, (E-pub ahead of print) In: Journal of Physiology.

    Research output: Contribution to journalArticlepeer-review

  101. Published
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